Publications

One size does not fit all: Lysosomes exist in biochemically and functionally distinct states

Authors (2)

PLOS Biology

Published 22 March 2024

Crick labs

Maximiliano Gutierrez

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Increased dosage of DYRK1A leads to congenital heart defects in a mouse model of Down syndrome

Authors (20)

Science Translational Medicine

Published 24 January 2024

Crick labs/ facilities

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MptpB inhibitor improves the action of antibiotics against Mycobacterium tuberculosis and nontuberculous Mycobacterium avium infections

Authors (8)

Pablo Rodríguez-Fernández
Laure Botella
Jennifer S Cavet
Jose Domínguez
Maximiliano Gutierrez
Colin J Suckling
Fraser J Scott
Lydia Tabernero

ACS Infectious Diseases

Published 12 January 2024

Crick labs

Maximiliano Gutierrez

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Stress granules plug and stabilize damaged endolysosomal membranes

Authors (12)

Claudio Bussi
Agustín Mangiarotti
Christian Vanhille-Campos
Beren Aylan
Enrica Pellegrino
Natalia Athanasiadi
[...]
Angela Rodgers
Titus M Franzmann
Anđela Šarić
Rumiana Dimova
Maximiliano Gutierrez

Nature

Published 30 November 2023

Crick labs/ facilities

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Peroxisomal ROS control cytosolic Mycobacterium tuberculosis replication in human macrophages

Authors (9)

The Journal of Cell Biology

Published 4 December 2023

Crick labs/ facilities

Full details

Host cell environments and antibiotic efficacy in tuberculosis

Authors (3)

Trends in Microbiology

Published 1 March 2024

Crick labs

Maximiliano Gutierrez

Full details

ER-dependent membrane repair of mycobacteria-induced vacuole damage

Authors (14)

Aby Anand
Anna-Carina Mazur
Patricia Rosell-Arevalo
Rico Franzkoch
Leonhard Breitsprecher
Stevanus A Listian
[...]
Simone Vormittag
Hubert Hilbi
Markus Maniak
Maximiliano Gutierrez
Caroline Barisch

mBio

Published 1 October 2023

Crick labs

Maximiliano Gutierrez

Full details

IL-1β turnover by the UBE2L3 ubiquitin conjugating enzyme and HECT E3 ligases limits inflammation

Authors (14)

Vishwas Mishra
Anna Crespo-Puig
Callum McCarthy
Tereza Masonou
Izabela Glegola-Madejska
Alice Dejoux
[...]
Meihan Meng
Shijie Wang
Daniel J Bennison
Rebecca Morrison
Avinash R Shenoy

Nature Communications

Published 20 July 2023

Crick labs

Maximiliano Gutierrez

Full details

Quantitative spatio-temporal analysis of phagosome maturation in live cells

Authors (3)

Patricia Rosell Arévalo
Beren Aylan
Maximiliano Gutierrez

Methods in Molecular Biology

Published 27 June 2023

Crick labs

Maximiliano Gutierrez

Full details

ATG7 and ATG14 restrict cytosolic and phagosomal Mycobacterium tuberculosis replication in human macrophages

Authors (9)

Nature Microbiology

Published 1 May 2023

Crick labs/ facilities

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A terpene nucleoside from M. tuberculosis induces lysosomal lipid storage in foamy macrophages

Authors (23)

Melissa Bedard
Sanne van der Niet
Elliott Bernard
Gregory Babunovic
Tan-Yun Cheng
Beren Aylan
[...]
Joseph Keane
Sho Yamasaki
Maximiliano Gutierrez
Nicole van der Wel
D Branch Moody

Journal of Clinical Investigation

Published 15 March 2023

Crick labs

Maximiliano Gutierrez

Full details

High content quantitative imaging of Mycobacterium tuberculosis responses to acidic microenvironments within human macrophages

Authors (4)

FEBS Open Bio

Published 1 July 2023

Crick labs/ facilities

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Lysosomal damage drives mitochondrial proteome remodelling and reprograms macrophage immunometabolism

Authors (17)

Nature Communications

Published 28 November 2022

Crick labs/ facilities

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Intracellular niche switching as host subversion strategy of bacterial pathogens

Authors (2)

Maximiliano Gutierrez
Jost Enninga

Current Opinion in Cell Biology

Published 1 June 2022

Crick labs

Maximiliano Gutierrez

Full details

Visualizing pyrazinamide action by live single-cell imaging of phagosome acidification and Mycobacterium tuberculosis pH homeostasis

Authors (8)

mBio

Published 1 April 2022

Crick labs

Maximiliano Gutierrez

Full details

Cell wall architecture and function in microbial physiology

Authors (1)

Pierre Santucci

Molecular Microbiology

Published 1 April 2022

Crick labs

Maximiliano Gutierrez

Full details

A sandPIT for Salmonella to play with efferosomes

Authors (3)

Cell Host and Microbe

Published 9 February 2022

Crick labs

Maximiliano Gutierrez

Full details

Intracellular localisation of Mycobacterium tuberculosis affects efficacy of the antibiotic pyrazinamide

Authors (6)

Nature Communications

Published 21 June 2021

Crick labs/ facilities

Full details

Human stem cell-based models for studying host-pathogen interactions

Authors (2)

Cellular Microbiology

Published 1 July 2021

Crick labs

Maximiliano Gutierrez

Full details

Progress in robotics for combating infectious diseases

Authors (15)

Anzhu Gao
Robin R Murphy
Weidong Chen
Giulio Dagnino
Peer Fischer
Maximiliano Gutierrez
[...]
Jingen Xia
Ajmal Zemmar
Dandan Zhang
Chen Wang
Guang-Zhong Yang

Science Robotics

Published 31 March 2021

Crick labs

Maximiliano Gutierrez

Full details

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One size does not fit all: Lysosomes exist in biochemically and functionally distinct states

Increased dosage of DYRK1A leads to congenital heart defects in a mouse model of Down syndrome

MptpB inhibitor improves the action of antibiotics against Mycobacterium tuberculosis and nontuberculous Mycobacterium avium infections

Stress granules plug and stabilize damaged endolysosomal membranes

Peroxisomal ROS control cytosolic Mycobacterium tuberculosis replication in human macrophages

Host cell environments and antibiotic efficacy in tuberculosis

ER-dependent membrane repair of mycobacteria-induced vacuole damage

IL-1β turnover by the UBE2L3 ubiquitin conjugating enzyme and HECT E3 ligases limits inflammation

Quantitative spatio-temporal analysis of phagosome maturation in live cells

ATG7 and ATG14 restrict cytosolic and phagosomal Mycobacterium tuberculosis replication in human macrophages

A terpene nucleoside from M. tuberculosis induces lysosomal lipid storage in foamy macrophages

High content quantitative imaging of Mycobacterium tuberculosis responses to acidic microenvironments within human macrophages

Lysosomal damage drives mitochondrial proteome remodelling and reprograms macrophage immunometabolism

Intracellular niche switching as host subversion strategy of bacterial pathogens

Visualizing pyrazinamide action by live single-cell imaging of phagosome acidification and Mycobacterium tuberculosis pH homeostasis

Cell wall architecture and function in microbial physiology

A sandPIT for Salmonella to play with efferosomes

Intracellular localisation of Mycobacterium tuberculosis affects efficacy of the antibiotic pyrazinamide

Human stem cell-based models for studying host-pathogen interactions

Progress in robotics for combating infectious diseases

The Francis Crick Institute is a unique partnership between

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Postdoctoral clinical fellows

Hello Brain!

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About us

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