Research case studies Explore a selection of reports that spotlight particular areas of research at the Crick over the past five years.
Postdoctoral clinical fellows Opportunities for postdoctoral clinicians to consolidate their research experience.
Breadcrumb Kate Bishop Bishop lab Retroviral Replication Laboratory : Publications Lab contentLab contentIn this section Overview Vacancies Areas of interest Publications Members Electron microscope image of mouse leukaemia virus-like particles containing a faulty p12 protein. Toggle to view hero caption PublicationsYear published2023 (1)2022 (1)2021 (2)2019 (1)2018 (1)2017 (1)2016 (1)2015 (2)2014 (2)2012 (2)2010 (2) Facet Year publishedResearch topicsBiochemistry & Proteomics (10)Cell Biology (10)Infectious Disease (10)Model Organisms (10)Structural Biology & Biophysics (8)Chemical Biology & High Throughput (5)Genetics & Genomics (5)Cell Cycle & Chromosomes (2)Computational & Systems Biology (2)Genome Integrity & Repair (2)Imaging (1)Metabolism (1)Signalling & Oncogenes (1)Tumour Biology (1) Facet Research topicsPublication typeJournal article (16) (-)Primary research (16) Facet Publication typeJournalPLOS Pathogens (5)Retrovirology (4)Proceedings of the National Academy of Sciences of the United States of America (2)Cell Host & Microbe (1)Journal of Virology (1)Nature (1)PLOS ONE (1)Scientific Reports (1) Facet Journal Publications Displaying 1 - 16 of 16Last updated : 29 March 2024 03:03 Attenuation of reverse transcriptase facilitates SAMHD1 restriction of HIV-1 in cycling cells Authors (9)Chloe TsaiSarah CaswellLiz Morris Melanie C Mann Simon PennellGeoff Kelly Harriet CT GroomIan TaylorKate Bishop Retrovirology Published 1 May 2023 Crick labs/ facilitiesIan TaylorSteve SmerdonKate BishopMRC Biomedical NMR CentreFull details SARS-CoV-2 ORF6 disrupts innate immune signalling by inhibiting cellular mRNA export Authors (7)Ross HallAnabel GuedanMelvyn YapGeorge Young Ruth HarveyJonathan StoyeKate Bishop PLOS Pathogens Published 25 August 2022 Crick labs/ facilitiesJonathan StoyeKate BishopWorldwide Influenza CentreBioinformatics and BiostatisticsAdvanced SequencingFull details HIV-1 requires capsid remodelling at the nuclear pore for nuclear entry and integration Authors (6)Anabel Guedan Callum D DonaldsonEve Caroe Ophélie CosnefroyIan TaylorKate Bishop PLOS Pathogens Published 20 September 2021 Crick labs/ facilitiesIan TaylorKate BishopLight MicroscopyFull details HIV-1 Gag recruits oligomeric Vpr via two binding sites in p6, but both mature p6 and Vpr are rapidly lost upon target cell entry Authors (2)Madushi WanaguruKate Bishop Journal of Virology Published 1 September 2021 Crick labsKate BishopFull details Positive selection in dNTPase SAMHD1 throughout mammalian evolution Authors (12) Christopher MonitLiz Morris Christopher RuisBart Szafran Grant ThiltgenChloe Tsai[...]Kate BishopJonathan StoyeIan Taylor Ariberto Fassati Richard A Goldstein Proceedings of the National Academy of Sciences of the United States of America Published 10 September 2019 Crick labsIan TaylorJonathan StoyeKate BishopFull details Murine leukemia virus p12 tethers the capsid-containing pre-integration complex to chromatin by binding directly to host nucleosomes in mitosis Authors (5)Madushi WanaguruDavid BarryDonald BentonNicola O'ReillyKate Bishop PLOS Pathogens Published 15 June 2018 Crick labs/ facilitiesSteve GamblinKate BishopLight MicroscopyStructural BiologyFull details SAMHD1 enhances nucleoside-analogue efficacy against HIV-1 in myeloid cells Authors (9)Paula Ordonez SuarezSimone Kunzelmann Harriet CT GroomMelvyn Yap Simon Weising Chris MeierKate BishopIan TaylorJonathan Stoye Scientific Reports Published 21 February 2017 Crick labs/ facilitiesIan TaylorJonathan StoyeKate BishopStructural BiologyFull details HIV-1 capsid uncoating initiates after the first strand transfer of reverse transcription Authors (3) Ophélie Cosnefroy Philip J MurrayKate Bishop Retrovirology Published 22 August 2016 Crick labsKate BishopFull details Phospho-dependent regulation of SAMHD1 oligomerisation couples catalysis and restriction Authors (15) Laurence H Arnold Harriet CT GroomSimone Kunzelmann David SchwefelSarah CaswellPaula Ordonez Suarez[...] Steven A HowellJonathan Stoye Michelle WebbIan TaylorKate Bishop PLOS Pathogens Published 2 October 2015 Crick labs/ facilitiesIan TaylorJonathan StoyeSteve SmerdonKate BishopStructural BiologyProteomicsFull details Molecular determinants for recognition of divergent SAMHD1 proteins by the lentiviral accessory protein Vpx Authors (7) David Schwefel Virginie C Boucherit Evangelos ChristodoulouPhilip WalkerJonathan StoyeKate BishopIan Taylor Cell Host & Microbe Published 8 April 2015 Crick labs/ facilitiesIan TaylorJonathan StoyeKate BishopStructural BiologyFull details Structural basis of lentiviral subversion of a cellular protein degradation pathway Authors (8) David Schwefel Harriet CT Groom Virginie C Boucherit Evangelos ChristodoulouPhilip WalkerJonathan StoyeKate BishopIan Taylor Nature Published 15 December 2014 Crick labs/ facilitiesIan TaylorJonathan StoyeKate BishopStructural BiologyFull details The N-terminus of murine leukaemia virus p12 protein is required for mature core stability Authors (9) Darren J Wight Virginie C Boucherit Madushi Wanaguru Efrat Elis Elizabeth MA Hirst Wilson Li Marcelo Ehrlich Eran BacharachKate Bishop PLOS Pathogens Published 1 October 2014 Crick labs/ facilitiesKate BishopElectron MicroscopyFull details No evidence for infection of UK prostate cancer patients with XMRV, BK virus, Trichomonas vaginalis or human papilloma viruses Authors (4) Harriet CT Groom Anne Y Warren David E NealKate Bishop PLOS ONE Published 1 January 2012 Crick labsKate BishopFull details The gammaretroviral p12 protein has multiple domains that function during the early stages of replication Authors (6) Darren J Wight Virginie C Boucherit Mirella Nader David J AllenIan TaylorKate Bishop Retrovirology Published 1 January 2012 Crick labsIan TaylorKate BishopFull details Susceptibility of xenotropic murine leukemia virus-related virus (XMRV) to retroviral restriction factors Authors (5) Harriet CT GroomMelvyn Yap Rui Pedro Galão Stuart JD NeilKate Bishop Proceedings of the National Academy of Sciences of the United States of America Published 16 March 2010 Crick labsKate BishopFull details Absence of xenotropic murine leukaemia virus-related virus in UK patients with chronic fatigue syndrome Authors (12) HCT Groom VC Boucherit K Makinson E Randal S Baptista S Hagan[...] FM Mattes J Breuer JR KerrJonathan StoyeKate Bishop Retrovirology Published 15 February 2010 Crick labsJonathan StoyeKate BishopFull details Share the page Share on Twitter Share on Facebook Share on LinkedIn Share on Email
Attenuation of reverse transcriptase facilitates SAMHD1 restriction of HIV-1 in cycling cells Authors (9)Chloe TsaiSarah CaswellLiz Morris Melanie C Mann Simon PennellGeoff Kelly Harriet CT GroomIan TaylorKate Bishop Retrovirology Published 1 May 2023 Crick labs/ facilitiesIan TaylorSteve SmerdonKate BishopMRC Biomedical NMR CentreFull details
SARS-CoV-2 ORF6 disrupts innate immune signalling by inhibiting cellular mRNA export Authors (7)Ross HallAnabel GuedanMelvyn YapGeorge Young Ruth HarveyJonathan StoyeKate Bishop PLOS Pathogens Published 25 August 2022 Crick labs/ facilitiesJonathan StoyeKate BishopWorldwide Influenza CentreBioinformatics and BiostatisticsAdvanced SequencingFull details
HIV-1 requires capsid remodelling at the nuclear pore for nuclear entry and integration Authors (6)Anabel Guedan Callum D DonaldsonEve Caroe Ophélie CosnefroyIan TaylorKate Bishop PLOS Pathogens Published 20 September 2021 Crick labs/ facilitiesIan TaylorKate BishopLight MicroscopyFull details
HIV-1 Gag recruits oligomeric Vpr via two binding sites in p6, but both mature p6 and Vpr are rapidly lost upon target cell entry Authors (2)Madushi WanaguruKate Bishop Journal of Virology Published 1 September 2021 Crick labsKate BishopFull details
Positive selection in dNTPase SAMHD1 throughout mammalian evolution Authors (12) Christopher MonitLiz Morris Christopher RuisBart Szafran Grant ThiltgenChloe Tsai[...]Kate BishopJonathan StoyeIan Taylor Ariberto Fassati Richard A Goldstein Proceedings of the National Academy of Sciences of the United States of America Published 10 September 2019 Crick labsIan TaylorJonathan StoyeKate BishopFull details
Murine leukemia virus p12 tethers the capsid-containing pre-integration complex to chromatin by binding directly to host nucleosomes in mitosis Authors (5)Madushi WanaguruDavid BarryDonald BentonNicola O'ReillyKate Bishop PLOS Pathogens Published 15 June 2018 Crick labs/ facilitiesSteve GamblinKate BishopLight MicroscopyStructural BiologyFull details
SAMHD1 enhances nucleoside-analogue efficacy against HIV-1 in myeloid cells Authors (9)Paula Ordonez SuarezSimone Kunzelmann Harriet CT GroomMelvyn Yap Simon Weising Chris MeierKate BishopIan TaylorJonathan Stoye Scientific Reports Published 21 February 2017 Crick labs/ facilitiesIan TaylorJonathan StoyeKate BishopStructural BiologyFull details
HIV-1 capsid uncoating initiates after the first strand transfer of reverse transcription Authors (3) Ophélie Cosnefroy Philip J MurrayKate Bishop Retrovirology Published 22 August 2016 Crick labsKate BishopFull details
Phospho-dependent regulation of SAMHD1 oligomerisation couples catalysis and restriction Authors (15) Laurence H Arnold Harriet CT GroomSimone Kunzelmann David SchwefelSarah CaswellPaula Ordonez Suarez[...] Steven A HowellJonathan Stoye Michelle WebbIan TaylorKate Bishop PLOS Pathogens Published 2 October 2015 Crick labs/ facilitiesIan TaylorJonathan StoyeSteve SmerdonKate BishopStructural BiologyProteomicsFull details
Molecular determinants for recognition of divergent SAMHD1 proteins by the lentiviral accessory protein Vpx Authors (7) David Schwefel Virginie C Boucherit Evangelos ChristodoulouPhilip WalkerJonathan StoyeKate BishopIan Taylor Cell Host & Microbe Published 8 April 2015 Crick labs/ facilitiesIan TaylorJonathan StoyeKate BishopStructural BiologyFull details
Structural basis of lentiviral subversion of a cellular protein degradation pathway Authors (8) David Schwefel Harriet CT Groom Virginie C Boucherit Evangelos ChristodoulouPhilip WalkerJonathan StoyeKate BishopIan Taylor Nature Published 15 December 2014 Crick labs/ facilitiesIan TaylorJonathan StoyeKate BishopStructural BiologyFull details
The N-terminus of murine leukaemia virus p12 protein is required for mature core stability Authors (9) Darren J Wight Virginie C Boucherit Madushi Wanaguru Efrat Elis Elizabeth MA Hirst Wilson Li Marcelo Ehrlich Eran BacharachKate Bishop PLOS Pathogens Published 1 October 2014 Crick labs/ facilitiesKate BishopElectron MicroscopyFull details
No evidence for infection of UK prostate cancer patients with XMRV, BK virus, Trichomonas vaginalis or human papilloma viruses Authors (4) Harriet CT Groom Anne Y Warren David E NealKate Bishop PLOS ONE Published 1 January 2012 Crick labsKate BishopFull details
The gammaretroviral p12 protein has multiple domains that function during the early stages of replication Authors (6) Darren J Wight Virginie C Boucherit Mirella Nader David J AllenIan TaylorKate Bishop Retrovirology Published 1 January 2012 Crick labsIan TaylorKate BishopFull details
Susceptibility of xenotropic murine leukemia virus-related virus (XMRV) to retroviral restriction factors Authors (5) Harriet CT GroomMelvyn Yap Rui Pedro Galão Stuart JD NeilKate Bishop Proceedings of the National Academy of Sciences of the United States of America Published 16 March 2010 Crick labsKate BishopFull details
Absence of xenotropic murine leukaemia virus-related virus in UK patients with chronic fatigue syndrome Authors (12) HCT Groom VC Boucherit K Makinson E Randal S Baptista S Hagan[...] FM Mattes J Breuer JR KerrJonathan StoyeKate Bishop Retrovirology Published 15 February 2010 Crick labsJonathan StoyeKate BishopFull details