Research case studies Explore a selection of reports that spotlight particular areas of research at the Crick over the past five years.
Postdoctoral clinical fellows Opportunities for postdoctoral clinicians to consolidate their research experience.
Breadcrumb Mike Blackman Blackman lab Malaria Biochemistry Laboratory : Publications Lab contentLab contentIn this section Overview Vacancies Areas of interest Publications Members Clusters of malaria parasites growing inside human red blood cells. Toggle to view hero caption PublicationsYear published2024 (2)2023 (8)2022 (8)2021 (10)2020 (9)2019 (8)2018 (6)2017 (8)2016 (8)2015 (7)2014 (7)2013 (9)2012 (5)2011 (3)2010 (4) Facet Year publishedResearch topicsBiochemistry & Proteomics (72)Cell Biology (72)Infectious Disease (72)Model Organisms (72)Immunology (71)Structural Biology & Biophysics (71)Computational & Systems Biology (19)Chemical Biology & High Throughput (14)Imaging (11)Human Biology & Physiology (6)Tumour Biology (6)Metabolism (5)Signalling & Oncogenes (5)Cell Cycle & Chromosomes (4)Developmental Biology (4)Stem Cells (4)Genetics & Genomics (3)Genome Integrity & Repair (3)Neurosciences (3)Gene Expression (2)Microfabrication & Bioengineering (2)Synthetic Biology (2) Facet Research topicsPublication typeJournal article (102)Primary research (84)Review (10)Method (5)Letter (2)Commentary (1) Facet Publication typeJournalPLOS Pathogens (9)mBio (7)eLife (5)PLOS ONE (5)Cellular Microbiology (4)Journal of Biological Chemistry (4)Journal of Medicinal Chemistry (4)Proceedings of the National Academy of Sciences of the United States of America (4)Bioorganic & Medicinal Chemistry Letters (3)Molecular Microbiology (3)PLOS Biology (3)Proceedings of the National Academy of Sciences of USA (3)Science (3)The Lancet (3)Wellcome Open Research (3)Cell Host & Microbe (2)Current Opinion in Microbiology (2)International Journal for Parasitology (2)Malaria Journal (2)Nature Communications (2)Scientific Reports (2)ACS Medicinal Chemistry Letters (1)Annals of Translational Medicine (1)Bio-Protocol (1)Biochemical Journal (1)Biochemical Society Transactions (1)Bioinformatics (1)Blood (1)Chemistry of Heterocyclic Compounds (1)European Journal of Medicinal Chemistry (1)FEBS Journal (1)FEMS Microbiology Reviews (1)Infection and Immunity (1)Journal of Cell Science (1)Journal of Chemical Information and Modeling (1)Journal of Infectious Diseases (1)Journal of Molecular Graphics & Modelling (1)Life Science Alliance (1)Nature (1)Nature Microbiology (1)Nature Reviews Microbiology (1)Parasitology International (1)PLOS Genetics (1)PLoS Neglected Tropical Diseases (1)RSC Advances (1)Science advances (1)The EMBO Journal (1)Traffic (1) Facet Journal Publications Displaying 81 - 100 of 102Last updated : 29 March 2024 02:14 The malaria parasite egress protease SUB1 is a calcium-dependent redox switch subtilisin Authors (9)Chrislaine Withers-Martinez Malcolm Strath Fiona Hackett Lesley F Haire Steven A HowellPhilip Walker Evangelos Christodoulou Guy G DodsonMichael Blackman Nature Communications Published 1 January 2014 Crick labs/ facilitiesMike BlackmanStructural BiologyProteomicsFull details The malarial serine protease SUB1 plays an essential role in parasite liver stage development Authors (5) Catherine Suarez Katrin Volkmann Ana Rita Gomes Oliver BillkerMichael Blackman PLOS Pathogens Published 1 December 2013 Crick labsMike BlackmanFull details Identification of a Plasmodium falciparum phospholipid transfer protein Authors (6) Christiaan van OoijChrislaine Withers-Martinez Alessa Ringel Shamshad Cockcroft Kasturi HaldarMichael Blackman Journal of Biological Chemistry Published 16 September 2013 Crick labsMike BlackmanFull details Malaria parasite cGMP-dependent protein kinase regulates blood stage merozoite secretory organelle discharge and egress Authors (7) CR Collins F Hackett M Strath M PenzoChrislaine Withers-Martinez DA BakerMichael Blackman PLOS Pathogens Published 1 May 2013 Crick labsMike BlackmanFull details A perforin-like protein mediates disruption of the erythrocyte membrane during egress of Plasmodium berghei male gametocytes Authors (10) Elena Deligianni Rhiannon N Morgan Lucia Bertuccini Christine C Wirth Natalie C Silmon de Monerri Lefteris SpanosMichael Blackman Christos Louis Gabriele Pradel Inga Siden-Kiamos Cellular Microbiology Published 1 January 2013 Crick labsMike BlackmanFull details Adaptation of the genetically tractable malaria pathogen Plasmodium knowlesi to continuous culture in human erythrocytes Authors (9) Robert W Moon Joanna Hall Farania Rangkuti Yung Shwen Ho Neil Almond Graham H Mitchell Arnab PainAnthony HolderMichael Blackman Proceedings of the National Academy of Sciences of the United States of America Published 1 January 2013 Crick labsTony HolderMike BlackmanFull details Molecular determinants for subcellular trafficking of the malarial sheddase PfSUB2 Authors (6) Matthew A Child Philippa K Harris Christine R CollinsChrislaine Withers-Martinez Sharon YeohMichael Blackman Traffic Published 1 January 2013 Crick labsMike BlackmanFull details Molecular determinants of binding to the Plasmodium subtilisin-like protease 1 Authors (5) Simone FulleChrislaine Withers-MartinezMichael Blackman Garrett M Morris Paul W Finn Journal of Chemical Information and Modeling Published 1 January 2013 Crick labsMike BlackmanFull details Recent insights into apicomplexan parasite egress provide new views to a kill Authors (2)Michael Blackman Vern B Carruthers Current Opinion in Microbiology Published 1 January 2013 Crick labsMike BlackmanFull details Robust inducible Cre recombinase activity in the human malaria parasite Plasmodium falciparum enables efficient gene deletion within a single asexual erythrocytic growth cycle Authors (10) Christine R Collins Sujaan Das Eleanor H Wong Nicole Andenmatten Robert Stallmach Fiona Hackett Jean-Paul Herman Sylke Müller Markus MeissnerMichael Blackman Molecular Microbiology Published 1 January 2013 Crick labsMike BlackmanFull details Plasmodium subtilisin-like protease 1 (SUB1): insights into the active-site structure, specificity and function of a pan-malaria drug target Authors (11)Chrislaine Withers-Martinez Catherine Suarez Simone Fulle Samir Kher Maria Penzo Jean-Paul EbejerKonstantinos Kousis Fiona Hackett Aigars Jirgensons Paul FinnMichael Blackman International Journal for Parasitology Published 26 April 2012 Crick labsMike BlackmanFull details Extracellular ATP triggers proteolysis and cytosolic Ca2+ rise in Plasmodium berghei and Plasmodium yoelii malaria parasites Authors (7) LN da Cruz MA Juliano A Budu L JulianoAnthony HolderMichael Blackman CRS Garcia Malaria Journal Published 15 March 2012 Crick labsTony HolderMike BlackmanFull details Apicomplexan AMA1 in host cell invasion: a model at the junction? Authors (2) Christine R CollinsMichael Blackman Cell Host & Microbe Published 1 January 2012 Crick labsMike BlackmanFull details Proteolytic activation of the essential parasitophorous vacuole cysteine protease SERA6 accompanies malaria parasite egress from its host erythrocyte Authors (8) Andrea Ruecker Michael Shea Fiona Hackett Catherine Suarez Elizabeth MA Hirst Katarina MilutinovicChrislaine Withers-MartinezMichael Blackman Journal of Biological Chemistry Published 1 January 2012 Crick labs/ facilitiesMike BlackmanElectron MicroscopyFull details Quinolylhydrazones as novel inhibitors of Plasmodium falciparum serine protease PfSUB1 Authors (12) Sandra Gemma Simone Giovani Margherita Brindisi Pierangela Tripaldi Simone Brogi Luisa Savini[...] Ettore Novellino Stefania Butini Giuseppe Campiani Maria PenzoMichael Blackman Bioorganic & Medicinal Chemistry Letters Published 1 January 2012 Crick labsMike BlackmanFull details Intramembrane cleavage of AMA1 triggers Toxoplasma to switch from an invasive to a replicative mode Authors (4) Joana M Santos David JP FergusonMichael Blackman Dominique Soldati-Favre Science Published 23 December 2011 Crick labsMike BlackmanFull details Juxtamembrane shedding of Plasmodium falciparum AMA1 is sequence independent and essential, and helps evade invasion-inhibitory antibodies Authors (8) Anna Olivieri Christine R Collins Fiona HackettChrislaine Withers-Martinez Joshua Marshall Helen R FlynnMark SkehelMichael Blackman PLOS Pathogens Published 1 December 2011 Crick labsMike BlackmanFull details Global identification of multiple substrates for Plasmodium falciparum SUB1, an essential malarial processing protease Authors (8) Natalie C Silmon de Monerri Helen R Flynn Marta G Campos Fiona HackettKonstantinos KousisChrislaine Withers-MartinezMark SkehelMichael Blackman Infection and Immunity Published 10 January 2011 Crick labsMike BlackmanFull details Regulated maturation of malaria merozoite surface protein-1 is essential for parasite growth Authors (4) MA Child C Epp H BujardMichael Blackman Molecular Microbiology Published 1 October 2010 Crick labsMike BlackmanFull details A plant-like kinase in Plasmodium falciparum regulates parasite egress from erythrocytes Authors (13) Jeffrey D Dvorin Derek C Martyn Saurabh D Patel Joshua S Grimley Christine R Collins Christine S Hopp[...] Elizabeth WinzelerMichael Blackman David A Baker Thomas J Wandless Manoj T Duraisingh Science Published 14 May 2010 Crick labsMike BlackmanFull details Pagination First page First Previous page Previous Page 1 Page 2 Page 3 Page 4 Current page 5 Page 6 Next page Next Last page Last Share the page Share on Twitter Share on Facebook Share on LinkedIn Share on Email
The malaria parasite egress protease SUB1 is a calcium-dependent redox switch subtilisin Authors (9)Chrislaine Withers-Martinez Malcolm Strath Fiona Hackett Lesley F Haire Steven A HowellPhilip Walker Evangelos Christodoulou Guy G DodsonMichael Blackman Nature Communications Published 1 January 2014 Crick labs/ facilitiesMike BlackmanStructural BiologyProteomicsFull details
The malarial serine protease SUB1 plays an essential role in parasite liver stage development Authors (5) Catherine Suarez Katrin Volkmann Ana Rita Gomes Oliver BillkerMichael Blackman PLOS Pathogens Published 1 December 2013 Crick labsMike BlackmanFull details
Identification of a Plasmodium falciparum phospholipid transfer protein Authors (6) Christiaan van OoijChrislaine Withers-Martinez Alessa Ringel Shamshad Cockcroft Kasturi HaldarMichael Blackman Journal of Biological Chemistry Published 16 September 2013 Crick labsMike BlackmanFull details
Malaria parasite cGMP-dependent protein kinase regulates blood stage merozoite secretory organelle discharge and egress Authors (7) CR Collins F Hackett M Strath M PenzoChrislaine Withers-Martinez DA BakerMichael Blackman PLOS Pathogens Published 1 May 2013 Crick labsMike BlackmanFull details
A perforin-like protein mediates disruption of the erythrocyte membrane during egress of Plasmodium berghei male gametocytes Authors (10) Elena Deligianni Rhiannon N Morgan Lucia Bertuccini Christine C Wirth Natalie C Silmon de Monerri Lefteris SpanosMichael Blackman Christos Louis Gabriele Pradel Inga Siden-Kiamos Cellular Microbiology Published 1 January 2013 Crick labsMike BlackmanFull details
Adaptation of the genetically tractable malaria pathogen Plasmodium knowlesi to continuous culture in human erythrocytes Authors (9) Robert W Moon Joanna Hall Farania Rangkuti Yung Shwen Ho Neil Almond Graham H Mitchell Arnab PainAnthony HolderMichael Blackman Proceedings of the National Academy of Sciences of the United States of America Published 1 January 2013 Crick labsTony HolderMike BlackmanFull details
Molecular determinants for subcellular trafficking of the malarial sheddase PfSUB2 Authors (6) Matthew A Child Philippa K Harris Christine R CollinsChrislaine Withers-Martinez Sharon YeohMichael Blackman Traffic Published 1 January 2013 Crick labsMike BlackmanFull details
Molecular determinants of binding to the Plasmodium subtilisin-like protease 1 Authors (5) Simone FulleChrislaine Withers-MartinezMichael Blackman Garrett M Morris Paul W Finn Journal of Chemical Information and Modeling Published 1 January 2013 Crick labsMike BlackmanFull details
Recent insights into apicomplexan parasite egress provide new views to a kill Authors (2)Michael Blackman Vern B Carruthers Current Opinion in Microbiology Published 1 January 2013 Crick labsMike BlackmanFull details
Robust inducible Cre recombinase activity in the human malaria parasite Plasmodium falciparum enables efficient gene deletion within a single asexual erythrocytic growth cycle Authors (10) Christine R Collins Sujaan Das Eleanor H Wong Nicole Andenmatten Robert Stallmach Fiona Hackett Jean-Paul Herman Sylke Müller Markus MeissnerMichael Blackman Molecular Microbiology Published 1 January 2013 Crick labsMike BlackmanFull details
Plasmodium subtilisin-like protease 1 (SUB1): insights into the active-site structure, specificity and function of a pan-malaria drug target Authors (11)Chrislaine Withers-Martinez Catherine Suarez Simone Fulle Samir Kher Maria Penzo Jean-Paul EbejerKonstantinos Kousis Fiona Hackett Aigars Jirgensons Paul FinnMichael Blackman International Journal for Parasitology Published 26 April 2012 Crick labsMike BlackmanFull details
Extracellular ATP triggers proteolysis and cytosolic Ca2+ rise in Plasmodium berghei and Plasmodium yoelii malaria parasites Authors (7) LN da Cruz MA Juliano A Budu L JulianoAnthony HolderMichael Blackman CRS Garcia Malaria Journal Published 15 March 2012 Crick labsTony HolderMike BlackmanFull details
Apicomplexan AMA1 in host cell invasion: a model at the junction? Authors (2) Christine R CollinsMichael Blackman Cell Host & Microbe Published 1 January 2012 Crick labsMike BlackmanFull details
Proteolytic activation of the essential parasitophorous vacuole cysteine protease SERA6 accompanies malaria parasite egress from its host erythrocyte Authors (8) Andrea Ruecker Michael Shea Fiona Hackett Catherine Suarez Elizabeth MA Hirst Katarina MilutinovicChrislaine Withers-MartinezMichael Blackman Journal of Biological Chemistry Published 1 January 2012 Crick labs/ facilitiesMike BlackmanElectron MicroscopyFull details
Quinolylhydrazones as novel inhibitors of Plasmodium falciparum serine protease PfSUB1 Authors (12) Sandra Gemma Simone Giovani Margherita Brindisi Pierangela Tripaldi Simone Brogi Luisa Savini[...] Ettore Novellino Stefania Butini Giuseppe Campiani Maria PenzoMichael Blackman Bioorganic & Medicinal Chemistry Letters Published 1 January 2012 Crick labsMike BlackmanFull details
Intramembrane cleavage of AMA1 triggers Toxoplasma to switch from an invasive to a replicative mode Authors (4) Joana M Santos David JP FergusonMichael Blackman Dominique Soldati-Favre Science Published 23 December 2011 Crick labsMike BlackmanFull details
Juxtamembrane shedding of Plasmodium falciparum AMA1 is sequence independent and essential, and helps evade invasion-inhibitory antibodies Authors (8) Anna Olivieri Christine R Collins Fiona HackettChrislaine Withers-Martinez Joshua Marshall Helen R FlynnMark SkehelMichael Blackman PLOS Pathogens Published 1 December 2011 Crick labsMike BlackmanFull details
Global identification of multiple substrates for Plasmodium falciparum SUB1, an essential malarial processing protease Authors (8) Natalie C Silmon de Monerri Helen R Flynn Marta G Campos Fiona HackettKonstantinos KousisChrislaine Withers-MartinezMark SkehelMichael Blackman Infection and Immunity Published 10 January 2011 Crick labsMike BlackmanFull details
Regulated maturation of malaria merozoite surface protein-1 is essential for parasite growth Authors (4) MA Child C Epp H BujardMichael Blackman Molecular Microbiology Published 1 October 2010 Crick labsMike BlackmanFull details
A plant-like kinase in Plasmodium falciparum regulates parasite egress from erythrocytes Authors (13) Jeffrey D Dvorin Derek C Martyn Saurabh D Patel Joshua S Grimley Christine R Collins Christine S Hopp[...] Elizabeth WinzelerMichael Blackman David A Baker Thomas J Wandless Manoj T Duraisingh Science Published 14 May 2010 Crick labsMike BlackmanFull details