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Breadcrumb Rickie Patani Patani lab Human Stem Cells and Neurodegeneration Laboratory : Publications Lab contentLab contentIn this section Overview Vacancies Lab news Publications Members Human stem cell derived spinal motor neurons (left) and astrocytes (right). Credit: Dr Giulia Tyzack (Patani Lab). Toggle to view hero caption PublicationsYear published2023 (10)2022 (5)2021 (13)2020 (14)2019 (4)2018 (6)2017 (4)2016 (1) Facet Year publishedResearch topicsCell Biology (57)Neurosciences (57)Stem Cells (57)Computational & Systems Biology (14)Genetics & Genomics (14)Gene Expression (13)Tumour Biology (11)Biochemistry & Proteomics (9)Chemical Biology & High Throughput (6)Imaging (5)Microfabrication & Bioengineering (5)Genome Integrity & Repair (4)Model Organisms (3)Structural Biology & Biophysics (2)Cell Cycle & Chromosomes (1)Developmental Biology (1)Human Biology & Physiology (1)Immunology (1)Infectious Disease (1)Signalling & Oncogenes (1) Facet Research topicsPublication typeJournal article (57)Primary research (39)Review (15)Biography (1)Commentary (1)Policy letter (1) Facet Publication typeJournalBrain (11)Cell Reports (3)Journal of Neurotrauma (3)Nature Communications (3)Genome Research (2)International Journal of Molecular Sciences (2)Neuron (2)Nucleic Acids Research (2)Advanced Healthcare Materials (1)Ageing Research Reviews (1)Aging Cell (1)Antioxidants (1)Applied Sciences (Switzerland) (1)Brain Communications (1)Brain Pathology (1)Cell (1)eLife (1)EMBO Reports (1)Expert opinion on therapeutic targets (1)Frontiers in Neurology (1)Glia (1)Journal of Cellular and Molecular Medicine (1)Journal of Neuroinflammation (1)Life Science Alliance (1)Medicinal Research Reviews (1)Molecular Cell (1)Molecular Neurobiology (1)Nature (1)Nature Human Behaviour (1)Nature Medicine (1)Nature Reviews Neurology (1)Neuropathology and Applied Neurobiology (1)npj Parkinsons Disease (1)Progress in Neurobiology (1)Scientific Reports (1)Stem Cells (1)Trends in Neurosciences (1) Facet Journal Publications Displaying 1 - 20 of 57Last updated : 22 September 2023 02:12 Transcriptome-wide RNA binding analysis of C9orf72 poly(PR) dipeptides Authors (14) Rubika BalendraIgor Ruiz De Los Mozos Hana M Odeh Idoia Glaria Carmelo Milioto Katherine M Wilson[...] Stephen MartinRickie Patani James ShorterJernej Ule Adrian M Isaacs Life Science Alliance Published 1 September 2023 Crick labs/ facilitiesJernej UleRickie PataniStructural BiologyHigh Throughput ScreeningFull details Nonsense-mediated mRNA decay in neuronal physiology and neurodegeneration Authors (2)Marija Petric HoweRickie Patani Trends in Neurosciences Published 3 August 2023 Crick labsRickie PataniFull details Amplifying the heat shock response ameliorates ALS and FTD pathology in mouse and human models Authors (7) Mhoriam Ahmed Charlotte SpicerJasmine Harley J Paul Taylor Michael HannaRickie Patani Linda Greensmith Molecular Neurobiology Published 29 July 2023 Crick labsRickie PataniFull details Nucleocytoplasmic mRNA redistribution accompanies RNA binding protein mislocalization in ALS motor neurons and is restored by VCP ATPase inhibition Authors (10)Oliver ZiffJasmine HarleyYiran WangJacob NeevesGiulia Tyzack Fairouz IbrahimMark SkehelAnob ChakrabartiGavin KellyRickie Patani Neuron Published 21 July 2023 Crick labs/ facilitiesJernej UleRickie PataniProteomicsBioinformatics and BiostatisticsFull details Direct m6A recognition by IMP1 underlays an alternative model of target selection for non-canonical methyl-readers Authors (12)Giuseppe Nicastro Giancarlo AbisPierre Klein Sofia Esteban-Serna Christopher Gallagher Belen Chaves-Arquero[...] Angelo Miguel Figueiredo Stephen R MartinRickie PataniIan Taylor Andres Ramos Nucleic Acids Research Published 8 September 2023 Crick labs/ facilitiesIan TaylorRickie PataniStructural BiologyMRC Biomedical NMR CentreFull details Functional roles of reactive astrocytes in neuroinflammation and neurodegeneration Authors (3)Rickie Patani Giles E Hardingham Shane A Liddelow Nature Reviews Neurology Published 1 July 2023 Crick labsRickie PataniFull details Modelling the inflammatory response of traumatic brain injury using human induced pluripotent stem cell derived microglia Authors (11) Aftab Alam Tanya Singh Saeed Kayhanian Jonathan Tjerkaski Nuria Marco Garcia Keri CarpenterRickie Patani Caroline Lindblad Eric Peter Thelin Yasir Ahmed Syed Adel Helmy Journal of Neurotrauma Published 1 June 2023 Crick labsRickie PataniFull details UK PhD students’ call to action amid the cost-of-living crisis Authors (2) Emma R FrancisHannah Franklin Nature Human Behaviour Published 17 May 2023 Crick labsRickie PataniFull details Integrated transcriptome landscape of ALS identifies genome instability linked to TDP-43 pathology Authors (14)Oliver ZiffJacob NeevesJamie MitchellGiulia Tyzack Carlos Martinez-Ruiz Raphaelle Luisier[...]Simon Boulton Ammar Al-ChalabiGavin Kelly Jack HumphreyRickie Patani Nature Communications Published 20 April 2023 Crick labs/ facilitiesJernej UleRickie PataniSimon BoultonBioinformatics and BiostatisticsScientific computingFull details Molecular mechanisms of amyotrophic lateral sclerosis as broad therapeutic targets for gene therapy applications utilizing adeno-associated viral vectors Authors (4) Jessica Merjane Roger ChungRickie Patani Leszek Lisowski Medicinal Research Reviews Published 1 July 2023 Crick labsRickie PataniFull details Protein aggregation and calcium dysregulation are hallmarks of familial Parkinson's disease in midbrain dopaminergic neurons Authors (26)Gurvir VirdiMinee ChoiJames EvansZhi YaoDilan Athauda Stephanie Strohbuecker[...] Tilo Kunath Mathew H Horrocks Andrey Y AbramovRickie PataniSonia Gandhi npj Parkinsons Disease Published 24 November 2022 Crick labs/ facilitiesRickie PataniSonia GandhiBioinformatics and BiostatisticsAdvanced SequencingLight MicroscopyFlow CytometryFull details Physiological intron retaining transcripts in the cytoplasm abound during human motor neurogenesis Authors (9)Marija Petric HoweHamish CrerarJacob NeevesJasmine HarleyGiulia TyzackPierre Klein Andres RamosRickie Patani Raphaëlle Luisier Genome Research Published 1 October 2022 Crick labsRickie PataniFull details The role of astrocytes in prion-like mechanisms of neurodegeneration Authors (5) Phillip SmethurstHannah FranklinBen Clarke Katie SidleRickie Patani Brain Published 1 January 2022 Crick labsRickie PataniFull details Axonal length determines distinct homeostatic phenotypes in human iPSC derived motor neurons on a bioengineered platform Authors (8)Cathleen Hagemann Carmen Moreno GonzalezLudovica GuettaGiulia Tyzack Ciro Chiappini Andrea LegatiRickie PataniAndrea Serio Advanced Healthcare Materials Published 18 May 2022 Crick labsAndrea SerioRickie PataniFull details Astrocytes display cell autonomous and diverse early reactive states in familial amyotrophic lateral sclerosis Authors (14)Doaa TahaBen Clarke Claire E HallGiulia TyzackOliver Ziff Linda Greensmith[...] Eric P Thelin Nuria Marco Garcia Adel Helmy Christopher R SibleyRickie Patani Brain Published 1 February 2022 Crick labsRickie PataniFull details Meta-analysis of human and mouse ALS astrocytes reveals multi-omic signatures of inflammatory reactive states Authors (6)Oliver ZiffBen ClarkeDoaa TahaHamish CrerarNicholas LuscombeRickie Patani Genome Research Published 1 January 2022 Crick labs/ facilitiesRickie PataniNicholas LuscombeScientific computingProteomicsBioinformatics and BiostatisticsAdvanced SequencingFull details Elevated 4R-tau in astrocytes from asymptomatic carriers of the MAPT 10+16 intronic mutation Authors (13) Núria Setó-Salvia Noemi Esteras Rohan de Silva Eduardo de Pablo-Fernandez Charles Arber Christina E Toomey[...] Jonathan D Rohrer Andrey Y AbramovRickie Patani Selina Wray Thomas T Warner Journal of Cellular and Molecular Medicine Published 1 February 2022 Crick labsRickie PataniFull details Image-based deep learning reveals the responses of human motor neurons to stress and VCP-related ALS Authors (4) Colombine VerzatJasmine HarleyRickie Patani Raphaëlle Luisier Neuropathology and Applied Neurobiology Published 1 February 2022 Crick labsRickie PataniFull details TDP-43 condensation properties specify its RNA-binding and regulatory repertoire Authors (17)Martina HalleggerAnob ChakrabartiFlora Lee Bo Lim Lee Aram G Amalietti Hana M Odeh[...]Rickie Patani Nicolas L Fawzi James ShorterNicholas LuscombeJernej Ule Cell Published 2 September 2021 Crick labs/ facilitiesJernej UleRickie PataniNicholas LuscombeLight MicroscopyAdvanced SequencingFull details TDP-43 and FUS mislocalization in VCP mutant motor neurons is reversed by pharmacological inhibition of the VCP D2 ATPase domain Authors (4)Jasmine HarleyCathleen HagemannAndrea SerioRickie Patani Brain Communications Published 6 August 2021 Crick labsAndrea SerioRickie PataniFull details Pagination Current page 1 Page 2 Page 3 Next page Next Last page Last Share the page Share on Twitter Share on Facebook Share on LinkedIn Share on Email
Transcriptome-wide RNA binding analysis of C9orf72 poly(PR) dipeptides Authors (14) Rubika BalendraIgor Ruiz De Los Mozos Hana M Odeh Idoia Glaria Carmelo Milioto Katherine M Wilson[...] Stephen MartinRickie Patani James ShorterJernej Ule Adrian M Isaacs Life Science Alliance Published 1 September 2023 Crick labs/ facilitiesJernej UleRickie PataniStructural BiologyHigh Throughput ScreeningFull details
Nonsense-mediated mRNA decay in neuronal physiology and neurodegeneration Authors (2)Marija Petric HoweRickie Patani Trends in Neurosciences Published 3 August 2023 Crick labsRickie PataniFull details
Amplifying the heat shock response ameliorates ALS and FTD pathology in mouse and human models Authors (7) Mhoriam Ahmed Charlotte SpicerJasmine Harley J Paul Taylor Michael HannaRickie Patani Linda Greensmith Molecular Neurobiology Published 29 July 2023 Crick labsRickie PataniFull details
Nucleocytoplasmic mRNA redistribution accompanies RNA binding protein mislocalization in ALS motor neurons and is restored by VCP ATPase inhibition Authors (10)Oliver ZiffJasmine HarleyYiran WangJacob NeevesGiulia Tyzack Fairouz IbrahimMark SkehelAnob ChakrabartiGavin KellyRickie Patani Neuron Published 21 July 2023 Crick labs/ facilitiesJernej UleRickie PataniProteomicsBioinformatics and BiostatisticsFull details
Direct m6A recognition by IMP1 underlays an alternative model of target selection for non-canonical methyl-readers Authors (12)Giuseppe Nicastro Giancarlo AbisPierre Klein Sofia Esteban-Serna Christopher Gallagher Belen Chaves-Arquero[...] Angelo Miguel Figueiredo Stephen R MartinRickie PataniIan Taylor Andres Ramos Nucleic Acids Research Published 8 September 2023 Crick labs/ facilitiesIan TaylorRickie PataniStructural BiologyMRC Biomedical NMR CentreFull details
Functional roles of reactive astrocytes in neuroinflammation and neurodegeneration Authors (3)Rickie Patani Giles E Hardingham Shane A Liddelow Nature Reviews Neurology Published 1 July 2023 Crick labsRickie PataniFull details
Modelling the inflammatory response of traumatic brain injury using human induced pluripotent stem cell derived microglia Authors (11) Aftab Alam Tanya Singh Saeed Kayhanian Jonathan Tjerkaski Nuria Marco Garcia Keri CarpenterRickie Patani Caroline Lindblad Eric Peter Thelin Yasir Ahmed Syed Adel Helmy Journal of Neurotrauma Published 1 June 2023 Crick labsRickie PataniFull details
UK PhD students’ call to action amid the cost-of-living crisis Authors (2) Emma R FrancisHannah Franklin Nature Human Behaviour Published 17 May 2023 Crick labsRickie PataniFull details
Integrated transcriptome landscape of ALS identifies genome instability linked to TDP-43 pathology Authors (14)Oliver ZiffJacob NeevesJamie MitchellGiulia Tyzack Carlos Martinez-Ruiz Raphaelle Luisier[...]Simon Boulton Ammar Al-ChalabiGavin Kelly Jack HumphreyRickie Patani Nature Communications Published 20 April 2023 Crick labs/ facilitiesJernej UleRickie PataniSimon BoultonBioinformatics and BiostatisticsScientific computingFull details
Molecular mechanisms of amyotrophic lateral sclerosis as broad therapeutic targets for gene therapy applications utilizing adeno-associated viral vectors Authors (4) Jessica Merjane Roger ChungRickie Patani Leszek Lisowski Medicinal Research Reviews Published 1 July 2023 Crick labsRickie PataniFull details
Protein aggregation and calcium dysregulation are hallmarks of familial Parkinson's disease in midbrain dopaminergic neurons Authors (26)Gurvir VirdiMinee ChoiJames EvansZhi YaoDilan Athauda Stephanie Strohbuecker[...] Tilo Kunath Mathew H Horrocks Andrey Y AbramovRickie PataniSonia Gandhi npj Parkinsons Disease Published 24 November 2022 Crick labs/ facilitiesRickie PataniSonia GandhiBioinformatics and BiostatisticsAdvanced SequencingLight MicroscopyFlow CytometryFull details
Physiological intron retaining transcripts in the cytoplasm abound during human motor neurogenesis Authors (9)Marija Petric HoweHamish CrerarJacob NeevesJasmine HarleyGiulia TyzackPierre Klein Andres RamosRickie Patani Raphaëlle Luisier Genome Research Published 1 October 2022 Crick labsRickie PataniFull details
The role of astrocytes in prion-like mechanisms of neurodegeneration Authors (5) Phillip SmethurstHannah FranklinBen Clarke Katie SidleRickie Patani Brain Published 1 January 2022 Crick labsRickie PataniFull details
Axonal length determines distinct homeostatic phenotypes in human iPSC derived motor neurons on a bioengineered platform Authors (8)Cathleen Hagemann Carmen Moreno GonzalezLudovica GuettaGiulia Tyzack Ciro Chiappini Andrea LegatiRickie PataniAndrea Serio Advanced Healthcare Materials Published 18 May 2022 Crick labsAndrea SerioRickie PataniFull details
Astrocytes display cell autonomous and diverse early reactive states in familial amyotrophic lateral sclerosis Authors (14)Doaa TahaBen Clarke Claire E HallGiulia TyzackOliver Ziff Linda Greensmith[...] Eric P Thelin Nuria Marco Garcia Adel Helmy Christopher R SibleyRickie Patani Brain Published 1 February 2022 Crick labsRickie PataniFull details
Meta-analysis of human and mouse ALS astrocytes reveals multi-omic signatures of inflammatory reactive states Authors (6)Oliver ZiffBen ClarkeDoaa TahaHamish CrerarNicholas LuscombeRickie Patani Genome Research Published 1 January 2022 Crick labs/ facilitiesRickie PataniNicholas LuscombeScientific computingProteomicsBioinformatics and BiostatisticsAdvanced SequencingFull details
Elevated 4R-tau in astrocytes from asymptomatic carriers of the MAPT 10+16 intronic mutation Authors (13) Núria Setó-Salvia Noemi Esteras Rohan de Silva Eduardo de Pablo-Fernandez Charles Arber Christina E Toomey[...] Jonathan D Rohrer Andrey Y AbramovRickie Patani Selina Wray Thomas T Warner Journal of Cellular and Molecular Medicine Published 1 February 2022 Crick labsRickie PataniFull details
Image-based deep learning reveals the responses of human motor neurons to stress and VCP-related ALS Authors (4) Colombine VerzatJasmine HarleyRickie Patani Raphaëlle Luisier Neuropathology and Applied Neurobiology Published 1 February 2022 Crick labsRickie PataniFull details
TDP-43 condensation properties specify its RNA-binding and regulatory repertoire Authors (17)Martina HalleggerAnob ChakrabartiFlora Lee Bo Lim Lee Aram G Amalietti Hana M Odeh[...]Rickie Patani Nicolas L Fawzi James ShorterNicholas LuscombeJernej Ule Cell Published 2 September 2021 Crick labs/ facilitiesJernej UleRickie PataniNicholas LuscombeLight MicroscopyAdvanced SequencingFull details
TDP-43 and FUS mislocalization in VCP mutant motor neurons is reversed by pharmacological inhibition of the VCP D2 ATPase domain Authors (4)Jasmine HarleyCathleen HagemannAndrea SerioRickie Patani Brain Communications Published 6 August 2021 Crick labsAndrea SerioRickie PataniFull details