Publications

Comparative analysis of N-terminal cysteine dioxygenation and prolyl-hydroxylation as oxygen-sensing pathways in mammalian cells

Authors (5)

Ya-Min Tian
Philip Holdship
Trang Quynh To
Peter Ratcliffe
Thomas P Keeley

Journal of Biological Chemistry

Published 1 September 2023

Crick labs

Peter Ratcliffe

Full details

Multi-level interaction between HIF and AHR transcriptional pathways in kidney carcinoma

Authors (5)

Véronique N Lafleur
Silvia Halim
Hani Choudhry
Peter Ratcliffe
David R Mole

Life Science Alliance

Published 1 April 2023

Crick labs

Peter Ratcliffe

Full details

Pan-cancer analysis of tissue and single-cell HIF-pathway activation using a conserved gene signature

Authors (6)

Olivia Lombardi
Ran Li
Silvia Halim
Hani Choudhry
Peter Ratcliffe
David R Mole

Cell Reports

Published 15 November 2022

Crick labs

Peter Ratcliffe

Full details

A global view of the aspiring physician-scientist

Authors (7)

Christopher S Williams
W Kimryn Rathmell
John M Carethers
Diane M Harper
YM Dennis Lo
Peter Ratcliffe
Mone Zaidi

eLife

Published 13 September 2022

Crick labs

Peter Ratcliffe

Full details

Isoform-resolved mRNA profiling of ribosome load defines interplay of HIF and mTOR dysregulation in kidney cancer

Authors (2)

Nature Structural and Molecular Biology

Published 1 September 2022

Crick labs

Peter Ratcliffe

Full details

Widespread hydroxylation of unstructured lysine-rich protein domains by JMJD6

Authors (10)

Matthew Cockman
Yoichiro Sugimoto
Hamish Pegg
Norma Masson
Eidarus Salah
Anthony Tumber
Helen R Flynn
Joanna Kirkpatrick
Christopher J Schofield
Peter Ratcliffe

Proceedings of the National Academy of Sciences of USA

Published 9 August 2022

Crick labs/ facilities

Full details

Hypoxia shapes the immune landscape in lung injury and promotes the persistence of inflammation

Authors (42)

Ananda S Mirchandani
Stephen J Jenkins
Calum C Bain
Manuel A Sanchez-Garcia
Hannah Lawson
Patricia Coelho
[...]
Christopher W Pugh
Kamil Kranc
Stuart J Forbes
Moira KB Whyte
Sarah R Walmsley

Nature Immunology

Published 1 June 2022

Crick labs

Peter Ratcliffe

Full details

Factor inhibiting HIF can catalyse two asparaginyl hydroxylations in VNVN motifs of ankyrin fold proteins

Authors (16)

Thomas M Leissing
Adam P Hardy
Hokfung Chan
Yihua Wang
Anthony Tumber
Rasheduzzaman Chowdhury
[...]
Roman Fischer
Benedikt M Kessler
Peter Ratcliffe
Xin Lu
Christopher J Schofield

Journal of Biological Chemistry

Published 1 June 2022

Crick labs

Peter Ratcliffe

Full details

USP25 promotes pathological HIF-1-driven metabolic reprogramming and is a potential therapeutic target in pancreatic cancer

Authors (19)

Jessica Nelson
May Zaw Thin
Theo Evan
Steven Howell
Mary Wu
Bruna Coelho Almeida
[...]
Bram Snijders
Andreas Prachalias
Yoh Zen
Debashis Sarker
Axel Behrens

Nature Communications

Published 19 April 2022

Crick labs/ facilities

Full details

Abnormal whole-body energy metabolism in iron-deficient humans despite preserved skeletal muscle oxidative phosphorylation

Authors (12)

Matthew C Frise
David A Holdsworth
Andrew W Johnson
Yu Jin Chung
M Kate Curtis
Pete J Cox
[...]
Damian J Tyler
David J Roberts
Peter Ratcliffe
Keith L Dorrington
Peter A Robbins

Scientific Reports

Published 19 January 2022

Crick labs

Peter Ratcliffe

Full details

Harveian Oration 2020: Elucidation of molecular oxygen sensing mechanisms in human cells: implications for medicine

Authors (1)

Peter Ratcliffe

Clinical medicine (London, England)

Published 1 January 2022

Crick labs

Peter Ratcliffe

Full details

Ogfod1 deletion increases cardiac beta-alanine levels and protects mice against ischaemia-reperfusion injury

Authors (11)

Michael Harris
Junhui Sun
Karen Keeran
Angel Aponte
Komudi Singh
Danielle Springer
Marjan Gucek
Mehdi Pirooznia
Matthew Cockman
Elizabeth Murphy
Leslie M Kennedy

Cardiovascular Research

Published 1 September 2022

Crick labs

Peter Ratcliffe

Full details

Developmental role of PHD2 in the pathogenesis of pseudohypoxic pheochromocytoma

Authors (10)

Luise Eckardt
Maria Prange-Barczynska
Emma Hodson
James W Fielding
Xiaotong Cheng
Joanna DCC Lima
Samvid Kurlekar
Gillian Douglas
Peter Ratcliffe
Tammie Bishop

Endocrine-Related Cancer

Published 18 October 2021

Crick labs

Peter Ratcliffe

Full details

The HIF complex recruits the histone methyltransferase SET1B to activate specific hypoxia-inducible genes

Authors (15)

Brian M Ortmann
Natalie Burrows
Ian T Lobb
Esther Arnaiz
Niek Wit
Peter SJ Bailey
[...]
Rachel Seear
David R Mole
Peter Ratcliffe
Patrick H Maxwell
James A Nathan

Nature Genetics

Published 1 July 2021

Crick labs

Peter Ratcliffe

Full details

Hypoxic and pharmacological activation of HIF inhibits SARS-CoV-2 infection of lung epithelial cells

Authors (23)

Peter AC Wing
Thomas P Keeley
Xiaodong Zhuang
Jeffrey Y Lee
Maria Prange-Barczynska
Senko Tsukuda
[...]
Peter Ratcliffe
Ilan Davis
Emma Hodson
Tammie Bishop
Jane A McKeating

Cell Reports

Published 20 April 2021

Crick labs

Peter Ratcliffe

Full details

Precisely tuned inhibition of HIF prolyl hydroxylases is key for cardioprotection after ischemia

Authors (11)

Aline Jatho
Anke Zieseniss
Katja Brechtel-Curth
Atsushi Yamamoto
Mathew L Coleman
Ana M Vergel Leon
Daniel Biggs
Ben Davies
Chris W Pugh
Peter Ratcliffe
Dörthe M Katschinski

Circulation Research

Published 16 April 2021

Crick labs

Peter Ratcliffe

Full details

Hypoxia drives glucose transporter 3 expression through hypoxia-inducible transcription factor (HIF)-mediated induction of the long noncoding RNA NICI

Authors (14)

Victoria Lauer
Steffen Grampp
James Platt
Veronique Lafleur
Olivia Lombardi
Hani Choudhry
[...]
Atsushi Yamamoto
Mathew L Coleman
Peter Ratcliffe
David R Mole
Johannes Schödel

Journal of Biological Chemistry

Published 27 March 2020

Crick labs

Peter Ratcliffe

Full details

Endothelial oxygen sensing in alveolar maintenance

Authors (2)

Emma Hodson
Peter Ratcliffe

American Journal of Respiratory and Critical Care Medicine

Published 1 October 2020

Crick labs

Peter Ratcliffe

Full details

Pandemic peak SARS-CoV-2 infection and seroconversion rates in London frontline health-care workers

Authors (341)

Catherine F Houlihan
Nina Vora
Thomas Byrne
Dan Lewer
Gavin Kelly
Judith Heaney
[...]
Andrew Hayward
Richard Gilson
Gavin Kelly
Fiona Roberts
Emine Hatipoglu

Scalable and robust SARS-CoV-2 testing in an academic center

Authors (81)

Jim Aitken
Karen Ambrose
Sam Barrell
Rupert Beale
Ganka Bineva-Todd
Dhruva Biswas
[...]
Sophia Ward
Wai Keong Wong
Joshua Wright
Mary Wu
The Crick COVID-19 Consortium

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Cut + Paste exhibition

From local to global: preparing for the next pandemic

About us

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Hypoxia Biology Laboratory
: Publications

Lab content

Publications

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Publication type

Journal

Comparative analysis of N-terminal cysteine dioxygenation and prolyl-hydroxylation as oxygen-sensing pathways in mammalian cells

Multi-level interaction between HIF and AHR transcriptional pathways in kidney carcinoma

Pan-cancer analysis of tissue and single-cell HIF-pathway activation using a conserved gene signature

A global view of the aspiring physician-scientist

Isoform-resolved mRNA profiling of ribosome load defines interplay of HIF and mTOR dysregulation in kidney cancer

Widespread hydroxylation of unstructured lysine-rich protein domains by JMJD6

Hypoxia shapes the immune landscape in lung injury and promotes the persistence of inflammation

Factor inhibiting HIF can catalyse two asparaginyl hydroxylations in VNVN motifs of ankyrin fold proteins

USP25 promotes pathological HIF-1-driven metabolic reprogramming and is a potential therapeutic target in pancreatic cancer

Abnormal whole-body energy metabolism in iron-deficient humans despite preserved skeletal muscle oxidative phosphorylation

Harveian Oration 2020: Elucidation of molecular oxygen sensing mechanisms in human cells: implications for medicine

Ogfod1 deletion increases cardiac beta-alanine levels and protects mice against ischaemia-reperfusion injury

Developmental role of PHD2 in the pathogenesis of pseudohypoxic pheochromocytoma

The HIF complex recruits the histone methyltransferase SET1B to activate specific hypoxia-inducible genes

Hypoxic and pharmacological activation of HIF inhibits SARS-CoV-2 infection of lung epithelial cells

Precisely tuned inhibition of HIF prolyl hydroxylases is key for cardioprotection after ischemia

Hypoxia drives glucose transporter 3 expression through hypoxia-inducible transcription factor (HIF)-mediated induction of the long noncoding RNA NICI

Endothelial oxygen sensing in alveolar maintenance

Pandemic peak SARS-CoV-2 infection and seroconversion rates in London frontline health-care workers

Scalable and robust SARS-CoV-2 testing in an academic center

The Francis Crick Institute is a unique partnership between

Research case studies

Vacancies

Cut + Paste exhibition

From local to global: preparing for the next pandemic

About us

Lab content

Publications

Year published

Research topics

Publication type

Journal

Publications

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