Publications

A pan-cancer compendium of chromosomal instability

Authors (14)

Ruben M Drews
Barbara Hernando
Maxime Tarabichi
Kerstin Haase
Tom Lesluyes
Philip S Smith
[...]
Michael Schneider
James D Brenton
Peter Van Loo
Geoff Macintyre
Florian Markowetz

Nature

Published 30 June 2022

Crick labs

Peter Van Loo

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Signatures of copy number alterations in human cancer

Authors (24)

Christopher D Steele
Ammal Abbasi
SM Ashiqul Islam
Amy Bowes
Azhar Khandekar
Kerstin Haase
[...]
Adrienne M Flanagan
Maxime Tarabichi
Peter Van Loo
Ludmil B Alexandrov
Nischalan Pillay

Nature

Published 30 June 2022

Crick labs

Peter Van Loo

Full details

Estimation of tumor cell total mRNA expression in 15 cancer types predicts disease progression

Authors (40)

Shaolong Cao
Jennifer R Wang
Shuangxi Ji
Peng Yang
Yaoyi Dai
Shuai Guo
[...]
Hongtu Zhu
Alfonso Urbanucci
Jonas Demeulemeester
Peter Van Loo
Wenyi Wang

Nature Biotechnology

Published 13 June 2022

Crick labs

Full details

Leveraging single cell sequencing to unravel intra-tumour heterogeneity and tumour evolution in human cancers

Authors (4)

Journal of Pathology

Published 19 April 2022

Crick labs

Peter Van Loo

Full details

Biallelic mutations in cancer genomes reveal local mutational determinants

Authors (3)

Stefan C Dentro
Moritz Gerstung
Peter Van Loo

Nature Genetics

Published 1 February 2022

Crick labs

Peter Van Loo

Full details

Whole-genome analysis of Nigerian patients with breast cancer reveals ethnic-driven somatic evolution and distinct genomic subtypes

Authors (28)

Naser Ansari-Pour
Yonglan Zheng
Toshio F Yoshimatsu
Ayodele Sanni
Mustapha Ajani
Jean-Baptiste Reynier
[...]
Oladosu Ojengbede
John Obafunwa
Dezheng Huo
David C Wedge
Olufunmilayo I Olopade

Nature Communications

Published 26 November 2021

Crick labs

Peter Van Loo

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Aberrant integration of Hepatitis B virus DNA promotes major restructuring of human hepatocellular carcinoma genome architecture

Authors (43)

Eva G Álvarez
Jonas Demeulemeester
Paula Otero
Clemency Jolly
Daniel García-Souto
Ana Pequeño-Valtierra
[...]
Urtzi Garaigorta
Peter J Campbell
Hidewaki Nakagawa
Peter Van Loo
Jose MC Tubio

Nature Communications

Published 25 November 2021

Crick labs

Peter Van Loo

Full details

DeCiFering the subclonal composition of tumors

Authors (4)

Cell systems

Published 20 October 2021

Crick labs

Peter Van Loo

Full details

A pan-cancer landscape of somatic mutations in non-unique regions of the human genome

Authors (5)

Jonas Demeulemeester
Annelien Verfaillie
Adrienne M Flanagan
Peter Van Loo
Tomasz Konopka

Nature Biotechnology

Published 1 December 2021

Crick labs/ facilities

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Chemotherapy induces canalization of cell state in childhood B-cell precursor acute lymphoblastic leukemia

Authors (28)

VA Turati
JA Guerra-Assunção
NE Potter
R Gupta
S Ecker
A Daneviciute
[...]
Peter Van Loo
SE Jacobsen
M Greaves
J Herrero
T Enver

Nature Cancer

Published 1 August 2021

Crick labs

Peter Van Loo

Full details

E3 ubiquitin ligase HECTD2 mediates melanoma progression and immune evasion

Authors (15)

Oncogene

Published 16 September 2021

Crick labs/ facilities

Full details

Allele-specific multi-sample copy number segmentation in ASCAT

Authors (4)

Edith M Ross
Kerstin Haase
Peter Van Loo
Florian Markowetz

Bioinformatics

Published 1 July 2021

Crick labs

Peter Van Loo

Full details

An integrative analysis of the age-associated multi-omic landscape across cancers

Authors (5)

Kasit Chatsirisupachai
Tom Lesluyes
Luminita Paraoan
Peter Van Loo
João Pedro de Magalhães

Nature Communications

Published 20 April 2021

Crick labs

Peter Van Loo

Full details

Characterizing genetic intra-tumor heterogeneity across 2,658 human cancer genomes

Authors (121)

Stefan C Dentro
Ignaty Leshchiner
Kerstin Haase
Maxime Tarabichi
Jeff Wintersinger
Amit G Deshwar
[...]
Paul T Spellman
David C Wedge
Peter Van Loo
PCAWG Evolution and Heterogeneity Working Group
PCAWG Consortium

Cell

Published 15 April 2021

Crick labs/ facilities

Full details

Promises and challenges of adoptive T-cell therapies for solid tumours

Authors (21)

Matteo Morotti
Ashwag Albukhari
Abdulkhaliq Alsaadi
Mara Artibani
James D Brenton
Stuart M Curbishley
[...]
Helen White
Nina Wietek
David N Church
David C Wedge
Ahmed A Ahmed

British Journal of Cancer

Published 25 May 2021

Crick labs

Peter Van Loo

Full details

Breast tumours maintain a reservoir of subclonal diversity during expansion

Authors (27)

Darlan C Minussi
Michael D Nicholson
Hanghui Ye
Alexander Davis
Kaile Wang
Toby Baker
[...]
Banu Arun
Funda Meric-Bernstam
Peter Van Loo
Franziska Michor
Nicholas E Navin

Nature

Published 8 April 2021

Crick labs

Peter Van Loo

Full details

Common clonal origin of conventional T cells and induced regulatory T cells in breast cancer patients

Authors (25)

Maria Xydia
Raheleh Rahbari
Eliana Ruggiero
Iain Macaulay
Maxime Tarabichi
Robert Lohmayer
[...]
Manfred Schmidt
Christof von Kalle
Florian Schütz
Thierry Voet
Philipp Beckhove

Nature Communications

Published 18 February 2021

Crick labs

Peter Van Loo

Full details

Meta-analysis of tumor- and T cell-intrinsic mechanisms of sensitization to checkpoint inhibition

Authors (28)

Kevin Litchfield
James L Reading
Clare Puttick
Krupa Thakkar
Chris Abbosh
Robert Bentham
[...]
Matthew D Hellmann
Samra Turajlic
Sergio A Quezada
Nicholas McGranahan
Charles Swanton

Cell

Published 4 February 2021

Crick labs

Full details

A practical guide to cancer subclonal reconstruction from DNA sequencing

Authors (9)

Maxime Tarabichi
Adriana Salcedo
Amit G Deshwar
Máire Ni Leathlobhair
Jeff Wintersinger
David C Wedge
Peter Van Loo
Quaid D Morris
Paul C Boutros

Nature Methods

Published 1 February 2021

Crick labs

Peter Van Loo

Full details

Retrospective evaluation of whole exome and genome mutation calls in 746 cancer samples

Authors (20)

MH Bailey
WU Meyerson
LJ Dursi
LB Wang
G Dong
WW Liang
[...]
G Getz
Jared T Simpson
MB Gerstein
L Ding
PCAWG Consortium

Nature Communications

Published 21 September 2020

Crick labs

Peter Van Loo

Full details

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Coronavirus (COVID-19) research

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A pan-cancer compendium of chromosomal instability

Signatures of copy number alterations in human cancer

Estimation of tumor cell total mRNA expression in 15 cancer types predicts disease progression

Leveraging single cell sequencing to unravel intra-tumour heterogeneity and tumour evolution in human cancers

Biallelic mutations in cancer genomes reveal local mutational determinants

Whole-genome analysis of Nigerian patients with breast cancer reveals ethnic-driven somatic evolution and distinct genomic subtypes

Aberrant integration of Hepatitis B virus DNA promotes major restructuring of human hepatocellular carcinoma genome architecture

DeCiFering the subclonal composition of tumors

A pan-cancer landscape of somatic mutations in non-unique regions of the human genome

Chemotherapy induces canalization of cell state in childhood B-cell precursor acute lymphoblastic leukemia

E3 ubiquitin ligase HECTD2 mediates melanoma progression and immune evasion

Allele-specific multi-sample copy number segmentation in ASCAT

An integrative analysis of the age-associated multi-omic landscape across cancers

Characterizing genetic intra-tumor heterogeneity across 2,658 human cancer genomes

Promises and challenges of adoptive T-cell therapies for solid tumours

Breast tumours maintain a reservoir of subclonal diversity during expansion

Common clonal origin of conventional T cells and induced regulatory T cells in breast cancer patients

Meta-analysis of tumor- and T cell-intrinsic mechanisms of sensitization to checkpoint inhibition

A practical guide to cancer subclonal reconstruction from DNA sequencing

Retrospective evaluation of whole exome and genome mutation calls in 746 cancer samples

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