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Clusters of malaria parasites growing inside human red blood cells. Toggle to view hero caption Mike Blackman : Publications Lab MenuLab Menu Overview Areas of interest View more Back Proteolytic processing Subtilisin-like proteases SERA family cGMP signalling Publications Members Breadcrumb Research A Z of research labs Mike Blackman PublicationsYear published2021 (6)2020 (9)2019 (8)2018 (6)2017 (8)2016 (8)2015 (7)2014 (7)2013 (9)2012 (5)2011 (3)2010 (4) Facet Year publishedResearch topicsBiochemistry & Proteomics (50)Cell Biology (50)Infectious Disease (50)Model Organisms (50)Immunology (49)Structural Biology & Biophysics (49)Computational & Systems Biology (14)Chemical Biology & High Throughput (10)Imaging (6)Cell Cycle & Chromosomes (1)Developmental Biology (1)Gene Expression (1)Genetics & Genomics (1)Genome Integrity & Repair (1)Human Biology & Physiology (1)Metabolism (1)Microfabrication & Bioengineering (1)Neurosciences (1)Signalling & Oncogenes (1)Stem Cells (1)Synthetic Biology (1)Tumour Biology (1) Facet Research topicsPublication typeJournal article (80)Primary research (68)Review (7)Method (4)Commentary (1) Facet Publication typeJournalPLOS Pathogens (8)PLOS ONE (5)Cellular Microbiology (4)Journal of Biological Chemistry (4)mBio (4)Proceedings of the National Academy of Sciences of the United States of America (4)Bioorganic & Medicinal Chemistry Letters (3)Molecular Microbiology (3)Science (3)Cell Host & Microbe (2)Current Opinion in Microbiology (2)eLife (2)International Journal for Parasitology (2)Journal of Medicinal Chemistry (2)Malaria Journal (2)PLOS Biology (2)Proceedings of the National Academy of Sciences of USA (2)Scientific Reports (2)ACS Medicinal Chemistry Letters (1)Annals of Translational Medicine (1)Bio-Protocol (1)Biochemical Journal (1)Blood (1)Chemistry of Heterocyclic Compounds (1)European Journal of Medicinal Chemistry (1)FEBS Journal (1)FEMS Microbiology Reviews (1)Infection and Immunity (1)Journal of Cell Science (1)Journal of Chemical Information and Modeling (1)Journal of Molecular Graphics & Modelling (1)Life Science Alliance (1)Nature Communications (1)Nature Microbiology (1)Nature Reviews Microbiology (1)PLOS Genetics (1)PLoS Neglected Tropical Diseases (1)RSC Advances (1)Science advances (1)The EMBO Journal (1)The Lancet (1)Traffic (1) Facet Journal Publications Displaying 1 - 20 of 80Last updated : 14 June 2021 03:32 Peptidic boronic acids are potent cell-permeable inhibitors of the malaria parasite egress serine protease SUB1 Authors (9) Elina LidumnieceChrislaine Withers-Martinez Fiona Hackett Christine R CollinsAbi PerrinKostas Kousis Claudine BissonMichael Blackman Aigars Jirgensons Proceedings of the National Academy of Sciences of USA Published 18 May 2021 Crick labsMike BlackmanFull details Autocatalytic activation of a malarial egress protease is druggable and requires a protein cofactor Authors (11)Michele TanKostas KousisChrislaine Withers-Martinez Steven A Howell James A Thomas Fiona HackettEllen Knuepfer Min Shen Matthew D HallBram SnijdersMichael Blackman The EMBO Journal Published 1 May 2021 Crick labs/ facilitiesMike BlackmanProteomicsFull details Ca2+ signals critical for egress and gametogenesis in malaria parasites depend on a multipass membrane protein that interacts with PKG Authors (19) Aurélia C BalestraKostas Kousis Natacha Klages Steven A Howell Helen R Flynn Marcus Bantscheff[...] Sonja Ghidelli-DisseBram Snijders David A BakerMichael Blackman Mathieu Brochet Science advances Published 24 March 2021 Crick labs/ facilitiesMike BlackmanProteomicsFull details Malaria parasite schizont egress antigen-1 plays an essential role in nuclear segregation during schizogony Authors (10)Abi Perrin Claudine BissonPeter FaullMatt Renshaw Rebecca A Lees Roland A Fleck Helen R SaibilBram Snijders David A BakerMichael Blackman mBio Published 1 March 2021 Crick labs/ facilitiesMike BlackmanProteomicsLight MicroscopyFull details Malaria parasite egress at a glance Authors (2)Michele TanMichael Blackman Journal of Cell Science Published 8 March 2021 Crick labsMike BlackmanFull details Plasmodium falciparum guanylyl cyclase-alpha and the activity of its appended P4-ATPase domain are essential for cGMP synthesis and blood-stage egress Authors (5) Stephanie D Nofal Avnish PatelMichael Blackman Christian Flueck David A Baker mBio Published 1 January 2021 Crick labsMike BlackmanFull details The malaria parasite sheddase SUB2 governs host red blood cell membrane sealing at invasion Authors (7) Christine R Collins Fiona Hackett Steven A HowellBram SnijdersMatt RussellLucy CollinsonMichael Blackman eLife Published 8 December 2020 Crick labs/ facilitiesMike BlackmanProteomicsElectron MicroscopyFull details cAMP signalling and its role in host cell invasion by malaria parasites Authors (5)Abi Perrin Avnish Patel Christian FlueckMichael Blackman David A Baker Current Opinion in Microbiology Published 1 December 2020 Crick labsMike BlackmanFull details An apicoplast-resident folate transporter is essential for sporogony of malaria parasites Authors (8) Francois Korbmacher Benjamin DrepperTheo Sanderson Peer Martin Thomas Stach Alexander G Maier Kai Matuschewski Joachim M Matz Cellular Microbiology Published 1 January 2021 Crick labsMike BlackmanFull details Genomic and transcriptomic evidence for descent from Plasmodium and loss of blood schizogony in Hepatocystis parasites from naturally infected red colobus monkeys Authors (10) Eerik Aunin Ulrike BöhmeTheo Sanderson Noah D Simons Tony L Goldberg Nelson Ting Colin A Chapman Chris I Newbold Matthew Berriman Adam J Reid PLOS Pathogens Published 3 August 2020 Crick labsMike BlackmanFull details Pandemic peak SARS-CoV-2 infection and seroconversion rates in London frontline health-care workers Authors (341) Catherine F Houlihan Nina Vora Thomas Byrne Dan LewerGavin Kelly Judith Heaney[...] Andrew Hayward Richard Gilson Gavin KellyFiona Roberts Emine Hatipoglu The Lancet Published 25 July 2020 Crick labs/ facilitiesAndreas WackKaren VousdenJernej UleJames TurnerMoritz TreeckCharles SwantonAdam SaterialeErik SahaiCaetano Reis e SousaPeter RatcliffeLucia Prieto-GodinoVenizelos PapayannopoulosAnne O’GarraPaul NurseGeorge KassiotisMaximiliano GutierrezSonia GandhiSteve GamblinPeter Cherepanov Luiz Pedro CarvalhoDominique BonnetMike BlackmanRupert BealeWorldwide Influenza CentreStructural BiologyPeptide ChemistryMetabolomicsHuman Embryonic Stem CellHigh Throughput ScreeningGenomics/Equipment ParkGenetic Modification ServiceFlow CytometryFermentationExperimental HistopathologyElectron MicroscopyCell ServicesBiological Research FacilityBioinformatics and BiostatisticsAdvanced SequencingScientific computingFull details A lipocalin mediates unidirectional heme biomineralization in malaria parasites Authors (11) Joachim M Matz Benjamin Drepper Thorsten B Blum Eric van Genderen Alana Burrell Peer Martin Thomas StachLucy Collinson Jan Pieter Abrahams Kai MatuschewskiMichael Blackman Proceedings of the National Academy of Sciences of USA Published 14 July 2020 Crick labs/ facilitiesMike BlackmanElectron MicroscopyLight MicroscopyFull details Simultaneous multiple allelic replacement in the malaria parasite enables dissection of PKG function Authors (4)Kostas KousisChrislaine Withers-Martinez David A BakerMichael Blackman Life Science Alliance Published 1 April 2020 Crick labsMike BlackmanFull details The parasitophorous vacuole of the blood-stage malaria parasite Authors (3) Joachim M Matz Josh R BeckMichael Blackman Nature Reviews Microbiology Published 1 July 2020 Crick labsMike BlackmanFull details A malaria parasite subtilisin propeptide-like protein is a potent inhibitor of the egress protease SUB1 Authors (8) Sarah J TarrChrislaine Withers-Martinez Helen R FlynnBram SnijdersLaura MasinoKostas Kousis David J ConwayMichael Blackman Biochemical Journal Published 31 January 2020 Crick labs/ facilitiesMike BlackmanStructural BiologyProteomicsFull details The Plasmodium falciparum rhoptry bulb protein RAMA plays an essential role in rhoptry neck morphogenesis and host red blood cell invasion Authors (7) Emma S SherlingAbi PerrinEllen KnuepferMatt RussellLucy Collinson Louis H MillerMichael Blackman PLOS Pathogens Published 6 September 2019 Crick labs/ facilitiesTony HolderMike BlackmanElectron MicroscopyFull details Deletion of Plasmodium falciparum protein RON3 affects the functional translocation of exported proteins and glucose uptake Authors (10) Leanne M Low Yvonne Azasi Emma S Sherling Matthias Garten Joshua Zimmerberg Takafumi Tsuboi Joseph Brzostowski Jianbing MuMichael Blackman Louis H Miller mBio Published 9 July 2019 Crick labsMike BlackmanFull details Structures of the cGMP-dependent protein kinase in malaria parasites reveal a unique structural relay mechanism for activation Authors (17) Majida El Bakkouri Imène Kouidmi Amy K Wernimont Mehrnaz Amani Ashley Hutchinson Peter Loppnau[...] Choel KimMichael Blackman Charles Calmettes David A Baker Raymond Hui Proceedings of the National Academy of Sciences of the United States of America Published 9 July 2019 Crick labsMike BlackmanFull details Characterization of P. falciparum dipeptidyl aminopeptidase 3 specificity identifies differences in amino acid preferences between peptide-based substrates and covalent inhibitors Authors (16) Laura E de Vries Mateo I Sanchez Katarzyna Groborz Laurie Kuppens Marcin Poreba Christine Lehmann[...] Martin Horn Michael Mares Matthew Bogyo Marcin DragEdgar Deu Sandoval FEBS Journal Published 1 October 2019 Crick labsEdgar DeuMike BlackmanFull details Cyclic AMP signalling controls key components of malaria parasite host cell invasion machinery Authors (14) Avnish PatelAbi Perrin Helen R Flynn Claudine BissonChrislaine Withers-MartinezMoritz Treeck[...] Andres Ramos Tim W GilbergerBram SnijdersMichael Blackman David A Baker PLOS Biology Published 10 May 2019 Crick labs/ facilitiesMoritz TreeckIan TaylorMike BlackmanProteomicsFull details Pagination Current page 1 Page 2 Page 3 Page 4 Next page 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Peptidic boronic acids are potent cell-permeable inhibitors of the malaria parasite egress serine protease SUB1 Authors (9) Elina LidumnieceChrislaine Withers-Martinez Fiona Hackett Christine R CollinsAbi PerrinKostas Kousis Claudine BissonMichael Blackman Aigars Jirgensons Proceedings of the National Academy of Sciences of USA Published 18 May 2021 Crick labsMike BlackmanFull details
Autocatalytic activation of a malarial egress protease is druggable and requires a protein cofactor Authors (11)Michele TanKostas KousisChrislaine Withers-Martinez Steven A Howell James A Thomas Fiona HackettEllen Knuepfer Min Shen Matthew D HallBram SnijdersMichael Blackman The EMBO Journal Published 1 May 2021 Crick labs/ facilitiesMike BlackmanProteomicsFull details
Ca2+ signals critical for egress and gametogenesis in malaria parasites depend on a multipass membrane protein that interacts with PKG Authors (19) Aurélia C BalestraKostas Kousis Natacha Klages Steven A Howell Helen R Flynn Marcus Bantscheff[...] Sonja Ghidelli-DisseBram Snijders David A BakerMichael Blackman Mathieu Brochet Science advances Published 24 March 2021 Crick labs/ facilitiesMike BlackmanProteomicsFull details
Malaria parasite schizont egress antigen-1 plays an essential role in nuclear segregation during schizogony Authors (10)Abi Perrin Claudine BissonPeter FaullMatt Renshaw Rebecca A Lees Roland A Fleck Helen R SaibilBram Snijders David A BakerMichael Blackman mBio Published 1 March 2021 Crick labs/ facilitiesMike BlackmanProteomicsLight MicroscopyFull details
Malaria parasite egress at a glance Authors (2)Michele TanMichael Blackman Journal of Cell Science Published 8 March 2021 Crick labsMike BlackmanFull details
Plasmodium falciparum guanylyl cyclase-alpha and the activity of its appended P4-ATPase domain are essential for cGMP synthesis and blood-stage egress Authors (5) Stephanie D Nofal Avnish PatelMichael Blackman Christian Flueck David A Baker mBio Published 1 January 2021 Crick labsMike BlackmanFull details
The malaria parasite sheddase SUB2 governs host red blood cell membrane sealing at invasion Authors (7) Christine R Collins Fiona Hackett Steven A HowellBram SnijdersMatt RussellLucy CollinsonMichael Blackman eLife Published 8 December 2020 Crick labs/ facilitiesMike BlackmanProteomicsElectron MicroscopyFull details
cAMP signalling and its role in host cell invasion by malaria parasites Authors (5)Abi Perrin Avnish Patel Christian FlueckMichael Blackman David A Baker Current Opinion in Microbiology Published 1 December 2020 Crick labsMike BlackmanFull details
An apicoplast-resident folate transporter is essential for sporogony of malaria parasites Authors (8) Francois Korbmacher Benjamin DrepperTheo Sanderson Peer Martin Thomas Stach Alexander G Maier Kai Matuschewski Joachim M Matz Cellular Microbiology Published 1 January 2021 Crick labsMike BlackmanFull details
Genomic and transcriptomic evidence for descent from Plasmodium and loss of blood schizogony in Hepatocystis parasites from naturally infected red colobus monkeys Authors (10) Eerik Aunin Ulrike BöhmeTheo Sanderson Noah D Simons Tony L Goldberg Nelson Ting Colin A Chapman Chris I Newbold Matthew Berriman Adam J Reid PLOS Pathogens Published 3 August 2020 Crick labsMike BlackmanFull details
Pandemic peak SARS-CoV-2 infection and seroconversion rates in London frontline health-care workers Authors (341) Catherine F Houlihan Nina Vora Thomas Byrne Dan LewerGavin Kelly Judith Heaney[...] Andrew Hayward Richard Gilson Gavin KellyFiona Roberts Emine Hatipoglu The Lancet Published 25 July 2020 Crick labs/ facilitiesAndreas WackKaren VousdenJernej UleJames TurnerMoritz TreeckCharles SwantonAdam SaterialeErik SahaiCaetano Reis e SousaPeter RatcliffeLucia Prieto-GodinoVenizelos PapayannopoulosAnne O’GarraPaul NurseGeorge KassiotisMaximiliano GutierrezSonia GandhiSteve GamblinPeter Cherepanov Luiz Pedro CarvalhoDominique BonnetMike BlackmanRupert BealeWorldwide Influenza CentreStructural BiologyPeptide ChemistryMetabolomicsHuman Embryonic Stem CellHigh Throughput ScreeningGenomics/Equipment ParkGenetic Modification ServiceFlow CytometryFermentationExperimental HistopathologyElectron MicroscopyCell ServicesBiological Research FacilityBioinformatics and BiostatisticsAdvanced SequencingScientific computingFull details
A lipocalin mediates unidirectional heme biomineralization in malaria parasites Authors (11) Joachim M Matz Benjamin Drepper Thorsten B Blum Eric van Genderen Alana Burrell Peer Martin Thomas StachLucy Collinson Jan Pieter Abrahams Kai MatuschewskiMichael Blackman Proceedings of the National Academy of Sciences of USA Published 14 July 2020 Crick labs/ facilitiesMike BlackmanElectron MicroscopyLight MicroscopyFull details
Simultaneous multiple allelic replacement in the malaria parasite enables dissection of PKG function Authors (4)Kostas KousisChrislaine Withers-Martinez David A BakerMichael Blackman Life Science Alliance Published 1 April 2020 Crick labsMike BlackmanFull details
The parasitophorous vacuole of the blood-stage malaria parasite Authors (3) Joachim M Matz Josh R BeckMichael Blackman Nature Reviews Microbiology Published 1 July 2020 Crick labsMike BlackmanFull details
A malaria parasite subtilisin propeptide-like protein is a potent inhibitor of the egress protease SUB1 Authors (8) Sarah J TarrChrislaine Withers-Martinez Helen R FlynnBram SnijdersLaura MasinoKostas Kousis David J ConwayMichael Blackman Biochemical Journal Published 31 January 2020 Crick labs/ facilitiesMike BlackmanStructural BiologyProteomicsFull details
The Plasmodium falciparum rhoptry bulb protein RAMA plays an essential role in rhoptry neck morphogenesis and host red blood cell invasion Authors (7) Emma S SherlingAbi PerrinEllen KnuepferMatt RussellLucy Collinson Louis H MillerMichael Blackman PLOS Pathogens Published 6 September 2019 Crick labs/ facilitiesTony HolderMike BlackmanElectron MicroscopyFull details
Deletion of Plasmodium falciparum protein RON3 affects the functional translocation of exported proteins and glucose uptake Authors (10) Leanne M Low Yvonne Azasi Emma S Sherling Matthias Garten Joshua Zimmerberg Takafumi Tsuboi Joseph Brzostowski Jianbing MuMichael Blackman Louis H Miller mBio Published 9 July 2019 Crick labsMike BlackmanFull details
Structures of the cGMP-dependent protein kinase in malaria parasites reveal a unique structural relay mechanism for activation Authors (17) Majida El Bakkouri Imène Kouidmi Amy K Wernimont Mehrnaz Amani Ashley Hutchinson Peter Loppnau[...] Choel KimMichael Blackman Charles Calmettes David A Baker Raymond Hui Proceedings of the National Academy of Sciences of the United States of America Published 9 July 2019 Crick labsMike BlackmanFull details
Characterization of P. falciparum dipeptidyl aminopeptidase 3 specificity identifies differences in amino acid preferences between peptide-based substrates and covalent inhibitors Authors (16) Laura E de Vries Mateo I Sanchez Katarzyna Groborz Laurie Kuppens Marcin Poreba Christine Lehmann[...] Martin Horn Michael Mares Matthew Bogyo Marcin DragEdgar Deu Sandoval FEBS Journal Published 1 October 2019 Crick labsEdgar DeuMike BlackmanFull details
Cyclic AMP signalling controls key components of malaria parasite host cell invasion machinery Authors (14) Avnish PatelAbi Perrin Helen R Flynn Claudine BissonChrislaine Withers-MartinezMoritz Treeck[...] Andres Ramos Tim W GilbergerBram SnijdersMichael Blackman David A Baker PLOS Biology Published 10 May 2019 Crick labs/ facilitiesMoritz TreeckIan TaylorMike BlackmanProteomicsFull details
