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Breadcrumb Luiz Pedro Carvalho Carvalho lab Mycobacterial Metabolism and Antibiotic Research Laboratory : Publications Lab contentLab contentIn this section Overview Areas of interest Publications Members Vacancies Close-up view of a scheme illustrating reactions from Mycobacterium tuberculosis core metabolism. Toggle to view hero caption PublicationsYear published2024 (2)2023 (4)2022 (7)2021 (6)2020 (3)2019 (11)2018 (2)2017 (6)2016 (4)2015 (4)2014 (4)2013 (6)2012 (1)2011 (1)2010 (3) Facet Year publishedResearch topicsBiochemistry & Proteomics (47)Computational & Systems Biology (47)Genetics & Genomics (47)Infectious Disease (47)Metabolism (47)Structural Biology & Biophysics (47)Chemical Biology & High Throughput (13)Cell Biology (10)Model Organisms (10)Immunology (8)Tumour Biology (8)Genome Integrity & Repair (7)Signalling & Oncogenes (7)Human Biology & Physiology (5)Developmental Biology (4)Gene Expression (4)Imaging (4)Synthetic Biology (4)Cell Cycle & Chromosomes (3)Stem Cells (3)Neurosciences (2)Microfabrication & Bioengineering (1) Facet Research topicsCrick/Pre-CrickCrick publications (61)Pre-Crick publications (3) Facet Crick/Pre-CrickPublication typeJournal article (64)Primary research (49)Review (6)Commentary (4)Method (2) Facet Publication typeJournalNature Communications (6)Biochemistry (5)Chemistry & Biology (3)Journal of Biological Chemistry (3)Journal of Medicinal Chemistry (3)Nature Microbiology (3)Molecular Microbiology (2)Nature Chemical Biology (2)PLOS Pathogens (2)Proceedings of the National Academy of Sciences of the United States of America (2)Structure (2)ACS Bio & Med Chem Au (1)ACS Chemical Biology (1)ACS Infectious Diseases (1)ACS Medicinal Chemistry Letters (1)Antimicrobial Agents and Chemotherapy (1)Autophagy (1)Biochemical Journal (1)Bioorganic & Medicinal Chemistry (1)Bioorganic & Medicinal Chemistry Letters (1)ChemistryOpen (1)Current Opinion in Chemical Biology (1)Current Opinion in Microbiology (1)Current Opinion in Systems Biology (1)eLife (1)EMBO Reports (1)European Journal of Medicinal Chemistry (1)FEBS Journal (1)Frontiers in Immunology (1)Frontiers in Molecular Biosciences (1)Journal of Bacteriology (1)Journal of Experimental Medicine (1)mBio (1)Methods in Enzymology (1)Methods in Molecular Biology (1)Microbiology (1)Molecular Cell (1)Nature (1)Nature Metabolism (1)Proceedings of the National Academy of Sciences of USA (1)The Lancet (1)Tuberculosis (1) Facet Journal Publications Displaying 1 - 20 of 64Last updated : 28 March 2024 02:39 microbeMASST: a taxonomically informed mass spectrometry search tool for microbial metabolomics data Authors (109) Simone Zuffa Robin Schmid Anelize Bauermeister Paulo Wender P Gomes Andres M Caraballo-Rodriguez Yasin El Abiead[...] Christopher M Rath Daniel McDonald Rob Knight Mingxun Wang Pieter C Dorrestein Nature Microbiology Published 1 February 2024 Crick labs/ facilitiesLuiz Pedro CarvalhoMetabolomicsFull details Vitamin B5 supports MYC oncogenic metabolism and tumor progression in breast cancer Authors (40) Peter Kreuzaler Paolo IngleseAvinash GhanateErsa Gjelaj Vincen WuYulia Panina[...] George Poulogiannis Greg McMahon Zoltan Takats Josephine BunchMariia Yuneva Nature Metabolism Published 1 November 2023 Crick labs/ facilitiesMariia YunevaLuiz Pedro CarvalhoMetabolomicsExperimental HistopathologyElectron MicroscopyBiological Research FacilityFull details ATG9B is a tissue-specific homotrimeric lipid scramblase that can compensate for ATG9A Authors (8)George ChiduzaAcely Garza-GarciaEugenia Almacellas I CanalsStefano De TitoVal PyeAlexander Van VlietPeter CherepanovSharon Tooze Autophagy Published 1 March 2024 Crick labs/ facilitiesSharon ToozePeter Cherepanov Luiz Pedro CarvalhoStructural BiologyScientific computingCell ServicesFull details CD4+ T cell memory is impaired by species-specific cytotoxic differentiation, but not by TCF-1 loss Authors (7)Tom HoflandLuca Danelli Georgina Cornish Tiziano Donnarumma Deborah M HuntLuiz Pedro CarvalhoGeorge Kassiotis Frontiers in Immunology Published 14 April 2023 Crick labs/ facilitiesGeorge KassiotisLuiz Pedro CarvalhoFlow CytometryBiological Research FacilityFull details Structure of the D-cycloserine-resistant variant D322N of alanine racemase from Mycobacterium tuberculosis Authors (4)Cesira De Chiara Gareth A ProsserRoksana OgrodowiczLuiz Pedro Carvalho ACS Bio & Med Chem Au Published 21 June 2023 Crick labs/ facilitiesLuiz Pedro CarvalhoStructural BiologyFull details Metabolomic profiling reveals bacterial metabolic adaptation strategies and new metabolites Authors (2) Hua WangLuiz Pedro Carvalho Current Opinion in Chemical Biology Published 1 June 2023 Crick labsLuiz Pedro CarvalhoFull details Divergent self-association properties of paralogous proteins TRIM2 and TRIM3 regulate their E3 ligase activity Authors (4)Diego EspositoJane DudleyAcely Garza-GarciaKatrin Rittinger Nature Communications Published 8 December 2022 Crick labs/ facilitiesKatrin RittingerLuiz Pedro CarvalhoStructural BiologyMRC Biomedical NMR CentreFull details Cell-specific bioorthogonal tagging of glycoproteins Authors (31)Anna CioceBea CalleTatiana Rizou Sarah C LoweryVicky Bridgeman Keira E Mahoney[...] Stuart M Haslam Sabine L Flitsch Stacy A MalakerIlaria MalanchiBen Schumann Nature Communications Published 25 October 2022 Crick labs/ facilitiesJernej UleBen SchumannIlaria MalanchiLuiz Pedro CarvalhoStructural BiologyProteomicsBioinformatics and BiostatisticsLight MicroscopyCell ServicesBiological Research FacilityAdvanced SequencingFull details Bottlenecks and opportunities in antibiotic discovery against Mycobacterium tuberculosis Authors (2)Peter CraggsLuiz Pedro Carvalho Current Opinion in Microbiology Published 1 October 2022 Crick labsLuiz Pedro CarvalhoFull details Expression of a novel mycobacterial phosphodiesterase successfully lowers cAMP levels resulting in reduced tolerance to cell wall-targeting antimicrobials Authors (8) Michael Thomson Yi Liu Kanokkan Nunta Ashleigh Cheyne Nadia Fernandes Richard WilliamsAcely Garza-Garcia Gerald Larrouy-Maumus Journal of Biological Chemistry Published 1 August 2022 Crick labsLuiz Pedro CarvalhoFull details Gene-drug potency screening in M. tuberculosis Authors (1)Luiz Pedro Carvalho Nature Microbiology Published 1 June 2022 Crick labsLuiz Pedro CarvalhoFull details A new strategy for hit generation: Novel in cellulo active inhibitors of CYP121A1 from Mycobacterium tuberculosis via a combined X-ray crystallographic and phenotypic screening approach (XP screen) Authors (16) M Frederickson IR SelvamDimitrios Evangelopoulos KJ McLean MM Katariya RB Tunnicliffe[...]Luiz Pedro Carvalho D Leys AW Munro AG Coyne C Abell European Journal of Medicinal Chemistry Published 15 February 2022 Crick labsLuiz Pedro CarvalhoFull details Metabolomic approaches for enzyme function and pathway discovery in bacteria Authors (2)Catherine HubertLuiz Pedro Carvalho Methods in Enzymology Published 1 January 2022 Crick labsLuiz Pedro CarvalhoFull details Transcriptomic characterization of tuberculous sputum reveals a host Warburg effect and microbial cholesterol catabolism Authors (11)Rachel Lai Teresa Cortes Suzaan Marais Neesha Rockwood Melissa L BurkeAcely Garza-Garcia Stuart Horswell Abdul K Sesay Anne O’Garra Douglas B YoungRobert Wilkinson mBio Published 7 December 2021 Crick labs/ facilitiesRobert J WilkinsonAnne O’GarraLuiz Pedro CarvalhoBioinformatics and BiostatisticsAdvanced SequencingFull details Human Mat2A uses an ordered kinetic mechanism and is stabilized but not regulated by Mat2B Authors (5)Jonathan BaileyHolly DouglasLaura MasinoLuiz Pedro Carvalho Argyrides Argyrou Biochemistry Published 30 November 2021 Crick labs/ facilitiesLuiz Pedro CarvalhoStructural BiologyProteomicsFull details A road map to structure-resistance correlations on Mycobacterium tuberculosis MmpL3 Authors (2)Jonathan BaileyLuiz Pedro Carvalho Structure Published 7 October 2021 Crick labsLuiz Pedro CarvalhoFull details Convergence and divergence in the metabolic network of Mycobacterium tuberculosis Authors (2)Catherine HubertLuiz Pedro Carvalho Current Opinion in Systems Biology Published 1 December 2021 Crick labsLuiz Pedro CarvalhoFull details Optimization of metabolic oligosaccharide engineering with Ac4GalNAlk and Ac4GlcNAlk by an engineered pyrophosphorylase Authors (14)Anna CioceGanka Bineva-Todd Anthony J Agbay Junwon Choi Thomas M Wood Marjoke F Debets[...]Omur Yilmaz TastanSvend Kjaer Jacob T Bush Carolyn R BertozziBen Schumann ACS Chemical Biology Published 15 October 2021 Crick labs/ facilitiesBen SchumannLuiz Pedro CarvalhoStructural BiologyLight MicroscopyCell ServicesFull details Functional characterization of the γ-aminobutyric acid transporter from Mycobacterium smegmatis MC2 155 reveals sodium-driven GABA transport Authors (11) Ana Pavić Yurui JiAgnese SerafiniAcely Garza-Garcia Martin J McPhillie Alexandra OM HolmesLuiz Pedro Carvalho Yingying Wang Mark Bartlam Adrian Goldman Vincent LG Postis Journal of Bacteriology Published 1 February 2021 Crick labsLuiz Pedro CarvalhoFull details Metabolic precision labeling enables selective probing of O-linked N-acetylgalactosamine glycosylation Authors (27) Marjoke F DebetsOmur Yilmaz Tastan Simon P Wisnovsky Stacy A MalakerNikos Angelis Leonhard KR Moeckl[...] Michael C Bassik WE MoernerVivian Li Carolyn R BertozziBen Schumann Proceedings of the National Academy of Sciences of USA Published 13 October 2020 Crick labs/ facilitiesBen SchumannNeil McDonaldVivian LiLuiz Pedro CarvalhoStructural BiologyProteomicsCell ServicesFull details Pagination Current page 1 Page 2 Page 3 Page 4 Next page Next Last page Last Share the page Share on Twitter Share on Facebook Share on LinkedIn Share on Email
microbeMASST: a taxonomically informed mass spectrometry search tool for microbial metabolomics data Authors (109) Simone Zuffa Robin Schmid Anelize Bauermeister Paulo Wender P Gomes Andres M Caraballo-Rodriguez Yasin El Abiead[...] Christopher M Rath Daniel McDonald Rob Knight Mingxun Wang Pieter C Dorrestein Nature Microbiology Published 1 February 2024 Crick labs/ facilitiesLuiz Pedro CarvalhoMetabolomicsFull details
Vitamin B5 supports MYC oncogenic metabolism and tumor progression in breast cancer Authors (40) Peter Kreuzaler Paolo IngleseAvinash GhanateErsa Gjelaj Vincen WuYulia Panina[...] George Poulogiannis Greg McMahon Zoltan Takats Josephine BunchMariia Yuneva Nature Metabolism Published 1 November 2023 Crick labs/ facilitiesMariia YunevaLuiz Pedro CarvalhoMetabolomicsExperimental HistopathologyElectron MicroscopyBiological Research FacilityFull details
ATG9B is a tissue-specific homotrimeric lipid scramblase that can compensate for ATG9A Authors (8)George ChiduzaAcely Garza-GarciaEugenia Almacellas I CanalsStefano De TitoVal PyeAlexander Van VlietPeter CherepanovSharon Tooze Autophagy Published 1 March 2024 Crick labs/ facilitiesSharon ToozePeter Cherepanov Luiz Pedro CarvalhoStructural BiologyScientific computingCell ServicesFull details
CD4+ T cell memory is impaired by species-specific cytotoxic differentiation, but not by TCF-1 loss Authors (7)Tom HoflandLuca Danelli Georgina Cornish Tiziano Donnarumma Deborah M HuntLuiz Pedro CarvalhoGeorge Kassiotis Frontiers in Immunology Published 14 April 2023 Crick labs/ facilitiesGeorge KassiotisLuiz Pedro CarvalhoFlow CytometryBiological Research FacilityFull details
Structure of the D-cycloserine-resistant variant D322N of alanine racemase from Mycobacterium tuberculosis Authors (4)Cesira De Chiara Gareth A ProsserRoksana OgrodowiczLuiz Pedro Carvalho ACS Bio & Med Chem Au Published 21 June 2023 Crick labs/ facilitiesLuiz Pedro CarvalhoStructural BiologyFull details
Metabolomic profiling reveals bacterial metabolic adaptation strategies and new metabolites Authors (2) Hua WangLuiz Pedro Carvalho Current Opinion in Chemical Biology Published 1 June 2023 Crick labsLuiz Pedro CarvalhoFull details
Divergent self-association properties of paralogous proteins TRIM2 and TRIM3 regulate their E3 ligase activity Authors (4)Diego EspositoJane DudleyAcely Garza-GarciaKatrin Rittinger Nature Communications Published 8 December 2022 Crick labs/ facilitiesKatrin RittingerLuiz Pedro CarvalhoStructural BiologyMRC Biomedical NMR CentreFull details
Cell-specific bioorthogonal tagging of glycoproteins Authors (31)Anna CioceBea CalleTatiana Rizou Sarah C LoweryVicky Bridgeman Keira E Mahoney[...] Stuart M Haslam Sabine L Flitsch Stacy A MalakerIlaria MalanchiBen Schumann Nature Communications Published 25 October 2022 Crick labs/ facilitiesJernej UleBen SchumannIlaria MalanchiLuiz Pedro CarvalhoStructural BiologyProteomicsBioinformatics and BiostatisticsLight MicroscopyCell ServicesBiological Research FacilityAdvanced SequencingFull details
Bottlenecks and opportunities in antibiotic discovery against Mycobacterium tuberculosis Authors (2)Peter CraggsLuiz Pedro Carvalho Current Opinion in Microbiology Published 1 October 2022 Crick labsLuiz Pedro CarvalhoFull details
Expression of a novel mycobacterial phosphodiesterase successfully lowers cAMP levels resulting in reduced tolerance to cell wall-targeting antimicrobials Authors (8) Michael Thomson Yi Liu Kanokkan Nunta Ashleigh Cheyne Nadia Fernandes Richard WilliamsAcely Garza-Garcia Gerald Larrouy-Maumus Journal of Biological Chemistry Published 1 August 2022 Crick labsLuiz Pedro CarvalhoFull details
Gene-drug potency screening in M. tuberculosis Authors (1)Luiz Pedro Carvalho Nature Microbiology Published 1 June 2022 Crick labsLuiz Pedro CarvalhoFull details
A new strategy for hit generation: Novel in cellulo active inhibitors of CYP121A1 from Mycobacterium tuberculosis via a combined X-ray crystallographic and phenotypic screening approach (XP screen) Authors (16) M Frederickson IR SelvamDimitrios Evangelopoulos KJ McLean MM Katariya RB Tunnicliffe[...]Luiz Pedro Carvalho D Leys AW Munro AG Coyne C Abell European Journal of Medicinal Chemistry Published 15 February 2022 Crick labsLuiz Pedro CarvalhoFull details
Metabolomic approaches for enzyme function and pathway discovery in bacteria Authors (2)Catherine HubertLuiz Pedro Carvalho Methods in Enzymology Published 1 January 2022 Crick labsLuiz Pedro CarvalhoFull details
Transcriptomic characterization of tuberculous sputum reveals a host Warburg effect and microbial cholesterol catabolism Authors (11)Rachel Lai Teresa Cortes Suzaan Marais Neesha Rockwood Melissa L BurkeAcely Garza-Garcia Stuart Horswell Abdul K Sesay Anne O’Garra Douglas B YoungRobert Wilkinson mBio Published 7 December 2021 Crick labs/ facilitiesRobert J WilkinsonAnne O’GarraLuiz Pedro CarvalhoBioinformatics and BiostatisticsAdvanced SequencingFull details
Human Mat2A uses an ordered kinetic mechanism and is stabilized but not regulated by Mat2B Authors (5)Jonathan BaileyHolly DouglasLaura MasinoLuiz Pedro Carvalho Argyrides Argyrou Biochemistry Published 30 November 2021 Crick labs/ facilitiesLuiz Pedro CarvalhoStructural BiologyProteomicsFull details
A road map to structure-resistance correlations on Mycobacterium tuberculosis MmpL3 Authors (2)Jonathan BaileyLuiz Pedro Carvalho Structure Published 7 October 2021 Crick labsLuiz Pedro CarvalhoFull details
Convergence and divergence in the metabolic network of Mycobacterium tuberculosis Authors (2)Catherine HubertLuiz Pedro Carvalho Current Opinion in Systems Biology Published 1 December 2021 Crick labsLuiz Pedro CarvalhoFull details
Optimization of metabolic oligosaccharide engineering with Ac4GalNAlk and Ac4GlcNAlk by an engineered pyrophosphorylase Authors (14)Anna CioceGanka Bineva-Todd Anthony J Agbay Junwon Choi Thomas M Wood Marjoke F Debets[...]Omur Yilmaz TastanSvend Kjaer Jacob T Bush Carolyn R BertozziBen Schumann ACS Chemical Biology Published 15 October 2021 Crick labs/ facilitiesBen SchumannLuiz Pedro CarvalhoStructural BiologyLight MicroscopyCell ServicesFull details
Functional characterization of the γ-aminobutyric acid transporter from Mycobacterium smegmatis MC2 155 reveals sodium-driven GABA transport Authors (11) Ana Pavić Yurui JiAgnese SerafiniAcely Garza-Garcia Martin J McPhillie Alexandra OM HolmesLuiz Pedro Carvalho Yingying Wang Mark Bartlam Adrian Goldman Vincent LG Postis Journal of Bacteriology Published 1 February 2021 Crick labsLuiz Pedro CarvalhoFull details
Metabolic precision labeling enables selective probing of O-linked N-acetylgalactosamine glycosylation Authors (27) Marjoke F DebetsOmur Yilmaz Tastan Simon P Wisnovsky Stacy A MalakerNikos Angelis Leonhard KR Moeckl[...] Michael C Bassik WE MoernerVivian Li Carolyn R BertozziBen Schumann Proceedings of the National Academy of Sciences of USA Published 13 October 2020 Crick labs/ facilitiesBen SchumannNeil McDonaldVivian LiLuiz Pedro CarvalhoStructural BiologyProteomicsCell ServicesFull details