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It is increasingly appreciated that the spatial organisation of chromosomes profoundly influences gene expression; however the details of how this is achieved are poorly understood. We will build on our successful collaborations with the Akhtar laboratory (Max Planck Institute of Immunobiology and Epigenetics, Freiburg) to study the effects of X-chromosomal positioning on dosage compensation. Excitingly, we recently initiated collaborations with Peter Fraser (Babraham Institute, Cambridge), a world-expert on ChIA-PET and Hi-C, to investigate nuclear organisation in mammalian cells.