Diagram showing how a key protein involved in chromosome segregation and DNA repair, called Ctf18 binds to its cellular partners.

Martin Singleton : Areas of interest

Introduction

Diagram showing the structure of a protein phosphatase subunit bound to the centromere factor, CENP-C.

Structure of a protein phosphatase subunit bound to the centromere factor, CENP-C (blue).

Our lab is interested in understanding how chromosomes, once replicated, are separated into daughter cells during cell division.

It is essential that this process works accurately over many generations, otherwise cells may gain or lose chromosomes, an event that can have severe consequences for the cell, and in turn lead to the onset or progression of diseases such as cancer.

Our lab is interested in understanding how chromosomes, once replicated, are separated into daughter cells during cell division. It is essential that this process works accurately over many generations, otherwise cells may gain or lose chromosomes, an event that can have severe consequences for the cell, and in turn lead to the onset or progression of diseases such as cancer.

We primarily study these processes by determining the three-dimensional structure of proteins that bind chromosomes using techniques such as X-ray crystallography and electron microscopy. By designing experiments based on the resulting structures, we can gain insights into the way in which the proteins operate in the cell.

Selected publications