Publications

Chromosomal instability selects gene copy-number variants encoding core regulators of proliferation in ER+ breast cancer

Authors (9)

David Endesfelder
Rebecca A Burrell
Nnennaya Kanu
Nicholas McGranahan
Michael Howell
Peter Parker
Julian Downward
Charles Swanton
Maik Kschischo

Cancer Research

Published 1 September 2014

Crick labs/ facilities

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The ErbB4 CYT2 variant protects EGFR from ligand-induced degradation to enhance cancer cell motility

Authors (32)

Tai Kiuchi
Elena Ortiz-Zapater
James Monypenny
Daniel R Matthews
Lan K Nguyen
Jody Barbeau
[...]
Marisa L Martin-Fernandez
Peter Parker
Andrew Tutt
Simon M Ameer-Beg
Tony Ng

Science Signaling

Published 19 August 2014

Crick labs

Peter Parker

Full details

A role for the pseudokinase HER3 in the acquired resistance against EGFR- and HER2-directed targeted therapy

Authors (4)

Jeroen Claus
Gargi Patel
Tony Ng
Peter Parker

Biochemical Society Transactions

Published 1 August 2014

Crick labs

Peter Parker

Full details

Control of MT1-MMP transport by atypical PKC during breast-cancer progression

Authors (19)

Carine Rossé
Catalina Lodillinsky
Laetitia Fuhrmann
Maya Nourieh
Pedro Monteiro
Marie Irondelle
[...]
Graça Raposo
Anne Vincent-Salomon
Ivan Bièche
Peter Parker
Philippe Chavrier

Proceedings of the National Academy of Sciences of the United States of America

Published 6 May 2014

Crick labs

Peter Parker

Full details

Atypical protein kinase Cι as a human oncogene and therapeutic target

Authors (5)

Peter Parker
Verline Justilien
Philippe Riou
Mark Linch
Alan P Fields

Biochemical Pharmacology

Published 1 March 2014

Crick labs

Peter Parker

Full details

Functional implications of assigned, assumed and assembled PKC structures

Authors (9)

Mark Linch
Philippe Riou
Jeroen Claus
Angus J Cameron
Julien de Naurois
Banafshe Larijani
Tony Ng
Neil McDonald
Peter Parker

Biochemical Society Transactions

Published 1 February 2014

Crick labs

Full details

Regulation of polarized morphogenesis by protein kinase C iota in oncogenic epithelial spheroids

Authors (13)

Mark Linch
Marta Sanz-Garcia
Carine Rosse
Philippe Riou
Nick Peel
Chris D Madsen
[...]
Asim Khwaja
Christian Dillon
Jon Roffey
Angus JM Cameron
Peter Parker

Carcinogenesis

Published 1 February 2014

Crick labs

Full details

Mitotic catenation is monitored and resolved by a PKCε-regulated pathway

Authors (5)

Nicola Brownlow
Tanya Pike
Daniel Zicha
Lucy Collinson
Peter Parker

Nature Communications

Published 1 January 2014

Crick labs/ facilities

Full details

Receptor tyrosine kinase c-Met controls the cytoskeleton from different endosomes via different pathways

Authors (3)

Ludovic Ménard
Peter Parker
Stéphanie Kermorgant

Nature Communications

Published 1 January 2014

Crick labs

Peter Parker

Full details

A cancer-associated mutation in atypical protein kinase Cι occurs in a substrate-specific recruitment motif

Authors (12)

Mark Linch
Marta Sanz-Garcia
Erika Soriano
Yixiao Zhang
Philippe Riou
Carine Rosse
[...]
Phillip Knowles
Andrew Purkiss
Svend Kjaer
Neil McDonald
Peter Parker

Science Signaling

Published 17 September 2013

Crick labs/ facilities

Full details

Pseudokinase drug intervention: a potentially poisoned chalice

Authors (3)

Jeroen Claus
Angus JM Cameron
Peter Parker

Biochemical Society Transactions

Published 1 August 2013

Crick labs

Peter Parker

Full details

Localised interventions in cellular processes

Authors (3)

Nick Peel
Banafshé Larijani
Peter Parker

Biochimica et Biophysica Acta

Published 1 July 2013

Crick labs

Peter Parker

Full details

ERK2 but not ERK1 mediates HGF-induced motility in non-small cell lung carcinoma cell lines

Authors (8)

Simone Radtke
Mina Milanovic
Carine Rossé
Manu De Rycker
Sylvie Lachmann
Andrew Hibbert
Stéphanie Kermorgant
Peter Parker

Journal of Cell Science

Published 1 June 2013

Crick labs

Peter Parker

Full details

14-3-3 proteins interact with a hybrid prenyl-phosphorylation motif to inhibit G proteins

Authors (14)

Philippe Riou
Svend Kjaer
Ritu Garg
Andrew Purkiss
Roger George
Robert J Cain
[...]
Andrew J Thompson
Nicola O'Reilly
Neil McDonald
Peter Parker
Anne J Ridley

Cell

Published 25 April 2013

Crick labs/ facilities

Full details

Adenosine-binding motif mimicry and cellular effects of a thieno[2,3-d]pyrimidine-based chemical inhibitor of atypical protein kinase C isoenzymes

Authors (17)

Svend Kjaer
Mark Linch
Andrew Purkiss
Brenda Kostelecky
Phillip P Knowles
Carine Rosse
[...]
Caroline Barton
Christian Dillon
Jon Roffey
Peter Parker
Neil McDonald

Biochemical Journal

Published 15 April 2013

Crick labs/ facilities

Full details

Binding of dynein intermediate chain 2 to paxillin controls focal adhesion dynamics and migration

Authors (10)

Carine Rosse
Katrina Boeckeler
Mark Linch
Simone Radtke
David Frith
Karin Barnouin
Ali Sayed Morsi
Majid Hafezparast
Michael Howell
Peter Parker

Journal of Cell Science

Published 15 August 2012

Crick labs/ facilities

Full details

Anomalous inhibition of c-Met by the kinesin inhibitor aurintricarboxylic acid

Authors (8)

Mina Milanovic
Simone Radtke
Nick Peel
Michael Howell
Virginie Carrière
Carine Joffre
Stéphanie Kermorgant
Peter Parker

International Journal of Cancer

Published 1 March 2012

Crick labs/ facilities

Full details

mTORC2 targets AGC kinases through Sin1-dependent recruitment

Authors (5)

Angus JM Cameron
Mark D Linch
Adrian T Saurin
Cristina Escribano
Peter Parker

Biochemical Journal

Published 15 October 2011

Crick labs

Peter Parker

Full details

Site recognition and substrate screens for PKN family proteins

Authors (8)

Alejandra Collazos
Nicholas Michael
Richard DH Whelan
Gavin Kelly
Harry Mellor
Leon CH Pang
Nick Totty
Peter Parker

Biochemical Journal

Published 15 September 2011

Crick labs/ facilities

Full details

Human epidermal growth factor receptor (EGFR) aligned on the plasma membrane adopts key features of Drosophila EGFR asymmetry

Authors (9)

Christopher J Tynan
Selene K Roberts
Daniel J Rolfe
David T Clarke
Hannes H Loeffler
Johannes Kästner
Martyn D Winn
Peter Parker
Marisa L Martin-Fernandez

Molecular and Cellular Biology

Published 1 June 2011

Crick labs

Peter Parker

Full details

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Chromosomal instability selects gene copy-number variants encoding core regulators of proliferation in ER+ breast cancer

The ErbB4 CYT2 variant protects EGFR from ligand-induced degradation to enhance cancer cell motility

A role for the pseudokinase HER3 in the acquired resistance against EGFR- and HER2-directed targeted therapy

Control of MT1-MMP transport by atypical PKC during breast-cancer progression

Atypical protein kinase Cι as a human oncogene and therapeutic target

Functional implications of assigned, assumed and assembled PKC structures

Regulation of polarized morphogenesis by protein kinase C iota in oncogenic epithelial spheroids

Mitotic catenation is monitored and resolved by a PKCε-regulated pathway

Receptor tyrosine kinase c-Met controls the cytoskeleton from different endosomes via different pathways

A cancer-associated mutation in atypical protein kinase Cι occurs in a substrate-specific recruitment motif

Pseudokinase drug intervention: a potentially poisoned chalice

Localised interventions in cellular processes

ERK2 but not ERK1 mediates HGF-induced motility in non-small cell lung carcinoma cell lines

14-3-3 proteins interact with a hybrid prenyl-phosphorylation motif to inhibit G proteins

Adenosine-binding motif mimicry and cellular effects of a thieno[2,3-d]pyrimidine-based chemical inhibitor of atypical protein kinase C isoenzymes

Binding of dynein intermediate chain 2 to paxillin controls focal adhesion dynamics and migration

Anomalous inhibition of c-Met by the kinesin inhibitor aurintricarboxylic acid

mTORC2 targets AGC kinases through Sin1-dependent recruitment

Site recognition and substrate screens for PKN family proteins

Human epidermal growth factor receptor (EGFR) aligned on the plasma membrane adopts key features of Drosophila EGFR asymmetry

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