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Breadcrumb Maximiliano Gutierrez Gutierrez lab Host-Pathogen Interactions in Tuberculosis Laboratory : Publications Lab contentLab contentIn this section Overview Areas of interest Publications Lab news Members Vacancies Human cells infected with Mycobacterium tuberculosis (credit: Tom Lerner). White is actin cytoskeleton, red is ubiquitin, bacteria is green and nuclei are blue. Toggle to view hero caption PublicationsYear published2024 (1)2022 (1)2020 (3)2019 (2)2017 (2)2016 (4) Facet Year publishedResearch topicsCell Biology (13)Infectious Disease (13)Model Organisms (13)Human Biology & Physiology (9)Computational & Systems Biology (8)Tumour Biology (6)Biochemistry & Proteomics (5)Chemical Biology & High Throughput (5)Genetics & Genomics (5)Genome Integrity & Repair (5)Imaging (5)Signalling & Oncogenes (5)Developmental Biology (4)Metabolism (3)Gene Expression (2)Cell Cycle & Chromosomes (1)Microfabrication & Bioengineering (1)Neurosciences (1)Stem Cells (1)Structural Biology & Biophysics (1)Synthetic Biology (1) (-)Immunology (13) Facet Research topicsCrick/Pre-CrickCrick publications (13) Facet Crick/Pre-CrickPublication typeJournal article (13)Primary research (12)Review (1) Facet Publication typeJournalImmunity (2)Autophagy (1)Cell Host & Microbe (1)JCI insight (1)Journal of Clinical Investigation (1)Journal of Infectious Diseases (1)Nature Communications (1)Science (1)Science Translational Medicine (1)Scientific Reports (1)The EMBO Journal (1)The Lancet (1) Facet Journal Publications Displaying 1 - 13 of 13Last updated : 28 March 2024 03:25 Increased dosage of DYRK1A leads to congenital heart defects in a mouse model of Down syndrome Authors (20)Eva Lana-ElolaRifdat Aoidi Miriam LlorianDorota GibbinsCallan BuechsenschuetzClaudio Bussi[...] Laurent MeijerBram SnijdersMaximiliano Gutierrez Elizabeth MC FisherVictor Tybulewicz Science Translational Medicine Published 24 January 2024 Crick labs/ facilitiesVictor TybulewiczMaximiliano GutierrezProteomicsHigh Throughput ScreeningBioinformatics and BiostatisticsFull details Lysosomal damage drives mitochondrial proteome remodelling and reprograms macrophage immunometabolism Authors (17)Claudio Bussi Tiaan HeunisEnrica PellegrinoElliott Bernard Nourdine BahMariana Silva Dos Santos[...]James MacraeMaria Greco Thomas Reinheckel Matthias TrostMaximiliano Gutierrez Nature Communications Published 28 November 2022 Crick labs/ facilitiesMaximiliano GutierrezJulian DownwardMetabolomicsBioinformatics and BiostatisticsAdvanced SequencingLight MicroscopyHuman Embryonic Stem CellElectron MicroscopyAdvanced SequencingFull details LRRK2 activation controls the repair of damaged endomembranes in macrophages Authors (8)Susanne Herbst Philip Campbell John HarveyElliott BernardVenizelos Papayannopoulos Nicholas W Wood Huw R MorrisMaximiliano Gutierrez The EMBO Journal Published 15 September 2020 Crick labs/ facilitiesVenizelos PapayannopoulosMaximiliano GutierrezLight MicroscopyFull details Pandemic peak SARS-CoV-2 infection and seroconversion rates in London frontline health-care workers Authors (341) Catherine F Houlihan Nina Vora Thomas Byrne Dan LewerGavin Kelly Judith Heaney[...] Andrew Hayward Richard Gilson Gavin KellyFiona Roberts Emine Hatipoglu The Lancet Published 25 July 2020 Crick labs/ facilitiesAndreas WackKaren VousdenJernej UleJames TurnerMoritz TreeckCharles SwantonAdam SaterialeErik SahaiCaetano Reis e SousaPeter RatcliffeLucia Prieto-GodinoVenizelos PapayannopoulosAnne O’GarraPaul NurseGeorge KassiotisMaximiliano GutierrezSonia GandhiSteve GamblinPeter Cherepanov Luiz Pedro CarvalhoDominique BonnetMike BlackmanRupert BealeWorldwide Influenza CentreStructural BiologyMetabolomicsHuman Embryonic Stem CellHigh Throughput ScreeningGenetic Modification ServiceFlow CytometryFermentationExperimental HistopathologyElectron MicroscopyCell ServicesBiological Research FacilityBioinformatics and BiostatisticsAdvanced SequencingScientific computingFull details Mycobacterium tuberculosis cords within lymphatic endothelial cells to evade host immunity Authors (9) Thomas R LernerChristophe QuevalRachel LaiMatt RussellTony FearnsDaniel GreenwoodLucy CollinsonRobert WilkinsonMaximiliano Gutierrez JCI insight Published 21 May 2020 Crick labs/ facilitiesRobert J WilkinsonMaximiliano GutierrezElectron MicroscopyFull details Subcellular antibiotic visualization reveals a dynamic drug reservoir in infected macrophages Authors (9)Daniel GreenwoodMariana Silva Dos Santos Song HuangMatt RussellLucy CollinsonJames Macrae Andy West Haibo JiangMaximiliano Gutierrez Science Published 28 June 2019 Crick labs/ facilitiesMaximiliano GutierrezMetabolomicsElectron MicroscopyBioinformatics and BiostatisticsFull details The intestine harbors functionally distinct homeostatic tissue-resident and inflammatory Th17 cells Authors (12)Sara OmenettiClaudio Bussi Amina Metidji Andrea Iseppon Sunjae LeeMauro Tolaini[...]Gavin Kelly Probir Chakravarty Saeed ShoaieMaximiliano GutierrezBrigitta Stockinger Immunity Published 16 July 2019 Crick labs/ facilitiesGitta StockingerMaximiliano GutierrezBioinformatics and BiostatisticsLight MicroscopyFlow CytometryBiological Research FacilityFull details A Rab20-dependent membrane trafficking pathway controls M. tuberculosis replication by regulating phagosome spaciousness and integrity Authors (9) Laura Schnettger Angela Rodgers Urska RepnikRachel Lai Gang Pei Martijn VerdoesRobert Wilkinson Douglas B YoungMaximiliano Gutierrez Cell Host & Microbe Published 10 May 2017 Crick labs/ facilitiesRobert J WilkinsonMaximiliano GutierrezLight MicroscopyBiological Research FacilityFull details Reactive oxygen species localization programs inflammation to clear microbes of different size Authors (8) Annika Warnatsch Theodora-Dorita Tsourouktsoglou Nora BranzkQian Wang Susanna ReinckeSusanne HerbstMaximiliano GutierrezVenizelos Papayannopoulos Immunity Published 21 March 2017 Crick labsVenizelos PapayannopoulosMaximiliano GutierrezFull details Relationship between HIV coinfection, interleukin 10 production, and Mycobacterium tuberculosis in human lymph node granulomas Authors (9) CR Diedrich J O'HernMaximiliano Gutierrez N Allie P Papier G Meintjes AK Coussens H WainwrightRobert Wilkinson Journal of Infectious Diseases Published 1 November 2016 Crick labsRobert J WilkinsonMaximiliano GutierrezFull details The proneurotrophin receptor sortilin is required for Mycobacterium tuberculosis control by macrophages Authors (10) Cristina L Vázquez Angela RodgersSusanne Herbst Stephen Coade Achim Gronow Carlos A Guzman Mark S Wilson Makoto Kanzaki Anders NykjaerMaximiliano Gutierrez Scientific Reports Published 8 July 2016 Crick labs/ facilitiesMaximiliano GutierrezExperimental HistopathologyBiological Research FacilityFull details Lymphatic endothelial cells are a replicative niche for Mycobacterium tuberculosis Authors (12) Thomas R Lerner Cristiane de Souza Carvalho-Wodarz Urska RepnikMatt Russell Sophie Borel Collin R Diedrich[...] Helen WainwrightLucy CollinsonRobert Wilkinson Gareth GriffithsMaximiliano Gutierrez Journal of Clinical Investigation Published 1 March 2016 Crick labs/ facilitiesRobert J WilkinsonMaximiliano GutierrezElectron MicroscopyExperimental HistopathologyFull details Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) Authors (10) Daniel J Klionsky Kotb Abdelmohsen ...Rupert Beale ...Maximiliano Gutierrez ...Charles Swanton ...Sharon Tooze Autophagy Published 2 January 2016 Crick labsSharon ToozeCharles SwantonMaximiliano GutierrezRupert BealeFull details Share the page Share on Twitter Share on Facebook Share on LinkedIn Share on Email
Increased dosage of DYRK1A leads to congenital heart defects in a mouse model of Down syndrome Authors (20)Eva Lana-ElolaRifdat Aoidi Miriam LlorianDorota GibbinsCallan BuechsenschuetzClaudio Bussi[...] Laurent MeijerBram SnijdersMaximiliano Gutierrez Elizabeth MC FisherVictor Tybulewicz Science Translational Medicine Published 24 January 2024 Crick labs/ facilitiesVictor TybulewiczMaximiliano GutierrezProteomicsHigh Throughput ScreeningBioinformatics and BiostatisticsFull details
Lysosomal damage drives mitochondrial proteome remodelling and reprograms macrophage immunometabolism Authors (17)Claudio Bussi Tiaan HeunisEnrica PellegrinoElliott Bernard Nourdine BahMariana Silva Dos Santos[...]James MacraeMaria Greco Thomas Reinheckel Matthias TrostMaximiliano Gutierrez Nature Communications Published 28 November 2022 Crick labs/ facilitiesMaximiliano GutierrezJulian DownwardMetabolomicsBioinformatics and BiostatisticsAdvanced SequencingLight MicroscopyHuman Embryonic Stem CellElectron MicroscopyAdvanced SequencingFull details
LRRK2 activation controls the repair of damaged endomembranes in macrophages Authors (8)Susanne Herbst Philip Campbell John HarveyElliott BernardVenizelos Papayannopoulos Nicholas W Wood Huw R MorrisMaximiliano Gutierrez The EMBO Journal Published 15 September 2020 Crick labs/ facilitiesVenizelos PapayannopoulosMaximiliano GutierrezLight MicroscopyFull details
Pandemic peak SARS-CoV-2 infection and seroconversion rates in London frontline health-care workers Authors (341) Catherine F Houlihan Nina Vora Thomas Byrne Dan LewerGavin Kelly Judith Heaney[...] Andrew Hayward Richard Gilson Gavin KellyFiona Roberts Emine Hatipoglu The Lancet Published 25 July 2020 Crick labs/ facilitiesAndreas WackKaren VousdenJernej UleJames TurnerMoritz TreeckCharles SwantonAdam SaterialeErik SahaiCaetano Reis e SousaPeter RatcliffeLucia Prieto-GodinoVenizelos PapayannopoulosAnne O’GarraPaul NurseGeorge KassiotisMaximiliano GutierrezSonia GandhiSteve GamblinPeter Cherepanov Luiz Pedro CarvalhoDominique BonnetMike BlackmanRupert BealeWorldwide Influenza CentreStructural BiologyMetabolomicsHuman Embryonic Stem CellHigh Throughput ScreeningGenetic Modification ServiceFlow CytometryFermentationExperimental HistopathologyElectron MicroscopyCell ServicesBiological Research FacilityBioinformatics and BiostatisticsAdvanced SequencingScientific computingFull details
Mycobacterium tuberculosis cords within lymphatic endothelial cells to evade host immunity Authors (9) Thomas R LernerChristophe QuevalRachel LaiMatt RussellTony FearnsDaniel GreenwoodLucy CollinsonRobert WilkinsonMaximiliano Gutierrez JCI insight Published 21 May 2020 Crick labs/ facilitiesRobert J WilkinsonMaximiliano GutierrezElectron MicroscopyFull details
Subcellular antibiotic visualization reveals a dynamic drug reservoir in infected macrophages Authors (9)Daniel GreenwoodMariana Silva Dos Santos Song HuangMatt RussellLucy CollinsonJames Macrae Andy West Haibo JiangMaximiliano Gutierrez Science Published 28 June 2019 Crick labs/ facilitiesMaximiliano GutierrezMetabolomicsElectron MicroscopyBioinformatics and BiostatisticsFull details
The intestine harbors functionally distinct homeostatic tissue-resident and inflammatory Th17 cells Authors (12)Sara OmenettiClaudio Bussi Amina Metidji Andrea Iseppon Sunjae LeeMauro Tolaini[...]Gavin Kelly Probir Chakravarty Saeed ShoaieMaximiliano GutierrezBrigitta Stockinger Immunity Published 16 July 2019 Crick labs/ facilitiesGitta StockingerMaximiliano GutierrezBioinformatics and BiostatisticsLight MicroscopyFlow CytometryBiological Research FacilityFull details
A Rab20-dependent membrane trafficking pathway controls M. tuberculosis replication by regulating phagosome spaciousness and integrity Authors (9) Laura Schnettger Angela Rodgers Urska RepnikRachel Lai Gang Pei Martijn VerdoesRobert Wilkinson Douglas B YoungMaximiliano Gutierrez Cell Host & Microbe Published 10 May 2017 Crick labs/ facilitiesRobert J WilkinsonMaximiliano GutierrezLight MicroscopyBiological Research FacilityFull details
Reactive oxygen species localization programs inflammation to clear microbes of different size Authors (8) Annika Warnatsch Theodora-Dorita Tsourouktsoglou Nora BranzkQian Wang Susanna ReinckeSusanne HerbstMaximiliano GutierrezVenizelos Papayannopoulos Immunity Published 21 March 2017 Crick labsVenizelos PapayannopoulosMaximiliano GutierrezFull details
Relationship between HIV coinfection, interleukin 10 production, and Mycobacterium tuberculosis in human lymph node granulomas Authors (9) CR Diedrich J O'HernMaximiliano Gutierrez N Allie P Papier G Meintjes AK Coussens H WainwrightRobert Wilkinson Journal of Infectious Diseases Published 1 November 2016 Crick labsRobert J WilkinsonMaximiliano GutierrezFull details
The proneurotrophin receptor sortilin is required for Mycobacterium tuberculosis control by macrophages Authors (10) Cristina L Vázquez Angela RodgersSusanne Herbst Stephen Coade Achim Gronow Carlos A Guzman Mark S Wilson Makoto Kanzaki Anders NykjaerMaximiliano Gutierrez Scientific Reports Published 8 July 2016 Crick labs/ facilitiesMaximiliano GutierrezExperimental HistopathologyBiological Research FacilityFull details
Lymphatic endothelial cells are a replicative niche for Mycobacterium tuberculosis Authors (12) Thomas R Lerner Cristiane de Souza Carvalho-Wodarz Urska RepnikMatt Russell Sophie Borel Collin R Diedrich[...] Helen WainwrightLucy CollinsonRobert Wilkinson Gareth GriffithsMaximiliano Gutierrez Journal of Clinical Investigation Published 1 March 2016 Crick labs/ facilitiesRobert J WilkinsonMaximiliano GutierrezElectron MicroscopyExperimental HistopathologyFull details
Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) Authors (10) Daniel J Klionsky Kotb Abdelmohsen ...Rupert Beale ...Maximiliano Gutierrez ...Charles Swanton ...Sharon Tooze Autophagy Published 2 January 2016 Crick labsSharon ToozeCharles SwantonMaximiliano GutierrezRupert BealeFull details