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Breadcrumb Maximiliano Gutierrez Gutierrez lab Host-Pathogen Interactions in Tuberculosis Laboratory : Publications Lab contentLab contentIn this section Overview Areas of interest Publications Lab news Members Vacancies Human cells infected with Mycobacterium tuberculosis (credit: Tom Lerner). White is actin cytoskeleton, red is ubiquitin, bacteria is green and nuclei are blue. 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Medicinal Chemistry (1)Journal of Microscopy (1)Journal of Visualized Experiments (1)Molecular Biology of the Cell (1)Nature (1)Nature Immunology (1)Nature Microbiology (1)PLOS Pathogens (1)Science Robotics (1)Scientific Reports (1)Small GTPases (1)The EMBO Journal (1)The Journal of Cell Biology (1)The Lancet (1)Trends in Microbiology (1)Virulence (1) Facet Journal Publications Displaying 1 - 20 of 78Last updated : 08 December 2023 03:58 Stress granules plug and stabilize damaged endolysosomal membranes Authors (12)Claudio Bussi Agustín Mangiarotti Christian Vanhille-CamposBeren AylanEnrica PellegrinoNatalia Athanasiadi[...] Angela Rodgers Titus M Franzmann Anđela Šarić Rumiana DimovaMaximiliano Gutierrez Nature Published 30 November 2023 Crick labs/ facilitiesMaximiliano GutierrezLight MicroscopyHuman Embryonic Stem CellHigh Throughput ScreeningFull details Peroxisomal ROS control cytosolic Mycobacterium tuberculosis replication in human macrophages Authors (9)Enrica PellegrinoBeren AylanClaudio BussiTony FearnsElliott BernardNatalia AthanasiadiPierre SantucciLaure BotellaMaximiliano Gutierrez The Journal of Cell Biology Published 4 December 2023 Crick labs/ facilitiesMaximiliano GutierrezLight MicroscopyHuman Embryonic Stem CellFull details Host cell environments and antibiotic efficacy in tuberculosis Authors (3)Nathan DayPierre SantucciMaximiliano Gutierrez Trends in Microbiology Published 12 September 2023 Crick labsMaximiliano GutierrezFull details ER-dependent membrane repair of mycobacteria-induced vacuole damage Authors (14) Aby Anand Anna-Carina Mazur Patricia Rosell-Arevalo Rico Franzkoch Leonhard Breitsprecher Stevanus A Listian[...] Simone Vormittag Hubert Hilbi Markus ManiakMaximiliano Gutierrez Caroline Barisch mBio Published 1 October 2023 Crick labsMaximiliano GutierrezFull details IL-1β turnover by the UBE2L3 ubiquitin conjugating enzyme and HECT E3 ligases limits inflammation Authors (14) Vishwas Mishra Anna Crespo-Puig Callum McCarthy Tereza Masonou Izabela Glegola-Madejska Alice Dejoux[...] Meihan Meng Shijie Wang Daniel J BennisonRebecca Morrison Avinash R Shenoy Nature Communications Published 20 July 2023 Crick labsMaximiliano GutierrezFull details Quantitative spatio-temporal analysis of phagosome maturation in live cells Authors (3) Patricia Rosell ArévaloBeren AylanMaximiliano Gutierrez Methods in Molecular Biology Published 27 June 2023 Crick labsMaximiliano GutierrezFull details ATG7 and ATG14 restrict cytosolic and phagosomal Mycobacterium tuberculosis replication in human macrophages Authors (9)Beren AylanElliott BernardEnrica PellegrinoLaure BotellaTony FearnsNatalia AthanasiadiClaudio BussiPierre SantucciMaximiliano Gutierrez Nature Microbiology Published 1 May 2023 Crick labs/ facilitiesMaximiliano GutierrezLight MicroscopyHuman Embryonic Stem CellElectron MicroscopyFull details A terpene nucleoside from M. tuberculosis induces lysosomal lipid storage in foamy macrophages Authors (23) Melissa Bedard Sanne van der NietElliott Bernard Gregory Babunovic Tan-Yun ChengBeren Aylan[...] Joseph Keane Sho YamasakiMaximiliano Gutierrez Nicole van der Wel D Branch Moody Journal of Clinical Investigation Published 15 March 2023 Crick labsMaximiliano GutierrezFull details High content quantitative imaging of Mycobacterium tuberculosis responses to acidic microenvironments within human macrophages Authors (4)Beren AylanLaure BotellaMaximiliano GutierrezPierre Santucci FEBS Open Bio Published 1 July 2023 Crick labs/ facilitiesMaximiliano GutierrezLight MicroscopyFull details Lysosomal damage drives mitochondrial proteome remodelling and reprograms macrophage immunometabolism Authors (17)Claudio Bussi Tiaan HeunisEnrica PellegrinoElliott Bernard Nourdine BahMariana Silva Dos Santos[...]James MacraeMaria Greco Thomas Reinheckel Matthias TrostMaximiliano Gutierrez Nature Communications Published 28 November 2022 Crick labs/ facilitiesMaximiliano GutierrezJulian DownwardMetabolomicsBioinformatics and BiostatisticsAdvanced SequencingLight MicroscopyHuman Embryonic Stem CellElectron MicroscopyAdvanced SequencingFull details Intracellular niche switching as host subversion strategy of bacterial pathogens Authors (2)Maximiliano Gutierrez Jost Enninga Current Opinion in Cell Biology Published 1 June 2022 Crick labsMaximiliano GutierrezFull details Visualizing pyrazinamide action by live single-cell imaging of phagosome acidification and Mycobacterium tuberculosis pH homeostasis Authors (8)Pierre SantucciBeren AylanLaure BotellaElliott BernardClaudio BussiEnrica PellegrinoNatalia AthanasiadiMaximiliano Gutierrez mBio Published 1 April 2022 Crick labsMaximiliano GutierrezFull details Cell wall architecture and function in microbial physiology Authors (1)Pierre Santucci Molecular Microbiology Published 1 April 2022 Crick labsMaximiliano GutierrezFull details A sandPIT for Salmonella to play with efferosomes Authors (3)Rebecca MorrisonJakson LukMaximiliano Gutierrez Cell Host and Microbe Published 9 February 2022 Crick labsMaximiliano GutierrezFull details Intracellular localisation of Mycobacterium tuberculosis affects efficacy of the antibiotic pyrazinamide Authors (6)Pierre SantucciDaniel GreenwoodTony Fearns Kai Chen Haibo JiangMaximiliano Gutierrez Nature Communications Published 21 June 2021 Crick labs/ facilitiesMaximiliano GutierrezLight MicroscopyElectron MicroscopyFull details Human stem cell-based models for studying host-pathogen interactions Authors (2)Enrica PellegrinoMaximiliano Gutierrez Cellular Microbiology Published 1 July 2021 Crick labsMaximiliano GutierrezFull details Progress in robotics for combating infectious diseases Authors (15) Anzhu Gao Robin R Murphy Weidong Chen Giulio Dagnino Peer FischerMaximiliano Gutierrez[...] Jingen Xia Ajmal Zemmar Dandan Zhang Chen Wang Guang-Zhong Yang Science Robotics Published 31 March 2021 Crick labsMaximiliano GutierrezFull details Macrophage-specific responses to human- and animal-adapted tubercle bacilli reveal pathogen and host factors driving multinucleated cell formation Authors (15)Christophe QuevalTony FearnsLaure Botella Alicia Smyth Laura Schnettger Morgane Mitermite[...] Matthias Trost Dirk Werling Francisco J Salguero Stephen V GordonMaximiliano Gutierrez PLOS Pathogens Published 15 March 2021 Crick labs/ facilitiesMaximiliano GutierrezLight MicroscopyElectron MicroscopyFull details First person – Elliott Bernard Authors (1)Elliott Bernard Journal of Cell Science Published 1 March 2021 Crick labsMaximiliano GutierrezFull details Correlative light electron ion microscopy reveals in vivo localisation of bedaquiline in Mycobacterium tuberculosis-infected lungs Authors (5)Tony FearnsDaniel Greenwood Angela Rodgers Haibo JiangMaximiliano Gutierrez PLOS Biology Published 31 December 2020 Crick labs/ facilitiesMaximiliano GutierrezLight MicroscopyElectron MicroscopyBiological Research FacilityFull details Pagination Current page 1 Page 2 Page 3 Page 4 Next page Next Last page Last 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Stress granules plug and stabilize damaged endolysosomal membranes Authors (12)Claudio Bussi Agustín Mangiarotti Christian Vanhille-CamposBeren AylanEnrica PellegrinoNatalia Athanasiadi[...] Angela Rodgers Titus M Franzmann Anđela Šarić Rumiana DimovaMaximiliano Gutierrez Nature Published 30 November 2023 Crick labs/ facilitiesMaximiliano GutierrezLight MicroscopyHuman Embryonic Stem CellHigh Throughput ScreeningFull details
Peroxisomal ROS control cytosolic Mycobacterium tuberculosis replication in human macrophages Authors (9)Enrica PellegrinoBeren AylanClaudio BussiTony FearnsElliott BernardNatalia AthanasiadiPierre SantucciLaure BotellaMaximiliano Gutierrez The Journal of Cell Biology Published 4 December 2023 Crick labs/ facilitiesMaximiliano GutierrezLight MicroscopyHuman Embryonic Stem CellFull details
Host cell environments and antibiotic efficacy in tuberculosis Authors (3)Nathan DayPierre SantucciMaximiliano Gutierrez Trends in Microbiology Published 12 September 2023 Crick labsMaximiliano GutierrezFull details
ER-dependent membrane repair of mycobacteria-induced vacuole damage Authors (14) Aby Anand Anna-Carina Mazur Patricia Rosell-Arevalo Rico Franzkoch Leonhard Breitsprecher Stevanus A Listian[...] Simone Vormittag Hubert Hilbi Markus ManiakMaximiliano Gutierrez Caroline Barisch mBio Published 1 October 2023 Crick labsMaximiliano GutierrezFull details
IL-1β turnover by the UBE2L3 ubiquitin conjugating enzyme and HECT E3 ligases limits inflammation Authors (14) Vishwas Mishra Anna Crespo-Puig Callum McCarthy Tereza Masonou Izabela Glegola-Madejska Alice Dejoux[...] Meihan Meng Shijie Wang Daniel J BennisonRebecca Morrison Avinash R Shenoy Nature Communications Published 20 July 2023 Crick labsMaximiliano GutierrezFull details
Quantitative spatio-temporal analysis of phagosome maturation in live cells Authors (3) Patricia Rosell ArévaloBeren AylanMaximiliano Gutierrez Methods in Molecular Biology Published 27 June 2023 Crick labsMaximiliano GutierrezFull details
ATG7 and ATG14 restrict cytosolic and phagosomal Mycobacterium tuberculosis replication in human macrophages Authors (9)Beren AylanElliott BernardEnrica PellegrinoLaure BotellaTony FearnsNatalia AthanasiadiClaudio BussiPierre SantucciMaximiliano Gutierrez Nature Microbiology Published 1 May 2023 Crick labs/ facilitiesMaximiliano GutierrezLight MicroscopyHuman Embryonic Stem CellElectron MicroscopyFull details
A terpene nucleoside from M. tuberculosis induces lysosomal lipid storage in foamy macrophages Authors (23) Melissa Bedard Sanne van der NietElliott Bernard Gregory Babunovic Tan-Yun ChengBeren Aylan[...] Joseph Keane Sho YamasakiMaximiliano Gutierrez Nicole van der Wel D Branch Moody Journal of Clinical Investigation Published 15 March 2023 Crick labsMaximiliano GutierrezFull details
High content quantitative imaging of Mycobacterium tuberculosis responses to acidic microenvironments within human macrophages Authors (4)Beren AylanLaure BotellaMaximiliano GutierrezPierre Santucci FEBS Open Bio Published 1 July 2023 Crick labs/ facilitiesMaximiliano GutierrezLight MicroscopyFull details
Lysosomal damage drives mitochondrial proteome remodelling and reprograms macrophage immunometabolism Authors (17)Claudio Bussi Tiaan HeunisEnrica PellegrinoElliott Bernard Nourdine BahMariana Silva Dos Santos[...]James MacraeMaria Greco Thomas Reinheckel Matthias TrostMaximiliano Gutierrez Nature Communications Published 28 November 2022 Crick labs/ facilitiesMaximiliano GutierrezJulian DownwardMetabolomicsBioinformatics and BiostatisticsAdvanced SequencingLight MicroscopyHuman Embryonic Stem CellElectron MicroscopyAdvanced SequencingFull details
Intracellular niche switching as host subversion strategy of bacterial pathogens Authors (2)Maximiliano Gutierrez Jost Enninga Current Opinion in Cell Biology Published 1 June 2022 Crick labsMaximiliano GutierrezFull details
Visualizing pyrazinamide action by live single-cell imaging of phagosome acidification and Mycobacterium tuberculosis pH homeostasis Authors (8)Pierre SantucciBeren AylanLaure BotellaElliott BernardClaudio BussiEnrica PellegrinoNatalia AthanasiadiMaximiliano Gutierrez mBio Published 1 April 2022 Crick labsMaximiliano GutierrezFull details
Cell wall architecture and function in microbial physiology Authors (1)Pierre Santucci Molecular Microbiology Published 1 April 2022 Crick labsMaximiliano GutierrezFull details
A sandPIT for Salmonella to play with efferosomes Authors (3)Rebecca MorrisonJakson LukMaximiliano Gutierrez Cell Host and Microbe Published 9 February 2022 Crick labsMaximiliano GutierrezFull details
Intracellular localisation of Mycobacterium tuberculosis affects efficacy of the antibiotic pyrazinamide Authors (6)Pierre SantucciDaniel GreenwoodTony Fearns Kai Chen Haibo JiangMaximiliano Gutierrez Nature Communications Published 21 June 2021 Crick labs/ facilitiesMaximiliano GutierrezLight MicroscopyElectron MicroscopyFull details
Human stem cell-based models for studying host-pathogen interactions Authors (2)Enrica PellegrinoMaximiliano Gutierrez Cellular Microbiology Published 1 July 2021 Crick labsMaximiliano GutierrezFull details
Progress in robotics for combating infectious diseases Authors (15) Anzhu Gao Robin R Murphy Weidong Chen Giulio Dagnino Peer FischerMaximiliano Gutierrez[...] Jingen Xia Ajmal Zemmar Dandan Zhang Chen Wang Guang-Zhong Yang Science Robotics Published 31 March 2021 Crick labsMaximiliano GutierrezFull details
Macrophage-specific responses to human- and animal-adapted tubercle bacilli reveal pathogen and host factors driving multinucleated cell formation Authors (15)Christophe QuevalTony FearnsLaure Botella Alicia Smyth Laura Schnettger Morgane Mitermite[...] Matthias Trost Dirk Werling Francisco J Salguero Stephen V GordonMaximiliano Gutierrez PLOS Pathogens Published 15 March 2021 Crick labs/ facilitiesMaximiliano GutierrezLight MicroscopyElectron MicroscopyFull details
First person – Elliott Bernard Authors (1)Elliott Bernard Journal of Cell Science Published 1 March 2021 Crick labsMaximiliano GutierrezFull details
Correlative light electron ion microscopy reveals in vivo localisation of bedaquiline in Mycobacterium tuberculosis-infected lungs Authors (5)Tony FearnsDaniel Greenwood Angela Rodgers Haibo JiangMaximiliano Gutierrez PLOS Biology Published 31 December 2020 Crick labs/ facilitiesMaximiliano GutierrezLight MicroscopyElectron MicroscopyBiological Research FacilityFull details