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Breadcrumb Luiz Pedro Carvalho Carvalho lab Mycobacterial Metabolism and Antibiotic Research Laboratory : Publications Lab contentLab contentIn this section Overview Areas of interest Publications Members Vacancies Close-up view of a scheme illustrating reactions from Mycobacterium tuberculosis core metabolism. Toggle to view hero caption PublicationsYear published2024 (2)2023 (4)2022 (7)2021 (6)2020 (3)2019 (11)2018 (2)2017 (6)2016 (4)2015 (4)2014 (4)2013 (6)2012 (1)2011 (1)2010 (3) Facet Year publishedResearch topicsBiochemistry & Proteomics (47)Computational & Systems Biology (47)Genetics & Genomics (47)Infectious Disease (47)Metabolism (47)Structural Biology & Biophysics (47)Chemical Biology & High Throughput (13)Cell Biology (10)Model Organisms (10)Immunology (8)Tumour Biology (8)Genome Integrity & Repair (7)Signalling & Oncogenes (7)Human Biology & Physiology (5)Developmental Biology (4)Gene Expression (4)Imaging (4)Synthetic Biology (4)Cell Cycle & Chromosomes (3)Stem Cells (3)Neurosciences (2)Microfabrication & Bioengineering (1) Facet Research topicsCrick/Pre-CrickCrick publications (61)Pre-Crick publications (3) Facet Crick/Pre-CrickPublication typeJournal article (64)Primary research (49)Review (6)Commentary (4)Method (2) Facet Publication typeJournalNature Communications (6)Biochemistry (5)Chemistry & Biology (3)Journal of Biological Chemistry (3)Journal of Medicinal Chemistry (3)Nature Microbiology (3)Molecular Microbiology (2)Nature Chemical Biology (2)PLOS Pathogens (2)Proceedings of the National Academy of Sciences of the United States of America (2)Structure (2)ACS Bio & Med Chem Au (1)ACS Chemical Biology (1)ACS Infectious Diseases (1)ACS Medicinal Chemistry Letters (1)Antimicrobial Agents and Chemotherapy (1)Autophagy (1)Biochemical Journal (1)Bioorganic & Medicinal Chemistry (1)Bioorganic & Medicinal Chemistry Letters (1)ChemistryOpen (1)Current Opinion in Chemical Biology (1)Current Opinion in Microbiology (1)Current Opinion in Systems Biology (1)eLife (1)EMBO Reports (1)European Journal of Medicinal Chemistry (1)FEBS Journal (1)Frontiers in Immunology (1)Frontiers in Molecular Biosciences (1)Journal of Bacteriology (1)Journal of Experimental Medicine (1)mBio (1)Methods in Enzymology (1)Methods in Molecular Biology (1)Microbiology (1)Molecular Cell (1)Nature (1)Nature Metabolism (1)Proceedings of the National Academy of Sciences of USA (1)The Lancet (1)Tuberculosis (1) Facet Journal Publications Displaying 41 - 60 of 64Last updated : 17 April 2024 02:10 Hybrid mass spectrometry approaches to determine how L-histidine feedback regulates the enzyzme MtATP-phosphoribosyltransferase Authors (11) Kamila J Pacholarz Rebecca J Burnley Thomas A Jowitt Victoria Ordsmith João Pedro Pisco Massimiliano Porrini Gérald Larrouy-Maumus Rachel A Garlish Richard J TaylorLuiz Pedro Carvalho Perdita E Barran Structure Published 2 May 2017 Crick labsLuiz Pedro CarvalhoFull details TPL-2 regulates macrophage lipid metabolism and M2 differentiation to control TH2-mediated immunopathology Authors (13) Yashaswini KannanJimena Perez-Lloret Yanda Li Lewis J Entwistle Hania Khouri Stamatia Papoutsopoulou[...] Stanley Ching-Cheng Huang Edward J PearceLuiz Pedro CarvalhoSteve Ley Mark S Wilson PLOS Pathogens Published 3 August 2016 Crick labs/ facilitiesSteve LeyLuiz Pedro CarvalhoExperimental HistopathologyGenetic Modification ServiceFlow CytometryBiological Research FacilityFull details Glutamate racemase is the primary target of β-chloro-ᴅ-alanine in Mycobacterium tuberculosis Authors (7) Gareth A Prosser Anne Rodenburg Hania KhouryCesira De Chiara Steve HowellBram SnijdersLuiz Pedro Carvalho Antimicrobial Agents and Chemotherapy Published 1 October 2016 Crick labs/ facilitiesLuiz Pedro CarvalhoProteomicsFull details Cell-envelope remodeling as a determinant of phenotypic antibacterial tolerance in Mycobacterium tuberculosis Authors (10) Gérald Larrouy-Maumus Leonardo B Marino Ashoka VR Madduri TJ Ragan Debbie M Hunt Lucrezia BassanoMaximiliano Gutierrez D Branch Moody Fernando R PavanLuiz Pedro Carvalho ACS Infectious Diseases Published 13 May 2016 Crick labs/ facilitiesMaximiliano GutierrezLuiz Pedro CarvalhoMRC Biomedical NMR CentreFull details Fragment-based approaches to the development of Mycobacterium tuberculosis CYP121 inhibitors Authors (13) Madeline E Kavanagh Anthony G Coyne Kirsty J McLean Guy G James Colin W Levy Leonardo B Marino[...] Sean A Hudson Sachin Surade David Leys Andrew W Munro Chris Abell Journal of Medicinal Chemistry Published 14 April 2016 Crick labsLuiz Pedro CarvalhoFull details Two enzymes with redundant fructose bisphosphatase activity sustain gluconeogenesis and virulence in Mycobacterium tuberculosis Authors (7) Uday Ganapathy Joeli Marrero Susannah Calhoun Hyungjin EohLuiz Pedro Carvalho Kyu Rhee Sabine Ehrt Nature Communications Published 10 August 2015 Crick labsLuiz Pedro CarvalhoFull details Thiophenecarboxamide derivatives activated by EthA kill Mycobacterium tuberculosis by inhibiting the CTP synthetase PyrG Authors (29) Giorgia Mori Laurent R Chiarelli Marta Esposito Vadim Makarov Marco Bellinzoni Ruben C Hartkoorn[...] Riccardo ManganelliLuiz Pedro Carvalho Giovanna Riccardi Stewart T Cole Maria Rosalia Pasca Chemistry & Biology Published 23 July 2015 Crick labsLuiz Pedro CarvalhoFull details Metabolomics of Mycobacterium tuberculosis Authors (4) Madhumitha Nandakumar Gareth A ProsserLuiz Pedro Carvalho Kyu Rhee Methods in Molecular Biology Published 1 January 2015 Crick labsLuiz Pedro CarvalhoFull details Phylogenetic analysis of vitamin B12-related metabolism in Mycobacterium tuberculosis Authors (3) Douglas B Young Iñaki ComasLuiz Pedro Carvalho Frontiers in Molecular Biosciences Published 1 January 2015 Crick labsLuiz Pedro CarvalhoFull details Chemical mechanism of glycerol 3-phosphate phosphatase: pH-dependent changes in the rate-limiting step Authors (3) Gérald Larrouy-MaumusGeoff KellyLuiz Pedro Carvalho Biochemistry Published 20 December 2014 Crick labs/ facilitiesMRC Biomedical NMR CentreLuiz Pedro CarvalhoMRC Biomedical NMR CentreFull details Biosynthesis and translocation of unsulfated acyltrehaloses in Mycobacterium tuberculosis Authors (6) Juan Manuel Belardinelli Gérald Larrouy-Maumus Victoria JonesLuiz Pedro Carvalho Michael R McNeil Mary Jackson Journal of Biological Chemistry Published 14 August 2014 Crick labsLuiz Pedro CarvalhoFull details Metabolomic strategies for the identification of new enzyme functions and metabolic pathways Authors (3) Gareth A Prosser Gerald Larrouy-MaumusLuiz Pedro Carvalho EMBO Reports Published 14 May 2014 Crick labsLuiz Pedro CarvalhoFull details Mycobacterium tuberculosis exploits asparagine to assimilate nitrogen and resist acid stress during infection Authors (16) A Gouzy G Larrouy-Maumus D Bottai F Levillain A Dumas JB Wallach[...] J-L Guerquin-Kern D SchnappingerLuiz Pedro Carvalho Y Poquet O Neyrolles PLOS Pathogens Published 1 February 2014 Crick labsLuiz Pedro CarvalhoFull details Metabolomics reveal D-Alanine:D-Alanine ligase as the target of D-Cycloserine in Mycobacterium tuberculosis Authors (2) GA ProsserLuiz Pedro Carvalho ACS Medicinal Chemistry Letters Published 1 December 2013 Crick labsLuiz Pedro CarvalhoFull details Mycobacterium tuberculosis nitrogen assimilation and host colonization require aspartate Authors (10) Alexandre Gouzy Gérald Larrouy-Maumus Ting-Di Wu Antonio Peixoto Florence Levillain Geanncarlo Lugo-Villarino Jean-Luc Guerquin-KernLuiz Pedro Carvalho Yannick Poquet Olivier Neyrolles Nature Chemical Biology Published 29 September 2013 Crick labsLuiz Pedro CarvalhoFull details Reinterpreting the mechanism of inhibition of Mycobacterium tuberculosis D-alanine:D-alanine ligase by D-cycloserine Authors (2) Gareth Adrian ProsserLuiz Pedro Carvalho Biochemistry Published 13 September 2013 Crick labsLuiz Pedro CarvalhoFull details Discovery of a glycerol 3-phosphate phosphatase reveals glycerophospholipid polar head recycling in Mycobacterium tuberculosis Authors (6) Gérald Larrouy-Maumus Tapan Biswas Debbie M HuntGeoff Kelly Oleg V TsodikovLuiz Pedro Carvalho Proceedings of the National Academy of Sciences of the United States of America Published 1 January 2013 Crick labs/ facilitiesLuiz Pedro CarvalhoMRC Biomedical NMR CentreFull details Functional assignment of Mycobacterium tuberculosis proteome revealed by genome-scale fold-recognition Authors (8) C Mao M Shukla G Larrouy-Maumus FL Dix LA Kelley MJ Sternberg BW SobralLuiz Pedro Carvalho Tuberculosis Published 1 January 2013 Crick labsLuiz Pedro CarvalhoFull details Kinetic mechanism and inhibition of Mycobacterium tuberculosis D-alanine:D-alanine ligase by the antibiotic D-cycloserine Authors (2) GA ProsserLuiz Pedro Carvalho FEBS Journal Published 1 January 2013 Crick labsLuiz Pedro CarvalhoFull details Mechanism of feedback allosteric inhibition of ATP phosphoribosyltransferase Authors (5) Sònia Pedreño João Pedro Pisco Gérald Larrouy-MaumusGeoff KellyLuiz Pedro Carvalho Biochemistry Published 1 January 2012 Crick labs/ facilitiesLuiz Pedro CarvalhoMRC Biomedical NMR CentreFull details Pagination First page First Previous page Previous Page 1 Page 2 Current page 3 Page 4 Next page Next Last page Last Share the page Share on 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Hybrid mass spectrometry approaches to determine how L-histidine feedback regulates the enzyzme MtATP-phosphoribosyltransferase Authors (11) Kamila J Pacholarz Rebecca J Burnley Thomas A Jowitt Victoria Ordsmith João Pedro Pisco Massimiliano Porrini Gérald Larrouy-Maumus Rachel A Garlish Richard J TaylorLuiz Pedro Carvalho Perdita E Barran Structure Published 2 May 2017 Crick labsLuiz Pedro CarvalhoFull details
TPL-2 regulates macrophage lipid metabolism and M2 differentiation to control TH2-mediated immunopathology Authors (13) Yashaswini KannanJimena Perez-Lloret Yanda Li Lewis J Entwistle Hania Khouri Stamatia Papoutsopoulou[...] Stanley Ching-Cheng Huang Edward J PearceLuiz Pedro CarvalhoSteve Ley Mark S Wilson PLOS Pathogens Published 3 August 2016 Crick labs/ facilitiesSteve LeyLuiz Pedro CarvalhoExperimental HistopathologyGenetic Modification ServiceFlow CytometryBiological Research FacilityFull details
Glutamate racemase is the primary target of β-chloro-ᴅ-alanine in Mycobacterium tuberculosis Authors (7) Gareth A Prosser Anne Rodenburg Hania KhouryCesira De Chiara Steve HowellBram SnijdersLuiz Pedro Carvalho Antimicrobial Agents and Chemotherapy Published 1 October 2016 Crick labs/ facilitiesLuiz Pedro CarvalhoProteomicsFull details
Cell-envelope remodeling as a determinant of phenotypic antibacterial tolerance in Mycobacterium tuberculosis Authors (10) Gérald Larrouy-Maumus Leonardo B Marino Ashoka VR Madduri TJ Ragan Debbie M Hunt Lucrezia BassanoMaximiliano Gutierrez D Branch Moody Fernando R PavanLuiz Pedro Carvalho ACS Infectious Diseases Published 13 May 2016 Crick labs/ facilitiesMaximiliano GutierrezLuiz Pedro CarvalhoMRC Biomedical NMR CentreFull details
Fragment-based approaches to the development of Mycobacterium tuberculosis CYP121 inhibitors Authors (13) Madeline E Kavanagh Anthony G Coyne Kirsty J McLean Guy G James Colin W Levy Leonardo B Marino[...] Sean A Hudson Sachin Surade David Leys Andrew W Munro Chris Abell Journal of Medicinal Chemistry Published 14 April 2016 Crick labsLuiz Pedro CarvalhoFull details
Two enzymes with redundant fructose bisphosphatase activity sustain gluconeogenesis and virulence in Mycobacterium tuberculosis Authors (7) Uday Ganapathy Joeli Marrero Susannah Calhoun Hyungjin EohLuiz Pedro Carvalho Kyu Rhee Sabine Ehrt Nature Communications Published 10 August 2015 Crick labsLuiz Pedro CarvalhoFull details
Thiophenecarboxamide derivatives activated by EthA kill Mycobacterium tuberculosis by inhibiting the CTP synthetase PyrG Authors (29) Giorgia Mori Laurent R Chiarelli Marta Esposito Vadim Makarov Marco Bellinzoni Ruben C Hartkoorn[...] Riccardo ManganelliLuiz Pedro Carvalho Giovanna Riccardi Stewart T Cole Maria Rosalia Pasca Chemistry & Biology Published 23 July 2015 Crick labsLuiz Pedro CarvalhoFull details
Metabolomics of Mycobacterium tuberculosis Authors (4) Madhumitha Nandakumar Gareth A ProsserLuiz Pedro Carvalho Kyu Rhee Methods in Molecular Biology Published 1 January 2015 Crick labsLuiz Pedro CarvalhoFull details
Phylogenetic analysis of vitamin B12-related metabolism in Mycobacterium tuberculosis Authors (3) Douglas B Young Iñaki ComasLuiz Pedro Carvalho Frontiers in Molecular Biosciences Published 1 January 2015 Crick labsLuiz Pedro CarvalhoFull details
Chemical mechanism of glycerol 3-phosphate phosphatase: pH-dependent changes in the rate-limiting step Authors (3) Gérald Larrouy-MaumusGeoff KellyLuiz Pedro Carvalho Biochemistry Published 20 December 2014 Crick labs/ facilitiesMRC Biomedical NMR CentreLuiz Pedro CarvalhoMRC Biomedical NMR CentreFull details
Biosynthesis and translocation of unsulfated acyltrehaloses in Mycobacterium tuberculosis Authors (6) Juan Manuel Belardinelli Gérald Larrouy-Maumus Victoria JonesLuiz Pedro Carvalho Michael R McNeil Mary Jackson Journal of Biological Chemistry Published 14 August 2014 Crick labsLuiz Pedro CarvalhoFull details
Metabolomic strategies for the identification of new enzyme functions and metabolic pathways Authors (3) Gareth A Prosser Gerald Larrouy-MaumusLuiz Pedro Carvalho EMBO Reports Published 14 May 2014 Crick labsLuiz Pedro CarvalhoFull details
Mycobacterium tuberculosis exploits asparagine to assimilate nitrogen and resist acid stress during infection Authors (16) A Gouzy G Larrouy-Maumus D Bottai F Levillain A Dumas JB Wallach[...] J-L Guerquin-Kern D SchnappingerLuiz Pedro Carvalho Y Poquet O Neyrolles PLOS Pathogens Published 1 February 2014 Crick labsLuiz Pedro CarvalhoFull details
Metabolomics reveal D-Alanine:D-Alanine ligase as the target of D-Cycloserine in Mycobacterium tuberculosis Authors (2) GA ProsserLuiz Pedro Carvalho ACS Medicinal Chemistry Letters Published 1 December 2013 Crick labsLuiz Pedro CarvalhoFull details
Mycobacterium tuberculosis nitrogen assimilation and host colonization require aspartate Authors (10) Alexandre Gouzy Gérald Larrouy-Maumus Ting-Di Wu Antonio Peixoto Florence Levillain Geanncarlo Lugo-Villarino Jean-Luc Guerquin-KernLuiz Pedro Carvalho Yannick Poquet Olivier Neyrolles Nature Chemical Biology Published 29 September 2013 Crick labsLuiz Pedro CarvalhoFull details
Reinterpreting the mechanism of inhibition of Mycobacterium tuberculosis D-alanine:D-alanine ligase by D-cycloserine Authors (2) Gareth Adrian ProsserLuiz Pedro Carvalho Biochemistry Published 13 September 2013 Crick labsLuiz Pedro CarvalhoFull details
Discovery of a glycerol 3-phosphate phosphatase reveals glycerophospholipid polar head recycling in Mycobacterium tuberculosis Authors (6) Gérald Larrouy-Maumus Tapan Biswas Debbie M HuntGeoff Kelly Oleg V TsodikovLuiz Pedro Carvalho Proceedings of the National Academy of Sciences of the United States of America Published 1 January 2013 Crick labs/ facilitiesLuiz Pedro CarvalhoMRC Biomedical NMR CentreFull details
Functional assignment of Mycobacterium tuberculosis proteome revealed by genome-scale fold-recognition Authors (8) C Mao M Shukla G Larrouy-Maumus FL Dix LA Kelley MJ Sternberg BW SobralLuiz Pedro Carvalho Tuberculosis Published 1 January 2013 Crick labsLuiz Pedro CarvalhoFull details
Kinetic mechanism and inhibition of Mycobacterium tuberculosis D-alanine:D-alanine ligase by the antibiotic D-cycloserine Authors (2) GA ProsserLuiz Pedro Carvalho FEBS Journal Published 1 January 2013 Crick labsLuiz Pedro CarvalhoFull details
Mechanism of feedback allosteric inhibition of ATP phosphoribosyltransferase Authors (5) Sònia Pedreño João Pedro Pisco Gérald Larrouy-MaumusGeoff KellyLuiz Pedro Carvalho Biochemistry Published 1 January 2012 Crick labs/ facilitiesLuiz Pedro CarvalhoMRC Biomedical NMR CentreFull details