Publications

Structural basis of CSN-mediated SCF deneddylation

Authors (6)

Shan Ding
Julie A Clapperton
Erik Maeots
Simone Kunzelmann
Mohammed Shaaban
Radoslav Enchev

Nature Communications

Published 27 January 2026

Crick labs/ facilities

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The ribosome synchronizes folding and assembly to promote oligomeric protein biogenesis

Authors (10)

Alzbeta Roeselova
Santosh Shivakumaraswamy
Gabija Jurkeviciute
Jessica He
Josef Auburger
Jaro L Schmitt
Günter Kramer
Bernd Bukau
Radoslav Enchev
David Balchin

Molecular Cell

Published 19 February 2026

Crick labs/ facilities

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GroEL/ES chaperonin unfolds then encapsulates a nascent protein on the ribosome

Authors (8)

Alzbeta Roeselova
Sarah L Maslen
Jessica He
Gabija Jurkeviciute
Aleksandra Pajak
Mark Skehel
Radoslav Enchev
David Balchin

Nature Communications

Published 13 November 2025

Crick labs/ facilities

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Chronobot: Deep learning guided time-resolved cryo-EM
captures molecular choreography of RecA in homology search

Preprint

Authors (8)

Erik Maeots
Simon Tupin
Mohammad Mehdi Nasr Esfahani
Juan B Rodriguez Molina
Julie A Clapperton
Aran Amin
Albane Imbert
Radoslav Enchev

bioRxiv

Published 22 April 2025

Crick labs/ facilities

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HSC70 coordinates COP9 signalosome and SCF ubiquitin ligase activity to enable a prompt stress response

Authors (14)

Shunsuke Nishimura
Hidetaka Kioka
Shan Ding
Hideyuki Hakui
Haruki Shinomiya
Kazuya Tanabe
[...]
Osamu Tsukamoto
Yoshihiro Asano
Seiji Takashima
Radoslav Enchev
Yasushi Sakata

EMBO Reports

Published 10 March 2025

Crick labs

Radoslav Enchev

Full details

BioStudies entry S-SCDT-10_1038-S44319-025-00376-X: HSC70 coordinates COP9 signalosome and SCF ubiquitin ligase activity to enable a prompt stress response

Authors (2)

Shan Ding
Radoslav Enchev

BioStudies

Published 4 February 2025

Crick labs

Radoslav Enchev

Full details

Nous sommes de jeunes scientifiques d'économies émergentes - le monde a besoin de plus de chercheurs comme nous pour résoudre les problèmes mondiaux

Authors (3)

Mohammed Shaaban
Abib Duut
Nana Mensah

Nature Africa

Published 7 August 2024

Crick labs

Full details

We are junior scientists from emerging economies - the world needs more researchers like us solving global problems

Authors (3)

Mohammed Shaaban
Abib Duut
Nana Mensah

Nature

Published 26 July 2024

Crick labs

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PRIDE entry PXD042178: Structural and mechanistic insights into the CAND1-mediated SCF substrate receptor exchange

Authors (2)

John Skehel
Radoslav Enchev

PRoteomics IDEntifications database (PRIDE)

Published 18 September 2023

Crick labs/ facilities

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EMDB entry EMD-17114: CAND1-CUL1-RBX1-SKP1-SKP2-CKS1-CDK2

Authors (7)

Mohammed Shaaban
Julie Clapperton
Shan Ding
Erik Maeots
Radoslav Enchev
Sarah Maslen
John Skehel

Electron Microscopy Data Bank (EMDB)

Published 28 June 2023

Crick labs/ facilities

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EMDB entry EMD-17115: CAND1-CUL1-RBX1-DCNL1

Authors (7)

Mohammed Shaaban
Julie Clapperton
Shan Ding
Erik Maeots
Radoslav Enchev
Sarah Maslen
John Skehel

Electron Microscopy Data Bank (EMDB)

Published 28 June 2023

Crick labs/ facilities

Full details

EMDB entry EMD-17116: CAND1-CUL1-RBX1-SKP1-SKP2-DCNL1

Authors (7)

Mohammed Shaaban
Julie Clapperton
Shan Ding
Erik Maeots
Radoslav Enchev
Sarah Maslen
John Skehel

Electron Microscopy Data Bank (EMDB)

Published 28 June 2023

Crick labs/ facilities

Full details

EMDB entry EMD-17117: Partially dissociated CAND1-CUL1-RBX1-SKP1-SKP2-CKS1-CDK2

Authors (7)

Mohammed Shaaban
Julie Clapperton
Shan Ding
Erik Maeots
Radoslav Enchev
Sarah Maslen
John Skehel

Electron Microscopy Data Bank (EMDB)

Published 28 June 2023

Crick labs/ facilities

Full details

PDB Entry 8OR0: CAND1-CUL1-RBX1-SKP1-SKP2-CKS1-CDK2

Authors (5)

Mohammed Shaaban
Julie Clapperton
Shan Ding
Erik Maeots
Radoslav Enchev

Protein Data Bank (RCSB PDB)

Published 28 June 2023

Crick labs/ facilities

Full details

PDB Entry 8OR2: CAND1-CUL1-RBX1-DCNL1

Authors (5)

Mohammed Shaaban
Julie Clapperton
Shan Ding
Erik Maeots
Radoslav Enchev

Protein Data Bank (RCSB PDB)

Published 28 June 2023

Crick labs/ facilities

Full details

PDB Entry 8OR3: CAND1-CUL1-RBX1-SKP1-SKP2-DCNL1

Authors (5)

Mohammed Shaaban
Julie Clapperton
Shan Ding
Erik Maeots
Radoslav Enchev

Protein Data Bank (RCSB PDB)

Published 28 June 2023

Crick labs/ facilities

Full details

PDB Entry 8OR4: Partially dissociated CAND1-CUL1-RBX1-SKP1-SKP2-CKS1-CDK2

Authors (5)

Mohammed Shaaban
Julie Clapperton
Shan Ding
Erik Maeots
Radoslav Enchev

Protein Data Bank (RCSB PDB)

Published 28 June 2023

Crick labs/ facilities

Full details

EMDB entry EMD-17124: CAND1-CUL1-RBX1

Authors (5)

Mohammed Shaaban
Julie Clapperton
Shan Ding
Erik Maeots
Radoslav Enchev

Electron Microscopy Data Bank (EMDB)

Published 21 June 2023

Crick labs/ facilities

Full details

Mendeley Data deposit: Structural and mechanistic insights into the CAND1-mediated SCF substrate receptor exchange. Shaaban et al

Authors (1)

Radoslav Enchev

Mendeley

Published 21 June 2023

Crick labs/ facilities

Full details

Structural and mechanistic insights into the CAND1-mediated SCF substrate receptor exchange

Authors (8)

Mohammed Shaaban
Julie A Clapperton
Shan Ding
Simone Kunzelmann
Erik Maeots
Sarah L Maslen
Mark Skehel
Radoslav Enchev

Molecular Cell

Published 6 July 2023

Crick labs/ facilities

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Structural basis of CSN-mediated SCF deneddylation

The ribosome synchronizes folding and assembly to promote oligomeric protein biogenesis

GroEL/ES chaperonin unfolds then encapsulates a nascent protein on the ribosome

Chronobot: Deep learning guided time-resolved cryo-EM
captures molecular choreography of RecA in homology search

HSC70 coordinates COP9 signalosome and SCF ubiquitin ligase activity to enable a prompt stress response

BioStudies entry S-SCDT-10_1038-S44319-025-00376-X: HSC70 coordinates COP9 signalosome and SCF ubiquitin ligase activity to enable a prompt stress response

Nous sommes de jeunes scientifiques d'économies émergentes - le monde a besoin de plus de chercheurs comme nous pour résoudre les problèmes mondiaux

We are junior scientists from emerging economies - the world needs more researchers like us solving global problems

PRIDE entry PXD042178: Structural and mechanistic insights into the CAND1-mediated SCF substrate receptor exchange

EMDB entry EMD-17114: CAND1-CUL1-RBX1-SKP1-SKP2-CKS1-CDK2

EMDB entry EMD-17115: CAND1-CUL1-RBX1-DCNL1

EMDB entry EMD-17116: CAND1-CUL1-RBX1-SKP1-SKP2-DCNL1

EMDB entry EMD-17117: Partially dissociated CAND1-CUL1-RBX1-SKP1-SKP2-CKS1-CDK2

PDB Entry 8OR0: CAND1-CUL1-RBX1-SKP1-SKP2-CKS1-CDK2

PDB Entry 8OR2: CAND1-CUL1-RBX1-DCNL1

PDB Entry 8OR3: CAND1-CUL1-RBX1-SKP1-SKP2-DCNL1

PDB Entry 8OR4: Partially dissociated CAND1-CUL1-RBX1-SKP1-SKP2-CKS1-CDK2

EMDB entry EMD-17124: CAND1-CUL1-RBX1

Mendeley Data deposit: Structural and mechanistic insights into the CAND1-mediated SCF substrate receptor exchange. Shaaban et al

Structural and mechanistic insights into the CAND1-mediated SCF substrate receptor exchange

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