Publications

Randomized controlled trial of molnupiravir SARS-CoV-2 viral and antibody response in at-risk adult outpatients

Authors (44)

Joseph F Standing
Laura Buggiotti
Jose Afonso Guerra-Assuncao
Maximillian Woodall
Samuel Ellis
Akosua A Agyeman
[...]
Saye Khoo
Christopher Butler
David M Lowe
Judith Breuer
PANORAMIC Virology Group

Nature Communications

Published 23 February 2024

Crick labs

Mike Blackman

Full details

A patatin-like phospholipase is important for mitochondrial function in malaria parasites

Authors (13)

Emma Pietsch
Abhinay Ramaprasad
Sabrina Bielfeld
Yvonne Wohlfarter
Bohumil Maco
Korbinian Niedermüller
[...]
Markus A Keller
Dominique Soldati-Favre
Michael Blackman
Tim-Wolf Gilberger
Paul-Christian Burda

mBio

Published 19 December 2023

Crick labs

Mike Blackman

Full details

A molnupiravir-associated mutational signature in global SARS-CoV-2 genomes

Authors (7)

Theo Sanderson
Ryan Hisner
I’ah Donovan-Banfield
Hassan Hartman
Alessandra Løchen
Thomas P Peacock
Christopher Ruis

Nature

Published 16 November 2023

Crick labs

Mike Blackman

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Macrocyclic peptidomimetic plasmepsin X inhibitors with potent in vitro and in vivo antimalarial activity

Authors (16)

Vadims Kovada
Chrislaine Withers-Martinez
Raitis Bobrovs
Hele̅na Ce̅rule
Edgars Liepins
Solveiga Grinberga
[...]
Dace Rasina
Edgars Suna
Kristaps Jaudzems
Michael Blackman
Aigars Jirgensons

Journal of Medicinal Chemistry

Published 10 August 2023

Crick labs

Mike Blackman

Full details

Global analysis of putative phospholipases in Plasmodium falciparum reveals an essential role of the phosphoinositide-specific phospholipase C in parasite maturation

Authors (13)

Paul-Christian Burda
Abhinay Ramaprasad
Sabrina Bielfeld
Emma Pietsch
Anna Woitalla
Christoph Söhnchen
[...]
Aaron Sait
Lucy Collinson
Dominik Schwudke
Michael Blackman
Tim-Wolf Gilberger

mBio

Published 31 August 2023

Crick labs/ facilities

Full details

The role of Plasmodium V-ATPase in vacuolar physiology and antimalarial drug uptake

Authors (8)

Arne Alder
Cecilia P Sanchez
Matt Russell
Lucy Collinson
Michael Lanzer
Michael Blackman
Tim-Wolf Gilberger
Joachim M Matz

Proceedings of the National Academy of Sciences of USA

Published 25 July 2023

Crick labs/ facilities

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A malaria parasite phospholipase facilitates efficient asexual blood stage egress

Authors (11)

Abhinay Ramaprasad
Paul-Christian Burda
Konstantinos Kousis
James A Thomas
Emma Pietsch
Enrica Calvani
Steven A Howell
James Macrae
Bram Snijders
Tim-Wolf Gilberger
Michael Blackman

PLOS Pathogens

Published 23 June 2023

Crick labs/ facilities

Full details

ProteInfer, deep neural networks for protein functional inference

Authors (4)

Theo Sanderson
Maxwell L Bileschi
David Belanger
Lucy J Colwell

eLife

Published 27 February 2023

Crick labs

Mike Blackman

Full details

A choline-releasing glycerophosphodiesterase essential for phosphatidylcholine biosynthesis and blood stage development in the malaria parasite

Authors (11)

eLife

Published 28 December 2022

Crick labs/ facilities

Full details

Integrative genetic manipulation of Plasmodium cynomolgi reveals multidrug resistance-1 Y976F associated with increased in vitro susceptibility to mefloquine

Authors (18)

Kurt E Ward
Peter Christensen
Annie Racklyeft
Satish K Dhingra
Adeline CY Chua
Caroline Remmert
[...]
Georges Snounou
Laurent Rénia
David A Fidock
Bruce Russell
Pablo Bifani

Journal of Infectious Diseases

Published 15 May 2023

Crick labs

Mike Blackman

Full details

Treenome Browser: co-visualization of enormous phylogenies and millions of genomes

Authors (3)

Alexander M Kramer
Theo Sanderson
Russell Corbett-Detig

Bioinformatics

Published 1 January 2023

Crick labs

Mike Blackman

Full details

Taxonium, a web-based tool for exploring large phylogenetic trees

Authors (1)

Theo Sanderson

eLife

Published 15 November 2022

Crick labs

Mike Blackman

Full details

CDC50 orthologues in Plasmodium falciparum have distinct roles in merozoite egress and trophozoite maturation

Authors (4)

Avnish Patel
Stephanie Nofal
Michael Blackman
David A Baker

mBio

Published 1 August 2022

Crick labs

Mike Blackman

Full details

Variation at Spike position 142 in SARS-CoV-2 Delta genomes is a technical artifact caused by dropout of a sequencing amplicon

Authors (2)

Theo Sanderson
Jeffrey C Barrett

Wellcome Open Research

Published 10 November 2021

Crick labs

Mike Blackman

Full details

Inhibition of protein N-myristoylation blocks Plasmodium falciparum intraerythrocytic development, egress and invasion

Authors (12)

Anja C Schlott
Ellen Knuepfer
Judith Green
Philip Hobson
Aaron J Borg
Julia Morales-Sanfrutos
[...]
Catherine Maclachlan
Lucy Collinson
Bram Snijders
Edward W Tate
Anthony Holder

PLOS Biology

Published 25 October 2021

Crick labs/ facilities

Full details

Synchrony between daily rhythms of malaria parasites and hosts is driven by an essential amino acid

Authors (9)

Kimberley F Prior
Benita Middleton
Alíz TY Owolabi
Mary L Westwood
Jacob Holland
Aidan J O'Donnell
Michael Blackman
Debra J Skene
Sarah E Reece

Wellcome Open Research

Published 20 October 2021

Crick labs

Mike Blackman

Full details

Peptidic boronic acids are potent cell-permeable inhibitors of the malaria parasite egress serine protease SUB1

Authors (9)

Elina Lidumniece
Chrislaine Withers-Martinez
Fiona Hackett
Christine R Collins
Abigail Perrin
Konstantinos Kousis
Claudine Bisson
Michael Blackman
Aigars Jirgensons

Proceedings of the National Academy of Sciences of USA

Published 18 May 2021

Crick labs

Mike Blackman

Full details

Autocatalytic activation of a malarial egress protease is druggable and requires a protein cofactor

Authors (11)

Ser Ying Tan
Konstantinos Kousis
Chrislaine Withers-Martinez
Steven A Howell
James A Thomas
Fiona Hackett
Ellen Knuepfer
Min Shen
Matthew D Hall
Bram Snijders
Michael Blackman

The EMBO Journal

Published 1 June 2021

Crick labs/ facilities

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Ca2+ signals critical for egress and gametogenesis in malaria parasites depend on a multipass membrane protein that interacts with PKG

Authors (19)

Aurélia C Balestra
Konstantinos Kousis
Natacha Klages
Steven A Howell
Helen R Flynn
Marcus Bantscheff
[...]
Sonja Ghidelli-Disse
Bram Snijders
David A Baker
Michael Blackman
Mathieu Brochet

Science advances

Published 24 March 2021

Crick labs/ facilities

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Malaria parasite schizont egress antigen-1 plays an essential role in nuclear segregation during schizogony

Authors (10)

Abigail Perrin
Claudine Bisson
Peter Faull
Matt Renshaw
Rebecca A Lees
Roland A Fleck
Helen R Saibil
Bram Snijders
David A Baker
Michael Blackman

mBio

Published 1 March 2021

Crick labs/ facilities

Full details

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Postdoctoral clinical fellows

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Publications

Year published

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Publication type

Journal

Randomized controlled trial of molnupiravir SARS-CoV-2 viral and antibody response in at-risk adult outpatients

A patatin-like phospholipase is important for mitochondrial function in malaria parasites

A molnupiravir-associated mutational signature in global SARS-CoV-2 genomes

Macrocyclic peptidomimetic plasmepsin X inhibitors with potent in vitro and in vivo antimalarial activity

Global analysis of putative phospholipases in Plasmodium falciparum reveals an essential role of the phosphoinositide-specific phospholipase C in parasite maturation

The role of Plasmodium V-ATPase in vacuolar physiology and antimalarial drug uptake

A malaria parasite phospholipase facilitates efficient asexual blood stage egress

ProteInfer, deep neural networks for protein functional inference

A choline-releasing glycerophosphodiesterase essential for phosphatidylcholine biosynthesis and blood stage development in the malaria parasite

Integrative genetic manipulation of Plasmodium cynomolgi reveals multidrug resistance-1 Y976F associated with increased in vitro susceptibility to mefloquine

Treenome Browser: co-visualization of enormous phylogenies and millions of genomes

Taxonium, a web-based tool for exploring large phylogenetic trees

CDC50 orthologues in Plasmodium falciparum have distinct roles in merozoite egress and trophozoite maturation

Variation at Spike position 142 in SARS-CoV-2 Delta genomes is a technical artifact caused by dropout of a sequencing amplicon

Inhibition of protein N-myristoylation blocks Plasmodium falciparum intraerythrocytic development, egress and invasion

Synchrony between daily rhythms of malaria parasites and hosts is driven by an essential amino acid

Peptidic boronic acids are potent cell-permeable inhibitors of the malaria parasite egress serine protease SUB1

Autocatalytic activation of a malarial egress protease is druggable and requires a protein cofactor

Ca2+ signals critical for egress and gametogenesis in malaria parasites depend on a multipass membrane protein that interacts with PKG

Malaria parasite schizont egress antigen-1 plays an essential role in nuclear segregation during schizogony

The Francis Crick Institute is a unique partnership between

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Hello Brain!

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