Publications

Vitamin B5 supports MYC oncogenic metabolism and tumor progression in breast cancer

Authors (40)

Peter Kreuzaler
Paolo Inglese
Avinash Ghanate
Ersa Gjelaj
Vincen Wu
Yulia Panina
[...]
George Poulogiannis
Greg McMahon
Zoltan Takats
Josephine Bunch
Mariia Yuneva

Nature Metabolism

Published 1 November 2023

Crick labs/ facilities

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Metabolic profiling stratifies colorectal cancer and reveals adenosylhomocysteinase as a therapeutic target

Authors (54)

Johan Vande Voorde
Rory T Steven
Arafath K Najumudeen
Catriona A Ford
Alex Dexter
Ariadna Gonzalez-Fernandez
[...]
David Sumpton
Zoltan Takats
Andrew D Campbell
Josephine Bunch
Owen J Sansom

Nature Metabolism

Published 1 August 2023

Crick labs/ facilities

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ALDH1L2 regulation of formate, formyl-methionine, and ROS controls cancer cell migration and metastasis

Authors (20)

Cell Reports

Published 26 May 2023

Crick labs/ facilities

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[18F]-(2S,4R)4-fluoroglutamine PET imaging of glutamine metabolism in murine models of hepatocellular carcinoma (HCC)

Authors (6)

Youngho Seo
Miranda C Craig
Stephanie T Murphy
Jinjin Feng
Xin Chen
Mariia Yuneva

Molecular Imaging

Published 25 July 2022

Crick labs

Mariia Yuneva

Full details

Constitutive activation of the PI3K-Akt-mTORC1 pathway sustains the m.3243 A > G mtDNA mutation

Authors (13)

Chih-Yao Chung
Kritarth Singh
Vassilios N Kotiadis
Gabriel E Valdebenito
Jee Hwan Ahn
Emilie Topley
[...]
Benoit Bilanges
Robert DS Pitceathly
Gyorgy Szabadkai
Mariia Yuneva
Michael R Duchen

Nature Communications

Published 4 November 2021

Crick labs/ facilities

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Cysteine and folate metabolism are targetable vulnerabilities of metastatic colorectal cancer

Authors (13)

Josep Tarrago Celada
Carles Foguet
Míriam Tarrado-Castellarnau
Silvia Marin
Xavier Hernández-Alias
Jordi Perarnau
[...]
Roger R Gomis
Eytan Ruppin
Mariia Yuneva
Pedro de Atauri
Marta Cascante

Cancers

Published 23 January 2021

Crick labs

Mariia Yuneva

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The amino acid transporter SLC7A5 is required for efficient growth of KRAS-mutant colorectal cancer

Authors (93)

AK Najumudeen
F Ceteci
SK Fey
G Hamm
RT Steven
H Hall
[...]
RJA Goodwin
J Bunch
M Bushell
AD Campbell
OJ Sansom

Nature Genetics

Published 1 January 2021

Crick labs

Mariia Yuneva

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Identifying strategies to target the metabolic flexibility of tumours

Authors (16)

Nature Metabolism

Published 1 April 2020

Crick labs/ facilities

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Metabolic reprogramming and Notch activity distinguish between non-small cell lung cancer subtypes

Authors (13)

Katherine Sellers
Thaddeus D Allen
Michael Bousamra
JinLian Tan
Andres Mendez-Lucas
Wei Lin
[...]
James Macrae
Richard M Higashi
Andrew N Lane
Teresa W-M Fan
Mariia Yuneva

British Journal of Cancer

Published 1 July 2019

Crick labs/ facilities

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Low catalytic activity is insufficient to induce disease pathology in triosephosphate isomerase deficiency

Authors (32)

Joanna Segal
Michael Muelleder
Antje Krüger
Thure Adler
Manuela Scholze-Wittler
Lore Becker
[...]
Helmut Fuchs
Martin H de Angelis
Heinrich Schrewe
Mariia Yuneva
Markus Ralser

Journal of Inherited Metabolic Disease

Published 1 September 2019

Crick labs/ facilities

Full details

Hyperpolarised 13C MRI: a new horizon for non-invasive diagnosis of aggressive breast cancer

Authors (24)

Oshaani Abeyakoon
Arash Latifoltojar
Fiona Gong
Marianthi-Vasiliki Papoutsaki
Rafat Chowdhury
Matthias Glaser
[...]
Rob Stein
Mariia Yuneva
Gyorgi Szabadkai
Steve Halligan
Shonit Punwani

BJR Case Reports

Published 1 September 2019

Crick labs

Mariia Yuneva

Full details

Evidence for an alternative fatty acid desaturation pathway increasing cancer plasticity

Authors (46)

Kim Vriens
Stefan Christen
Sweta Parik
Dorien Broekaert
Kazuaki Yoshinaga
Ali Talebi
[...]
Chris Verslype
Sven Christian
Sylvia Grünewald
Thomas GP Grünewald
Sarah-Maria Fendt

Nature

Published 6 February 2019

Crick labs

Mariia Yuneva

Full details

De novo MYC addiction as an adaptive response of cancer cells to CDK4/6 inhibition

Authors (7)

Míriam Tarrado-Castellarnau
Pedro de Atauri
Josep Tarrago Celada
Jordi Perarnau
Mariia Yuneva
Timothy M Thomson
Marta Cascante

Molecular Systems Biology

Published 1 October 2017

Crick labs

Mariia Yuneva

Full details

Glucose catabolism in liver tumors induced by c-MYC can be sustained by various PKM1/PKM2 ratios and pyruvate kinase activities

Authors (13)

Andres Mendez-Lucas
Xiaolei Li
Junjie Hu
Li Che
Xinhua Song
Jiaoyuan Jia
[...]
Paul Driscoll
Darjus F Tschaharganeh
Diego F Calvisi
Mariia Yuneva
Xin Chen

Cancer Research

Published 1 August 2017

Crick labs/ facilities

Full details

MYC/PGC-1α balance determines the metabolic phenotype and plasticity of pancreatic cancer stem cells

Authors (14)

Patricia Sancho
Emma Burgos-Ramos
Alejandra Tavera
Tony Bou Kheir
Petra Jagust
Matthieu Schoenhals
[...]
Osvaldo Graña
Catarina R Viera
Mariia Yuneva
Bruno Sainz
Christopher Heeschen

Cell Metabolism

Published 6 October 2015

Crick labs

Mariia Yuneva

Full details

Pyruvate carboxylase is critical for non-small-cell lung cancer proliferation

Authors (12)

Katherine Sellers
Matthew P Fox
Michael Bousamra
Stephen P Slone
Richard M Higashi
Donald M Miller
[...]
Jun Yan
Mariia Yuneva
Rahul Deshpande
Andrew N Lane
Teresa W-M Fan

Journal of Clinical Investigation

Published 2 February 2015

Crick labs

Mariia Yuneva

Full details

Glutamine sensitivity analysis identifies the xCT antiporter as a common triple-negative breast tumor therapeutic target

Authors (13)

Luika A Timmerman
Thomas Holton
Mariia Yuneva
Raymond J Louie
Mercè Padró
Anneleen Daemen
[...]
Stephen P Ethier
Laura J van 't Veer
Kornelia Polyak
Frank McCormick
Joe W Gray

Cancer Cell

Published 1 October 2013

Crick labs

Mariia Yuneva

Full details

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Vitamin B5 supports MYC oncogenic metabolism and tumor progression in breast cancer

Metabolic profiling stratifies colorectal cancer and reveals adenosylhomocysteinase as a therapeutic target

ALDH1L2 regulation of formate, formyl-methionine, and ROS controls cancer cell migration and metastasis

[18F]-(2S,4R)4-fluoroglutamine PET imaging of glutamine metabolism in murine models of hepatocellular carcinoma (HCC)

Constitutive activation of the PI3K-Akt-mTORC1 pathway sustains the m.3243 A > G mtDNA mutation

Cysteine and folate metabolism are targetable vulnerabilities of metastatic colorectal cancer

The amino acid transporter SLC7A5 is required for efficient growth of KRAS-mutant colorectal cancer

Identifying strategies to target the metabolic flexibility of tumours

Metabolic reprogramming and Notch activity distinguish between non-small cell lung cancer subtypes

Low catalytic activity is insufficient to induce disease pathology in triosephosphate isomerase deficiency

Hyperpolarised 13C MRI: a new horizon for non-invasive diagnosis of aggressive breast cancer

Evidence for an alternative fatty acid desaturation pathway increasing cancer plasticity

De novo MYC addiction as an adaptive response of cancer cells to CDK4/6 inhibition

Glucose catabolism in liver tumors induced by c-MYC can be sustained by various PKM1/PKM2 ratios and pyruvate kinase activities

MYC/PGC-1α balance determines the metabolic phenotype and plasticity of pancreatic cancer stem cells

Pyruvate carboxylase is critical for non-small-cell lung cancer proliferation

Glutamine sensitivity analysis identifies the xCT antiporter as a common triple-negative breast tumor therapeutic target

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