Publications

The metabolic domestication syndrome of budding yeast

Authors (12)

Roland Tengölics
Balázs Szappanos
Michael Mülleder
Dorottya Kalapis
Gábor Grézal
Csilla Sajben
[...]
João Benhur Mokochinski
Balázs Bálint
László G Nagy
Markus Ralser
Balázs Papp

Proceedings of the National Academy of Sciences of USA

Published 12 March 2024

Crick labs

Markus Ralser

Full details

The yeast RNA methylation complex consists of conserved yet reconfigured components with m6A-dependent and independent roles

Authors (16)

Imke Ensinck
Alexander Maman
Waleed S Albihlal
Michelangelo Lassandro
Giulia Salzano
Theodora Sideri
[...]
Bram Snijders
Mark Skehel
Ana Casañal
Schraga Schwartz
Folkert Van Werven

eLife

Published 25 July 2023

Crick labs/ facilities

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C. elegans ageing is accelerated by a self-destructive reproductive programme

Authors (12)

Carina C Kern
Shivangi Srivastava
Marina Ezcurra
Kuei Ching Hsiung
Nancy Hui
St John Townsend
[...]
Bruce Zhang
Victoria Tse
Viktoras Konstantellos
Jürg Bähler
David Gems

Nature Communications

Published 20 July 2023

Crick labs

Markus Ralser

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Oxonium ion scanning mass spectrometry for large-scale plasma glycoproteomics

Authors (15)

Matthew EH White
Ludwig R Sinn
D Marc Jones
Joost de Folter
Simran Aulakh
Ziyue Wang
[...]
Florian Kurth
Michael Mülleder
Véronique Blanchard
Christoph Messner
Markus Ralser

Nature Biomedical Engineering

Published 20 July 2023

Crick labs/ facilities

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Spontaneously established syntrophic yeast communities improve bioproduction

Authors (8)

Simran Aulakh
Lara Sellés Vidal
Eric J South
Huadong Peng
Sreejith Jayasree Varma
Lucia Herrera-Dominguez
Markus Ralser
Rodrigo Ledesma-Amaro

Nature Chemical Biology

Published 1 August 2023

Crick labs/ facilities

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90K/LGALS3BP expression is upregulated in COVID-19 but may not restrict SARS-CoV-2 infection

Authors (29)

Laure Bosquillon de Jarcy
Bengisu Akbil
Baxolele Mhlekude
Johanna Leyens
Dylan Postmus
Greta Harnisch
[...]
Markus Ralser
Roland Eils
Florian Kurth
Leif Sander
Christine Goffinet

Clinical and Experimental Medicine

Published 1 November 2023

Crick labs

Markus Ralser

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Determinants of recovery from post-COVID-19 dyspnoea: analysis of UK prospective cohorts of hospitalised COVID-19 patients and community-based controls

Authors (37)

B Zheng
G Vivaldi
L Daines
OC Leavy
M Richardson
O Elneima
[...]
RA Evans
CE Brightling
A Martineau
A Sheikh
The PHOSP-COVID Study Collaborative Group

The Lancet Regional Health - Europe

Published 1 June 2023

Crick labs

Full details

The proteomic landscape of genome-wide genetic perturbations

Authors (19)

Christoph Messner
Vadim Demichev
Julia Muenzner
Simran Aulakh
Natalie Barthel
Annika Röhl
[...]
Michael Mülleder
Kathryn S Lilley
Charles Boone
Georg Kustatscher
Markus Ralser

Cell

Published 27 April 2023

Crick labs/ facilities

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RECAST: Study protocol for an observational study for the understanding of the increased resilience of children compared to adults in SARS-CoV-2 infection

Authors (19)

Sebastian Stricker
Niklas Ziegahn
Martin Karsten
Thomas Boeckel
Heike Stich-Boeckel
Jakob Maske
[...]
Markus Ralser
Victor M Corman
Marcus A Mall
Birgit Sawitzki
Jobst Roehmel

BMJ Open

Published 17 April 2023

Crick labs

Markus Ralser

Full details

Effects of sleep disturbance on dyspnoea and impaired lung function following hospital admission due to COVID-19 in the UK: a prospective multicentre cohort study

Authors (62)

Callum Jackson
Iain D Stewart
Tatiana Plekhanova
Peter S Cunningham
Andrew L Hazel
Bashar Al-Sheklly
[...]
Rachael A Evans
Samuel E Jones
Martin K Rutter
John F Blaikley
PHOSP-COVID Study Collaborative Group

The Lancet Respiratory Medicine

Published 1 August 2023

Crick labs

Full details

Prevalence of physical frailty, including risk factors, up to 1 year after hospitalisation for COVID-19 in the UK: a multicentre, longitudinal cohort study

Authors (38)

HJC McAuley
RA Evans
CE Bolton
CE Brightling
JD Chalmers
AB Docherty
[...]
J Whitney
MD Witham
J Lord
NJ Greening
The PHOSP-COVID Study Collaborative Group

EClinicalMedicine

Published 1 March 2023

Crick labs

Full details

Metabolic heterogeneity and cross-feeding within isogenic yeast populations captured by DILAC

Authors (8)

Stephan Kamrad
Clara Correia-Melo
Lukasz Szyrwiel
Simran Aulakh
Jürg Bähler
Vadim Demichev
Michael Mülleder
Markus Ralser

Nature Microbiology

Published 1 March 2023

Crick labs/ facilities

Full details

The impact of acute nutritional interventions on the plasma proteome

Authors (21)

Spyros Vernardis
Vadim Demichev
Oliver Lemke
Nana-Maria Grüning
Christoph Messner
Matt White
[...]
Aleksej Zelezniak
Nicholas J Wareham
Claudia Langenberg
I Sadaf Farooqi
Markus Ralser

Journal of Clinical Endocrinology and Metabolism

Published 1 August 2023

Crick labs

Markus Ralser

Full details

Cell-cell metabolite exchange creates a pro-survival metabolic environment that extends lifespan

Authors (20)

Cell

Published 5 January 2023

Crick labs/ facilities

Full details

SARS-CoV-2-specific nasal IgA wanes 9 months after hospitalisation with COVID-19 and is not induced by subsequent vaccination

Authors (43)

Felicity Liew
Shubha Talwar
Andy Cross
Brian J Willett
Sam Scott
Nicola Logan
[...]
Ryan S Thwaites
Lance Turtle
Peter JM Openshaw
ISARIC4C Investigators
PHOSP-COVID collaborative group

EBioMedicine

Published 1 January 2023

Crick labs

Markus Ralser

Full details

Inorganic sulfur fixation via a new homocysteine synthase allows yeast cells to cooperatively compensate for methionine auxotrophy

Authors (13)

Jason SL Yu
Benjamin M Heineike
Johannes Hartl
Simran Aulakh
Clara Correia-Melo
Andrea Lehmann
[...]
Cory T Lee
Vadim Demichev
Christoph Messner
Michael Mülleder
Markus Ralser

PLOS Biology

Published 1 December 2022

Crick labs/ facilities

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High-throughput proteomics of nanogram-scale samples with Zeno SWATH MS

Authors (12)

Ziyue Wang
Michael Mülleder
Ihor Batruch
Anjali Chelur
Kathrin Textoris-Taube
Torsten Schwecke
[...]
Jason Causon
Jose Castro-Perez
Vadim Demichev
Stephen Tate
Markus Ralser

eLife

Published 30 November 2022

Crick labs

Markus Ralser

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N6-methyladenosine (m6A) reader Pho92 is recruited co-transcriptionally and couples translation to mRNA decay to promote meiotic fitness in yeast

Authors (18)

eLife

Published 24 November 2022

Crick labs/ facilities

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Functional proteomic profiling links deficient DNA clearance with increased mortality in individuals with severe COVID-19 pneumonia

Authors (22)

Iker Valle Aramburu
Dennis Hoving
Spyros Vernardis
Martha CF Tin
Marianna Ioannou
Mia Temkin
[...]
Sascha David
Christian Bode
Florian Kurth
Markus Ralser
Venizelos Papayannopoulos

Immunity

Published 13 December 2022

Crick labs

Full details

Metal ion availability and homeostasis as drivers of metabolic evolution and enzyme function

Authors (3)

Simran Aulakh
Sreejith Jayasree Varma
Markus Ralser

Current Opinion in Genetics and Development

Published 1 December 2022

Crick labs

Markus Ralser

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The metabolic domestication syndrome of budding yeast

The yeast RNA methylation complex consists of conserved yet reconfigured components with m6A-dependent and independent roles

C. elegans ageing is accelerated by a self-destructive reproductive programme

Oxonium ion scanning mass spectrometry for large-scale plasma glycoproteomics

Spontaneously established syntrophic yeast communities improve bioproduction

90K/LGALS3BP expression is upregulated in COVID-19 but may not restrict SARS-CoV-2 infection

Determinants of recovery from post-COVID-19 dyspnoea: analysis of UK prospective cohorts of hospitalised COVID-19 patients and community-based controls

The proteomic landscape of genome-wide genetic perturbations

RECAST: Study protocol for an observational study for the understanding of the increased resilience of children compared to adults in SARS-CoV-2 infection

Effects of sleep disturbance on dyspnoea and impaired lung function following hospital admission due to COVID-19 in the UK: a prospective multicentre cohort study

Prevalence of physical frailty, including risk factors, up to 1 year after hospitalisation for COVID-19 in the UK: a multicentre, longitudinal cohort study

Metabolic heterogeneity and cross-feeding within isogenic yeast populations captured by DILAC

The impact of acute nutritional interventions on the plasma proteome

Cell-cell metabolite exchange creates a pro-survival metabolic environment that extends lifespan

SARS-CoV-2-specific nasal IgA wanes 9 months after hospitalisation with COVID-19 and is not induced by subsequent vaccination

Inorganic sulfur fixation via a new homocysteine synthase allows yeast cells to cooperatively compensate for methionine auxotrophy

High-throughput proteomics of nanogram-scale samples with Zeno SWATH MS

N6-methyladenosine (m6A) reader Pho92 is recruited co-transcriptionally and couples translation to mRNA decay to promote meiotic fitness in yeast

Functional proteomic profiling links deficient DNA clearance with increased mortality in individuals with severe COVID-19 pneumonia

Metal ion availability and homeostasis as drivers of metabolic evolution and enzyme function

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