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Breadcrumb Luiz Pedro Carvalho Carvalho lab Mycobacterial Metabolism and Antibiotic Research Laboratory : Publications Lab contentLab contentIn this section Overview Areas of interest Publications Members Vacancies Close-up view of a scheme illustrating reactions from Mycobacterium tuberculosis core metabolism. 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40 of 64Last updated : 19 April 2024 03:14 Pandemic peak SARS-CoV-2 infection and seroconversion rates in London frontline health-care workers Authors (341) Catherine F Houlihan Nina Vora Thomas Byrne Dan LewerGavin Kelly Judith Heaney[...] Andrew Hayward Richard Gilson Gavin KellyFiona Roberts Emine Hatipoglu The Lancet Published 25 July 2020 Crick labs/ facilitiesAndreas WackKaren VousdenJernej UleJames TurnerMoritz TreeckCharles SwantonAdam SaterialeErik SahaiCaetano Reis e SousaPeter RatcliffeLucia Prieto-GodinoVenizelos PapayannopoulosAnne O’GarraPaul NurseGeorge KassiotisMaximiliano GutierrezSonia GandhiSteve GamblinPeter Cherepanov Luiz Pedro CarvalhoDominique BonnetMike BlackmanRupert BealeWorldwide Influenza CentreStructural BiologyMetabolomicsHuman Embryonic Stem CellHigh Throughput ScreeningGenetic Modification ServiceFlow CytometryFermentationExperimental HistopathologyElectron MicroscopyCell ServicesBiological Research FacilityBioinformatics and BiostatisticsAdvanced SequencingScientific computingFull details D-Cycloserine destruction by alanine racemase and the limit of irreversible inhibition Authors (9)Cesira De Chiara Miha Homšak Gareth A ProsserHolly DouglasAcely Garza-GarciaGeoff Kelly Andrew G Purkiss Edward W TateLuiz Pedro Carvalho Nature Chemical Biology Published 1 June 2020 Crick labs/ facilitiesEd TateLuiz Pedro CarvalhoStructural BiologyMRC Biomedical NMR CentreFull details Comparative fitness analysis of D-cycloserine resistant mutants reveals both fitness-neutral and high-fitness cost genotypes Authors (9)Dimitrios Evangelopoulos Gareth A Prosser Angela Rodgers Belinda M Dagg Bhagwati Khatri Mei Mei HoMaximiliano Gutierrez Teresa CortesLuiz Pedro Carvalho Nature Communications Published 13 September 2019 Crick labs/ facilitiesMaximiliano GutierrezLuiz Pedro CarvalhoBiological Research FacilityAdvanced SequencingFull details Mycobacterium tuberculosis requires glyoxylate shunt and reverse methylcitrate cycle for lactate and pyruvate metabolism Authors (17)Agnese Serafini Lendl Tan Stuart Horswell Steven HowellDaniel Greenwood Deborah M Hunt[...]Bram Snijders Brian VanderVenMaximiliano Gutierrez Nicholas P WestLuiz Pedro Carvalho Molecular Microbiology Published 1 October 2019 Crick labs/ facilitiesMaximiliano GutierrezLuiz Pedro CarvalhoProteomicsBioinformatics and BiostatisticsFull details Design and synthesis of imidazole and triazole pyrazolesas Mycobacterium tuberculosis CYP121A1 inhibitors Authors (13) Safaa M Kishk Kirsty J McLean Sakshi Sood Darren Smith Jack WD Evans Mohamed A Helal[...] Samia M MostafaLuiz Pedro Carvalho Colin W Levy Andrew W Munro Claire Simons ChemistryOpen Published 23 July 2019 Crick labsLuiz Pedro CarvalhoFull details An essential bifunctional enzyme in Mycobacterium tuberculosis for itaconate dissimilation and leucine catabolism Authors (10) Hua Wang Alexander A Fedorov Elena V Fedorov Debbie M Hunt Angela RodgersHolly DouglasAcely Garza-Garcia Jeffrey B Bonanno Steven C AlmoLuiz Pedro Carvalho Proceedings of the National Academy of Sciences of the United States of America Published 6 August 2019 Crick labs/ facilitiesLuiz Pedro CarvalhoMRC Biomedical NMR CentreFull details Crucial role for central carbon metabolism in the bacterial L-form switch and killing by β-lactam antibiotics Authors (6) Yoshikazu Kawai Romain Mercier Katarzyna MickiewiczAgnese Serafini Luiz Pedro Sório de Carvalho Jeff Errington Nature Microbiology Published 1 October 2019 Crick labsLuiz Pedro CarvalhoFull details "Salmonella, meet mycobacteria." Authors (2)Stephanie Lovell-ReadLuiz Pedro Carvalho Journal of Experimental Medicine Published 1 March 2019 Crick labsLuiz Pedro CarvalhoFull details The tuberculosis necrotizing toxin is an NAD+ and NADP+ glycohydrolase with distinct enzymatic properties Authors (8) Uday Tak Jiri VlachAcely Garza-Garcia Doreen William Olga DanilchankaLuiz Pedro Carvalho Jamil S Saad Michael Niederweis Journal of Biological Chemistry Published 1 March 2019 Crick labsLuiz Pedro CarvalhoFull details Synthesis and biological evaluation of novel cYY analogues targeting Mycobacterium tuberculosis CYP121A1 Authors (10) Safaa M Kishk Kirsty J McLean Sakshi Sood Mohamed A Helal Mohamed S Gomaa Ismail Salama Samia M MostafaLuiz Pedro Carvalho Andrew W Munro Claire Simons Bioorganic & Medicinal Chemistry Published 27 February 2019 Crick labsLuiz Pedro CarvalhoFull details An NAD+ phosphorylase toxin triggers Mycobacterium tuberculosis cell death Authors (23) Diana Mendes Freire Claude GutierrezAcely Garza-Garcia Anna D Grabowska Ambre J Sala Kanchiyaphat Ariyachaokun[...] Pierre GenevauxLuiz Pedro Carvalho Matthias Wilmanns Annabel HA Parret Olivier Neyrolles Molecular Cell Published 18 February 2019 Crick labs/ facilitiesLuiz Pedro CarvalhoMRC Biomedical NMR CentreFull details Flexible nitrogen utilisation by the metabolic generalist pathogen Mycobacterium tuberculosis Authors (7)Aleksandra AgapovaAgnese Serafini Michael Petridis Debbie M HuntAcely Garza-Garcia Charles D SohaskeyLuiz Pedro Carvalho eLife Published 31 January 2019 Crick labsLuiz Pedro CarvalhoFull details Streptococcal dTDP-L-rhamnose biosynthesis enzymes: functional characterization and lead compound identification Authors (11) Samantha L van der Beek Azul Zorzoli Ebru Çanak Robert N Chapman Kieron Lucas Benjamin H MeyerDimitrios EvangelopoulosLuiz Pedro Carvalho Geert-Jan Boons Helge C Dorfmueller Nina M van Sorge Molecular Microbiology Published 1 April 2019 Crick labsLuiz Pedro CarvalhoFull details A novel regulatory factor affecting the transcription of methionine biosynthesis genes in Escherichia coli experiencing sustained nitrogen starvation Authors (6) Amy SwitzerDimitrios Evangelopoulos Rita FigueiraLuiz Pedro Carvalho Daniel R Brown Sivaramesh Wigneshweraraj Microbiology Published 29 June 2018 Crick labsLuiz Pedro CarvalhoFull details The mechanism of acetyl transfer catalyzed by Mycobacterium tuberculosis GlmU Authors (8)Peter CraggsStephane Mouilleron Martin RejzekCesira De Chiara Robert J Young Robert A Field Argyrides ArgyrouLuiz Pedro Carvalho Biochemistry Published 19 June 2018 Crick labs/ facilitiesLuiz Pedro CarvalhoStructural BiologyMRC Biomedical NMR CentreFull details Inhibition of D-Ala:D-Ala ligase through a phosphorylated form of the antibiotic D-cycloserine Authors (13) Sarah BatsonCesira De Chiara Vita Majce Adrian J Lloyd Stanislav Gobec Dean Rea[...] Katie J Simmons Christopher G Dowson Colin WG FishwickLuiz Pedro Carvalho David I Roper Nature Communications Published 5 December 2017 Crick labs/ facilitiesLuiz Pedro CarvalhoMRC Biomedical NMR CentreFull details Novel aryl substituted pyrazoles as small molecule inhibitors of cytochrome P450 CYP121A1: Synthesis and antimycobacterial evaluation Authors (14) Ismail M Taban Hosam EAE Elshihawy Beyza Torun Benedetta Zucchini Clare J Williamson Dania Altuwairigi[...] Sakshi Sood Leonardo B Marino Andrew W MunroLuiz Pedro Carvalho Claire Simons Journal of Medicinal Chemistry Published 28 December 2017 Crick labsLuiz Pedro CarvalhoFull details Design, synthesis and characterization of N-oxide-containing heterocycles with in vivo sterilizing antitubercular activity Authors (26) Guilherme Felipe dos Santos Fernandes Paula Carolina de Souza Elsa Moreno-Viguri Mery Santivañez-Veliz Rocio Paucar Silvia Pérez-Silanes[...] Sang Hyun Cho Yuehong Wang Scott Gary Franzblau Fernando Rogério Pavan Jean Leandro dos Santos Journal of Medicinal Chemistry Published 2 October 2017 Crick labsLuiz Pedro CarvalhoFull details Protein CoAlation: a redox-linked post-translational modification Authors (2)Steve LeyLuiz Pedro Carvalho Biochemical Journal Published 10 August 2017 Crick labsSteve LeyLuiz Pedro CarvalhoFull details Uncoupling conformational states from activity in an allosteric enzyme Authors (9) João P PiscoCesira De Chiara Kamila J PacholarzAcely Garza-GarciaRoksana OgrodowiczPhilip Walker Perdita E Barran Stephen J SmerdonLuiz Pedro Carvalho Nature Communications Published 7 August 2017 Crick labs/ facilitiesSteve SmerdonLuiz Pedro CarvalhoStructural BiologyFull details Pagination First page First Previous page Previous Page 1 Current page 2 Page 3 Page 4 Next page Next Last page Last Share the page Share on Twitter Share on Facebook Share on LinkedIn Share on Email
Pandemic peak SARS-CoV-2 infection and seroconversion rates in London frontline health-care workers Authors (341) Catherine F Houlihan Nina Vora Thomas Byrne Dan LewerGavin Kelly Judith Heaney[...] Andrew Hayward Richard Gilson Gavin KellyFiona Roberts Emine Hatipoglu The Lancet Published 25 July 2020 Crick labs/ facilitiesAndreas WackKaren VousdenJernej UleJames TurnerMoritz TreeckCharles SwantonAdam SaterialeErik SahaiCaetano Reis e SousaPeter RatcliffeLucia Prieto-GodinoVenizelos PapayannopoulosAnne O’GarraPaul NurseGeorge KassiotisMaximiliano GutierrezSonia GandhiSteve GamblinPeter Cherepanov Luiz Pedro CarvalhoDominique BonnetMike BlackmanRupert BealeWorldwide Influenza CentreStructural BiologyMetabolomicsHuman Embryonic Stem CellHigh Throughput ScreeningGenetic Modification ServiceFlow CytometryFermentationExperimental HistopathologyElectron MicroscopyCell ServicesBiological Research FacilityBioinformatics and BiostatisticsAdvanced SequencingScientific computingFull details
D-Cycloserine destruction by alanine racemase and the limit of irreversible inhibition Authors (9)Cesira De Chiara Miha Homšak Gareth A ProsserHolly DouglasAcely Garza-GarciaGeoff Kelly Andrew G Purkiss Edward W TateLuiz Pedro Carvalho Nature Chemical Biology Published 1 June 2020 Crick labs/ facilitiesEd TateLuiz Pedro CarvalhoStructural BiologyMRC Biomedical NMR CentreFull details
Comparative fitness analysis of D-cycloserine resistant mutants reveals both fitness-neutral and high-fitness cost genotypes Authors (9)Dimitrios Evangelopoulos Gareth A Prosser Angela Rodgers Belinda M Dagg Bhagwati Khatri Mei Mei HoMaximiliano Gutierrez Teresa CortesLuiz Pedro Carvalho Nature Communications Published 13 September 2019 Crick labs/ facilitiesMaximiliano GutierrezLuiz Pedro CarvalhoBiological Research FacilityAdvanced SequencingFull details
Mycobacterium tuberculosis requires glyoxylate shunt and reverse methylcitrate cycle for lactate and pyruvate metabolism Authors (17)Agnese Serafini Lendl Tan Stuart Horswell Steven HowellDaniel Greenwood Deborah M Hunt[...]Bram Snijders Brian VanderVenMaximiliano Gutierrez Nicholas P WestLuiz Pedro Carvalho Molecular Microbiology Published 1 October 2019 Crick labs/ facilitiesMaximiliano GutierrezLuiz Pedro CarvalhoProteomicsBioinformatics and BiostatisticsFull details
Design and synthesis of imidazole and triazole pyrazolesas Mycobacterium tuberculosis CYP121A1 inhibitors Authors (13) Safaa M Kishk Kirsty J McLean Sakshi Sood Darren Smith Jack WD Evans Mohamed A Helal[...] Samia M MostafaLuiz Pedro Carvalho Colin W Levy Andrew W Munro Claire Simons ChemistryOpen Published 23 July 2019 Crick labsLuiz Pedro CarvalhoFull details
An essential bifunctional enzyme in Mycobacterium tuberculosis for itaconate dissimilation and leucine catabolism Authors (10) Hua Wang Alexander A Fedorov Elena V Fedorov Debbie M Hunt Angela RodgersHolly DouglasAcely Garza-Garcia Jeffrey B Bonanno Steven C AlmoLuiz Pedro Carvalho Proceedings of the National Academy of Sciences of the United States of America Published 6 August 2019 Crick labs/ facilitiesLuiz Pedro CarvalhoMRC Biomedical NMR CentreFull details
Crucial role for central carbon metabolism in the bacterial L-form switch and killing by β-lactam antibiotics Authors (6) Yoshikazu Kawai Romain Mercier Katarzyna MickiewiczAgnese Serafini Luiz Pedro Sório de Carvalho Jeff Errington Nature Microbiology Published 1 October 2019 Crick labsLuiz Pedro CarvalhoFull details
"Salmonella, meet mycobacteria." Authors (2)Stephanie Lovell-ReadLuiz Pedro Carvalho Journal of Experimental Medicine Published 1 March 2019 Crick labsLuiz Pedro CarvalhoFull details
The tuberculosis necrotizing toxin is an NAD+ and NADP+ glycohydrolase with distinct enzymatic properties Authors (8) Uday Tak Jiri VlachAcely Garza-Garcia Doreen William Olga DanilchankaLuiz Pedro Carvalho Jamil S Saad Michael Niederweis Journal of Biological Chemistry Published 1 March 2019 Crick labsLuiz Pedro CarvalhoFull details
Synthesis and biological evaluation of novel cYY analogues targeting Mycobacterium tuberculosis CYP121A1 Authors (10) Safaa M Kishk Kirsty J McLean Sakshi Sood Mohamed A Helal Mohamed S Gomaa Ismail Salama Samia M MostafaLuiz Pedro Carvalho Andrew W Munro Claire Simons Bioorganic & Medicinal Chemistry Published 27 February 2019 Crick labsLuiz Pedro CarvalhoFull details
An NAD+ phosphorylase toxin triggers Mycobacterium tuberculosis cell death Authors (23) Diana Mendes Freire Claude GutierrezAcely Garza-Garcia Anna D Grabowska Ambre J Sala Kanchiyaphat Ariyachaokun[...] Pierre GenevauxLuiz Pedro Carvalho Matthias Wilmanns Annabel HA Parret Olivier Neyrolles Molecular Cell Published 18 February 2019 Crick labs/ facilitiesLuiz Pedro CarvalhoMRC Biomedical NMR CentreFull details
Flexible nitrogen utilisation by the metabolic generalist pathogen Mycobacterium tuberculosis Authors (7)Aleksandra AgapovaAgnese Serafini Michael Petridis Debbie M HuntAcely Garza-Garcia Charles D SohaskeyLuiz Pedro Carvalho eLife Published 31 January 2019 Crick labsLuiz Pedro CarvalhoFull details
Streptococcal dTDP-L-rhamnose biosynthesis enzymes: functional characterization and lead compound identification Authors (11) Samantha L van der Beek Azul Zorzoli Ebru Çanak Robert N Chapman Kieron Lucas Benjamin H MeyerDimitrios EvangelopoulosLuiz Pedro Carvalho Geert-Jan Boons Helge C Dorfmueller Nina M van Sorge Molecular Microbiology Published 1 April 2019 Crick labsLuiz Pedro CarvalhoFull details
A novel regulatory factor affecting the transcription of methionine biosynthesis genes in Escherichia coli experiencing sustained nitrogen starvation Authors (6) Amy SwitzerDimitrios Evangelopoulos Rita FigueiraLuiz Pedro Carvalho Daniel R Brown Sivaramesh Wigneshweraraj Microbiology Published 29 June 2018 Crick labsLuiz Pedro CarvalhoFull details
The mechanism of acetyl transfer catalyzed by Mycobacterium tuberculosis GlmU Authors (8)Peter CraggsStephane Mouilleron Martin RejzekCesira De Chiara Robert J Young Robert A Field Argyrides ArgyrouLuiz Pedro Carvalho Biochemistry Published 19 June 2018 Crick labs/ facilitiesLuiz Pedro CarvalhoStructural BiologyMRC Biomedical NMR CentreFull details
Inhibition of D-Ala:D-Ala ligase through a phosphorylated form of the antibiotic D-cycloserine Authors (13) Sarah BatsonCesira De Chiara Vita Majce Adrian J Lloyd Stanislav Gobec Dean Rea[...] Katie J Simmons Christopher G Dowson Colin WG FishwickLuiz Pedro Carvalho David I Roper Nature Communications Published 5 December 2017 Crick labs/ facilitiesLuiz Pedro CarvalhoMRC Biomedical NMR CentreFull details
Novel aryl substituted pyrazoles as small molecule inhibitors of cytochrome P450 CYP121A1: Synthesis and antimycobacterial evaluation Authors (14) Ismail M Taban Hosam EAE Elshihawy Beyza Torun Benedetta Zucchini Clare J Williamson Dania Altuwairigi[...] Sakshi Sood Leonardo B Marino Andrew W MunroLuiz Pedro Carvalho Claire Simons Journal of Medicinal Chemistry Published 28 December 2017 Crick labsLuiz Pedro CarvalhoFull details
Design, synthesis and characterization of N-oxide-containing heterocycles with in vivo sterilizing antitubercular activity Authors (26) Guilherme Felipe dos Santos Fernandes Paula Carolina de Souza Elsa Moreno-Viguri Mery Santivañez-Veliz Rocio Paucar Silvia Pérez-Silanes[...] Sang Hyun Cho Yuehong Wang Scott Gary Franzblau Fernando Rogério Pavan Jean Leandro dos Santos Journal of Medicinal Chemistry Published 2 October 2017 Crick labsLuiz Pedro CarvalhoFull details
Protein CoAlation: a redox-linked post-translational modification Authors (2)Steve LeyLuiz Pedro Carvalho Biochemical Journal Published 10 August 2017 Crick labsSteve LeyLuiz Pedro CarvalhoFull details
Uncoupling conformational states from activity in an allosteric enzyme Authors (9) João P PiscoCesira De Chiara Kamila J PacholarzAcely Garza-GarciaRoksana OgrodowiczPhilip Walker Perdita E Barran Stephen J SmerdonLuiz Pedro Carvalho Nature Communications Published 7 August 2017 Crick labs/ facilitiesSteve SmerdonLuiz Pedro CarvalhoStructural BiologyFull details