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Breadcrumb Mike Blackman Blackman lab Malaria Biochemistry Laboratory : Publications Lab contentLab contentIn this section Overview Vacancies Areas of interest Publications Members Clusters of malaria parasites growing inside human red blood cells. Toggle to view hero caption PublicationsYear published2023 (8)2022 (8)2021 (10)2020 (9)2019 (8)2018 (6)2017 (8)2016 (8)2015 (7)2014 (7)2013 (9)2012 (5)2011 (3)2010 (4) Facet Year publishedResearch topicsBiochemistry & Proteomics (70)Cell Biology (70)Infectious Disease (70)Model Organisms (70)Immunology (69)Structural Biology & Biophysics (69)Computational & Systems Biology (18)Chemical Biology & High Throughput (13)Imaging (11)Human Biology & Physiology (5)Tumour Biology (5)Developmental Biology (4)Metabolism (4)Signalling & Oncogenes (4)Cell Cycle & Chromosomes (3)Stem Cells (3)Gene Expression (2)Genetics & Genomics (2)Genome Integrity & Repair (2)Microfabrication & Bioengineering (2)Neurosciences (2)Synthetic Biology (2) Facet Research topicsPublication typeJournal article (100)Primary research (83)Review (10)Method (5)Commentary (1)Letter (1) Facet Publication typeJournalPLOS Pathogens (9)mBio (7)eLife (5)PLOS ONE (5)Cellular Microbiology (4)Journal of Biological Chemistry 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(1)Nature Microbiology (1)Nature Reviews Microbiology (1)Parasitology International (1)PLOS Genetics (1)PLoS Neglected Tropical Diseases (1)RSC Advances (1)Science advances (1)The EMBO Journal (1)Traffic (1) Facet Journal Publications Displaying 1 - 20 of 100Last updated : 01 December 2023 03:34 A patatin-like phospholipase is important for mitochondrial function in malaria parasites Authors (13) Emma PietschAbhinay Ramaprasad Sabrina Bielfeld Yvonne Wohlfarter Bohumil Maco Korbinian Niedermüller[...] Markus A Keller Dominique Soldati-FavreMichael Blackman Tim-Wolf Gilberger Paul-Christian Burda mBio Published 26 October 2023 Crick labsMike BlackmanFull details A molnupiravir-associated mutational signature in global SARS-CoV-2 genomes Authors (7)Theo Sanderson Ryan Hisner I’ah Donovan-Banfield Hassan Hartman Alessandra Løchen Thomas P Peacock Christopher Ruis Nature Published 16 November 2023 Crick labsMike BlackmanFull details Macrocyclic peptidomimetic plasmepsin X inhibitors with potent in vitro and in vivo antimalarial activity Authors (16) Vadims KovadaChrislaine Withers-Martinez Raitis Bobrovs Hele̅na Ce̅rule Edgars Liepins Solveiga Grinberga[...] Dace Rasina Edgars Suna Kristaps JaudzemsMichael Blackman Aigars Jirgensons Journal of Medicinal Chemistry Published 10 August 2023 Crick labsMike BlackmanFull details Global analysis of putative phospholipases in Plasmodium falciparum reveals an essential role of the phosphoinositide-specific phospholipase C in parasite maturation Authors (13) Paul-Christian BurdaAbhinay Ramaprasad Sabrina Bielfeld Emma Pietsch Anna Woitalla Christoph Söhnchen[...]Aaron SaitLucy Collinson Dominik SchwudkeMichael Blackman Tim-Wolf Gilberger mBio Published 31 August 2023 Crick labs/ facilitiesMike BlackmanElectron MicroscopyFull details The role of Plasmodium V-ATPase in vacuolar physiology and antimalarial drug uptake Authors (8) Arne Alder Cecilia P SanchezMatt RussellLucy Collinson Michael LanzerMichael Blackman Tim-Wolf Gilberger Joachim M Matz Proceedings of the National Academy of Sciences of USA Published 25 July 2023 Crick labs/ facilitiesMike BlackmanElectron MicroscopyFull details A malaria parasite phospholipase facilitates efficient asexual blood stage egress Authors (11)Abhinay Ramaprasad Paul-Christian BurdaKostas Kousis James A Thomas Emma PietschEnrica Calvani Steven A HowellJames MacraeBram Snijders Tim-Wolf GilbergerMichael Blackman PLOS Pathogens Published 23 June 2023 Crick labs/ facilitiesMike BlackmanProteomicsMetabolomicsFull details Independent SARS-CoV-2 staff testing protected academic and health-care institutions in northwest London Authors (54) Chris BaileyTheo Sanderson Hermaleigh Townsley Jacki Goldman James RM BlackGeorge Young[...]Jerome NicodSonia GandhiDavid LV Bauer Emma C WallCharles Swanton The Lancet Published 1 July 2023 Crick labs/ facilitiesSamra TurajlicCharles SwantonSam RodriquesSonia GandhiSteve GamblinMike BlackmanRupert BealeDavid LV BauerWorldwide Influenza CentreStructural BiologyMetabolomicsHigh Throughput ScreeningFlow CytometryBioinformatics and BiostatisticsAdvanced SequencingScientific computingBiological Research FacilityFull details ProteInfer, deep neural networks for protein functional inference Authors (4)Theo Sanderson Maxwell L Bileschi David Belanger Lucy J Colwell eLife Published 27 February 2023 Crick labsMike BlackmanFull details A choline-releasing glycerophosphodiesterase essential for phosphatidylcholine biosynthesis and blood stage development in the malaria parasite Authors (11)Abhinay Ramaprasad Paul-Christian BurdaEnrica CalvaniAaron SaitSusana Alejandra Palma DuranChrislaine Withers-Martinez Fiona HackettJames MacraeLucy Collinson Tim Wolf GilbergerMichael Blackman eLife Published 28 December 2022 Crick labs/ facilitiesMike BlackmanMetabolomicsElectron MicroscopyLight MicroscopyFull details Integrative genetic manipulation of Plasmodium cynomolgi reveals multidrug resistance-1 Y976F associated with increased in vitro susceptibility to mefloquine Authors (18) Kurt E Ward Peter Christensen Annie Racklyeft Satish K Dhingra Adeline CY Chua Caroline Remmert[...] Georges Snounou Laurent Rénia David A Fidock Bruce Russell Pablo Bifani Journal of Infectious Diseases Published 15 May 2023 Crick labsMike BlackmanFull details Treenome Browser: co-visualization of enormous phylogenies and millions of genomes Authors (3) Alexander M KramerTheo Sanderson Russell Corbett-Detig Bioinformatics Published 1 January 2023 Crick labsMike BlackmanFull details Taxonium, a web-based tool for exploring large phylogenetic trees Authors (1)Theo Sanderson eLife Published 15 November 2022 Crick labsMike BlackmanFull details Subtilisin-like serine protease 1 (SUB1) as an emerging antimalarial drug target: Current achievements in inhibitor discovery Authors (5) Elina LidumnieceChrislaine Withers-Martinez Fiona HackettMichael Blackman Aigars Jirgensons Journal of Medicinal Chemistry Published 13 October 2022 Crick labsMike BlackmanFull details A song for the unsung: The relevance of Plasmodium vinckei as a laboratory rodent malaria system Authors (2)Abhinay Ramaprasad Richard Culleton Parasitology International Published 1 February 2023 Crick labsMike BlackmanFull details CDC50 orthologues in Plasmodium falciparum have distinct roles in merozoite egress and trophozoite maturation Authors (4) Avnish PatelStephanie NofalMichael Blackman David A Baker mBio Published 1 August 2022 Crick labsMike BlackmanFull details CRISPR/Cas9 and genetic screens in malaria parasites: small genomes, big impact Authors (5) Takahiro Ishizaki Sophia Hernandez Martina S PaolettaTheo Sanderson Ellen SC Bushell Biochemical Society Transactions Published 1 June 2022 Crick labsMike BlackmanFull details Variation at Spike position 142 in SARS-CoV-2 Delta genomes is a technical artifact caused by dropout of a sequencing amplicon Authors (2)Theo Sanderson Jeffrey C Barrett Wellcome Open Research Published 10 November 2021 Crick labsMike BlackmanFull details Inhibition of protein N-myristoylation blocks Plasmodium falciparum intraerythrocytic development, egress and invasion Authors (12) Anja C SchlottEllen KnuepferJudith GreenPhilip Hobson Aaron J Borg Julia Morales-Sanfrutos[...]Catherine MaclachlanLucy CollinsonBram Snijders Edward W TateAnthony Holder PLOS Biology Published 25 October 2021 Crick labs/ facilitiesEd TateTony HolderMike BlackmanProteomicsFlow CytometryElectron MicroscopyAdvanced SequencingFull details Synchrony between daily rhythms of malaria parasites and hosts is driven by an essential amino acid Authors (9) Kimberley F Prior Benita Middleton Alíz TY Owolabi Mary L Westwood Jacob Holland Aidan J O'DonnellMichael Blackman Debra J Skene Sarah E Reece Wellcome Open Research Published 20 October 2021 Crick labsMike BlackmanFull details Mixology: A tool for calculating required masses and volumes for laboratory solutions Authors (1)Theo Sanderson Wellcome Open Research Published 26 May 2021 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A patatin-like phospholipase is important for mitochondrial function in malaria parasites Authors (13) Emma PietschAbhinay Ramaprasad Sabrina Bielfeld Yvonne Wohlfarter Bohumil Maco Korbinian Niedermüller[...] Markus A Keller Dominique Soldati-FavreMichael Blackman Tim-Wolf Gilberger Paul-Christian Burda mBio Published 26 October 2023 Crick labsMike BlackmanFull details
A molnupiravir-associated mutational signature in global SARS-CoV-2 genomes Authors (7)Theo Sanderson Ryan Hisner I’ah Donovan-Banfield Hassan Hartman Alessandra Løchen Thomas P Peacock Christopher Ruis Nature Published 16 November 2023 Crick labsMike BlackmanFull details
Macrocyclic peptidomimetic plasmepsin X inhibitors with potent in vitro and in vivo antimalarial activity Authors (16) Vadims KovadaChrislaine Withers-Martinez Raitis Bobrovs Hele̅na Ce̅rule Edgars Liepins Solveiga Grinberga[...] Dace Rasina Edgars Suna Kristaps JaudzemsMichael Blackman Aigars Jirgensons Journal of Medicinal Chemistry Published 10 August 2023 Crick labsMike BlackmanFull details
Global analysis of putative phospholipases in Plasmodium falciparum reveals an essential role of the phosphoinositide-specific phospholipase C in parasite maturation Authors (13) Paul-Christian BurdaAbhinay Ramaprasad Sabrina Bielfeld Emma Pietsch Anna Woitalla Christoph Söhnchen[...]Aaron SaitLucy Collinson Dominik SchwudkeMichael Blackman Tim-Wolf Gilberger mBio Published 31 August 2023 Crick labs/ facilitiesMike BlackmanElectron MicroscopyFull details
The role of Plasmodium V-ATPase in vacuolar physiology and antimalarial drug uptake Authors (8) Arne Alder Cecilia P SanchezMatt RussellLucy Collinson Michael LanzerMichael Blackman Tim-Wolf Gilberger Joachim M Matz Proceedings of the National Academy of Sciences of USA Published 25 July 2023 Crick labs/ facilitiesMike BlackmanElectron MicroscopyFull details
A malaria parasite phospholipase facilitates efficient asexual blood stage egress Authors (11)Abhinay Ramaprasad Paul-Christian BurdaKostas Kousis James A Thomas Emma PietschEnrica Calvani Steven A HowellJames MacraeBram Snijders Tim-Wolf GilbergerMichael Blackman PLOS Pathogens Published 23 June 2023 Crick labs/ facilitiesMike BlackmanProteomicsMetabolomicsFull details
Independent SARS-CoV-2 staff testing protected academic and health-care institutions in northwest London Authors (54) Chris BaileyTheo Sanderson Hermaleigh Townsley Jacki Goldman James RM BlackGeorge Young[...]Jerome NicodSonia GandhiDavid LV Bauer Emma C WallCharles Swanton The Lancet Published 1 July 2023 Crick labs/ facilitiesSamra TurajlicCharles SwantonSam RodriquesSonia GandhiSteve GamblinMike BlackmanRupert BealeDavid LV BauerWorldwide Influenza CentreStructural BiologyMetabolomicsHigh Throughput ScreeningFlow CytometryBioinformatics and BiostatisticsAdvanced SequencingScientific computingBiological Research FacilityFull details
ProteInfer, deep neural networks for protein functional inference Authors (4)Theo Sanderson Maxwell L Bileschi David Belanger Lucy J Colwell eLife Published 27 February 2023 Crick labsMike BlackmanFull details
A choline-releasing glycerophosphodiesterase essential for phosphatidylcholine biosynthesis and blood stage development in the malaria parasite Authors (11)Abhinay Ramaprasad Paul-Christian BurdaEnrica CalvaniAaron SaitSusana Alejandra Palma DuranChrislaine Withers-Martinez Fiona HackettJames MacraeLucy Collinson Tim Wolf GilbergerMichael Blackman eLife Published 28 December 2022 Crick labs/ facilitiesMike BlackmanMetabolomicsElectron MicroscopyLight MicroscopyFull details
Integrative genetic manipulation of Plasmodium cynomolgi reveals multidrug resistance-1 Y976F associated with increased in vitro susceptibility to mefloquine Authors (18) Kurt E Ward Peter Christensen Annie Racklyeft Satish K Dhingra Adeline CY Chua Caroline Remmert[...] Georges Snounou Laurent Rénia David A Fidock Bruce Russell Pablo Bifani Journal of Infectious Diseases Published 15 May 2023 Crick labsMike BlackmanFull details
Treenome Browser: co-visualization of enormous phylogenies and millions of genomes Authors (3) Alexander M KramerTheo Sanderson Russell Corbett-Detig Bioinformatics Published 1 January 2023 Crick labsMike BlackmanFull details
Taxonium, a web-based tool for exploring large phylogenetic trees Authors (1)Theo Sanderson eLife Published 15 November 2022 Crick labsMike BlackmanFull details
Subtilisin-like serine protease 1 (SUB1) as an emerging antimalarial drug target: Current achievements in inhibitor discovery Authors (5) Elina LidumnieceChrislaine Withers-Martinez Fiona HackettMichael Blackman Aigars Jirgensons Journal of Medicinal Chemistry Published 13 October 2022 Crick labsMike BlackmanFull details
A song for the unsung: The relevance of Plasmodium vinckei as a laboratory rodent malaria system Authors (2)Abhinay Ramaprasad Richard Culleton Parasitology International Published 1 February 2023 Crick labsMike BlackmanFull details
CDC50 orthologues in Plasmodium falciparum have distinct roles in merozoite egress and trophozoite maturation Authors (4) Avnish PatelStephanie NofalMichael Blackman David A Baker mBio Published 1 August 2022 Crick labsMike BlackmanFull details
CRISPR/Cas9 and genetic screens in malaria parasites: small genomes, big impact Authors (5) Takahiro Ishizaki Sophia Hernandez Martina S PaolettaTheo Sanderson Ellen SC Bushell Biochemical Society Transactions Published 1 June 2022 Crick labsMike BlackmanFull details
Variation at Spike position 142 in SARS-CoV-2 Delta genomes is a technical artifact caused by dropout of a sequencing amplicon Authors (2)Theo Sanderson Jeffrey C Barrett Wellcome Open Research Published 10 November 2021 Crick labsMike BlackmanFull details
Inhibition of protein N-myristoylation blocks Plasmodium falciparum intraerythrocytic development, egress and invasion Authors (12) Anja C SchlottEllen KnuepferJudith GreenPhilip Hobson Aaron J Borg Julia Morales-Sanfrutos[...]Catherine MaclachlanLucy CollinsonBram Snijders Edward W TateAnthony Holder PLOS Biology Published 25 October 2021 Crick labs/ facilitiesEd TateTony HolderMike BlackmanProteomicsFlow CytometryElectron MicroscopyAdvanced SequencingFull details
Synchrony between daily rhythms of malaria parasites and hosts is driven by an essential amino acid Authors (9) Kimberley F Prior Benita Middleton Alíz TY Owolabi Mary L Westwood Jacob Holland Aidan J O'DonnellMichael Blackman Debra J Skene Sarah E Reece Wellcome Open Research Published 20 October 2021 Crick labsMike BlackmanFull details
Mixology: A tool for calculating required masses and volumes for laboratory solutions Authors (1)Theo Sanderson Wellcome Open Research Published 26 May 2021 Crick labsMike BlackmanFull details