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Breadcrumb Katrin Rittinger Rittinger lab Molecular Structure of Cell Signalling Laboratory : Publications Lab contentLab contentIn this section Overview Areas of interest Publications Members Vacancies Two different representations of tetra-ubiquitin - a molecular 'tag' used to mark proteins inside cells. Toggle to view hero caption PublicationsYear published2023 (4)2022 (2)2020 (2)2019 (3)2018 (5)2017 (2)2016 (5)2015 (1)2014 (2)2013 (1)2012 (5)2011 (1)2010 (4) Facet Year publishedResearch topicsBiochemistry & Proteomics (24)Chemical Biology & High Throughput (24)Immunology (24)Infectious Disease (24)Signalling & Oncogenes (24)Structural Biology & Biophysics (24)Computational & Systems Biology (4)Metabolism (2)Model Organisms (2)Tumour Biology (2)Cell Biology (1)Developmental Biology (1)Genetics & Genomics (1)Human Biology & Physiology (1)Imaging (1) Facet Research topicsPublication typeJournal article (37) (-)Primary research (37) Facet Publication typeJournalJournal of Biological Chemistry (4)EMBO Reports (3)PLOS ONE (3)Scientific Reports (3)Structure (3)ACS Chemical Biology (2)Biophysical Journal (2)Cell Reports (2)Nature (2)Nature Communications (2)Acta Crystallographica Section F (1)Cell Chemical Biology (1)Cell Reports Physical Science (1)EMBO Journal (1)FEBS Letters (1)Frontiers in Molecular Biosciences (1)Journal of Cell Science (1)Journal of the American Chemical Society (1)Life Science Alliance (1)RNA Biology (1)Science Signaling (1) Facet Journal Publications Displaying 1 - 20 of 37Last updated : 23 April 2024 02:44 A chemoproteomic platform for selective deubiquitinase inhibitor discovery Authors (12)Rosa Cookson Aini Vuorinen Jonathan PettingerCassandra KennedyJoanna Kirkpatrick Rachel E Peltier-Heap[...]Bram SnijdersMark Skehel David HouseKatrin Rittinger Jacob T Bush Cell Reports Physical Science Published 18 October 2023 Crick labs/ facilitiesKatrin RittingerProteomicsFull details Efficient ligand discovery using sulfur(VI) fluoride reactive fragments Authors (12) Arron Aatkar Aini Vuorinen Oliver E Longfield Katharine Gilbert Rachel Peltier-Heap Craig D Wagner[...]Katrin Rittinger Chun-Wa ChungDavid House Nicholas CO Tomkinson Jacob T Bush ACS Chemical Biology Published 15 September 2023 Crick labs/ facilitiesKatrin RittingerTranslation teamFull details Profiling sulfur(VI) fluorides as reactive functionalities for chemical biology tools and expansion of the ligandable proteome Authors (11) Katharine E Gilbert Aini Vuorinen Arron Aatkar Peter Pogány Jonathan Pettinger Emma K GrantJoanna KirkpatrickKatrin Rittinger David House Glenn A Burley Jacob T Bush ACS Chemical Biology Published 17 February 2023 Crick labs/ facilitiesKatrin RittingerProteomicsFull details Structural basis for ubiquitylation by HOIL-1 Authors (4) Qilong Wu Marios G KoliopoulosKatrin Rittinger Benjamin Stieglitz Frontiers in Molecular Biosciences Published 6 January 2023 Crick labs/ facilitiesKatrin RittingerStructural BiologyFull details Divergent self-association properties of paralogous proteins TRIM2 and TRIM3 regulate their E3 ligase activity Authors (4)Diego EspositoJane DudleyAcely Garza-GarciaKatrin Rittinger Nature Communications Published 8 December 2022 Crick labs/ facilitiesKatrin RittingerLuiz Pedro CarvalhoStructural BiologyMRC Biomedical NMR CentreFull details Characterisation of HOIP RBR E3 ligase conformational dynamics using integrative modelling Authors (4)Marius KausasDiego EspositoKatrin Rittinger Franca Fraternali Scientific Reports Published 8 September 2022 Crick labsKatrin RittingerFull details Structural dynamics in the La-module of La-related proteins Authors (4) Javier Lizarrondo Anne-Catherine Dock-BregeonLuigi Martino Maria R Conte RNA Biology Published 18 March 2020 Crick labs/ facilitiesKatrin RittingerStructural BiologyFull details The parkin-coregulated gene product PACRG promotes TNF signaling by stabilizing LUBAC Authors (18) Jens Meschede Maria Šadić Nikolas Furthmann Tim Miedema Dominik A Sehr A Kathrin Müller-Rischart[...] Fumiyo Ikeda Katrin Marcus Liliana Schaefer Jörg Tatzelt Konstanze F Winklhofer Science Signaling Published 4 February 2020 Crick labsKatrin RittingerFull details Single-domain antibodies as crystallization chaperones to enable structure-based inhibitor development for RBR E3 ubiquitin ligases Authors (8)Yi-Chun TsaiKarl Johansson David Dixon Stephen Martin Chun-Wa Chung Jane ClarksonDavid HouseKatrin Rittinger Cell Chemical Biology Published 16 January 2020 Crick labs/ facilitiesKatrin RittingerStructural BiologyProteomicsFull details Characterisation of class VI TRIM RING domains: linking RING activity to C-terminal domain identity Authors (3)Rebecca StevensDiego EspositoKatrin Rittinger Life Science Alliance Published 1 June 2019 Crick labs/ facilitiesKatrin RittingerStructural BiologyMRC Biomedical NMR CentreFull details Fragment-based covalent ligand screening enables rapid discovery of inhibitors for the RBR E3 ubiquitin ligase HOIP Authors (11) Henrik JohanssonYi-Chun Tsai Ken Fantom Chun-Wa Chung Sandra Kümper Luigi Martino Daniel A Thomas H Christian Eberl Marcel MuelbaierDavid HouseKatrin Rittinger Journal of the American Chemical Society Published 18 January 2019 Crick labs/ facilitiesKatrin RittingerStructural BiologyFull details Structure-function analyses of the bacterial zinc metalloprotease effector protein GtgA uncovers key residues required for deactivating NF-κB Authors (4) Elliott JenningsDiego EspositoKatrin Rittinger Teresa LM Thurston Journal of Biological Chemistry Published 26 July 2018 Crick labs/ facilitiesKatrin RittingerStructural BiologyFull details Dynamic allostery in PLCγ1 and its modulation by a cancer mutation revealed by MD simulation and NMR Authors (6) H Koss TD BunneyDiego Esposito M Martins M KatanPaul Driscoll Biophysical Journal Published 3 July 2018 Crick labs/ facilitiesKatrin RittingerMetabolomicsMRC Biomedical NMR CentreFull details Molecular mechanism of influenza A NS1-mediated TRIM25 recognition and inhibition Authors (11) Marios G Koliopoulos Mathilde Lethier Annemarthe G van der Veen Kevin Haubrich Janosch Hennig Eva KowalinskiRebecca Stevens Stephen R MartinCaetano Reis e Sousa Stephen CusackKatrin Rittinger Nature Communications Published 8 May 2018 Crick labs/ facilitiesKatrin RittingerCaetano Reis e SousaStructural BiologyProteomicsFull details Structural basis for the glycosyltransferase activity of the Salmonella effector SseK3 Authors (7)Diego Esposito Regina A GünsterLuigi Martino Kamel El Omari Armin Wagner Teresa LM ThurstonKatrin Rittinger Journal of Biological Chemistry Published 6 April 2018 Crick labs/ facilitiesKatrin RittingerStructural BiologyProteomicsFull details Determinants of E2-ubiquitin conjugate recognition by RBR E3 ligases Authors (5)Luigi Martino Nicholas R BrownLaura MasinoDiego EspositoKatrin Rittinger Scientific Reports Published 8 January 2018 Crick labs/ facilitiesKatrin RittingerStructural BiologyStructural BiologyProteomicsFull details Structural studies of HHARI/UbcH7∼Ub reveal unique E2∼Ub conformational restriction by RBR RING1 Authors (10) Katja K Dove Jennifer L OlszewskiLuigi Martino David M Duda Xiaoli S Wu Darcie J Miller Katherine H ReiterKatrin Rittinger Brenda A Schulman Rachel E Klevit Structure Published 6 June 2017 Crick labsKatrin RittingerFull details Determination of the pKa of the N-terminal amino group of ubiquitin by NMR Authors (5)Alain Oregioni Benjamin StieglitzGeoff KellyKatrin RittingerTom Frenkiel Scientific Reports Published 2 March 2017 Crick labs/ facilitiesKatrin RittingerMRC Biomedical NMR CentreMRC Biomedical NMR CentreFull details The biophysical characterisation and SAXS analysis of human NLRP1 uncover a new level of complexity of NLR proteins Authors (6)Luigi Martino Louise Holland Evangelos ChristodoulouSimone KunzelmannDiego EspositoKatrin Rittinger PLOS ONE Published 11 October 2016 Crick labs/ facilitiesKatrin RittingerStructural BiologyProteomicsFull details Linear ubiquitination by LUBEL has a role in Drosophila heat stress response Authors (15) Tomoko Asaoka Jorge Almagro Christine EhrhardtYi-Chun Tsai Alexander Schleiffer Luiza Deszcz[...] Attila Gyenesei Kay Hofmann Peter DuchekKatrin Rittinger Fumiyo Ikeda EMBO Reports Published 1 November 2016 Crick labsKatrin RittingerFull details Pagination Current page 1 Page 2 Next page Next Last page Last Share the page Share on Twitter Share on Facebook Share on LinkedIn Share on Email
A chemoproteomic platform for selective deubiquitinase inhibitor discovery Authors (12)Rosa Cookson Aini Vuorinen Jonathan PettingerCassandra KennedyJoanna Kirkpatrick Rachel E Peltier-Heap[...]Bram SnijdersMark Skehel David HouseKatrin Rittinger Jacob T Bush Cell Reports Physical Science Published 18 October 2023 Crick labs/ facilitiesKatrin RittingerProteomicsFull details
Efficient ligand discovery using sulfur(VI) fluoride reactive fragments Authors (12) Arron Aatkar Aini Vuorinen Oliver E Longfield Katharine Gilbert Rachel Peltier-Heap Craig D Wagner[...]Katrin Rittinger Chun-Wa ChungDavid House Nicholas CO Tomkinson Jacob T Bush ACS Chemical Biology Published 15 September 2023 Crick labs/ facilitiesKatrin RittingerTranslation teamFull details
Profiling sulfur(VI) fluorides as reactive functionalities for chemical biology tools and expansion of the ligandable proteome Authors (11) Katharine E Gilbert Aini Vuorinen Arron Aatkar Peter Pogány Jonathan Pettinger Emma K GrantJoanna KirkpatrickKatrin Rittinger David House Glenn A Burley Jacob T Bush ACS Chemical Biology Published 17 February 2023 Crick labs/ facilitiesKatrin RittingerProteomicsFull details
Structural basis for ubiquitylation by HOIL-1 Authors (4) Qilong Wu Marios G KoliopoulosKatrin Rittinger Benjamin Stieglitz Frontiers in Molecular Biosciences Published 6 January 2023 Crick labs/ facilitiesKatrin RittingerStructural BiologyFull details
Divergent self-association properties of paralogous proteins TRIM2 and TRIM3 regulate their E3 ligase activity Authors (4)Diego EspositoJane DudleyAcely Garza-GarciaKatrin Rittinger Nature Communications Published 8 December 2022 Crick labs/ facilitiesKatrin RittingerLuiz Pedro CarvalhoStructural BiologyMRC Biomedical NMR CentreFull details
Characterisation of HOIP RBR E3 ligase conformational dynamics using integrative modelling Authors (4)Marius KausasDiego EspositoKatrin Rittinger Franca Fraternali Scientific Reports Published 8 September 2022 Crick labsKatrin RittingerFull details
Structural dynamics in the La-module of La-related proteins Authors (4) Javier Lizarrondo Anne-Catherine Dock-BregeonLuigi Martino Maria R Conte RNA Biology Published 18 March 2020 Crick labs/ facilitiesKatrin RittingerStructural BiologyFull details
The parkin-coregulated gene product PACRG promotes TNF signaling by stabilizing LUBAC Authors (18) Jens Meschede Maria Šadić Nikolas Furthmann Tim Miedema Dominik A Sehr A Kathrin Müller-Rischart[...] Fumiyo Ikeda Katrin Marcus Liliana Schaefer Jörg Tatzelt Konstanze F Winklhofer Science Signaling Published 4 February 2020 Crick labsKatrin RittingerFull details
Single-domain antibodies as crystallization chaperones to enable structure-based inhibitor development for RBR E3 ubiquitin ligases Authors (8)Yi-Chun TsaiKarl Johansson David Dixon Stephen Martin Chun-Wa Chung Jane ClarksonDavid HouseKatrin Rittinger Cell Chemical Biology Published 16 January 2020 Crick labs/ facilitiesKatrin RittingerStructural BiologyProteomicsFull details
Characterisation of class VI TRIM RING domains: linking RING activity to C-terminal domain identity Authors (3)Rebecca StevensDiego EspositoKatrin Rittinger Life Science Alliance Published 1 June 2019 Crick labs/ facilitiesKatrin RittingerStructural BiologyMRC Biomedical NMR CentreFull details
Fragment-based covalent ligand screening enables rapid discovery of inhibitors for the RBR E3 ubiquitin ligase HOIP Authors (11) Henrik JohanssonYi-Chun Tsai Ken Fantom Chun-Wa Chung Sandra Kümper Luigi Martino Daniel A Thomas H Christian Eberl Marcel MuelbaierDavid HouseKatrin Rittinger Journal of the American Chemical Society Published 18 January 2019 Crick labs/ facilitiesKatrin RittingerStructural BiologyFull details
Structure-function analyses of the bacterial zinc metalloprotease effector protein GtgA uncovers key residues required for deactivating NF-κB Authors (4) Elliott JenningsDiego EspositoKatrin Rittinger Teresa LM Thurston Journal of Biological Chemistry Published 26 July 2018 Crick labs/ facilitiesKatrin RittingerStructural BiologyFull details
Dynamic allostery in PLCγ1 and its modulation by a cancer mutation revealed by MD simulation and NMR Authors (6) H Koss TD BunneyDiego Esposito M Martins M KatanPaul Driscoll Biophysical Journal Published 3 July 2018 Crick labs/ facilitiesKatrin RittingerMetabolomicsMRC Biomedical NMR CentreFull details
Molecular mechanism of influenza A NS1-mediated TRIM25 recognition and inhibition Authors (11) Marios G Koliopoulos Mathilde Lethier Annemarthe G van der Veen Kevin Haubrich Janosch Hennig Eva KowalinskiRebecca Stevens Stephen R MartinCaetano Reis e Sousa Stephen CusackKatrin Rittinger Nature Communications Published 8 May 2018 Crick labs/ facilitiesKatrin RittingerCaetano Reis e SousaStructural BiologyProteomicsFull details
Structural basis for the glycosyltransferase activity of the Salmonella effector SseK3 Authors (7)Diego Esposito Regina A GünsterLuigi Martino Kamel El Omari Armin Wagner Teresa LM ThurstonKatrin Rittinger Journal of Biological Chemistry Published 6 April 2018 Crick labs/ facilitiesKatrin RittingerStructural BiologyProteomicsFull details
Determinants of E2-ubiquitin conjugate recognition by RBR E3 ligases Authors (5)Luigi Martino Nicholas R BrownLaura MasinoDiego EspositoKatrin Rittinger Scientific Reports Published 8 January 2018 Crick labs/ facilitiesKatrin RittingerStructural BiologyStructural BiologyProteomicsFull details
Structural studies of HHARI/UbcH7∼Ub reveal unique E2∼Ub conformational restriction by RBR RING1 Authors (10) Katja K Dove Jennifer L OlszewskiLuigi Martino David M Duda Xiaoli S Wu Darcie J Miller Katherine H ReiterKatrin Rittinger Brenda A Schulman Rachel E Klevit Structure Published 6 June 2017 Crick labsKatrin RittingerFull details
Determination of the pKa of the N-terminal amino group of ubiquitin by NMR Authors (5)Alain Oregioni Benjamin StieglitzGeoff KellyKatrin RittingerTom Frenkiel Scientific Reports Published 2 March 2017 Crick labs/ facilitiesKatrin RittingerMRC Biomedical NMR CentreMRC Biomedical NMR CentreFull details
The biophysical characterisation and SAXS analysis of human NLRP1 uncover a new level of complexity of NLR proteins Authors (6)Luigi Martino Louise Holland Evangelos ChristodoulouSimone KunzelmannDiego EspositoKatrin Rittinger PLOS ONE Published 11 October 2016 Crick labs/ facilitiesKatrin RittingerStructural BiologyProteomicsFull details
Linear ubiquitination by LUBEL has a role in Drosophila heat stress response Authors (15) Tomoko Asaoka Jorge Almagro Christine EhrhardtYi-Chun Tsai Alexander Schleiffer Luiza Deszcz[...] Attila Gyenesei Kay Hofmann Peter DuchekKatrin Rittinger Fumiyo Ikeda EMBO Reports Published 1 November 2016 Crick labsKatrin RittingerFull details