Publications

Covalent fragment-based drug discovery for target tractability

Authors (4)

William McCarthy
Antonie J van der Zouwen
Jacob T Bush
Katrin Rittinger

Current Opinion in Structural Biology

Published 1 June 2024

Crick labs

Katrin Rittinger

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It’s a TRIM-endous view from the top: the varied roles of TRIpartite Motif proteins in brain development and disease

Authors (2)

Frontiers in Molecular Neuroscience

Published 5 December 2023

Crick labs

Katrin Rittinger

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A chemoproteomic platform for selective deubiquitinase inhibitor discovery

Authors (12)

Rosa Cookson
Aini Vuorinen
Jonathan Pettinger
Cassandra Kennedy
Joanna Kirkpatrick
Rachel E Peltier-Heap
[...]
Bram Snijders
Mark Skehel
David House
Katrin Rittinger
Jacob T Bush

Cell Reports Physical Science

Published 18 October 2023

Crick labs/ facilities

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Speaking the host language: how Salmonella effector proteins manipulate the host

Authors (8)

Timesh Pillay
Sahampath U Hettiarachchi
Jiyao Gan
Ines Diaz-Del-Olmo
Xiu-Jun Yu
Janina Muench
Teresa Thurston
Jaclyn S Pearson

Microbiology

Published 6 June 2023

Crick labs

Katrin Rittinger

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Efficient ligand discovery using sulfur(VI) fluoride reactive fragments

Authors (12)

Arron Aatkar
Aini Vuorinen
Oliver E Longfield
Katharine Gilbert
Rachel Peltier-Heap
Craig D Wagner
[...]
Katrin Rittinger
Chun-Wa Chung
David House
Nicholas CO Tomkinson
Jacob T Bush

ACS Chemical Biology

Published 15 September 2023

Crick labs/ facilities

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Profiling sulfur(VI) fluorides as reactive functionalities for chemical biology tools and expansion of the ligandable proteome

Authors (11)

Katharine E Gilbert
Aini Vuorinen
Arron Aatkar
Peter Pogány
Jonathan Pettinger
Emma K Grant
Joanna Kirkpatrick
Katrin Rittinger
David House
Glenn A Burley
Jacob T Bush

ACS Chemical Biology

Published 17 February 2023

Crick labs/ facilities

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Structural basis for ubiquitylation by HOIL-1

Authors (4)

Qilong Wu
Marios G Koliopoulos
Katrin Rittinger
Benjamin Stieglitz

Frontiers in Molecular Biosciences

Published 6 January 2023

Crick labs/ facilities

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Divergent self-association properties of paralogous proteins TRIM2 and TRIM3 regulate their E3 ligase activity

Authors (4)

Nature Communications

Published 8 December 2022

Crick labs/ facilities

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Targeting the ubiquitin system by fragment-based drug discovery

Authors (3)

Frontiers in Molecular Biosciences

Published 27 September 2022

Crick labs

Katrin Rittinger

Full details

Characterisation of HOIP RBR E3 ligase conformational dynamics using integrative modelling

Authors (4)

Scientific Reports

Published 8 September 2022

Crick labs

Katrin Rittinger

Full details

Does it take two to tango? RING domain self-association and activity in TRIM E3 ubiquitin ligases

Authors (3)

Biochemical Society Transactions

Published 1 December 2020

Crick labs

Katrin Rittinger

Full details

Advanced rules of relays

Authors (2)

Sonja Lorenz
Katrin Rittinger

Nature Chemical Biology

Published 1 November 2020

Crick labs

Katrin Rittinger

Full details

Structural dynamics in the La-module of La-related proteins

Authors (4)

Javier Lizarrondo
Anne-Catherine Dock-Bregeon
Luigi Martino
Maria R Conte

RNA Biology

Published 18 March 2020

Crick labs/ facilities

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The parkin-coregulated gene product PACRG promotes TNF signaling by stabilizing LUBAC

Authors (18)

Jens Meschede
Maria Šadić
Nikolas Furthmann
Tim Miedema
Dominik A Sehr
A Kathrin Müller-Rischart
[...]
Fumiyo Ikeda
Katrin Marcus
Liliana Schaefer
Jörg Tatzelt
Konstanze F Winklhofer

Science Signaling

Published 4 February 2020

Crick labs

Katrin Rittinger

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Single-domain antibodies as crystallization chaperones to enable structure-based inhibitor development for RBR E3 ubiquitin ligases

Authors (8)

Yi-Chun Tsai
Karl Johansson
David Dixon
Stephen Martin
Chun-Wa Chung
Jane Clarkson
David House
Katrin Rittinger

Cell Chemical Biology

Published 16 January 2020

Crick labs/ facilities

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Characterisation of class VI TRIM RING domains: linking RING activity to C-terminal domain identity

Authors (3)

Life Science Alliance

Published 1 June 2019

Crick labs/ facilities

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Fragment-based covalent ligand screening enables rapid discovery of inhibitors for the RBR E3 ubiquitin ligase HOIP

Authors (11)

Henrik Johansson
Yi-Chun Tsai
Ken Fantom
Chun-Wa Chung
Sandra Kümper
Luigi Martino
Daniel A Thomas
H Christian Eberl
Marcel Muelbaier
David House
Katrin Rittinger

Journal of the American Chemical Society

Published 18 January 2019

Crick labs/ facilities

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Structure-function analyses of the bacterial zinc metalloprotease effector protein GtgA uncovers key residues required for deactivating NF-κB

Authors (4)

Elliott Jennings
Diego Esposito
Katrin Rittinger
Teresa LM Thurston

Journal of Biological Chemistry

Published 26 July 2018

Crick labs/ facilities

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Dynamic allostery in PLCγ1 and its modulation by a cancer mutation revealed by MD simulation and NMR

Authors (6)

H Koss
TD Bunney
Diego Esposito
M Martins
M Katan
Paul Driscoll

Biophysical Journal

Published 3 July 2018

Crick labs/ facilities

Full details

Molecular mechanism of influenza A NS1-mediated TRIM25 recognition and inhibition

Authors (11)

Marios G Koliopoulos
Mathilde Lethier
Annemarthe G van der Veen
Kevin Haubrich
Janosch Hennig
Eva Kowalinski
Rebecca Stevens
Stephen R Martin
Caetano Reis e Sousa
Stephen Cusack
Katrin Rittinger

Nature Communications

Published 8 May 2018

Crick labs/ facilities

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Publications

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Journal

Covalent fragment-based drug discovery for target tractability

It’s a TRIM-endous view from the top: the varied roles of TRIpartite Motif proteins in brain development and disease

A chemoproteomic platform for selective deubiquitinase inhibitor discovery

Speaking the host language: how Salmonella effector proteins manipulate the host

Efficient ligand discovery using sulfur(VI) fluoride reactive fragments

Profiling sulfur(VI) fluorides as reactive functionalities for chemical biology tools and expansion of the ligandable proteome

Structural basis for ubiquitylation by HOIL-1

Divergent self-association properties of paralogous proteins TRIM2 and TRIM3 regulate their E3 ligase activity

Targeting the ubiquitin system by fragment-based drug discovery

Characterisation of HOIP RBR E3 ligase conformational dynamics using integrative modelling

Does it take two to tango? RING domain self-association and activity in TRIM E3 ubiquitin ligases

Advanced rules of relays

Structural dynamics in the La-module of La-related proteins

The parkin-coregulated gene product PACRG promotes TNF signaling by stabilizing LUBAC

Single-domain antibodies as crystallization chaperones to enable structure-based inhibitor development for RBR E3 ubiquitin ligases

Characterisation of class VI TRIM RING domains: linking RING activity to C-terminal domain identity

Fragment-based covalent ligand screening enables rapid discovery of inhibitors for the RBR E3 ubiquitin ligase HOIP

Structure-function analyses of the bacterial zinc metalloprotease effector protein GtgA uncovers key residues required for deactivating NF-κB

Dynamic allostery in PLCγ1 and its modulation by a cancer mutation revealed by MD simulation and NMR

Molecular mechanism of influenza A NS1-mediated TRIM25 recognition and inhibition

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