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Breadcrumb Peter Ratcliffe Ratcliffe lab Hypoxia Biology Laboratory : Publications Lab contentLab contentIn this section Overview Areas of interest Publications Members Vacancies Cell proliferation (blue nuclei) with excessive vascularisation (in red): early stage cancer in a hypoxic state. Toggle to view hero caption PublicationsYear published (-)2022 (8) Facet Year publishedResearch topicsBiochemistry & Proteomics (8)Cell Biology (8)Metabolism (8)Signalling & Oncogenes (8)Chemical Biology & High Throughput (2)Computational & Systems Biology (2)Developmental Biology (1)Gene Expression (1)Genetics & Genomics (1)Genome Integrity & Repair (1)Human Biology & Physiology (1)Immunology (1)Infectious Disease (1)Model Organisms (1)Stem Cells (1)Tumour Biology (1) Facet Research topicsPublication typeJournal article (8)Primary research (7)Review (1) Facet Publication typeJournalCell Reports (1)eLife (1)Journal of Biological Chemistry (1)Nature Communications (1)Nature Immunology (1)Nature Structural and Molecular Biology (1)Proceedings of the National Academy of Sciences of USA (1)Scientific Reports (1) Facet Journal Publications Displaying 1 - 8 of 8Last updated : 23 April 2024 02:10 Pan-cancer analysis of tissue and single-cell HIF-pathway activation using a conserved gene signature Authors (6) Olivia Lombardi Ran Li Silvia Halim Hani ChoudhryPeter Ratcliffe David R Mole Cell Reports Published 15 November 2022 Crick labsPeter RatcliffeFull details A global view of the aspiring physician-scientist Authors (7) Christopher S Williams W Kimryn Rathmell John M Carethers Diane M Harper YM Dennis LoPeter Ratcliffe Mone Zaidi eLife Published 13 September 2022 Crick labsPeter RatcliffeFull details Isoform-resolved mRNA profiling of ribosome load defines interplay of HIF and mTOR dysregulation in kidney cancer Authors (2)Yoichiro SugimotoPeter Ratcliffe Nature Structural and Molecular Biology Published 1 September 2022 Crick labsPeter RatcliffeFull details Widespread hydroxylation of unstructured lysine-rich protein domains by JMJD6 Authors (10)Matthew CockmanYoichiro SugimotoHamish Pegg Norma Masson Eidarus Salah Anthony Tumber Helen R FlynnJoanna Kirkpatrick Christopher J SchofieldPeter Ratcliffe Proceedings of the National Academy of Sciences of USA Published 9 August 2022 Crick labs/ facilitiesPeter RatcliffeProteomicsFull details Hypoxia shapes the immune landscape in lung injury and promotes the persistence of inflammation Authors (42) Ananda S Mirchandani Stephen J Jenkins Calum C Bain Manuel A Sanchez-Garcia Hannah Lawson Patricia Coelho[...] Christopher W Pugh Kamil Kranc Stuart J Forbes Moira KB Whyte Sarah R Walmsley Nature Immunology Published 1 June 2022 Crick labsPeter RatcliffeFull details Factor inhibiting HIF can catalyse two asparaginyl hydroxylations in VNVN motifs of ankyrin fold proteins Authors (16) Thomas M Leissing Adam P Hardy Hokfung Chan Yihua Wang Anthony Tumber Rasheduzzaman Chowdhury[...] Roman Fischer Benedikt M KesslerPeter Ratcliffe Xin Lu Christopher J Schofield Journal of Biological Chemistry Published 1 June 2022 Crick labsPeter RatcliffeFull details USP25 promotes pathological HIF-1-driven metabolic reprogramming and is a potential therapeutic target in pancreatic cancer Authors (19)Jessica Nelson May Zaw ThinTheo Evan Steven HowellMary WuBruna Almeida[...]Bram Snijders Andreas Prachalias Yoh Zen Debashis SarkerAxel Behrens Nature Communications Published 19 April 2022 Crick labs/ facilitiesPeter RatcliffeAxel BehrensProteomicsMetabolomicsHigh Throughput ScreeningExperimental HistopathologyBioinformatics and BiostatisticsAdvanced SequencingFull details Abnormal whole-body energy metabolism in iron-deficient humans despite preserved skeletal muscle oxidative phosphorylation Authors (12) Matthew C Frise David A Holdsworth Andrew W Johnson Yu Jin Chung M Kate Curtis Pete J Cox[...] Damian J Tyler David J RobertsPeter Ratcliffe Keith L Dorrington Peter A Robbins Scientific Reports Published 19 January 2022 Crick labsPeter RatcliffeFull details Share the page Share on Twitter Share on Facebook Share on LinkedIn Share on Email
Pan-cancer analysis of tissue and single-cell HIF-pathway activation using a conserved gene signature Authors (6) Olivia Lombardi Ran Li Silvia Halim Hani ChoudhryPeter Ratcliffe David R Mole Cell Reports Published 15 November 2022 Crick labsPeter RatcliffeFull details
A global view of the aspiring physician-scientist Authors (7) Christopher S Williams W Kimryn Rathmell John M Carethers Diane M Harper YM Dennis LoPeter Ratcliffe Mone Zaidi eLife Published 13 September 2022 Crick labsPeter RatcliffeFull details
Isoform-resolved mRNA profiling of ribosome load defines interplay of HIF and mTOR dysregulation in kidney cancer Authors (2)Yoichiro SugimotoPeter Ratcliffe Nature Structural and Molecular Biology Published 1 September 2022 Crick labsPeter RatcliffeFull details
Widespread hydroxylation of unstructured lysine-rich protein domains by JMJD6 Authors (10)Matthew CockmanYoichiro SugimotoHamish Pegg Norma Masson Eidarus Salah Anthony Tumber Helen R FlynnJoanna Kirkpatrick Christopher J SchofieldPeter Ratcliffe Proceedings of the National Academy of Sciences of USA Published 9 August 2022 Crick labs/ facilitiesPeter RatcliffeProteomicsFull details
Hypoxia shapes the immune landscape in lung injury and promotes the persistence of inflammation Authors (42) Ananda S Mirchandani Stephen J Jenkins Calum C Bain Manuel A Sanchez-Garcia Hannah Lawson Patricia Coelho[...] Christopher W Pugh Kamil Kranc Stuart J Forbes Moira KB Whyte Sarah R Walmsley Nature Immunology Published 1 June 2022 Crick labsPeter RatcliffeFull details
Factor inhibiting HIF can catalyse two asparaginyl hydroxylations in VNVN motifs of ankyrin fold proteins Authors (16) Thomas M Leissing Adam P Hardy Hokfung Chan Yihua Wang Anthony Tumber Rasheduzzaman Chowdhury[...] Roman Fischer Benedikt M KesslerPeter Ratcliffe Xin Lu Christopher J Schofield Journal of Biological Chemistry Published 1 June 2022 Crick labsPeter RatcliffeFull details
USP25 promotes pathological HIF-1-driven metabolic reprogramming and is a potential therapeutic target in pancreatic cancer Authors (19)Jessica Nelson May Zaw ThinTheo Evan Steven HowellMary WuBruna Almeida[...]Bram Snijders Andreas Prachalias Yoh Zen Debashis SarkerAxel Behrens Nature Communications Published 19 April 2022 Crick labs/ facilitiesPeter RatcliffeAxel BehrensProteomicsMetabolomicsHigh Throughput ScreeningExperimental HistopathologyBioinformatics and BiostatisticsAdvanced SequencingFull details
Abnormal whole-body energy metabolism in iron-deficient humans despite preserved skeletal muscle oxidative phosphorylation Authors (12) Matthew C Frise David A Holdsworth Andrew W Johnson Yu Jin Chung M Kate Curtis Pete J Cox[...] Damian J Tyler David J RobertsPeter Ratcliffe Keith L Dorrington Peter A Robbins Scientific Reports Published 19 January 2022 Crick labsPeter RatcliffeFull details