Publications

microbeMASST: a taxonomically informed mass spectrometry search tool for microbial metabolomics data

Authors (109)

Simone Zuffa
Robin Schmid
Anelize Bauermeister
Paulo Wender P Gomes
Andres M Caraballo-Rodriguez
Yasin El Abiead
[...]
Christopher M Rath
Daniel McDonald
Rob Knight
Mingxun Wang
Pieter C Dorrestein

Nature Microbiology

Published 1 February 2024

Crick labs/ facilities

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Vitamin B5 supports MYC oncogenic metabolism and tumor progression in breast cancer

Authors (40)

Peter Kreuzaler
Paolo Inglese
Avinash Ghanate
Ersa Gjelaj
Vincen Wu
Yulia Panina
[...]
George Poulogiannis
Greg McMahon
Zoltan Takats
Josephine Bunch
Mariia Yuneva

Nature Metabolism

Published 1 November 2023

Crick labs/ facilities

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ATG9B is a tissue-specific homotrimeric lipid scramblase that can compensate for ATG9A

Authors (8)

Autophagy

Published 1 March 2024

Crick labs/ facilities

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CD4+ T cell memory is impaired by species-specific cytotoxic differentiation, but not by TCF-1 loss

Authors (7)

Tom Hofland
Luca Danelli
Georgina Cornish
Tiziano Donnarumma
Deborah M Hunt
Luiz Pedro Carvalho
George Kassiotis

Frontiers in Immunology

Published 14 April 2023

Crick labs/ facilities

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Structure of the D-cycloserine-resistant variant D322N of alanine racemase from Mycobacterium tuberculosis

Authors (4)

ACS Bio & Med Chem Au

Published 21 June 2023

Crick labs/ facilities

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Metabolomic profiling reveals bacterial metabolic adaptation strategies and new metabolites

Authors (2)

Hua Wang
Luiz Pedro Carvalho

Current Opinion in Chemical Biology

Published 1 June 2023

Crick labs

Luiz Pedro Carvalho

Full details

Divergent self-association properties of paralogous proteins TRIM2 and TRIM3 regulate their E3 ligase activity

Authors (4)

Nature Communications

Published 8 December 2022

Crick labs/ facilities

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Cell-specific bioorthogonal tagging of glycoproteins

Authors (31)

Anna Cioce
Bea Calle
Tatiana Rizou
Sarah C Lowery
Vicky Bridgeman
Keira E Mahoney
[...]
Stuart M Haslam
Sabine L Flitsch
Stacy A Malaker
Ilaria Malanchi
Ben Schumann

Nature Communications

Published 25 October 2022

Crick labs/ facilities

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Bottlenecks and opportunities in antibiotic discovery against Mycobacterium tuberculosis

Authors (2)

Current Opinion in Microbiology

Published 1 October 2022

Crick labs

Luiz Pedro Carvalho

Full details

Expression of a novel mycobacterial phosphodiesterase successfully lowers cAMP levels resulting in reduced tolerance to cell wall-targeting antimicrobials

Authors (8)

Michael Thomson
Yi Liu
Kanokkan Nunta
Ashleigh Cheyne
Nadia Fernandes
Richard Williams
Acely Garza-Garcia
Gerald Larrouy-Maumus

Journal of Biological Chemistry

Published 1 August 2022

Crick labs

Luiz Pedro Carvalho

Full details

Gene-drug potency screening in M. tuberculosis

Authors (1)

Luiz Pedro Carvalho

Nature Microbiology

Published 1 June 2022

Crick labs

Luiz Pedro Carvalho

Full details

A new strategy for hit generation: Novel in cellulo active inhibitors of CYP121A1 from Mycobacterium tuberculosis via a combined X-ray crystallographic and phenotypic screening approach (XP screen)

Authors (16)

M Frederickson
IR Selvam
Dimitrios Evangelopoulos
KJ McLean
MM Katariya
RB Tunnicliffe
[...]
Luiz Pedro Carvalho
D Leys
AW Munro
AG Coyne
C Abell

European Journal of Medicinal Chemistry

Published 15 February 2022

Crick labs

Luiz Pedro Carvalho

Full details

Metabolomic approaches for enzyme function and pathway discovery in bacteria

Authors (2)

Methods in Enzymology

Published 1 January 2022

Crick labs

Luiz Pedro Carvalho

Full details

Transcriptomic characterization of tuberculous sputum reveals a host Warburg effect and microbial cholesterol catabolism

Authors (11)

Rachel Lai
Teresa Cortes
Suzaan Marais
Neesha Rockwood
Melissa L Burke
Acely Garza-Garcia
Stuart Horswell
Abdul K Sesay
Anne O’Garra
Douglas B Young
Robert Wilkinson

mBio

Published 7 December 2021

Crick labs/ facilities

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Human Mat2A uses an ordered kinetic mechanism and is stabilized but not regulated by Mat2B

Authors (5)

Biochemistry

Published 30 November 2021

Crick labs/ facilities

Full details

A road map to structure-resistance correlations on Mycobacterium tuberculosis MmpL3

Authors (2)

Structure

Published 7 October 2021

Crick labs

Luiz Pedro Carvalho

Full details

Convergence and divergence in the metabolic network of Mycobacterium tuberculosis

Authors (2)

Current Opinion in Systems Biology

Published 1 December 2021

Crick labs

Luiz Pedro Carvalho

Full details

Optimization of metabolic oligosaccharide engineering with Ac4GalNAlk and Ac4GlcNAlk by an engineered pyrophosphorylase

Authors (14)

Anna Cioce
Ganka Bineva-Todd
Anthony J Agbay
Junwon Choi
Thomas M Wood
Marjoke F Debets
[...]
Omur Yilmaz Tastan
Svend Kjaer
Jacob T Bush
Carolyn R Bertozzi
Ben Schumann

ACS Chemical Biology

Published 15 October 2021

Crick labs/ facilities

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Functional characterization of the γ-aminobutyric acid transporter from Mycobacterium smegmatis MC2 155 reveals sodium-driven GABA transport

Authors (11)

Ana Pavić
Yurui Ji
Agnese Serafini
Acely Garza-Garcia
Martin J McPhillie
Alexandra OM Holmes
Luiz Pedro Carvalho
Yingying Wang
Mark Bartlam
Adrian Goldman
Vincent LG Postis

Journal of Bacteriology

Published 1 February 2021

Crick labs

Luiz Pedro Carvalho

Full details

Metabolic precision labeling enables selective probing of O-linked N-acetylgalactosamine glycosylation

Authors (27)

Marjoke F Debets
Omur Yilmaz Tastan
Simon P Wisnovsky
Stacy A Malaker
Nikos Angelis
Leonhard KR Moeckl
[...]
Michael C Bassik
WE Moerner
Vivian Li
Carolyn R Bertozzi
Ben Schumann

Proceedings of the National Academy of Sciences of USA

Published 13 October 2020

Crick labs/ facilities

Full details

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microbeMASST: a taxonomically informed mass spectrometry search tool for microbial metabolomics data

Vitamin B5 supports MYC oncogenic metabolism and tumor progression in breast cancer

ATG9B is a tissue-specific homotrimeric lipid scramblase that can compensate for ATG9A

CD4+ T cell memory is impaired by species-specific cytotoxic differentiation, but not by TCF-1 loss

Structure of the D-cycloserine-resistant variant D322N of alanine racemase from Mycobacterium tuberculosis

Metabolomic profiling reveals bacterial metabolic adaptation strategies and new metabolites

Divergent self-association properties of paralogous proteins TRIM2 and TRIM3 regulate their E3 ligase activity

Cell-specific bioorthogonal tagging of glycoproteins

Bottlenecks and opportunities in antibiotic discovery against Mycobacterium tuberculosis

Expression of a novel mycobacterial phosphodiesterase successfully lowers cAMP levels resulting in reduced tolerance to cell wall-targeting antimicrobials

Gene-drug potency screening in M. tuberculosis

A new strategy for hit generation: Novel in cellulo active inhibitors of CYP121A1 from Mycobacterium tuberculosis via a combined X-ray crystallographic and phenotypic screening approach (XP screen)

Metabolomic approaches for enzyme function and pathway discovery in bacteria

Transcriptomic characterization of tuberculous sputum reveals a host Warburg effect and microbial cholesterol catabolism

Human Mat2A uses an ordered kinetic mechanism and is stabilized but not regulated by Mat2B

A road map to structure-resistance correlations on Mycobacterium tuberculosis MmpL3

Convergence and divergence in the metabolic network of Mycobacterium tuberculosis

Optimization of metabolic oligosaccharide engineering with Ac4GalNAlk and Ac4GlcNAlk by an engineered pyrophosphorylase

Functional characterization of the γ-aminobutyric acid transporter from Mycobacterium smegmatis MC2 155 reveals sodium-driven GABA transport

Metabolic precision labeling enables selective probing of O-linked N-acetylgalactosamine glycosylation

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