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Breadcrumb Mike Blackman Blackman lab Malaria Biochemistry Laboratory : Publications Lab contentLab contentIn this section Overview Vacancies Areas of interest Publications Members Clusters of malaria parasites growing inside human red blood cells. Toggle to view hero caption PublicationsYear published2024 (1)2023 (2)2022 (1)2021 (4)2020 (3)2019 (3)2018 (2)2016 (2)2015 (1) Facet Year publishedResearch topicsBiochemistry & Proteomics (19)Cell Biology (19)Infectious Disease (19)Model Organisms (19)Immunology (18)Structural Biology & Biophysics (18)Chemical Biology & High Throughput (14)Human Biology & Physiology (6)Imaging (6)Tumour Biology (6)Metabolism (5)Signalling & Oncogenes (5)Cell Cycle & Chromosomes (4)Developmental Biology (4)Stem Cells (4)Genetics & Genomics (3)Genome Integrity & Repair (3)Neurosciences (3)Gene Expression (2)Microfabrication & Bioengineering (2)Synthetic Biology (2) (-)Computational & Systems Biology (19) Facet Research topicsPublication typeJournal article (19)Primary research (17)Letter (2) Facet Publication typeJournalPLOS Biology (3)The Lancet (3)eLife (2)PLOS Pathogens (2)Biochemical Journal (1)Cell Host & Microbe (1)FEBS Journal (1)mBio (1)Nature Microbiology (1)PLOS ONE (1)Science advances (1)Scientific Reports (1)The EMBO Journal (1) Facet Journal Publications Displaying 1 - 19 of 19Last updated : 28 March 2024 02:34 Divergent performance of vaccines in the UK autumn 2023 COVID-19 booster campaign Authors (22) Marianne Shawe-Taylor David Greenwood Agnieszka Hobbs Giulia DowgierBecky PennTheo Sanderson[...]Sonia GandhiEdward CarrMary WuDavid LV Bauer Emma C Wall The Lancet Published 11 March 2024 Crick labs/ facilitiesCharles SwantonGeorge KassiotisSonia GandhiSteve GamblinMike BlackmanRupert BealeDavid LV BauerWorldwide Influenza CentreStructural BiologyHigh Throughput ScreeningBioinformatics and BiostatisticsAdvanced SequencingScientific computingFull details A malaria parasite phospholipase facilitates efficient asexual blood stage egress Authors (11)Abhinay Ramaprasad Paul-Christian BurdaKonstantinos Kousis James A Thomas Emma PietschEnrica Calvani Steven A HowellJames MacraeBram Snijders Tim-Wolf GilbergerMichael Blackman PLOS Pathogens Published 23 June 2023 Crick labs/ facilitiesMike BlackmanProteomicsMetabolomicsFull details Independent SARS-CoV-2 staff testing protected academic and health-care institutions in northwest London Authors (54) Chris BaileyTheo Sanderson Hermaleigh Townsley Jacki Goldman James RM BlackGeorge Young[...]Jerome NicodSonia GandhiDavid LV Bauer Emma C WallCharles Swanton The Lancet Published 1 July 2023 Crick labs/ facilitiesSamra TurajlicCharles SwantonSam RodriquesSonia GandhiSteve GamblinMike BlackmanRupert BealeDavid LV BauerWorldwide Influenza CentreStructural BiologyMetabolomicsHigh Throughput ScreeningFlow CytometryBioinformatics and BiostatisticsAdvanced SequencingScientific computingBiological Research FacilityFull details A choline-releasing glycerophosphodiesterase essential for phosphatidylcholine biosynthesis and blood stage development in the malaria parasite Authors (11)Abhinay Ramaprasad Paul-Christian BurdaEnrica CalvaniAaron SaitSusana Palma-DuranChrislaine Withers-Martinez Fiona HackettJames MacraeLucy Collinson Tim Wolf GilbergerMichael Blackman eLife Published 28 December 2022 Crick labs/ facilitiesMike BlackmanMetabolomicsElectron MicroscopyLight MicroscopyFull details Inhibition of protein N-myristoylation blocks Plasmodium falciparum intraerythrocytic development, egress and invasion Authors (12) Anja C SchlottEllen KnuepferJudith GreenPhilip Hobson Aaron J Borg Julia Morales-Sanfrutos[...]Catherine MaclachlanLucy CollinsonBram Snijders Edward W TateAnthony Holder PLOS Biology Published 25 October 2021 Crick labs/ facilitiesEd TateTony HolderMike BlackmanProteomicsFlow CytometryElectron MicroscopyAdvanced SequencingFull details Autocatalytic activation of a malarial egress protease is druggable and requires a protein cofactor Authors (11)Ser Ying TanKonstantinos KousisChrislaine Withers-Martinez Steven A Howell James A Thomas Fiona HackettEllen Knuepfer Min Shen Matthew D HallBram SnijdersMichael Blackman The EMBO Journal Published 1 June 2021 Crick labs/ facilitiesMike BlackmanProteomicsFull details Ca2+ signals critical for egress and gametogenesis in malaria parasites depend on a multipass membrane protein that interacts with PKG Authors (19) Aurélia C BalestraKonstantinos Kousis Natacha Klages Steven A Howell Helen R Flynn Marcus Bantscheff[...] Sonja Ghidelli-DisseBram Snijders David A BakerMichael Blackman Mathieu Brochet Science advances Published 24 March 2021 Crick labs/ facilitiesMike BlackmanProteomicsFull details Malaria parasite schizont egress antigen-1 plays an essential role in nuclear segregation during schizogony Authors (10)Abigail Perrin Claudine BissonPeter FaullMatt Renshaw Rebecca A Lees Roland A Fleck Helen R SaibilBram Snijders David A BakerMichael Blackman mBio Published 1 March 2021 Crick labs/ facilitiesMike BlackmanProteomicsLight MicroscopyFull details The malaria parasite sheddase SUB2 governs host red blood cell membrane sealing at invasion Authors (7) Christine R Collins Fiona Hackett Steven A HowellBram SnijdersMatt RussellLucy CollinsonMichael Blackman eLife Published 8 December 2020 Crick labs/ facilitiesMike BlackmanProteomicsElectron MicroscopyFull details Pandemic peak SARS-CoV-2 infection and seroconversion rates in London frontline health-care workers Authors (341) Catherine F Houlihan Nina Vora Thomas Byrne Dan LewerGavin Kelly Judith Heaney[...] Andrew Hayward Richard Gilson Gavin KellyFiona Roberts Emine Hatipoglu The Lancet Published 25 July 2020 Crick labs/ facilitiesAndreas WackKaren VousdenJernej UleJames TurnerMoritz TreeckCharles SwantonAdam SaterialeErik SahaiCaetano Reis e SousaPeter RatcliffeLucia Prieto-GodinoVenizelos PapayannopoulosAnne O’GarraPaul NurseGeorge KassiotisMaximiliano GutierrezSonia GandhiSteve GamblinPeter Cherepanov Luiz Pedro CarvalhoDominique BonnetMike BlackmanRupert BealeWorldwide Influenza CentreStructural BiologyMetabolomicsHuman Embryonic Stem CellHigh Throughput ScreeningGenetic Modification ServiceFlow CytometryFermentationExperimental HistopathologyElectron MicroscopyCell ServicesBiological Research FacilityBioinformatics and BiostatisticsAdvanced SequencingScientific computingFull details A malaria parasite subtilisin propeptide-like protein is a potent inhibitor of the egress protease SUB1 Authors (8) Sarah J TarrChrislaine Withers-Martinez Helen R FlynnBram SnijdersLaura MasinoKonstantinos Kousis David J ConwayMichael Blackman Biochemical Journal Published 31 January 2020 Crick labs/ facilitiesMike BlackmanStructural BiologyProteomicsFull details Characterization of P. falciparum dipeptidyl aminopeptidase 3 specificity identifies differences in amino acid preferences between peptide-based substrates and covalent inhibitors Authors (16) Laura E de Vries Mateo I Sanchez Katarzyna Groborz Laurie Kuppens Marcin Poreba Christine Lehmann[...] Martin Horn Michael Mares Matthew Bogyo Marcin DragEdgar Deu Sandoval FEBS Journal Published 1 October 2019 Crick labsEdgar DeuMike BlackmanFull details Cyclic AMP signalling controls key components of malaria parasite host cell invasion machinery Authors (14) Avnish PatelAbigail Perrin Helen R Flynn Claudine BissonChrislaine Withers-MartinezMoritz Treeck[...] Andres Ramos Tim W GilbergerBram SnijdersMichael Blackman David A Baker PLOS Biology Published 10 May 2019 Crick labs/ facilitiesMoritz TreeckIan TaylorMike BlackmanProteomicsFull details Phosphodiesterase beta is the master regulator of cAMP signalling during malaria parasite invasion Authors (10) Christian Flueck Laura G DroughtAndrew Jones Avnish PatelAbigail Perrin Eloise M WalkerStephanie NofalBram SnijdersMichael Blackman David A Baker PLOS Biology Published 22 February 2019 Crick labs/ facilitiesMike BlackmanProteomicsFull details Plasmodium falciparum dipeptidyl aminopeptidase 3 activity is important for efficient erythrocyte invasion by the malaria parasite Authors (7) Christine LehmannSer Ying Tan Laura E de Vries Ilaria Russo Mateo I Sanchez Daniel E GoldbergEdgar Deu Sandoval PLOS Pathogens Published 16 May 2018 Crick labsEdgar DeuMike BlackmanFull details A protease cascade regulates release of the human malaria parasite Plasmodium falciparum from host red blood cells Authors (12) James A ThomasSer Ying Tan Claudine Bisson Aaron Borg Trishant R Umrekar Fiona Hackett[...] Gema Vizcay-Barrena Roland A FleckBram Snijders Helen R SaibilMichael Blackman Nature Microbiology Published 1 April 2018 Crick labs/ facilitiesMike BlackmanProteomicsFull details Development and application of a simple plaque assay for the human malaria parasite Plasmodium falciparum Authors (8) James A Thomas Christine R Collins Sujaan Das Fiona Hackett Arnault GraindorgeDonald BellEdgar Deu SandovalMichael Blackman PLOS ONE Published 22 June 2016 Crick labs/ facilitiesEdgar DeuMike BlackmanLight MicroscopyFull details A versatile strategy for rapid conditional genome engineering using loxP sites in a small synthetic intron in Plasmodium falciparum Authors (6) Matthew L Jones Sujaan DasHugo Belda Christine R CollinsMichael BlackmanMoritz Treeck Scientific Reports Published 19 February 2016 Crick labsMoritz TreeckMike BlackmanFull details Processing of Plasmodium falciparum merozoite surface protein MSP1 activates a spectrin-binding function enabling parasite egress from RBCs Authors (14) Sujaan Das Nadine HertrichAbigail PerrinChrislaine Withers-Martinez Christine R Collins Matthew L Jones[...] Helen R Saibil Gavin J WrightMoritz Treeck Christian EppMichael Blackman Cell Host & Microbe Published 14 October 2015 Crick labs/ facilitiesMoritz TreeckMike BlackmanStructural BiologyFull details Share the page Share on Twitter Share on Facebook Share on LinkedIn Share on Email
Divergent performance of vaccines in the UK autumn 2023 COVID-19 booster campaign Authors (22) Marianne Shawe-Taylor David Greenwood Agnieszka Hobbs Giulia DowgierBecky PennTheo Sanderson[...]Sonia GandhiEdward CarrMary WuDavid LV Bauer Emma C Wall The Lancet Published 11 March 2024 Crick labs/ facilitiesCharles SwantonGeorge KassiotisSonia GandhiSteve GamblinMike BlackmanRupert BealeDavid LV BauerWorldwide Influenza CentreStructural BiologyHigh Throughput ScreeningBioinformatics and BiostatisticsAdvanced SequencingScientific computingFull details
A malaria parasite phospholipase facilitates efficient asexual blood stage egress Authors (11)Abhinay Ramaprasad Paul-Christian BurdaKonstantinos Kousis James A Thomas Emma PietschEnrica Calvani Steven A HowellJames MacraeBram Snijders Tim-Wolf GilbergerMichael Blackman PLOS Pathogens Published 23 June 2023 Crick labs/ facilitiesMike BlackmanProteomicsMetabolomicsFull details
Independent SARS-CoV-2 staff testing protected academic and health-care institutions in northwest London Authors (54) Chris BaileyTheo Sanderson Hermaleigh Townsley Jacki Goldman James RM BlackGeorge Young[...]Jerome NicodSonia GandhiDavid LV Bauer Emma C WallCharles Swanton The Lancet Published 1 July 2023 Crick labs/ facilitiesSamra TurajlicCharles SwantonSam RodriquesSonia GandhiSteve GamblinMike BlackmanRupert BealeDavid LV BauerWorldwide Influenza CentreStructural BiologyMetabolomicsHigh Throughput ScreeningFlow CytometryBioinformatics and BiostatisticsAdvanced SequencingScientific computingBiological Research FacilityFull details
A choline-releasing glycerophosphodiesterase essential for phosphatidylcholine biosynthesis and blood stage development in the malaria parasite Authors (11)Abhinay Ramaprasad Paul-Christian BurdaEnrica CalvaniAaron SaitSusana Palma-DuranChrislaine Withers-Martinez Fiona HackettJames MacraeLucy Collinson Tim Wolf GilbergerMichael Blackman eLife Published 28 December 2022 Crick labs/ facilitiesMike BlackmanMetabolomicsElectron MicroscopyLight MicroscopyFull details
Inhibition of protein N-myristoylation blocks Plasmodium falciparum intraerythrocytic development, egress and invasion Authors (12) Anja C SchlottEllen KnuepferJudith GreenPhilip Hobson Aaron J Borg Julia Morales-Sanfrutos[...]Catherine MaclachlanLucy CollinsonBram Snijders Edward W TateAnthony Holder PLOS Biology Published 25 October 2021 Crick labs/ facilitiesEd TateTony HolderMike BlackmanProteomicsFlow CytometryElectron MicroscopyAdvanced SequencingFull details
Autocatalytic activation of a malarial egress protease is druggable and requires a protein cofactor Authors (11)Ser Ying TanKonstantinos KousisChrislaine Withers-Martinez Steven A Howell James A Thomas Fiona HackettEllen Knuepfer Min Shen Matthew D HallBram SnijdersMichael Blackman The EMBO Journal Published 1 June 2021 Crick labs/ facilitiesMike BlackmanProteomicsFull details
Ca2+ signals critical for egress and gametogenesis in malaria parasites depend on a multipass membrane protein that interacts with PKG Authors (19) Aurélia C BalestraKonstantinos Kousis Natacha Klages Steven A Howell Helen R Flynn Marcus Bantscheff[...] Sonja Ghidelli-DisseBram Snijders David A BakerMichael Blackman Mathieu Brochet Science advances Published 24 March 2021 Crick labs/ facilitiesMike BlackmanProteomicsFull details
Malaria parasite schizont egress antigen-1 plays an essential role in nuclear segregation during schizogony Authors (10)Abigail Perrin Claudine BissonPeter FaullMatt Renshaw Rebecca A Lees Roland A Fleck Helen R SaibilBram Snijders David A BakerMichael Blackman mBio Published 1 March 2021 Crick labs/ facilitiesMike BlackmanProteomicsLight MicroscopyFull details
The malaria parasite sheddase SUB2 governs host red blood cell membrane sealing at invasion Authors (7) Christine R Collins Fiona Hackett Steven A HowellBram SnijdersMatt RussellLucy CollinsonMichael Blackman eLife Published 8 December 2020 Crick labs/ facilitiesMike BlackmanProteomicsElectron MicroscopyFull details
Pandemic peak SARS-CoV-2 infection and seroconversion rates in London frontline health-care workers Authors (341) Catherine F Houlihan Nina Vora Thomas Byrne Dan LewerGavin Kelly Judith Heaney[...] Andrew Hayward Richard Gilson Gavin KellyFiona Roberts Emine Hatipoglu The Lancet Published 25 July 2020 Crick labs/ facilitiesAndreas WackKaren VousdenJernej UleJames TurnerMoritz TreeckCharles SwantonAdam SaterialeErik SahaiCaetano Reis e SousaPeter RatcliffeLucia Prieto-GodinoVenizelos PapayannopoulosAnne O’GarraPaul NurseGeorge KassiotisMaximiliano GutierrezSonia GandhiSteve GamblinPeter Cherepanov Luiz Pedro CarvalhoDominique BonnetMike BlackmanRupert BealeWorldwide Influenza CentreStructural BiologyMetabolomicsHuman Embryonic Stem CellHigh Throughput ScreeningGenetic Modification ServiceFlow CytometryFermentationExperimental HistopathologyElectron MicroscopyCell ServicesBiological Research FacilityBioinformatics and BiostatisticsAdvanced SequencingScientific computingFull details
A malaria parasite subtilisin propeptide-like protein is a potent inhibitor of the egress protease SUB1 Authors (8) Sarah J TarrChrislaine Withers-Martinez Helen R FlynnBram SnijdersLaura MasinoKonstantinos Kousis David J ConwayMichael Blackman Biochemical Journal Published 31 January 2020 Crick labs/ facilitiesMike BlackmanStructural BiologyProteomicsFull details
Characterization of P. falciparum dipeptidyl aminopeptidase 3 specificity identifies differences in amino acid preferences between peptide-based substrates and covalent inhibitors Authors (16) Laura E de Vries Mateo I Sanchez Katarzyna Groborz Laurie Kuppens Marcin Poreba Christine Lehmann[...] Martin Horn Michael Mares Matthew Bogyo Marcin DragEdgar Deu Sandoval FEBS Journal Published 1 October 2019 Crick labsEdgar DeuMike BlackmanFull details
Cyclic AMP signalling controls key components of malaria parasite host cell invasion machinery Authors (14) Avnish PatelAbigail Perrin Helen R Flynn Claudine BissonChrislaine Withers-MartinezMoritz Treeck[...] Andres Ramos Tim W GilbergerBram SnijdersMichael Blackman David A Baker PLOS Biology Published 10 May 2019 Crick labs/ facilitiesMoritz TreeckIan TaylorMike BlackmanProteomicsFull details
Phosphodiesterase beta is the master regulator of cAMP signalling during malaria parasite invasion Authors (10) Christian Flueck Laura G DroughtAndrew Jones Avnish PatelAbigail Perrin Eloise M WalkerStephanie NofalBram SnijdersMichael Blackman David A Baker PLOS Biology Published 22 February 2019 Crick labs/ facilitiesMike BlackmanProteomicsFull details
Plasmodium falciparum dipeptidyl aminopeptidase 3 activity is important for efficient erythrocyte invasion by the malaria parasite Authors (7) Christine LehmannSer Ying Tan Laura E de Vries Ilaria Russo Mateo I Sanchez Daniel E GoldbergEdgar Deu Sandoval PLOS Pathogens Published 16 May 2018 Crick labsEdgar DeuMike BlackmanFull details
A protease cascade regulates release of the human malaria parasite Plasmodium falciparum from host red blood cells Authors (12) James A ThomasSer Ying Tan Claudine Bisson Aaron Borg Trishant R Umrekar Fiona Hackett[...] Gema Vizcay-Barrena Roland A FleckBram Snijders Helen R SaibilMichael Blackman Nature Microbiology Published 1 April 2018 Crick labs/ facilitiesMike BlackmanProteomicsFull details
Development and application of a simple plaque assay for the human malaria parasite Plasmodium falciparum Authors (8) James A Thomas Christine R Collins Sujaan Das Fiona Hackett Arnault GraindorgeDonald BellEdgar Deu SandovalMichael Blackman PLOS ONE Published 22 June 2016 Crick labs/ facilitiesEdgar DeuMike BlackmanLight MicroscopyFull details
A versatile strategy for rapid conditional genome engineering using loxP sites in a small synthetic intron in Plasmodium falciparum Authors (6) Matthew L Jones Sujaan DasHugo Belda Christine R CollinsMichael BlackmanMoritz Treeck Scientific Reports Published 19 February 2016 Crick labsMoritz TreeckMike BlackmanFull details
Processing of Plasmodium falciparum merozoite surface protein MSP1 activates a spectrin-binding function enabling parasite egress from RBCs Authors (14) Sujaan Das Nadine HertrichAbigail PerrinChrislaine Withers-Martinez Christine R Collins Matthew L Jones[...] Helen R Saibil Gavin J WrightMoritz Treeck Christian EppMichael Blackman Cell Host & Microbe Published 14 October 2015 Crick labs/ facilitiesMoritz TreeckMike BlackmanStructural BiologyFull details