Publications

ProteInfer, deep neural networks for protein functional inference

Authors (4)

Theo Sanderson
Maxwell L Bileschi
David Belanger
Lucy J Colwell

eLife

Published 27 February 2023

Crick labs

Mike Blackman

Full details

A choline-releasing glycerophosphodiesterase essential for phosphatidylcholine biosynthesis and blood stage development in the malaria parasite

Authors (11)

eLife

Published 28 December 2022

Crick labs/ facilities

Full details

Integrative genetic manipulation of Plasmodium cynomolgi reveals multidrug resistance-1 Y976F associated with increased in vitro susceptibility to mefloquine

Authors (18)

Kurt E Ward
Peter Christensen
Annie Racklyeft
Satish K Dhingra
Adeline CY Chua
Caroline Remmert
[...]
Georges Snounou
Laurent Rénia
David A Fidock
Bruce Russell
Pablo Bifani

Journal of Infectious Diseases

Published 7 December 2022

Crick labs

Mike Blackman

Full details

Treenome Browser: co-visualization of enormous phylogenies and millions of genomes

Authors (3)

Alexander M Kramer
Theo Sanderson
Russell Corbett-Detig

Bioinformatics

Published 1 January 2023

Crick labs

Mike Blackman

Full details

Taxonium, a web-based tool for exploring large phylogenetic trees

Authors (1)

Theo Sanderson

eLife

Published 15 November 2022

Crick labs

Mike Blackman

Full details

Subtilisin-like serine protease 1 (SUB1) as an emerging antimalarial drug target: Current achievements in inhibitor discovery

Authors (5)

Elina Lidumniece
Chrislaine Withers-Martinez
Fiona Hackett
Michael Blackman
Aigars Jirgensons

Journal of Medicinal Chemistry

Published 13 October 2022

Crick labs

Mike Blackman

Full details

A song for the unsung: The relevance of Plasmodium vinckei as a laboratory rodent malaria system

Authors (2)

Abhinay Ramaprasad
Richard Culleton

Parasitology International

Published 1 February 2023

Crick labs

Mike Blackman

Full details

CDC50 orthologues in Plasmodium falciparum have distinct roles in merozoite egress and trophozoite maturation

Authors (4)

Avnish Patel
Stephanie D Nofal
Michael Blackman
David A Baker

mBio

Published 1 August 2022

Crick labs

Mike Blackman

Full details

CRISPR/Cas9 and genetic screens in malaria parasites: small genomes, big impact

Authors (5)

Takahiro Ishizaki
Sophia Hernandez
Martina S Paoletta
Theo Sanderson
Ellen SC Bushell

Biochemical Society Transactions

Published 1 June 2022

Crick labs

Mike Blackman

Full details

Variation at Spike position 142 in SARS-CoV-2 Delta genomes is a technical artifact caused by dropout of a sequencing amplicon

Authors (2)

Theo Sanderson
Jeffrey C Barrett

Wellcome Open Research

Published 10 November 2021

Crick labs

Mike Blackman

Full details

Inhibition of protein N-myristoylation blocks Plasmodium falciparum intraerythrocytic development, egress and invasion

Authors (12)

Anja C Schlott
Ellen Knuepfer
Judith Green
Philip Hobson
Aaron J Borg
Julia Morales-Sanfrutos
[...]
Catherine Maclachlan
Lucy Collinson
Bram Snijders
Edward W Tate
Anthony Holder

PLOS Biology

Published 25 October 2021

Crick labs/ facilities

Full details

Synchrony between daily rhythms of malaria parasites and hosts is driven by an essential amino acid

Authors (9)

Kimberley F Prior
Benita Middleton
Alíz TY Owolabi
Mary L Westwood
Jacob Holland
Aidan J O'Donnell
Michael Blackman
Debra J Skene
Sarah E Reece

Wellcome Open Research

Published 20 October 2021

Crick labs

Mike Blackman

Full details

Mixology: A tool for calculating required masses and volumes for laboratory solutions

Authors (1)

Theo Sanderson

Wellcome Open Research

Published 26 May 2021

Crick labs

Mike Blackman

Full details

Peptidic boronic acids are potent cell-permeable inhibitors of the malaria parasite egress serine protease SUB1

Authors (9)

Elina Lidumniece
Chrislaine Withers-Martinez
Fiona Hackett
Christine R Collins
Abi Perrin
Kostas Kousis
Claudine Bisson
Michael Blackman
Aigars Jirgensons

Proceedings of the National Academy of Sciences of USA

Published 18 May 2021

Crick labs

Mike Blackman

Full details

Autocatalytic activation of a malarial egress protease is druggable and requires a protein cofactor

Authors (11)

Michele Tan
Kostas Kousis
Chrislaine Withers-Martinez
Steven A Howell
James A Thomas
Fiona Hackett
Ellen Knuepfer
Min Shen
Matthew D Hall
Bram Snijders
Michael Blackman

The EMBO Journal

Published 1 June 2021

Crick labs/ facilities

Full details

Ca2+ signals critical for egress and gametogenesis in malaria parasites depend on a multipass membrane protein that interacts with PKG

Authors (19)

Aurélia C Balestra
Kostas Kousis
Natacha Klages
Steven A Howell
Helen R Flynn
Marcus Bantscheff
[...]
Sonja Ghidelli-Disse
Bram Snijders
David A Baker
Michael Blackman
Mathieu Brochet

Science advances

Published 24 March 2021

Crick labs/ facilities

Full details

Malaria parasite schizont egress antigen-1 plays an essential role in nuclear segregation during schizogony

Authors (10)

Abi Perrin
Claudine Bisson
Peter Faull
Matt Renshaw
Rebecca A Lees
Roland A Fleck
Helen R Saibil
Bram Snijders
David A Baker
Michael Blackman

mBio

Published 1 March 2021

Crick labs/ facilities

Full details

Malaria parasite egress at a glance

Authors (2)

Journal of Cell Science

Published 8 March 2021

Crick labs

Mike Blackman

Full details

Plasmodium falciparum guanylyl cyclase-alpha and the activity of its appended P4-ATPase domain are essential for cGMP synthesis and blood-stage egress

Authors (5)

Stephanie D Nofal
Avnish Patel
Michael Blackman
Christian Flueck
David A Baker

mBio

Published 1 January 2021

Crick labs

Mike Blackman

Full details

The malaria parasite sheddase SUB2 governs host red blood cell membrane sealing at invasion

Authors (7)

Christine R Collins
Fiona Hackett
Steven A Howell
Bram Snijders
Matt Russell
Lucy Collinson
Michael Blackman

eLife

Published 8 December 2020

Crick labs/ facilities

Full details

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Journal

ProteInfer, deep neural networks for protein functional inference

A choline-releasing glycerophosphodiesterase essential for phosphatidylcholine biosynthesis and blood stage development in the malaria parasite

Integrative genetic manipulation of Plasmodium cynomolgi reveals multidrug resistance-1 Y976F associated with increased in vitro susceptibility to mefloquine

Treenome Browser: co-visualization of enormous phylogenies and millions of genomes

Taxonium, a web-based tool for exploring large phylogenetic trees

Subtilisin-like serine protease 1 (SUB1) as an emerging antimalarial drug target: Current achievements in inhibitor discovery

A song for the unsung: The relevance of Plasmodium vinckei as a laboratory rodent malaria system

CDC50 orthologues in Plasmodium falciparum have distinct roles in merozoite egress and trophozoite maturation

CRISPR/Cas9 and genetic screens in malaria parasites: small genomes, big impact

Variation at Spike position 142 in SARS-CoV-2 Delta genomes is a technical artifact caused by dropout of a sequencing amplicon

Inhibition of protein N-myristoylation blocks Plasmodium falciparum intraerythrocytic development, egress and invasion

Synchrony between daily rhythms of malaria parasites and hosts is driven by an essential amino acid

Mixology: A tool for calculating required masses and volumes for laboratory solutions

Peptidic boronic acids are potent cell-permeable inhibitors of the malaria parasite egress serine protease SUB1

Autocatalytic activation of a malarial egress protease is druggable and requires a protein cofactor

Ca2+ signals critical for egress and gametogenesis in malaria parasites depend on a multipass membrane protein that interacts with PKG

Malaria parasite schizont egress antigen-1 plays an essential role in nuclear segregation during schizogony

Malaria parasite egress at a glance

Plasmodium falciparum guanylyl cyclase-alpha and the activity of its appended P4-ATPase domain are essential for cGMP synthesis and blood-stage egress

The malaria parasite sheddase SUB2 governs host red blood cell membrane sealing at invasion

The Francis Crick Institute is a unique partnership between

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