Publications

Architecture and regulation of a GDNF-GFRα1 synaptic adhesion assembly

Authors (8)

Nature Communications

Published 20 November 2023

Crick labs/ facilities

Full details

Molecular mechanism of decision-making in glycosaminoglycan biosynthesis

Authors (8)

Douglas Sammon
Anja Krueger
Marta Busse-Wicher
Rhodri Marc Morgan
Stuart M Haslam
Ben Schumann
David Briggs
Erhard Hohenester

Nature Communications

Published 13 October 2023

Crick labs/ facilities

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Control of atypical PKCι membrane dissociation by tyrosine phosphorylation within a PB1-C1 interdomain interface

Authors (3)

Journal of Biological Chemistry

Published 1 July 2023

Crick labs/ facilities

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Structural biology of SARS-CoV-2 accessory proteins

Authors (5)

David Briggs
Luise Kandler
Lisa Schmidt
Gianluca Santoni
Andrea Thorn

Crystallography Reviews

Published 17 May 2023

Crick labs

Neil McDonald

Full details

Oligonucleotide-recognizing topoisomerase inhibitors (OTIs): Precision gene editors for neurodegenerative diseases?

Authors (5)

Ben D Bax
Dmitry Sutormin
Neil McDonald
Glenn A Burley
Tatyana Shelkovnikova

International Journal of Molecular Sciences

Published 29 September 2022

Crick labs

Neil McDonald

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Structure of PLA2R reveals presentation of the dominant membranous nephropathy epitope and an immunogenic patch

Authors (8)

Maryline Fresquet
Michael P Lockhart-Cairns
Samuel J Rhoden
Thomas A Jowitt
David Briggs
Clair Baldock
Paul E Brenchley
Rachel Lennon

Proceedings of the National Academy of Sciences

Published 19 July 2022

Crick labs

Neil McDonald

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Bimodal regulation of axonal transport by the GDNF-RET signalling axis in healthy and diseased motor neurons

Authors (6)

Elena R Rhymes
Andrew P Tosolini
Alexander D Fellows
William Mahy
Neil McDonald
Giampietro Schiavo

Cell Death and Disease

Published 7 July 2022

Crick labs

Neil McDonald

Full details

The impact of AlphaFold2 on experimental structure solution

Authors (5)

Maximilian Edich
David Briggs
Oliver Kippes
Yunyun Gao
Andrea Thorn

Faraday Discussions

Published 1 November 2022

Crick labs

Neil McDonald

Full details

Discovery of N-trisubstituted pyrimidine derivatives as type I RET and RET gatekeeper mutant inhibitors with a novel kinase binding pose

Authors (16)

Lingtian Zhang
Marialuisa Moccia
David Briggs
Jaideep B Bharate
Naga Rajiv Lakkaniga
Phillip Knowles
[...]
Brendan Frett
Massimo Santoro
Neil McDonald
Francesca Carlomagno
Hongy-yu Li

Journal of Medicinal Chemistry

Published 27 January 2022

Crick labs

Neil McDonald

Full details

A genetically-encoded crosslinker screen identifies SERBP1 as a PKCε substrate influencing translation and cell division

Authors (12)

Nature Communications

Published 26 November 2021

Crick labs/ facilities

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Characterization of humoral and SARS-CoV-2 specific T cell responses in people living with HIV

Authors (21)

Aljawharah Alrubayyi
Ester Gea-Mallorquí
Emma Touizer
Dan Hameiri-Bowen
Jakub Kopycinski
Bethany Charlton
[...]
Tao Dong
Lucy Dorrell
Sarah Rowland-Jones
Laura E McCoy
Dimitra Peppa

Nature Communications

Published 5 October 2021

Crick labs/ facilities

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Favourable antibody responses to human coronaviruses in children and adolescents with autoimmune rheumatic diseases

Authors (31)

Claire T Deakin
Georgina H Cornish
Kevin Ng
Nikhil Faulkner
William Bolland
Joshua Hope
[...]
Michael Levin
Peter Cherepanov
Coziana Ciurtin
Lucy R Wedderburn
George Kassiotis

Med

Published 10 September 2021

Crick labs/ facilities

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Co-ordinated control of the Aurora B abscission checkpoint by PKCε complex assembly, midbody recruitment and retention

Authors (14)

Lisa Watson
Tanya Soliman
Khalil Davis
Joanna Kelly
Nicola Lockwood
Xiaoping Yang
[...]
Neil McDonald
David J Mann
Alan Armstrong
Ulrike Eggert
Peter J Parker

Biochemical Journal

Published 25 June 2021

Crick labs/ facilities

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A two-site flexible clamp mechanism for RET-GDNF-GFRα1 assembly reveals both conformational adaptation and strict geometric spacing

Authors (14)

Sarah Adams
Andrew G Purkiss
Phillip P Knowles
Andrea Nans
David Briggs
Annabel Borg
[...]
Aaron J Borg
Pauline B McIntosh
Frankie Houghton
Svend Kjaer
Neil McDonald

Structure

Published 1 July 2021

Crick labs/ facilities

Full details

Equivocal, explicit and emergent actions of PKC isoforms in cancer

Authors (11)

Nature Reviews Cancer

Published 1 January 2021

Crick labs/ facilities

Full details

Metabolic precision labeling enables selective probing of O-linked N-acetylgalactosamine glycosylation

Authors (27)

Marjoke F Debets
Omur Yilmaz Tastan
Simon P Wisnovsky
Stacy A Malaker
Nikos Angelis
Leonhard KR Moeckl
[...]
Michael C Bassik
WE Moerner
Vivian Li
Carolyn R Bertozzi
Ben Schumann

Proceedings of the National Academy of Sciences of USA

Published 13 October 2020

Crick labs/ facilities

Full details

Activation of the receptor tyrosine kinase RET improves long-term hematopoietic stem cell outgrowth and potency

Authors (7)

Blood

Published 26 November 2020

Crick labs/ facilities

Full details

Bioisosteric discovery of NPA101.3, a second generation RET/VEGFR2 inhibitor optimized for single-agent polypharmacology

Authors (13)

Marialuisa Moccia
Brendan Frett
Lingtain Zhang
Naga Rajiv Lakkaniga
David Briggs
Rakhee Chauhan
[...]
Wei Yan
Massimo Santoro
Neil McDonald
Hong-yu Li
Francesca Carlomagno

Journal of Medicinal Chemistry

Published 14 May 2020

Crick labs

Neil McDonald

Full details

Cryo-EM structures of the XPF-ERCC1 endonuclease reveal how DNA-junction engagement disrupts an auto-inhibited conformation

Authors (11)

Morgan Jones
Fabienne Beuron
Aaron Borg
Andrea Nans
Chris Earl
David Briggs
Bram Snijders
Maureen Bowles
Edward P Morris
Mark Linch
Neil McDonald

Nature Communications

Published 28 February 2020

Crick labs/ facilities

Full details

Optimised oligonucleotide substrates to assay XPF-ERCC1 nuclease activity for the discovery of DNA repair inhibitors

Authors (9)

Adam M Thomas
Sanja Brolih
Joanna F McGouran
Afaf H El-Sagheer
Denis Ptchelkine
Morgan Jones
Neil McDonald
Peter J McHugh
Tom Brown

Chemical Communications

Published 7 October 2019

Crick labs

Neil McDonald

Full details

Research case studies

Doctoral clinical fellows

Cut + Paste exhibition

News and reports

About us

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Signalling and Structural Biology Laboratory
: Publications

Lab content

Publications

Year published

Research topics

Publication type

Journal

Architecture and regulation of a GDNF-GFRα1 synaptic adhesion assembly

Molecular mechanism of decision-making in glycosaminoglycan biosynthesis

Control of atypical PKCι membrane dissociation by tyrosine phosphorylation within a PB1-C1 interdomain interface

Structural biology of SARS-CoV-2 accessory proteins

Oligonucleotide-recognizing topoisomerase inhibitors (OTIs): Precision gene editors for neurodegenerative diseases?

Structure of PLA2R reveals presentation of the dominant membranous nephropathy epitope and an immunogenic patch

Bimodal regulation of axonal transport by the GDNF-RET signalling axis in healthy and diseased motor neurons

The impact of AlphaFold2 on experimental structure solution

Discovery of N-trisubstituted pyrimidine derivatives as type I RET and RET gatekeeper mutant inhibitors with a novel kinase binding pose

A genetically-encoded crosslinker screen identifies SERBP1 as a PKCε substrate influencing translation and cell division

Characterization of humoral and SARS-CoV-2 specific T cell responses in people living with HIV

Favourable antibody responses to human coronaviruses in children and adolescents with autoimmune rheumatic diseases

Co-ordinated control of the Aurora B abscission checkpoint by PKCε complex assembly, midbody recruitment and retention

A two-site flexible clamp mechanism for RET-GDNF-GFRα1 assembly reveals both conformational adaptation and strict geometric spacing

Equivocal, explicit and emergent actions of PKC isoforms in cancer

Metabolic precision labeling enables selective probing of O-linked N-acetylgalactosamine glycosylation

Activation of the receptor tyrosine kinase RET improves long-term hematopoietic stem cell outgrowth and potency

Bioisosteric discovery of NPA101.3, a second generation RET/VEGFR2 inhibitor optimized for single-agent polypharmacology

Cryo-EM structures of the XPF-ERCC1 endonuclease reveal how DNA-junction engagement disrupts an auto-inhibited conformation

Optimised oligonucleotide substrates to assay XPF-ERCC1 nuclease activity for the discovery of DNA repair inhibitors

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Research case studies

Doctoral clinical fellows

Cut + Paste exhibition

News and reports

About us

Lab content

Publications

Year published

Research topics

Publication type

Journal

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