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Breadcrumb Peter Cherepanov Cherepanov lab Chromatin Structure and Mobile DNA Laboratory : Publications Lab contentLab contentIn this section Overview Vacancies Areas of interest Publications Members Three-dimensional model of the retroviral intasome and chemical structures of some of the clinical HIV-1 integrase inhibitors studied in the lab; the background is an X-ray diffraction pattern from a single crystal of the intasome. 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Methods & Clinical Development (1)Nature Biotechnology (1)Nature Structural & Molecular Biology (1)Nature Structural and Molecular Biology (1)PLOS ONE (1)Retrovirology (1)Science advances (1)Science Translational Medicine (1)The Lancet (1)Thorax (1)Vaccines (Basel) (1)Virology (1) Facet Journal Publications Displaying 1 - 20 of 83Last updated : 25 April 2024 03:50 Multiplexed detection of viral antigen and RNA using nanopore sensing and encoded molecular probes Authors (26) Ren Ren Shenglin Cai Xiaona Fang Xiaoyi Wang Zheng Zhang Micol Damiani[...] Zhaofeng Luo Weihong Tan Yuri Korchev Aleksandar P Ivanov Joshua B Edel Nature Communications Published 14 November 2023 Crick labsPeter Cherepanov Full details ATG9B is a tissue-specific homotrimeric lipid scramblase that can compensate for ATG9A Authors (8)George ChiduzaAcely Garza-GarciaEugenia Almacellas I CanalsStefano De TitoVal PyeAlexander Van VlietPeter CherepanovSharon Tooze Autophagy Published 1 March 2024 Crick labs/ facilitiesSharon ToozePeter Cherepanov Luiz Pedro CarvalhoStructural BiologyScientific computingCell ServicesFull details Immunogenicity and pre-clinical efficacy of an OMV-based SARS-CoV-2 vaccine Authors (27) Alberto Grandi Michele Tomasi Irfan Ullah Cinzia Bertelli Teresa Vanzo Silvia Accordini[...] Pradeep D UchilPeter Cherepanov Martino Bolognesi Massimo Pizzato Guido Grandi Vaccines (Basel) Published 29 September 2023 Crick labsPeter Cherepanov Full details TMEM106B is a receptor mediating ACE2-independent SARS-CoV-2 cell entry Authors (25) Jim Baggen Maarten Jacquemyn Leentje Persoons Els VanstreelsVal PyeAntoni Wrobel[...] Alusha Andre Mamchak Maxime Ah Young-Chapon Eric BrownPeter Cherepanov Dirk Daelemans Cell Published 3 August 2023 Crick labs/ facilitiesSteve GamblinPeter Cherepanov Structural BiologyFull details Heme binding to the SARS-CoV-2 spike glycoprotein Authors (9) Samuel L Freeman A Sofia F Oliveira Andrea E GallioAnnachiara Rosa Maria K Simitakou Christopher J Arthur Adrian J MulhollandPeter Cherepanov Emma L Raven Journal of Biological Chemistry Published 1 August 2023 Crick labsPeter Cherepanov Full details Biological and structural analyses of new potent allosteric inhibitors of HIV-1 integrase Authors (16) Damien Bonnard Erwann Le RouzicMatthew Singer Zhe Yu Frédéric Le Strat Claire Batisse[...] Benoit Ledoussal Marc Ruff François MoreauPeter Cherepanov Richard Benarous Antimicrobial Agents and Chemotherapy Published 18 July 2023 Crick labs/ facilitiesPeter Cherepanov Structural BiologyFull details SARS-CoV-2 antibody responses associate with sex, age and disease severity in previously uninfected people admitted to hospital with COVID-19: An ISARIC4C prospective study Authors (29) Eleanor Parker Jordan Thomas Kelly J Roper Samreen Ijaz Tansy Edwards Federica Marchesin[...] Malcolm G Semple William A Paxton Richard S Tedder Georgios Pollakis ISARIC4C Investigators Frontiers in Immunology Published 15 March 2023 Crick labsPeter Cherepanov Full details National and regional prevalence of SARS-CoV-2 antibodies in primary and secondary school children in England: the School Infection Survey, a national open cohort study, November 2021SARS-CoV-2 antibody prevalence in school children Authors (37) Annabel A Powell Georgina Ireland Rebecca Leeson Andrea Lacey Ben Ford John Poh[...] Neisha Sundaram Elliot McClenaghan Gillian McKay John Edmunds Paul Fine Journal of Infection Published 1 April 2023 Crick labsPeter Cherepanov Full details The drug-induced interface that drives HIV-1 integrase hypermultimerization and loss of function Authors (15)Matthew Singer Tung Dinh Lev Levintov Arun S Annamalai Juan S Rey Lorenzo Briganti[...] Alan N Engelman Baek Kim Juan R Perilla Mamuka KvaratskheliaPeter Cherepanov mBio Published 1 February 2023 Crick labs/ facilitiesIan TaylorPeter Cherepanov Structural BiologyFull details Plasmodium infection is associated with cross-reactive antibodies to carbohydrate epitopes on the SARS-CoV-2 Spike protein Authors (63) Sarah Lapidus Feimei Liu Arnau Casanovas-Massana Yile Dai John D Huck Carolina Lucas[...] Akiko Iwasaki Craig B Wilen Albert I Ko Aaron M Ring Amy K Bei Scientific Reports Published 22 December 2022 Crick labsPeter Cherepanov Full details ATG9A and ATG2A form a heteromeric complex essential for autophagosome formation Authors (15)Alexander Van VlietGeorge Chiduza Sarah L MaslenVal PyeDhira JoshiStefano De Tito[...]Javier HervasNicola O'ReillyMark SkehelPeter CherepanovSharon Tooze Molecular Cell Published 17 November 2022 Crick labs/ facilitiesSharon ToozePeter Cherepanov Structural BiologyProteomicsLight MicroscopyElectron MicroscopyFull details A neutralizing epitope on the SD1 domain of SARS-CoV-2 spike targeted following infection and vaccination Authors (13) Jeffrey Seow Hataf KhanAnnachiara Rosa Valeria Calvaresi Carl Graham Suzanne Pickering[...] Isabella Huettner Michael H Malim Argyris PolitisPeter Cherepanov Katie J Doores Cell Reports Published 11 August 2022 Crick labs/ facilitiesPeter Cherepanov Structural BiologyFull details B-to-A transition in target DNA during retroviral integration Authors (10) Ilona K Jóźwik Wen Li Da-Wei Zhang Doris Wong Julia GrawenhoffAllison Ballandras-Colas Sriram AiyerPeter Cherepanov Alan N Engelman Dmitry Lyumkis Nucleic Acids Research Published 26 August 2022 Crick labsPeter Cherepanov Full details SARS-CoV-2 S2-targeted vaccination elicits broadly neutralizing antibodies Authors (21)Kevin NgNikhil FaulknerKatja FinsterbuschMary Wu Ruth HarveySaira Hussain[...]Michael Howell Hisashi AraseAndreas WackDavid LV BauerGeorge Kassiotis Science Translational Medicine Published 27 July 2022 Crick labs/ facilitiesAndreas WackCharles SwantonNicola LewisGeorge KassiotisSonia GandhiSteve GamblinPeter Cherepanov Rupert BealeDavid LV BauerWorldwide Influenza CentreStructural BiologyHigh Throughput ScreeningFlow CytometryCell ServicesBiological Research FacilityFull details Mapping of SARS-CoV-2 IgM and IgG in gingival crevicular fluid: antibody dynamics and linkage to severity of COVID-19 in hospital inpatients Authors (20) Samreen Ijaz Steve Dicks Keerthana Jegatheesan Eleanor Parker Ksenia Katsanovskaja Elen Vink[...] Peter JM Openshaw J Kenneth Baillie Malcolm G Semple Richard S Tedder for ISARIC4C Investigators Journal of Infection Published 1 August 2022 Crick labsPeter Cherepanov Full details Multivalent interactions essential for lentiviral integrase function Authors (20)Allison Ballandras-ColasVidya ChivukulaDominika Gruszka Zelin Shan Parmit K SinghVal Pye[...]Ian Taylor Dmitry LyumkisHasan Yardimci Alan N EngelmanPeter Cherepanov Nature Communications Published 3 May 2022 Crick labs/ facilitiesHasan YardimciIan TaylorPeter Cherepanov Structural BiologyFull details Simple, sensitive, specific self-sampling assay secures SARS-CoV-2 antibody signals in sero-prevalence and post-vaccine studies Authors (23) Maryam Khan Carolina Rosadas Ksenia Katsanovskaja Isaac D Weber Justin Shute Samreen Ijaz[...] Graham S CookePeter Cherepanov Eleanor Parker Myra O McClure Richard S Tedder Scientific Reports Published 3 February 2022 Crick labs/ facilitiesPeter Cherepanov Structural BiologyFull details Detection and quantification of antibody to SARS CoV 2 receptor binding domain provides enhanced sensitivity, specificity and utility Authors (39) Carolina Rosadas Maryam Khan Eleanor Parker Federica Marchesin Ksenia Katsanovskaja Macià Sureda-Vives[...] Malcolm G SemplePeter Cherepanov Myra O McClure Richard S Tedder ISARIC4C Investigators Journal of Virological Methods Published 1 April 2022 Crick labs/ facilitiesNicola LewisPeter Cherepanov Worldwide Influenza CentreStructural BiologyFull details Reduced neutralisation of the Delta (B.1.617.2) SARS-CoV-2 variant of concern following vaccination Authors (20) Chris Davis Nicola Logan Grace Tyson Richard Orton William T Harvey Jonathan S Perkins[...] David L Robertson John Haughney Emma C Thomson Brian J Willett COVID-19 DeplOyed VaccinE (DOVE) Cohort Study investigators PLOS Pathogens Published 2 December 2021 Crick labsPeter Cherepanov Full details Characterization of humoral and SARS-CoV-2 specific T cell responses in people living with HIV Authors (21) Aljawharah Alrubayyi Ester Gea-Mallorquí Emma Touizer Dan Hameiri-Bowen Jakub Kopycinski Bethany Charlton[...] Tao Dong Lucy Dorrell Sarah Rowland-Jones Laura E McCoy Dimitra Peppa Nature Communications Published 5 October 2021 Crick labs/ facilitiesNeil McDonaldPeter Cherepanov Structural BiologyFull details Pagination Current page 1 Page 2 Page 3 Page 4 Page 5 Next page Next Last page Last Share the page Share on Twitter Share on Facebook Share on LinkedIn Share on Email
Multiplexed detection of viral antigen and RNA using nanopore sensing and encoded molecular probes Authors (26) Ren Ren Shenglin Cai Xiaona Fang Xiaoyi Wang Zheng Zhang Micol Damiani[...] Zhaofeng Luo Weihong Tan Yuri Korchev Aleksandar P Ivanov Joshua B Edel Nature Communications Published 14 November 2023 Crick labsPeter Cherepanov Full details
ATG9B is a tissue-specific homotrimeric lipid scramblase that can compensate for ATG9A Authors (8)George ChiduzaAcely Garza-GarciaEugenia Almacellas I CanalsStefano De TitoVal PyeAlexander Van VlietPeter CherepanovSharon Tooze Autophagy Published 1 March 2024 Crick labs/ facilitiesSharon ToozePeter Cherepanov Luiz Pedro CarvalhoStructural BiologyScientific computingCell ServicesFull details
Immunogenicity and pre-clinical efficacy of an OMV-based SARS-CoV-2 vaccine Authors (27) Alberto Grandi Michele Tomasi Irfan Ullah Cinzia Bertelli Teresa Vanzo Silvia Accordini[...] Pradeep D UchilPeter Cherepanov Martino Bolognesi Massimo Pizzato Guido Grandi Vaccines (Basel) Published 29 September 2023 Crick labsPeter Cherepanov Full details
TMEM106B is a receptor mediating ACE2-independent SARS-CoV-2 cell entry Authors (25) Jim Baggen Maarten Jacquemyn Leentje Persoons Els VanstreelsVal PyeAntoni Wrobel[...] Alusha Andre Mamchak Maxime Ah Young-Chapon Eric BrownPeter Cherepanov Dirk Daelemans Cell Published 3 August 2023 Crick labs/ facilitiesSteve GamblinPeter Cherepanov Structural BiologyFull details
Heme binding to the SARS-CoV-2 spike glycoprotein Authors (9) Samuel L Freeman A Sofia F Oliveira Andrea E GallioAnnachiara Rosa Maria K Simitakou Christopher J Arthur Adrian J MulhollandPeter Cherepanov Emma L Raven Journal of Biological Chemistry Published 1 August 2023 Crick labsPeter Cherepanov Full details
Biological and structural analyses of new potent allosteric inhibitors of HIV-1 integrase Authors (16) Damien Bonnard Erwann Le RouzicMatthew Singer Zhe Yu Frédéric Le Strat Claire Batisse[...] Benoit Ledoussal Marc Ruff François MoreauPeter Cherepanov Richard Benarous Antimicrobial Agents and Chemotherapy Published 18 July 2023 Crick labs/ facilitiesPeter Cherepanov Structural BiologyFull details
SARS-CoV-2 antibody responses associate with sex, age and disease severity in previously uninfected people admitted to hospital with COVID-19: An ISARIC4C prospective study Authors (29) Eleanor Parker Jordan Thomas Kelly J Roper Samreen Ijaz Tansy Edwards Federica Marchesin[...] Malcolm G Semple William A Paxton Richard S Tedder Georgios Pollakis ISARIC4C Investigators Frontiers in Immunology Published 15 March 2023 Crick labsPeter Cherepanov Full details
National and regional prevalence of SARS-CoV-2 antibodies in primary and secondary school children in England: the School Infection Survey, a national open cohort study, November 2021SARS-CoV-2 antibody prevalence in school children Authors (37) Annabel A Powell Georgina Ireland Rebecca Leeson Andrea Lacey Ben Ford John Poh[...] Neisha Sundaram Elliot McClenaghan Gillian McKay John Edmunds Paul Fine Journal of Infection Published 1 April 2023 Crick labsPeter Cherepanov Full details
The drug-induced interface that drives HIV-1 integrase hypermultimerization and loss of function Authors (15)Matthew Singer Tung Dinh Lev Levintov Arun S Annamalai Juan S Rey Lorenzo Briganti[...] Alan N Engelman Baek Kim Juan R Perilla Mamuka KvaratskheliaPeter Cherepanov mBio Published 1 February 2023 Crick labs/ facilitiesIan TaylorPeter Cherepanov Structural BiologyFull details
Plasmodium infection is associated with cross-reactive antibodies to carbohydrate epitopes on the SARS-CoV-2 Spike protein Authors (63) Sarah Lapidus Feimei Liu Arnau Casanovas-Massana Yile Dai John D Huck Carolina Lucas[...] Akiko Iwasaki Craig B Wilen Albert I Ko Aaron M Ring Amy K Bei Scientific Reports Published 22 December 2022 Crick labsPeter Cherepanov Full details
ATG9A and ATG2A form a heteromeric complex essential for autophagosome formation Authors (15)Alexander Van VlietGeorge Chiduza Sarah L MaslenVal PyeDhira JoshiStefano De Tito[...]Javier HervasNicola O'ReillyMark SkehelPeter CherepanovSharon Tooze Molecular Cell Published 17 November 2022 Crick labs/ facilitiesSharon ToozePeter Cherepanov Structural BiologyProteomicsLight MicroscopyElectron MicroscopyFull details
A neutralizing epitope on the SD1 domain of SARS-CoV-2 spike targeted following infection and vaccination Authors (13) Jeffrey Seow Hataf KhanAnnachiara Rosa Valeria Calvaresi Carl Graham Suzanne Pickering[...] Isabella Huettner Michael H Malim Argyris PolitisPeter Cherepanov Katie J Doores Cell Reports Published 11 August 2022 Crick labs/ facilitiesPeter Cherepanov Structural BiologyFull details
B-to-A transition in target DNA during retroviral integration Authors (10) Ilona K Jóźwik Wen Li Da-Wei Zhang Doris Wong Julia GrawenhoffAllison Ballandras-Colas Sriram AiyerPeter Cherepanov Alan N Engelman Dmitry Lyumkis Nucleic Acids Research Published 26 August 2022 Crick labsPeter Cherepanov Full details
SARS-CoV-2 S2-targeted vaccination elicits broadly neutralizing antibodies Authors (21)Kevin NgNikhil FaulknerKatja FinsterbuschMary Wu Ruth HarveySaira Hussain[...]Michael Howell Hisashi AraseAndreas WackDavid LV BauerGeorge Kassiotis Science Translational Medicine Published 27 July 2022 Crick labs/ facilitiesAndreas WackCharles SwantonNicola LewisGeorge KassiotisSonia GandhiSteve GamblinPeter Cherepanov Rupert BealeDavid LV BauerWorldwide Influenza CentreStructural BiologyHigh Throughput ScreeningFlow CytometryCell ServicesBiological Research FacilityFull details
Mapping of SARS-CoV-2 IgM and IgG in gingival crevicular fluid: antibody dynamics and linkage to severity of COVID-19 in hospital inpatients Authors (20) Samreen Ijaz Steve Dicks Keerthana Jegatheesan Eleanor Parker Ksenia Katsanovskaja Elen Vink[...] Peter JM Openshaw J Kenneth Baillie Malcolm G Semple Richard S Tedder for ISARIC4C Investigators Journal of Infection Published 1 August 2022 Crick labsPeter Cherepanov Full details
Multivalent interactions essential for lentiviral integrase function Authors (20)Allison Ballandras-ColasVidya ChivukulaDominika Gruszka Zelin Shan Parmit K SinghVal Pye[...]Ian Taylor Dmitry LyumkisHasan Yardimci Alan N EngelmanPeter Cherepanov Nature Communications Published 3 May 2022 Crick labs/ facilitiesHasan YardimciIan TaylorPeter Cherepanov Structural BiologyFull details
Simple, sensitive, specific self-sampling assay secures SARS-CoV-2 antibody signals in sero-prevalence and post-vaccine studies Authors (23) Maryam Khan Carolina Rosadas Ksenia Katsanovskaja Isaac D Weber Justin Shute Samreen Ijaz[...] Graham S CookePeter Cherepanov Eleanor Parker Myra O McClure Richard S Tedder Scientific Reports Published 3 February 2022 Crick labs/ facilitiesPeter Cherepanov Structural BiologyFull details
Detection and quantification of antibody to SARS CoV 2 receptor binding domain provides enhanced sensitivity, specificity and utility Authors (39) Carolina Rosadas Maryam Khan Eleanor Parker Federica Marchesin Ksenia Katsanovskaja Macià Sureda-Vives[...] Malcolm G SemplePeter Cherepanov Myra O McClure Richard S Tedder ISARIC4C Investigators Journal of Virological Methods Published 1 April 2022 Crick labs/ facilitiesNicola LewisPeter Cherepanov Worldwide Influenza CentreStructural BiologyFull details
Reduced neutralisation of the Delta (B.1.617.2) SARS-CoV-2 variant of concern following vaccination Authors (20) Chris Davis Nicola Logan Grace Tyson Richard Orton William T Harvey Jonathan S Perkins[...] David L Robertson John Haughney Emma C Thomson Brian J Willett COVID-19 DeplOyed VaccinE (DOVE) Cohort Study investigators PLOS Pathogens Published 2 December 2021 Crick labsPeter Cherepanov Full details
Characterization of humoral and SARS-CoV-2 specific T cell responses in people living with HIV Authors (21) Aljawharah Alrubayyi Ester Gea-Mallorquí Emma Touizer Dan Hameiri-Bowen Jakub Kopycinski Bethany Charlton[...] Tao Dong Lucy Dorrell Sarah Rowland-Jones Laura E McCoy Dimitra Peppa Nature Communications Published 5 October 2021 Crick labs/ facilitiesNeil McDonaldPeter Cherepanov Structural BiologyFull details