Research case studies Explore a selection of reports that spotlight particular areas of research at the Crick over the past five years.
Postdoctoral clinical fellows Opportunities for postdoctoral clinicians to consolidate their research experience.
Breadcrumb Kate Bishop Bishop lab Retroviral Replication Laboratory : Publications Lab contentLab contentIn this section Overview Vacancies Areas of interest Publications Members Electron microscope image of mouse leukaemia virus-like particles containing a faulty p12 protein. Toggle to view hero caption PublicationsYear published2023 (1)2022 (1)2021 (4)2019 (1)2018 (2)2017 (1)2016 (1)2015 (2) Facet Year publishedResearch topicsBiochemistry & Proteomics (13)Cell Biology (13)Model Organisms (13)Structural Biology & Biophysics (9)Genetics & Genomics (6)Chemical Biology & High Throughput (5)Cell Cycle & Chromosomes (2)Computational & Systems Biology (2)Genome Integrity & Repair (2)Imaging (1)Metabolism (1)Signalling & Oncogenes (1)Tumour Biology (1) (-)Infectious Disease (13) Facet Research topicsPublication typeJournal article (13)Primary research (10)Commentary (1)Method (1)Review (1) Facet Publication typeJournalPLOS Pathogens (4)Retrovirology (2)Cell Host & Microbe (1)Journal of Virology (1)Journal of Visualized Experiments (1)Microbial Cell (1)Proceedings of the National Academy of Sciences of the United States of America (1)Scientific Reports (1)Viruses (1) Facet Journal Publications Displaying 1 - 13 of 13Last updated : 28 March 2024 03:53 Attenuation of reverse transcriptase facilitates SAMHD1 restriction of HIV-1 in cycling cells Authors (9)Chloe TsaiSarah CaswellLiz Morris Melanie C Mann Simon PennellGeoff Kelly Harriet CT GroomIan TaylorKate Bishop Retrovirology Published 1 May 2023 Crick labs/ facilitiesIan TaylorSteve SmerdonKate BishopMRC Biomedical NMR CentreFull details SARS-CoV-2 ORF6 disrupts innate immune signalling by inhibiting cellular mRNA export Authors (7)Ross HallAnabel GuedanMelvyn YapGeorge Young Ruth HarveyJonathan StoyeKate Bishop PLOS Pathogens Published 25 August 2022 Crick labs/ facilitiesJonathan StoyeKate BishopWorldwide Influenza CentreBioinformatics and BiostatisticsAdvanced SequencingFull details HIV-1 requires capsid remodelling at the nuclear pore for nuclear entry and integration Authors (6)Anabel Guedan Callum D DonaldsonEve Caroe Ophélie CosnefroyIan TaylorKate Bishop PLOS Pathogens Published 20 September 2021 Crick labs/ facilitiesIan TaylorKate BishopLight MicroscopyFull details The role of capsid in HIV-1 nuclear entry Authors (4)Anabel GuedanEve CaroeGenevieve BarrKate Bishop Viruses Published 1 August 2021 Crick labsKate BishopFull details Analysis of SAMHD1 restriction by flow cytometry in human myeloid U937 cells Authors (4)Paula Ordonez SuarezKate BishopJonathan Stoye Harriet Cordelia Theed Groom Journal of Visualized Experiments Published 13 June 2021 Crick labsJonathan StoyeKate BishopFull details HIV-1 Gag recruits oligomeric Vpr via two binding sites in p6, but both mature p6 and Vpr are rapidly lost upon target cell entry Authors (2)Madushi WanaguruKate Bishop Journal of Virology Published 1 September 2021 Crick labsKate BishopFull details Positive selection in dNTPase SAMHD1 throughout mammalian evolution Authors (12) Christopher MonitLiz Morris Christopher RuisBart Szafran Grant ThiltgenChloe Tsai[...]Kate BishopJonathan StoyeIan Taylor Ariberto Fassati Richard A Goldstein Proceedings of the National Academy of Sciences of the United States of America Published 10 September 2019 Crick labsIan TaylorJonathan StoyeKate BishopFull details Gammaretroviruses tether to mitotic chromatin by directly binding nucleosomal histone proteins Authors (2)Madushi WanaguruKate Bishop Microbial Cell Published 1 August 2018 Crick labsKate BishopFull details Murine leukemia virus p12 tethers the capsid-containing pre-integration complex to chromatin by binding directly to host nucleosomes in mitosis Authors (5)Madushi WanaguruDavid BarryDonald BentonNicola O'ReillyKate Bishop PLOS Pathogens Published 15 June 2018 Crick labs/ facilitiesSteve GamblinKate BishopLight MicroscopyStructural BiologyFull details SAMHD1 enhances nucleoside-analogue efficacy against HIV-1 in myeloid cells Authors (9)Paula Ordonez SuarezSimone Kunzelmann Harriet CT GroomMelvyn Yap Simon Weising Chris MeierKate BishopIan TaylorJonathan Stoye Scientific Reports Published 21 February 2017 Crick labs/ facilitiesIan TaylorJonathan StoyeKate BishopStructural BiologyFull details HIV-1 capsid uncoating initiates after the first strand transfer of reverse transcription Authors (3) Ophélie Cosnefroy Philip J MurrayKate Bishop Retrovirology Published 22 August 2016 Crick labsKate BishopFull details Phospho-dependent regulation of SAMHD1 oligomerisation couples catalysis and restriction Authors (15) Laurence H Arnold Harriet CT GroomSimone Kunzelmann David SchwefelSarah CaswellPaula Ordonez Suarez[...] Steven A HowellJonathan Stoye Michelle WebbIan TaylorKate Bishop PLOS Pathogens Published 2 October 2015 Crick labs/ facilitiesIan TaylorJonathan StoyeSteve SmerdonKate BishopStructural BiologyProteomicsFull details Molecular determinants for recognition of divergent SAMHD1 proteins by the lentiviral accessory protein Vpx Authors (7) David Schwefel Virginie C Boucherit Evangelos ChristodoulouPhilip WalkerJonathan StoyeKate BishopIan Taylor Cell Host & Microbe Published 8 April 2015 Crick labs/ facilitiesIan TaylorJonathan StoyeKate BishopStructural BiologyFull details Share the page Share on Twitter Share on Facebook Share on LinkedIn Share on Email
Attenuation of reverse transcriptase facilitates SAMHD1 restriction of HIV-1 in cycling cells Authors (9)Chloe TsaiSarah CaswellLiz Morris Melanie C Mann Simon PennellGeoff Kelly Harriet CT GroomIan TaylorKate Bishop Retrovirology Published 1 May 2023 Crick labs/ facilitiesIan TaylorSteve SmerdonKate BishopMRC Biomedical NMR CentreFull details
SARS-CoV-2 ORF6 disrupts innate immune signalling by inhibiting cellular mRNA export Authors (7)Ross HallAnabel GuedanMelvyn YapGeorge Young Ruth HarveyJonathan StoyeKate Bishop PLOS Pathogens Published 25 August 2022 Crick labs/ facilitiesJonathan StoyeKate BishopWorldwide Influenza CentreBioinformatics and BiostatisticsAdvanced SequencingFull details
HIV-1 requires capsid remodelling at the nuclear pore for nuclear entry and integration Authors (6)Anabel Guedan Callum D DonaldsonEve Caroe Ophélie CosnefroyIan TaylorKate Bishop PLOS Pathogens Published 20 September 2021 Crick labs/ facilitiesIan TaylorKate BishopLight MicroscopyFull details
The role of capsid in HIV-1 nuclear entry Authors (4)Anabel GuedanEve CaroeGenevieve BarrKate Bishop Viruses Published 1 August 2021 Crick labsKate BishopFull details
Analysis of SAMHD1 restriction by flow cytometry in human myeloid U937 cells Authors (4)Paula Ordonez SuarezKate BishopJonathan Stoye Harriet Cordelia Theed Groom Journal of Visualized Experiments Published 13 June 2021 Crick labsJonathan StoyeKate BishopFull details
HIV-1 Gag recruits oligomeric Vpr via two binding sites in p6, but both mature p6 and Vpr are rapidly lost upon target cell entry Authors (2)Madushi WanaguruKate Bishop Journal of Virology Published 1 September 2021 Crick labsKate BishopFull details
Positive selection in dNTPase SAMHD1 throughout mammalian evolution Authors (12) Christopher MonitLiz Morris Christopher RuisBart Szafran Grant ThiltgenChloe Tsai[...]Kate BishopJonathan StoyeIan Taylor Ariberto Fassati Richard A Goldstein Proceedings of the National Academy of Sciences of the United States of America Published 10 September 2019 Crick labsIan TaylorJonathan StoyeKate BishopFull details
Gammaretroviruses tether to mitotic chromatin by directly binding nucleosomal histone proteins Authors (2)Madushi WanaguruKate Bishop Microbial Cell Published 1 August 2018 Crick labsKate BishopFull details
Murine leukemia virus p12 tethers the capsid-containing pre-integration complex to chromatin by binding directly to host nucleosomes in mitosis Authors (5)Madushi WanaguruDavid BarryDonald BentonNicola O'ReillyKate Bishop PLOS Pathogens Published 15 June 2018 Crick labs/ facilitiesSteve GamblinKate BishopLight MicroscopyStructural BiologyFull details
SAMHD1 enhances nucleoside-analogue efficacy against HIV-1 in myeloid cells Authors (9)Paula Ordonez SuarezSimone Kunzelmann Harriet CT GroomMelvyn Yap Simon Weising Chris MeierKate BishopIan TaylorJonathan Stoye Scientific Reports Published 21 February 2017 Crick labs/ facilitiesIan TaylorJonathan StoyeKate BishopStructural BiologyFull details
HIV-1 capsid uncoating initiates after the first strand transfer of reverse transcription Authors (3) Ophélie Cosnefroy Philip J MurrayKate Bishop Retrovirology Published 22 August 2016 Crick labsKate BishopFull details
Phospho-dependent regulation of SAMHD1 oligomerisation couples catalysis and restriction Authors (15) Laurence H Arnold Harriet CT GroomSimone Kunzelmann David SchwefelSarah CaswellPaula Ordonez Suarez[...] Steven A HowellJonathan Stoye Michelle WebbIan TaylorKate Bishop PLOS Pathogens Published 2 October 2015 Crick labs/ facilitiesIan TaylorJonathan StoyeSteve SmerdonKate BishopStructural BiologyProteomicsFull details
Molecular determinants for recognition of divergent SAMHD1 proteins by the lentiviral accessory protein Vpx Authors (7) David Schwefel Virginie C Boucherit Evangelos ChristodoulouPhilip WalkerJonathan StoyeKate BishopIan Taylor Cell Host & Microbe Published 8 April 2015 Crick labs/ facilitiesIan TaylorJonathan StoyeKate BishopStructural BiologyFull details