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Breadcrumb Maximiliano Gutierrez Gutierrez lab Host-Pathogen Interactions in Tuberculosis Laboratory : Publications Lab contentLab contentIn this section Overview Areas of interest Publications Lab news Members Vacancies Human cells infected with Mycobacterium tuberculosis (credit: Tom Lerner). White is actin cytoskeleton, red is ubiquitin, bacteria is green and nuclei are blue. 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(1)Journal of Visualized Experiments (1)mBio (1)Methods in Molecular Biology (1)Molecular Biology of the Cell (1)Nature Immunology (1)Nature Microbiology (1)PLOS Pathogens (1)Science Robotics (1)Scientific Reports (1)Small GTPases (1)The EMBO Journal (1)The Lancet (1)Virulence (1) Facet Journal Publications Displaying 1 - 20 of 72Last updated : 28 May 2023 03:20 ATG7 and ATG14 restrict cytosolic and phagosomal Mycobacterium tuberculosis replication in human macrophages Authors (9)Beren AylanElliott BernardEnrica PellegrinoLaure BotellaTony FearnsNatalia AthanasiadiClaudio BussiPierre SantucciMaximiliano Gutierrez Nature Microbiology Published 1 May 2023 Crick labs/ facilitiesMaximiliano GutierrezLight MicroscopyHuman Embryonic Stem CellElectron MicroscopyFull details A terpene nucleoside from M. tuberculosis induces lysosomal lipid storage in foamy macrophages Authors (23) Melissa Bedard Sanne van der NietElliott Bernard Gregory Babunovic Tan-Yun ChengBeren Aylan[...] Joseph Keane Sho YamasakiMaximiliano Gutierrez Nicole van der Wel D Branch Moody Journal of Clinical Investigation Published 15 March 2023 Crick labsMaximiliano GutierrezFull details High content quantitative imaging of Mycobacterium tuberculosis responses to acidic microenvironments within human macrophages Authors (4)Beren AylanLaure BotellaMaximiliano GutierrezPierre Santucci FEBS Open Bio Published 15 December 2022 Crick labs/ facilitiesMaximiliano GutierrezLight MicroscopyFull details Lysosomal damage drives mitochondrial proteome remodelling and reprograms macrophage immunometabolism Authors (17)Claudio Bussi Tiaan HeunisEnrica PellegrinoElliott Bernard Nourdine BahMariana Silva Dos Santos[...]James MacraeMaria Greco Thomas Reinheckel Matthias TrostMaximiliano Gutierrez Nature Communications Published 28 November 2022 Crick labs/ facilitiesMaximiliano GutierrezJulian DownwardMetabolomicsGenomics/Equipment ParkBioinformatics and BiostatisticsLight MicroscopyHuman Embryonic Stem CellElectron MicroscopyAdvanced SequencingFull details Intracellular niche switching as host subversion strategy of bacterial pathogens Authors (2)Maximiliano Gutierrez Jost Enninga Current Opinion in Cell Biology Published 1 June 2022 Crick labsMaximiliano GutierrezFull details Visualizing pyrazinamide action by live single-cell imaging of phagosome acidification and Mycobacterium tuberculosis pH homeostasis Authors (8)Pierre SantucciBeren AylanLaure BotellaElliott BernardClaudio BussiEnrica PellegrinoNatalia AthanasiadiMaximiliano Gutierrez mBio Published 1 April 2022 Crick labsMaximiliano GutierrezFull details Cell wall architecture and function in microbial physiology Authors (1)Pierre Santucci Molecular Microbiology Published 1 April 2022 Crick labsMaximiliano GutierrezFull details A sandPIT for Salmonella to play with efferosomes Authors (3)Rebecca MorrisonJakson LukMaximiliano Gutierrez Cell Host and Microbe Published 9 February 2022 Crick labsMaximiliano GutierrezFull details Intracellular localisation of Mycobacterium tuberculosis affects efficacy of the antibiotic pyrazinamide Authors (6)Pierre SantucciDaniel GreenwoodTony Fearns Kai Chen Haibo JiangMaximiliano Gutierrez Nature Communications Published 21 June 2021 Crick labs/ facilitiesMaximiliano GutierrezLight MicroscopyElectron MicroscopyFull details Human stem cell-based models for studying host-pathogen interactions Authors (2)Enrica PellegrinoMaximiliano Gutierrez Cellular Microbiology Published 1 July 2021 Crick labsMaximiliano GutierrezFull details Progress in robotics for combating infectious diseases Authors (15) Anzhu Gao Robin R Murphy Weidong Chen Giulio Dagnino Peer FischerMaximiliano Gutierrez[...] Jingen Xia Ajmal Zemmar Dandan Zhang Chen Wang Guang-Zhong Yang Science Robotics Published 31 March 2021 Crick labsMaximiliano GutierrezFull details Macrophage-specific responses to human- and animal-adapted tubercle bacilli reveal pathogen and host factors driving multinucleated cell formation Authors (15)Christophe QuevalTony FearnsLaure Botella Alicia Smyth Laura Schnettger Morgane Mitermite[...] Matthias Trost Dirk Werling Francisco J Salguero Stephen V GordonMaximiliano Gutierrez PLOS Pathogens Published 15 March 2021 Crick labs/ facilitiesMaximiliano GutierrezLight MicroscopyElectron MicroscopyFull details First person – Elliott Bernard Authors (1)Elliott Bernard Journal of Cell Science Published 1 March 2021 Crick labsMaximiliano GutierrezFull details Correlative light electron ion microscopy reveals in vivo localisation of bedaquiline in Mycobacterium tuberculosis-infected lungs Authors (5)Tony FearnsDaniel Greenwood Angela Rodgers Haibo JiangMaximiliano Gutierrez PLOS Biology Published 31 December 2020 Crick labs/ facilitiesMaximiliano GutierrezLight MicroscopyElectron MicroscopyBiological Research FacilityFull details Intracellular pathogens, membrane damage and cytosolic access Authors (1)Pierre Santucci Cellular Microbiology Published 1 April 2021 Crick labsMaximiliano GutierrezFull details Rv2577 of Mycobacterium tuberculosis is a virulence factor with dual phosphatase and phosphodiesterase functions Authors (10) Marina Andrea Forrellad Federico Carlos Blanco Rubén Marrero Diaz de Villegas Cristina Lourdes Vázquez Agustín Yaneff Elizabeth Andrea GarcíaMaximiliano Gutierrez Rosario Durán Andrea Villarino Fabiana Bigi Frontiers in Microbiology Published 22 October 2020 Crick labsMaximiliano GutierrezFull details M. tuberculosis infection of human iPSC-derived macrophages reveals complex membrane dynamics during xenophagy evasion Authors (8)Elliott BernardTony FearnsClaudio BussiPierre SantucciChris PeddieRachel LaiLucy CollinsonMaximiliano Gutierrez Journal of Cell Science Published 1 March 2021 Crick labs/ facilitiesMaximiliano GutierrezElectron MicroscopyLight MicroscopyHuman Embryonic Stem CellFlow CytometryAdvanced SequencingFull details The great host-pathogen war: U.K. cellular microbiology meeting 2020 Authors (6) Jason S King Daniel Humphreys Jennifer L Rohn Meera UnnikrishnanMaximiliano Gutierrez Serge Mostowy Cellular Microbiology Published 1 November 2020 Crick labsMaximiliano GutierrezFull details LRRK2 activation controls the repair of damaged endomembranes in macrophages Authors (8)Susanne Herbst Philip Campbell John HarveyElliott BernardVenizelos Papayannopoulos Nicholas W Wood Huw R MorrisMaximiliano Gutierrez The EMBO Journal Published 15 September 2020 Crick labs/ facilitiesVenizelos PapayannopoulosMaximiliano GutierrezLight MicroscopyFull details Pandemic peak SARS-CoV-2 infection and seroconversion rates in London frontline health-care workers Authors (341) Catherine F Houlihan Nina Vora Thomas Byrne Dan LewerGavin Kelly Judith Heaney[...] Andrew Hayward Richard Gilson Gavin KellyFiona Roberts Emine Hatipoglu The Lancet Published 25 July 2020 Crick labs/ facilitiesAndreas WackKaren VousdenJernej UleJames TurnerMoritz TreeckCharles SwantonAdam SaterialeErik SahaiCaetano Reis e SousaPeter RatcliffeLucia Prieto-GodinoVenizelos PapayannopoulosAnne O’GarraPaul NurseGeorge KassiotisMaximiliano GutierrezSonia GandhiSteve GamblinPeter Cherepanov Luiz Pedro CarvalhoDominique BonnetMike BlackmanRupert BealeWorldwide Influenza CentreStructural BiologyPeptide ChemistryMetabolomicsHuman Embryonic Stem CellHigh Throughput ScreeningGenomics/Equipment ParkGenetic Modification ServiceFlow CytometryFermentationExperimental HistopathologyElectron MicroscopyCell ServicesBiological Research FacilityBioinformatics and BiostatisticsAdvanced SequencingScientific computingFull details Pagination Current page 1 Page 2 Page 3 Page 4 Next page Next Last page Last Share the page Share on Twitter Share on Facebook Share on LinkedIn Share on Email
ATG7 and ATG14 restrict cytosolic and phagosomal Mycobacterium tuberculosis replication in human macrophages Authors (9)Beren AylanElliott BernardEnrica PellegrinoLaure BotellaTony FearnsNatalia AthanasiadiClaudio BussiPierre SantucciMaximiliano Gutierrez Nature Microbiology Published 1 May 2023 Crick labs/ facilitiesMaximiliano GutierrezLight MicroscopyHuman Embryonic Stem CellElectron MicroscopyFull details
A terpene nucleoside from M. tuberculosis induces lysosomal lipid storage in foamy macrophages Authors (23) Melissa Bedard Sanne van der NietElliott Bernard Gregory Babunovic Tan-Yun ChengBeren Aylan[...] Joseph Keane Sho YamasakiMaximiliano Gutierrez Nicole van der Wel D Branch Moody Journal of Clinical Investigation Published 15 March 2023 Crick labsMaximiliano GutierrezFull details
High content quantitative imaging of Mycobacterium tuberculosis responses to acidic microenvironments within human macrophages Authors (4)Beren AylanLaure BotellaMaximiliano GutierrezPierre Santucci FEBS Open Bio Published 15 December 2022 Crick labs/ facilitiesMaximiliano GutierrezLight MicroscopyFull details
Lysosomal damage drives mitochondrial proteome remodelling and reprograms macrophage immunometabolism Authors (17)Claudio Bussi Tiaan HeunisEnrica PellegrinoElliott Bernard Nourdine BahMariana Silva Dos Santos[...]James MacraeMaria Greco Thomas Reinheckel Matthias TrostMaximiliano Gutierrez Nature Communications Published 28 November 2022 Crick labs/ facilitiesMaximiliano GutierrezJulian DownwardMetabolomicsGenomics/Equipment ParkBioinformatics and BiostatisticsLight MicroscopyHuman Embryonic Stem CellElectron MicroscopyAdvanced SequencingFull details
Intracellular niche switching as host subversion strategy of bacterial pathogens Authors (2)Maximiliano Gutierrez Jost Enninga Current Opinion in Cell Biology Published 1 June 2022 Crick labsMaximiliano GutierrezFull details
Visualizing pyrazinamide action by live single-cell imaging of phagosome acidification and Mycobacterium tuberculosis pH homeostasis Authors (8)Pierre SantucciBeren AylanLaure BotellaElliott BernardClaudio BussiEnrica PellegrinoNatalia AthanasiadiMaximiliano Gutierrez mBio Published 1 April 2022 Crick labsMaximiliano GutierrezFull details
Cell wall architecture and function in microbial physiology Authors (1)Pierre Santucci Molecular Microbiology Published 1 April 2022 Crick labsMaximiliano GutierrezFull details
A sandPIT for Salmonella to play with efferosomes Authors (3)Rebecca MorrisonJakson LukMaximiliano Gutierrez Cell Host and Microbe Published 9 February 2022 Crick labsMaximiliano GutierrezFull details
Intracellular localisation of Mycobacterium tuberculosis affects efficacy of the antibiotic pyrazinamide Authors (6)Pierre SantucciDaniel GreenwoodTony Fearns Kai Chen Haibo JiangMaximiliano Gutierrez Nature Communications Published 21 June 2021 Crick labs/ facilitiesMaximiliano GutierrezLight MicroscopyElectron MicroscopyFull details
Human stem cell-based models for studying host-pathogen interactions Authors (2)Enrica PellegrinoMaximiliano Gutierrez Cellular Microbiology Published 1 July 2021 Crick labsMaximiliano GutierrezFull details
Progress in robotics for combating infectious diseases Authors (15) Anzhu Gao Robin R Murphy Weidong Chen Giulio Dagnino Peer FischerMaximiliano Gutierrez[...] Jingen Xia Ajmal Zemmar Dandan Zhang Chen Wang Guang-Zhong Yang Science Robotics Published 31 March 2021 Crick labsMaximiliano GutierrezFull details
Macrophage-specific responses to human- and animal-adapted tubercle bacilli reveal pathogen and host factors driving multinucleated cell formation Authors (15)Christophe QuevalTony FearnsLaure Botella Alicia Smyth Laura Schnettger Morgane Mitermite[...] Matthias Trost Dirk Werling Francisco J Salguero Stephen V GordonMaximiliano Gutierrez PLOS Pathogens Published 15 March 2021 Crick labs/ facilitiesMaximiliano GutierrezLight MicroscopyElectron MicroscopyFull details
First person – Elliott Bernard Authors (1)Elliott Bernard Journal of Cell Science Published 1 March 2021 Crick labsMaximiliano GutierrezFull details
Correlative light electron ion microscopy reveals in vivo localisation of bedaquiline in Mycobacterium tuberculosis-infected lungs Authors (5)Tony FearnsDaniel Greenwood Angela Rodgers Haibo JiangMaximiliano Gutierrez PLOS Biology Published 31 December 2020 Crick labs/ facilitiesMaximiliano GutierrezLight MicroscopyElectron MicroscopyBiological Research FacilityFull details
Intracellular pathogens, membrane damage and cytosolic access Authors (1)Pierre Santucci Cellular Microbiology Published 1 April 2021 Crick labsMaximiliano GutierrezFull details
Rv2577 of Mycobacterium tuberculosis is a virulence factor with dual phosphatase and phosphodiesterase functions Authors (10) Marina Andrea Forrellad Federico Carlos Blanco Rubén Marrero Diaz de Villegas Cristina Lourdes Vázquez Agustín Yaneff Elizabeth Andrea GarcíaMaximiliano Gutierrez Rosario Durán Andrea Villarino Fabiana Bigi Frontiers in Microbiology Published 22 October 2020 Crick labsMaximiliano GutierrezFull details
M. tuberculosis infection of human iPSC-derived macrophages reveals complex membrane dynamics during xenophagy evasion Authors (8)Elliott BernardTony FearnsClaudio BussiPierre SantucciChris PeddieRachel LaiLucy CollinsonMaximiliano Gutierrez Journal of Cell Science Published 1 March 2021 Crick labs/ facilitiesMaximiliano GutierrezElectron MicroscopyLight MicroscopyHuman Embryonic Stem CellFlow CytometryAdvanced SequencingFull details
The great host-pathogen war: U.K. cellular microbiology meeting 2020 Authors (6) Jason S King Daniel Humphreys Jennifer L Rohn Meera UnnikrishnanMaximiliano Gutierrez Serge Mostowy Cellular Microbiology Published 1 November 2020 Crick labsMaximiliano GutierrezFull details
LRRK2 activation controls the repair of damaged endomembranes in macrophages Authors (8)Susanne Herbst Philip Campbell John HarveyElliott BernardVenizelos Papayannopoulos Nicholas W Wood Huw R MorrisMaximiliano Gutierrez The EMBO Journal Published 15 September 2020 Crick labs/ facilitiesVenizelos PapayannopoulosMaximiliano GutierrezLight MicroscopyFull details
Pandemic peak SARS-CoV-2 infection and seroconversion rates in London frontline health-care workers Authors (341) Catherine F Houlihan Nina Vora Thomas Byrne Dan LewerGavin Kelly Judith Heaney[...] Andrew Hayward Richard Gilson Gavin KellyFiona Roberts Emine Hatipoglu The Lancet Published 25 July 2020 Crick labs/ facilitiesAndreas WackKaren VousdenJernej UleJames TurnerMoritz TreeckCharles SwantonAdam SaterialeErik SahaiCaetano Reis e SousaPeter RatcliffeLucia Prieto-GodinoVenizelos PapayannopoulosAnne O’GarraPaul NurseGeorge KassiotisMaximiliano GutierrezSonia GandhiSteve GamblinPeter Cherepanov Luiz Pedro CarvalhoDominique BonnetMike BlackmanRupert BealeWorldwide Influenza CentreStructural BiologyPeptide ChemistryMetabolomicsHuman Embryonic Stem CellHigh Throughput ScreeningGenomics/Equipment ParkGenetic Modification ServiceFlow CytometryFermentationExperimental HistopathologyElectron MicroscopyCell ServicesBiological Research FacilityBioinformatics and BiostatisticsAdvanced SequencingScientific computingFull details