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Breadcrumb Peter Ratcliffe Ratcliffe lab Hypoxia Biology Laboratory : Publications Lab contentLab contentIn this section Overview Areas of interest Publications Members Vacancies Cell proliferation (blue nuclei) with excessive vascularisation (in red): early stage cancer in a hypoxic state. Toggle to view hero caption PublicationsYear published2024 (1)2023 (2)2022 (8)2021 (7)2020 (5)2019 (7)2018 (2)2017 (3)2016 (1)2015 (1) Facet Year publishedResearch topicsCell Biology (36)Metabolism (36)Signalling & Oncogenes (36)Biochemistry & Proteomics (35)Chemical Biology & High Throughput (4)Computational & Systems Biology (4)Genetics & Genomics (3)Genome Integrity & Repair (3)Human Biology & Physiology (3)Infectious Disease (3)Stem Cells (3)Tumour Biology (3)Cell Cycle & Chromosomes (2)Developmental Biology (2)Gene Expression (2)Imaging (2)Immunology (2)Model Organisms (2)Neurosciences (2)Structural Biology & Biophysics (2)Microfabrication & Bioengineering (1)Synthetic Biology (1) Facet Research topicsPublication typeJournal article (37)Primary research (28)Review (6)Commentary (2)Method (1) Facet Publication typeJournalJournal of Biological Chemistry (3)Cell Reports (2)eLife (2)Journal of Clinical Investigation (2)Nature Communications (2)Scientific Reports (2)American Journal of Respiratory and Critical Care Medicine (1)Cancer Research (1)Cardiovascular Research (1)Chemical Science (1)ChemMedChem (1)Circulation Research (1)Clinical medicine (London, England) (1)EMBO Reports (1)Endocrine-Related Cancer (1)Experimental Cell Research (1)Hypoxia (1)JAMA (1)Journal of Physiology (1)Life Science Alliance (1)Nature Biotechnology (1)Nature Chemical Biology (1)Nature Genetics (1)Nature Immunology (1)Nature Reviews Nephrology (1)Nature Structural and Molecular Biology (1)Proceedings of the National Academy of Sciences of USA (1)Science (1)Science Signaling (1)The Lancet (1) Facet Journal Publications Displaying 21 - 37 of 37Last updated : 29 March 2024 03:52 Scalable and robust SARS-CoV-2 testing in an academic center Authors (81) Jim Aitken Karen Ambrose Sam BarrellRupert Beale Ganka Bineva-Todd Dhruva Biswas[...]Sophie Ward Wai Keong WongJoshua Wright Mary Wu The Crick COVID-19 Consortium Nature Biotechnology Published 1 August 2020 Crick labs/ facilitiesAndreas WackJames TurnerCharles SwantonCaetano Reis e SousaPeter RatcliffeVenizelos PapayannopoulosGeorge KassiotisSonia GandhiSteve GamblinPeter Cherepanov Rupert BealeStructural BiologyMetabolomicsHigh Throughput ScreeningGenetic Modification ServiceFermentationBiological Research FacilityAdvanced SequencingScientific computingFull details Marked and rapid effects of pharmacological HIF-2α antagonism on hypoxic ventilatory control Authors (17) Xiaotong Cheng Maria Prange-Barczynska James W Fielding Minghao Zhang Alana L Burrell Joanna DCC Lima[...] Richard K BruickLucy Collinson Fraydoon Rastinejad Tammie BishopPeter Ratcliffe Journal of Clinical Investigation Published 1 May 2020 Crick labs/ facilitiesPeter RatcliffeElectron MicroscopyFull details Genetic basis of oxygen sensing in the carotid body: HIF2α and an isoform switch in cytochrome c oxidase subunit 4 Authors (2) Tammie BishopPeter Ratcliffe Science Signaling Published 21 January 2020 Crick labsPeter RatcliffeFull details Co-incidence of RCC-susceptibility polymorphisms with HIF cis-acting sequences supports a pathway tuning model of cancer Authors (10) Virginia Schmid Veronique N Lafleur Olivia Lombardi Ran Li Rafik Salama Leandro Colli Hani Choudhry Stephen ChanockPeter Ratcliffe David R Mole Scientific Reports Published 10 December 2019 Crick labsPeter RatcliffeFull details Structure-activity relationship and crystallographic studies on 4-hydroxypyrimidine HIF prolyl hydroxylase domain inhibitors Authors (13) James P Holt-Martyn Rasheduzzaman Chowdhury Anthony Tumber Tzu-Lan Yeh Martine I Abboud Kerstin Lippl[...] Jr Figg Michael A McDonough Christopher W PughPeter Ratcliffe Christopher J Schofield ChemMedChem Published 5 February 2020 Crick labsPeter RatcliffeFull details Lack of activity of recombinant HIF prolyl hydroxylases (PHDs) on reported non-HIF substrates Authors (11)Matthew Cockman Kerstin Lippl Ya-Min TianHamish Pegg William D Figg Martine I Abboud Raphael Heilig Roman Fischer Johanna Myllyharju Christopher J SchofieldPeter Ratcliffe eLife Published 10 September 2019 Crick labs/ facilitiesPeter RatcliffeProteomicsFull details Mechanisms of hypoxia signalling: new implications for nephrology Authors (2) Johannes SchödelPeter Ratcliffe Nature Reviews Nephrology Published 1 October 2019 Crick labsPeter RatcliffeFull details Conserved N-terminal cysteine dioxygenases transduce responses to hypoxia in animals and plants Authors (10) Norma Masson Thomas P Keeley Beatrice Giuntoli Mark D White Mikel Lavilla Puerta Pierdomenico Perata Richard J Hopkinson Emily Flashman Francesco LicausiPeter Ratcliffe Science Published 5 July 2019 Crick labsPeter RatcliffeFull details Systemic silencing of Phd2 causes reversible immune regulatory dysfunction Authors (25) Atsushi Yamamoto Joanna Hester Philip S Macklin Kento Kawai Masateru Uchiyama Daniel Biggs[...] Cheryl L Scudamore Elizabeth Soilleux Fadi IssaPeter Ratcliffe Chris W Pugh Journal of Clinical Investigation Published 3 September 2019 Crick labsPeter RatcliffeFull details Inherent DNA-binding specificities of the HIF-1α and HIF-2α transcription factors in chromatin Authors (11) James A Smythies Min Sun Norma Masson Rafik Salama Peter D Simpson Elizabeth Murray Viviana NeumannMatthew Cockman Hani ChoudhryPeter Ratcliffe David R Mole EMBO Reports Published 1 January 2019 Crick labsPeter RatcliffeFull details PHD2 inactivation in Type I cells drives HIF-2α dependent multilineage hyperplasia and the formation of paraganglioma-like carotid bodies Authors (13) James W FieldingEmma Hodson Xiaotong Cheng David JP Ferguson Luise Eckardt Julie Adam[...] Indrika Ratnayaka Christopher W Pugh Keith J BucklerPeter Ratcliffe Tammie Bishop Journal of Physiology Published 14 September 2018 Crick labsPeter RatcliffeFull details The Jumonji-C oxygenase JMJD7 catalyzes (3S)-lysyl hydroxylation of TRAFAC GTPases Authors (23) Suzana Markolovic Qinqin Zhuang Sarah E Wilkins Charlotte D Eaton Martine I Abboud Maximiliano J Katz[...] Roman Fischer Pablo Wappner Rasheduzzaman Chowdhury Mathew L Coleman Christopher J Schofield Nature Chemical Biology Published 18 June 2018 Crick labsKaren VousdenPeter RatcliffeFull details Molecular and cellular mechanisms of HIF prolyl hydroxylase inhibitors in clinical trials Authors (21) T-L Yeh TM Leissing MI Abboud CC Thinnes O Atasoylu JP Holt-Martyn[...] X LuPeter Ratcliffe R Chowdhury CW Pugh CJ Schofield Chemical Science Published 1 November 2017 Crick labsPeter RatcliffeFull details New horizons in hypoxia signaling pathways Authors (2) Christopher W PughPeter Ratcliffe Experimental Cell Research Published 14 March 2017 Crick labsPeter RatcliffeFull details Update on hypoxia-inducible factors and hydroxylases in oxygen regulatory pathways: from physiology to therapeutics Authors (11)Peter Ratcliffe P Koivunen J Myllyharju J Ragoussis JVMG Bovée I Batinic-Haberle C Vinatier V Trichet F Robriquet L Oliver B Gardie Hypoxia Published 1 January 2017 Crick labsPeter RatcliffeFull details Pathways for oxygen regulation and homeostasis: The 2016 Albert Lasker Basic Medical Research Award Authors (3) William G KaelinPeter Ratcliffe Gregg L Semenza JAMA Published 27 September 2016 Crick labsPeter RatcliffeFull details Recurrent chromosomal gains and heterogeneous driver mutations characterise papillary renal cancer evolution Authors (45) Michal Kovac Carolina Navas Stuart Horswell Max Salm Chiara BardellaAndrew Rowan[...] Stewart FlemingPeter Ratcliffe Karl HeinimannCharles Swanton Ian Tomlinson Nature Communications Published 19 March 2015 Crick labs/ facilitiesCharles SwantonPeter RatcliffeExperimental HistopathologyBioinformatics and BiostatisticsAdvanced SequencingFull details Pagination First page First Previous page Previous Page 1 Current page 2 Share the page Share on Twitter Share on Facebook Share on LinkedIn Share on Email
Scalable and robust SARS-CoV-2 testing in an academic center Authors (81) Jim Aitken Karen Ambrose Sam BarrellRupert Beale Ganka Bineva-Todd Dhruva Biswas[...]Sophie Ward Wai Keong WongJoshua Wright Mary Wu The Crick COVID-19 Consortium Nature Biotechnology Published 1 August 2020 Crick labs/ facilitiesAndreas WackJames TurnerCharles SwantonCaetano Reis e SousaPeter RatcliffeVenizelos PapayannopoulosGeorge KassiotisSonia GandhiSteve GamblinPeter Cherepanov Rupert BealeStructural BiologyMetabolomicsHigh Throughput ScreeningGenetic Modification ServiceFermentationBiological Research FacilityAdvanced SequencingScientific computingFull details
Marked and rapid effects of pharmacological HIF-2α antagonism on hypoxic ventilatory control Authors (17) Xiaotong Cheng Maria Prange-Barczynska James W Fielding Minghao Zhang Alana L Burrell Joanna DCC Lima[...] Richard K BruickLucy Collinson Fraydoon Rastinejad Tammie BishopPeter Ratcliffe Journal of Clinical Investigation Published 1 May 2020 Crick labs/ facilitiesPeter RatcliffeElectron MicroscopyFull details
Genetic basis of oxygen sensing in the carotid body: HIF2α and an isoform switch in cytochrome c oxidase subunit 4 Authors (2) Tammie BishopPeter Ratcliffe Science Signaling Published 21 January 2020 Crick labsPeter RatcliffeFull details
Co-incidence of RCC-susceptibility polymorphisms with HIF cis-acting sequences supports a pathway tuning model of cancer Authors (10) Virginia Schmid Veronique N Lafleur Olivia Lombardi Ran Li Rafik Salama Leandro Colli Hani Choudhry Stephen ChanockPeter Ratcliffe David R Mole Scientific Reports Published 10 December 2019 Crick labsPeter RatcliffeFull details
Structure-activity relationship and crystallographic studies on 4-hydroxypyrimidine HIF prolyl hydroxylase domain inhibitors Authors (13) James P Holt-Martyn Rasheduzzaman Chowdhury Anthony Tumber Tzu-Lan Yeh Martine I Abboud Kerstin Lippl[...] Jr Figg Michael A McDonough Christopher W PughPeter Ratcliffe Christopher J Schofield ChemMedChem Published 5 February 2020 Crick labsPeter RatcliffeFull details
Lack of activity of recombinant HIF prolyl hydroxylases (PHDs) on reported non-HIF substrates Authors (11)Matthew Cockman Kerstin Lippl Ya-Min TianHamish Pegg William D Figg Martine I Abboud Raphael Heilig Roman Fischer Johanna Myllyharju Christopher J SchofieldPeter Ratcliffe eLife Published 10 September 2019 Crick labs/ facilitiesPeter RatcliffeProteomicsFull details
Mechanisms of hypoxia signalling: new implications for nephrology Authors (2) Johannes SchödelPeter Ratcliffe Nature Reviews Nephrology Published 1 October 2019 Crick labsPeter RatcliffeFull details
Conserved N-terminal cysteine dioxygenases transduce responses to hypoxia in animals and plants Authors (10) Norma Masson Thomas P Keeley Beatrice Giuntoli Mark D White Mikel Lavilla Puerta Pierdomenico Perata Richard J Hopkinson Emily Flashman Francesco LicausiPeter Ratcliffe Science Published 5 July 2019 Crick labsPeter RatcliffeFull details
Systemic silencing of Phd2 causes reversible immune regulatory dysfunction Authors (25) Atsushi Yamamoto Joanna Hester Philip S Macklin Kento Kawai Masateru Uchiyama Daniel Biggs[...] Cheryl L Scudamore Elizabeth Soilleux Fadi IssaPeter Ratcliffe Chris W Pugh Journal of Clinical Investigation Published 3 September 2019 Crick labsPeter RatcliffeFull details
Inherent DNA-binding specificities of the HIF-1α and HIF-2α transcription factors in chromatin Authors (11) James A Smythies Min Sun Norma Masson Rafik Salama Peter D Simpson Elizabeth Murray Viviana NeumannMatthew Cockman Hani ChoudhryPeter Ratcliffe David R Mole EMBO Reports Published 1 January 2019 Crick labsPeter RatcliffeFull details
PHD2 inactivation in Type I cells drives HIF-2α dependent multilineage hyperplasia and the formation of paraganglioma-like carotid bodies Authors (13) James W FieldingEmma Hodson Xiaotong Cheng David JP Ferguson Luise Eckardt Julie Adam[...] Indrika Ratnayaka Christopher W Pugh Keith J BucklerPeter Ratcliffe Tammie Bishop Journal of Physiology Published 14 September 2018 Crick labsPeter RatcliffeFull details
The Jumonji-C oxygenase JMJD7 catalyzes (3S)-lysyl hydroxylation of TRAFAC GTPases Authors (23) Suzana Markolovic Qinqin Zhuang Sarah E Wilkins Charlotte D Eaton Martine I Abboud Maximiliano J Katz[...] Roman Fischer Pablo Wappner Rasheduzzaman Chowdhury Mathew L Coleman Christopher J Schofield Nature Chemical Biology Published 18 June 2018 Crick labsKaren VousdenPeter RatcliffeFull details
Molecular and cellular mechanisms of HIF prolyl hydroxylase inhibitors in clinical trials Authors (21) T-L Yeh TM Leissing MI Abboud CC Thinnes O Atasoylu JP Holt-Martyn[...] X LuPeter Ratcliffe R Chowdhury CW Pugh CJ Schofield Chemical Science Published 1 November 2017 Crick labsPeter RatcliffeFull details
New horizons in hypoxia signaling pathways Authors (2) Christopher W PughPeter Ratcliffe Experimental Cell Research Published 14 March 2017 Crick labsPeter RatcliffeFull details
Update on hypoxia-inducible factors and hydroxylases in oxygen regulatory pathways: from physiology to therapeutics Authors (11)Peter Ratcliffe P Koivunen J Myllyharju J Ragoussis JVMG Bovée I Batinic-Haberle C Vinatier V Trichet F Robriquet L Oliver B Gardie Hypoxia Published 1 January 2017 Crick labsPeter RatcliffeFull details
Pathways for oxygen regulation and homeostasis: The 2016 Albert Lasker Basic Medical Research Award Authors (3) William G KaelinPeter Ratcliffe Gregg L Semenza JAMA Published 27 September 2016 Crick labsPeter RatcliffeFull details
Recurrent chromosomal gains and heterogeneous driver mutations characterise papillary renal cancer evolution Authors (45) Michal Kovac Carolina Navas Stuart Horswell Max Salm Chiara BardellaAndrew Rowan[...] Stewart FlemingPeter Ratcliffe Karl HeinimannCharles Swanton Ian Tomlinson Nature Communications Published 19 March 2015 Crick labs/ facilitiesCharles SwantonPeter RatcliffeExperimental HistopathologyBioinformatics and BiostatisticsAdvanced SequencingFull details