Publications

Architecture and DNA recognition elements of the Fanconi anemia FANCM-FAAP24 complex

Authors (7)

Rachel Coulthard
Andrew J Deans
Paolo Swuec
Maureen Bowles
Alessandro Costa
Stephen West
Neil McDonald

Structure

Published 3 September 2013

Crick labs

Full details

14-3-3 proteins interact with a hybrid prenyl-phosphorylation motif to inhibit G proteins

Authors (14)

Philippe Riou
Svend Kjaer
Ritu Garg
Andrew Purkiss
Roger George
Robert J Cain
[...]
Andrew J Thompson
Nicola O'Reilly
Neil McDonald
Peter Parker
Anne J Ridley

Cell

Published 25 April 2013

Crick labs/ facilities

Full details

Adenosine-binding motif mimicry and cellular effects of a thieno[2,3-d]pyrimidine-based chemical inhibitor of atypical protein kinase C isoenzymes

Authors (17)

Svend Kjaer
Mark Linch
Andrew Purkiss
Brenda Kostelecky
Phillip P Knowles
Carine Rosse
[...]
Caroline Barton
Christian Dillon
Jon Roffey
Peter Parker
Neil McDonald

Biochemical Journal

Published 15 April 2013

Crick labs/ facilities

Full details

G-actin regulates the shuttling and PP1 binding of the RPEL protein Phactr1 to control actomyosin assembly

Authors (7)

Journal of Cell Science

Published 1 December 2012

Crick labs/ facilities

Full details

Structures of the Phactr1 RPEL domain and RPEL motif complexes with G-actin reveal the molecular basis for actin binding cooperativity

Authors (5)

Structure

Published 7 November 2012

Crick labs/ facilities

Full details

Fluorescence-based incision assay for human XPF-ERCC1 activity identifies important elements of DNA junction recognition

Authors (6)

Maureen Bowles
John Lally
Andrew J Fadden
Stephane Mouilleron
Timothy Hammonds
Neil McDonald

Nucleic Acids Research

Published 1 July 2012

Crick labs/ facilities

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Intratumor heterogeneity and branched evolution revealed by multiregion sequencing

Authors (30)

Marco Gerlinger
Andrew Rowan
Stuart Horswell
James Larkin
David Endesfelder
Eva Gronroos
[...]
Martin Gore
Zoltan Szallasi
Julian Downward
P Andrew Futreal
Charles Swanton

New England Journal of Medicine

Published 8 March 2012

Crick labs/ facilities

Full details

Focal adhesion kinase (FAK) binds RET kinase via its FERM domain, priming a direct and reciprocal RET-FAK transactivation mechanism

Authors (10)

Iván Plaza-Menacho
Andrea Morandi
Luca Mologni
Piet Boender
Carlo Gambacorti-Passerini
Anthony I Magee
Robert MW Hofstra
Phillip Knowles
Neil McDonald
Clare M Isacke

Journal of Biological Chemistry

Published 13 May 2011

Crick labs

Neil McDonald

Full details

Molecular recognition of the Tes LIM2-3 domains by the actin-related protein Arp7A

Authors (8)

Batiste Boëda
Phillip P Knowles
David Briggs
Judith Murray-Rust
Erika Soriano
Boyan K Garvalov
Neil McDonald
Michael Way

Journal of Biological Chemistry

Published 1 April 2011

Crick labs

Full details

Structure of a pentavalent G-actin•MRTF-A complex reveals how G-actin controls nucleocytoplasmic shuttling of a transcriptional coactivator

Authors (5)

Stephane Mouilleron
Carola A Langer
Sebastian Guettler
Neil McDonald
Richard Treisman

Science Signaling

Published 1 January 2011

Crick labs/ facilities

Full details

Mammal-restricted elements predispose human RET to folding impairment by HSCR mutations

Authors (4)

Svend Kjaer
Sarah Hanrahan
Nick Totty
Neil McDonald

Nature Structural & Molecular Biology

Published 1 June 2010

Crick labs/ facilities

Full details

Synthesis, structure-activity relationship and crystallographic studies of 3-substituted indolin-2-one RET inhibitors

Authors (12)

Luca Mologni
Roberta Rostagno
Stefania Brussolo
Phillip P Knowles
Svend Kjaer
Judith Murray-Rust
[...]
Alfonso Zambon
Leonardo Scapozza
Neil McDonald
Vittorio Lucchini
Carlo Gambacorti-Passerini

Bioorganic & Medicinal Chemistry

Published 15 February 2010

Crick labs/ facilities

Full details

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Architecture and DNA recognition elements of the Fanconi anemia FANCM-FAAP24 complex

14-3-3 proteins interact with a hybrid prenyl-phosphorylation motif to inhibit G proteins

Adenosine-binding motif mimicry and cellular effects of a thieno[2,3-d]pyrimidine-based chemical inhibitor of atypical protein kinase C isoenzymes

G-actin regulates the shuttling and PP1 binding of the RPEL protein Phactr1 to control actomyosin assembly

Structures of the Phactr1 RPEL domain and RPEL motif complexes with G-actin reveal the molecular basis for actin binding cooperativity

Fluorescence-based incision assay for human XPF-ERCC1 activity identifies important elements of DNA junction recognition

Intratumor heterogeneity and branched evolution revealed by multiregion sequencing

Focal adhesion kinase (FAK) binds RET kinase via its FERM domain, priming a direct and reciprocal RET-FAK transactivation mechanism

Molecular recognition of the Tes LIM2-3 domains by the actin-related protein Arp7A

Structure of a pentavalent G-actin•MRTF-A complex reveals how G-actin controls nucleocytoplasmic shuttling of a transcriptional coactivator

Mammal-restricted elements predispose human RET to folding impairment by HSCR mutations

Synthesis, structure-activity relationship and crystallographic studies of 3-substituted indolin-2-one RET inhibitors

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