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Clusters of malaria parasites growing inside human red blood cells. Toggle to view hero caption Mike Blackman : Publications Lab MenuLab Menu Overview Areas of interest View more Back Proteolytic processing Subtilisin-like proteases SERA family cGMP signalling Publications Members Breadcrumb Home Research Labs Mike Blackman Publications PublicationsYear published2020 (9)2019 (8)2018 (6)2017 (8)2016 (8)2015 (7)2014 (7)2013 (9)2012 (5)2011 (3)2010 (4) Facet Year publishedResearch topicsBiochemistry & Proteomics (44)Cell Biology (44)Infectious Disease (44)Model Organisms (44)Immunology (43)Structural Biology & Biophysics (43)Computational & Systems Biology (11)Chemical Biology & High Throughput (7)Imaging (5)Cell Cycle & Chromosomes (1)Developmental Biology (1)Gene Expression (1)Genetics & Genomics (1)Genome Integrity & Repair (1)Human Biology & Physiology (1)Metabolism (1)Microfabrication & Bioengineering (1)Neurosciences (1)Signalling & Oncogenes (1)Stem Cells (1)Synthetic Biology (1)Tumour Biology (1) Facet Research topicsPublication typeJournal article (74)Primary research (63)Review (6)Method (4)Commentary (1) Facet Publication typeJournalPLOS Pathogens (8)PLOS ONE (5)Cellular Microbiology (4)Journal of Biological Chemistry (4)Proceedings of the National Academy of Sciences of the United States of America (4)Bioorganic & Medicinal Chemistry Letters (3)Molecular Microbiology (3)Science (3)Cell Host & Microbe (2)Current Opinion in Microbiology (2)eLife (2)International Journal for Parasitology (2)Journal of Medicinal Chemistry (2)Malaria Journal (2)mBio (2)PLOS Biology (2)Scientific Reports (2)ACS Medicinal Chemistry Letters (1)Annals of Translational Medicine (1)Bio-Protocol (1)Biochemical Journal (1)Blood (1)Chemistry of Heterocyclic Compounds (1)European Journal of Medicinal Chemistry (1)FEBS Journal (1)FEMS Microbiology Reviews (1)Infection and Immunity (1)Journal of Chemical Information and Modeling (1)Journal of Molecular Graphics & Modelling (1)Life Science Alliance (1)Nature Communications (1)Nature Microbiology (1)Nature Reviews Microbiology (1)PLOS Genetics (1)PLoS Neglected Tropical Diseases (1)Proceedings of the National Academy of Sciences of USA (1)RSC Advances (1)The Lancet (1)Traffic (1) Facet Journal Publications Displaying 1 - 20 of 74Last updated : 28 January 2021 03:02 The malaria parasite sheddase SUB2 governs host red blood cell membrane sealing at invasion Authors (7) Christine R Collins Fiona Hackett Steven A HowellBram SnijdersMatt RussellLucy CollinsonMike Blackman eLife Published 8 December 2020 Crick labs/ facilitiesMike BlackmanProteomicsElectron MicroscopyFull details cAMP signalling and its role in host cell invasion by malaria parasites Authors (5)Abi Perrin Avnish Patel Christian FlueckMike Blackman David A Baker Current Opinion in Microbiology Published 1 December 2020 Crick labsMike BlackmanFull details An apicoplast-resident folate transporter is essential for sporogony of malaria parasites Authors (8) Francois Korbmacher Benjamin DrepperTheo Sanderson Peer Martin Thomas Stach Alexander G Maier Kai Matuschewski Joachim M Matz Cellular Microbiology Published 1 January 2021 Crick labsMike BlackmanFull details Genomic and transcriptomic evidence for descent from Plasmodium and loss of blood schizogony in Hepatocystis parasites from naturally infected red colobus monkeys Authors (10) Eerik Aunin Ulrike BöhmeTheo Sanderson Noah D Simons Tony L Goldberg Nelson Ting Colin A Chapman Chris I Newbold Matthew Berriman Adam J Reid PLOS Pathogens Published 3 August 2020 Crick labsMike BlackmanFull details Pandemic peak SARS-CoV-2 infection and seroconversion rates in London frontline health-care workers Authors (341) Catherine F Houlihan Nina Vora Thomas Byrne Dan Lewer Gavin Kelly Judith Heaney[...] Andrew Hayward Richard GilsonGavin KellyFiona Roberts Emine Hatipoglu The Lancet Published 25 July 2020 Crick labs/ facilitiesAndreas WackKaren VousdenJernej UleJames TurnerMoritz TreeckCharles SwantonAdam SaterialeErik SahaiCaetano Reis e SousaPeter RatcliffeLucia Prieto-GodinoVenizelos PapayannopoulosAnne O’GarraPaul NurseGeorge KassiotisMaximiliano GutierrezSonia GandhiSteve GamblinPeter Cherepanov Luiz Pedro CarvalhoDominique BonnetMike BlackmanRupert BealeWorldwide Influenza CentreStructural BiologyPeptide ChemistryMetabolomicsHuman Embryonic Stem CellHigh Throughput ScreeningGenomics/Equipment ParkFlow CytometryFermentationExperimental HistopathologyElectron MicroscopyCell ServicesBioinformatics and BiostatisticsAdvanced SequencingScientific computingFull details A lipocalin mediates unidirectional heme biomineralization in malaria parasites Authors (11) Joachim M Matz Benjamin Drepper Thorsten B Blum Eric van Genderen Alana Burrell Peer Martin Thomas StachLucy Collinson Jan Pieter Abrahams Kai MatuschewskiMike Blackman Proceedings of the National Academy of Sciences of USA Published 14 July 2020 Crick labs/ facilitiesMike BlackmanElectron MicroscopyLight MicroscopyFull details Simultaneous multiple allelic replacement in the malaria parasite enables dissection of PKG function Authors (4)Kostas KousisChrislaine Withers-Martinez David A BakerMike Blackman Life Science Alliance Published 1 April 2020 Crick labsMike BlackmanFull details The parasitophorous vacuole of the blood-stage malaria parasite Authors (3) Joachim M Matz Josh R BeckMike Blackman Nature Reviews Microbiology Published 1 July 2020 Crick labsMike BlackmanFull details A malaria parasite subtilisin propeptide-like protein is a potent inhibitor of the egress protease SUB1 Authors (8) Sarah J TarrChrislaine Withers-Martinez Helen R FlynnBram SnijdersLaura MasinoKostas Kousis David J ConwayMike Blackman Biochemical Journal Published 31 January 2020 Crick labs/ facilitiesMike BlackmanStructural BiologyProteomicsFull details The Plasmodium falciparum rhoptry bulb protein RAMA plays an essential role in rhoptry neck morphogenesis and host red blood cell invasion Authors (7) Emma S SherlingAbi PerrinEllen KnuepferMatt RussellLucy Collinson Louis H MillerMike Blackman PLOS Pathogens Published 6 September 2019 Crick labs/ facilitiesTony HolderMike BlackmanElectron MicroscopyFull details Deletion of Plasmodium falciparum protein RON3 affects the functional translocation of exported proteins and glucose uptake Authors (10) Leanne M Low Yvonne Azasi Emma S Sherling Matthias Garten Joshua Zimmerberg Takafumi Tsuboi Joseph Brzostowski Jianbing MuMike Blackman Louis H Miller mBio Published 9 July 2019 Crick labsMike BlackmanFull details Structures of the cGMP-dependent protein kinase in malaria parasites reveal a unique structural relay mechanism for activation Authors (17) Majida El Bakkouri Imène Kouidmi Amy K Wernimont Mehrnaz Amani Ashley Hutchinson Peter Loppnau[...] Choel KimMike Blackman Charles Calmettes David A Baker Raymond Hui Proceedings of the National Academy of Sciences of the United States of America Published 9 July 2019 Crick labsMike BlackmanFull details Characterization of P. falciparum dipeptidyl aminopeptidase 3 specificity identifies differences in amino acid preferences between peptide-based substrates and covalent inhibitors Authors (16) Laura E de Vries Mateo I Sanchez Katarzyna Groborz Laurie Kuppens Marcin Poreba Christine Lehmann[...] Martin Horn Michael Mares Matthew Bogyo Marcin DragEdgar Deu FEBS Journal Published 1 October 2019 Crick labsEdgar DeuMike BlackmanFull details Cyclic AMP signalling controls key components of malaria parasite host cell invasion machinery Authors (14) Avnish PatelAbi Perrin Helen R Flynn Claudine BissonChrislaine Withers-MartinezMoritz Treeck[...] Andres Ramos Tim W GilbergerBram SnijdersMike Blackman David A Baker PLOS Biology Published 10 May 2019 Crick labs/ facilitiesMoritz TreeckIan TaylorMike BlackmanProteomicsFull details The Plasmodium berghei serine protease PbSUB1 plays an important role in male gamete egress Authors (7) Tomasino Pace Felicia Grasso Grazia Camarda Catherine SuarezMike Blackman Marta Ponzi Anna Olivieri Cellular Microbiology Published 1 July 2019 Crick labsMike BlackmanFull details Phosphodiesterase beta is the master regulator of cAMP signalling during malaria parasite invasion Authors (10) Christian Flueck Laura G DroughtAndrew Jones Avnish PatelAbi Perrin Eloise M Walker Stephanie D NofalBram SnijdersMike Blackman David A Baker PLOS Biology Published 22 February 2019 Crick labs/ facilitiesMike BlackmanProteomicsFull details Peptidomimetic plasmepsin inhibitors with potent anti-malarial activity and selectivity against cathepsin D Authors (11) Rimants Zogota Linda KinenaChrislaine Withers-MartinezMike Blackman Raitis Bobrovs Teodors Pantelejevs Iveta Kanepe-Lapsa Vita Ozola Kristaps Jaudzems Edgars Suna Aigars Jirgensons European Journal of Medicinal Chemistry Published 1 January 2019 Crick labsMike BlackmanFull details Essentiality of Plasmodium falciparum plasmepsin V Authors (5) Nonlawat Boonyalai Christine R Collins Fiona HackettChrislaine Withers-MartinezMike Blackman PLOS ONE Published 5 December 2018 Crick labsMike BlackmanFull details Essential role of Plasmodium perforin-like protein 4 in ookinete midgut passage Authors (11) Elena Deligianni Natalie C Silmon de Monerri Paul J McMillan Lucia Bertuccini Fabiana Superti Maria Manola Lefteris Spanos Christos LouisMike Blackman Leann Tilley Inga Siden-Kiamos PLOS ONE Published 13 August 2018 Crick labsMike BlackmanFull details The actinomyosin motor drives malaria parasite red blood cell invasion but not egress Authors (6)Abi Perrin Christine R CollinsMatt RussellLucy Collinson David A BakerMike Blackman mBio Published 3 July 2018 Crick labs/ facilitiesMike BlackmanElectron MicroscopyFull details Pagination Current page 1 Page 2 Page 3 Page 4 Next page Next Last page Last Share the page Share on Twitter Share on Facebook Share on LinkedIn Share on Email
The malaria parasite sheddase SUB2 governs host red blood cell membrane sealing at invasion Authors (7) Christine R Collins Fiona Hackett Steven A HowellBram SnijdersMatt RussellLucy CollinsonMike Blackman eLife Published 8 December 2020 Crick labs/ facilitiesMike BlackmanProteomicsElectron MicroscopyFull details
cAMP signalling and its role in host cell invasion by malaria parasites Authors (5)Abi Perrin Avnish Patel Christian FlueckMike Blackman David A Baker Current Opinion in Microbiology Published 1 December 2020 Crick labsMike BlackmanFull details
An apicoplast-resident folate transporter is essential for sporogony of malaria parasites Authors (8) Francois Korbmacher Benjamin DrepperTheo Sanderson Peer Martin Thomas Stach Alexander G Maier Kai Matuschewski Joachim M Matz Cellular Microbiology Published 1 January 2021 Crick labsMike BlackmanFull details
Genomic and transcriptomic evidence for descent from Plasmodium and loss of blood schizogony in Hepatocystis parasites from naturally infected red colobus monkeys Authors (10) Eerik Aunin Ulrike BöhmeTheo Sanderson Noah D Simons Tony L Goldberg Nelson Ting Colin A Chapman Chris I Newbold Matthew Berriman Adam J Reid PLOS Pathogens Published 3 August 2020 Crick labsMike BlackmanFull details
Pandemic peak SARS-CoV-2 infection and seroconversion rates in London frontline health-care workers Authors (341) Catherine F Houlihan Nina Vora Thomas Byrne Dan Lewer Gavin Kelly Judith Heaney[...] Andrew Hayward Richard GilsonGavin KellyFiona Roberts Emine Hatipoglu The Lancet Published 25 July 2020 Crick labs/ facilitiesAndreas WackKaren VousdenJernej UleJames TurnerMoritz TreeckCharles SwantonAdam SaterialeErik SahaiCaetano Reis e SousaPeter RatcliffeLucia Prieto-GodinoVenizelos PapayannopoulosAnne O’GarraPaul NurseGeorge KassiotisMaximiliano GutierrezSonia GandhiSteve GamblinPeter Cherepanov Luiz Pedro CarvalhoDominique BonnetMike BlackmanRupert BealeWorldwide Influenza CentreStructural BiologyPeptide ChemistryMetabolomicsHuman Embryonic Stem CellHigh Throughput ScreeningGenomics/Equipment ParkFlow CytometryFermentationExperimental HistopathologyElectron MicroscopyCell ServicesBioinformatics and BiostatisticsAdvanced SequencingScientific computingFull details
A lipocalin mediates unidirectional heme biomineralization in malaria parasites Authors (11) Joachim M Matz Benjamin Drepper Thorsten B Blum Eric van Genderen Alana Burrell Peer Martin Thomas StachLucy Collinson Jan Pieter Abrahams Kai MatuschewskiMike Blackman Proceedings of the National Academy of Sciences of USA Published 14 July 2020 Crick labs/ facilitiesMike BlackmanElectron MicroscopyLight MicroscopyFull details
Simultaneous multiple allelic replacement in the malaria parasite enables dissection of PKG function Authors (4)Kostas KousisChrislaine Withers-Martinez David A BakerMike Blackman Life Science Alliance Published 1 April 2020 Crick labsMike BlackmanFull details
The parasitophorous vacuole of the blood-stage malaria parasite Authors (3) Joachim M Matz Josh R BeckMike Blackman Nature Reviews Microbiology Published 1 July 2020 Crick labsMike BlackmanFull details
A malaria parasite subtilisin propeptide-like protein is a potent inhibitor of the egress protease SUB1 Authors (8) Sarah J TarrChrislaine Withers-Martinez Helen R FlynnBram SnijdersLaura MasinoKostas Kousis David J ConwayMike Blackman Biochemical Journal Published 31 January 2020 Crick labs/ facilitiesMike BlackmanStructural BiologyProteomicsFull details
The Plasmodium falciparum rhoptry bulb protein RAMA plays an essential role in rhoptry neck morphogenesis and host red blood cell invasion Authors (7) Emma S SherlingAbi PerrinEllen KnuepferMatt RussellLucy Collinson Louis H MillerMike Blackman PLOS Pathogens Published 6 September 2019 Crick labs/ facilitiesTony HolderMike BlackmanElectron MicroscopyFull details
Deletion of Plasmodium falciparum protein RON3 affects the functional translocation of exported proteins and glucose uptake Authors (10) Leanne M Low Yvonne Azasi Emma S Sherling Matthias Garten Joshua Zimmerberg Takafumi Tsuboi Joseph Brzostowski Jianbing MuMike Blackman Louis H Miller mBio Published 9 July 2019 Crick labsMike BlackmanFull details
Structures of the cGMP-dependent protein kinase in malaria parasites reveal a unique structural relay mechanism for activation Authors (17) Majida El Bakkouri Imène Kouidmi Amy K Wernimont Mehrnaz Amani Ashley Hutchinson Peter Loppnau[...] Choel KimMike Blackman Charles Calmettes David A Baker Raymond Hui Proceedings of the National Academy of Sciences of the United States of America Published 9 July 2019 Crick labsMike BlackmanFull details
Characterization of P. falciparum dipeptidyl aminopeptidase 3 specificity identifies differences in amino acid preferences between peptide-based substrates and covalent inhibitors Authors (16) Laura E de Vries Mateo I Sanchez Katarzyna Groborz Laurie Kuppens Marcin Poreba Christine Lehmann[...] Martin Horn Michael Mares Matthew Bogyo Marcin DragEdgar Deu FEBS Journal Published 1 October 2019 Crick labsEdgar DeuMike BlackmanFull details
Cyclic AMP signalling controls key components of malaria parasite host cell invasion machinery Authors (14) Avnish PatelAbi Perrin Helen R Flynn Claudine BissonChrislaine Withers-MartinezMoritz Treeck[...] Andres Ramos Tim W GilbergerBram SnijdersMike Blackman David A Baker PLOS Biology Published 10 May 2019 Crick labs/ facilitiesMoritz TreeckIan TaylorMike BlackmanProteomicsFull details
The Plasmodium berghei serine protease PbSUB1 plays an important role in male gamete egress Authors (7) Tomasino Pace Felicia Grasso Grazia Camarda Catherine SuarezMike Blackman Marta Ponzi Anna Olivieri Cellular Microbiology Published 1 July 2019 Crick labsMike BlackmanFull details
Phosphodiesterase beta is the master regulator of cAMP signalling during malaria parasite invasion Authors (10) Christian Flueck Laura G DroughtAndrew Jones Avnish PatelAbi Perrin Eloise M Walker Stephanie D NofalBram SnijdersMike Blackman David A Baker PLOS Biology Published 22 February 2019 Crick labs/ facilitiesMike BlackmanProteomicsFull details
Peptidomimetic plasmepsin inhibitors with potent anti-malarial activity and selectivity against cathepsin D Authors (11) Rimants Zogota Linda KinenaChrislaine Withers-MartinezMike Blackman Raitis Bobrovs Teodors Pantelejevs Iveta Kanepe-Lapsa Vita Ozola Kristaps Jaudzems Edgars Suna Aigars Jirgensons European Journal of Medicinal Chemistry Published 1 January 2019 Crick labsMike BlackmanFull details
Essentiality of Plasmodium falciparum plasmepsin V Authors (5) Nonlawat Boonyalai Christine R Collins Fiona HackettChrislaine Withers-MartinezMike Blackman PLOS ONE Published 5 December 2018 Crick labsMike BlackmanFull details
Essential role of Plasmodium perforin-like protein 4 in ookinete midgut passage Authors (11) Elena Deligianni Natalie C Silmon de Monerri Paul J McMillan Lucia Bertuccini Fabiana Superti Maria Manola Lefteris Spanos Christos LouisMike Blackman Leann Tilley Inga Siden-Kiamos PLOS ONE Published 13 August 2018 Crick labsMike BlackmanFull details
The actinomyosin motor drives malaria parasite red blood cell invasion but not egress Authors (6)Abi Perrin Christine R CollinsMatt RussellLucy Collinson David A BakerMike Blackman mBio Published 3 July 2018 Crick labs/ facilitiesMike BlackmanElectron MicroscopyFull details