Publications

Transcriptome-wide RNA binding analysis of C9orf72 poly(PR) dipeptides

Authors (14)

Rubika Balendra
Igor Ruiz De Los Mozos
Hana M Odeh
Idoia Glaria
Carmelo Milioto
Katherine M Wilson
[...]
Stephen Martin
Rickie Patani
James Shorter
Jernej Ule
Adrian M Isaacs

Life Science Alliance

Published 1 September 2023

Crick labs/ facilities

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Nonsense-mediated mRNA decay in neuronal physiology and neurodegeneration

Authors (2)

Trends in Neurosciences

Published 3 August 2023

Crick labs

Rickie Patani

Full details

Amplifying the heat shock response ameliorates ALS and FTD pathology in mouse and human models

Authors (7)

Mhoriam Ahmed
Charlotte Spicer
Jasmine Harley
J Paul Taylor
Michael Hanna
Rickie Patani
Linda Greensmith

Molecular Neurobiology

Published 29 July 2023

Crick labs

Rickie Patani

Full details

Nucleocytoplasmic mRNA redistribution accompanies RNA binding protein mislocalization in ALS motor neurons and is restored by VCP ATPase inhibition

Authors (10)

Neuron

Published 21 July 2023

Crick labs/ facilities

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Direct m6A recognition by IMP1 underlays an alternative model of target selection for non-canonical methyl-readers

Authors (12)

Giuseppe Nicastro
Giancarlo Abis
Pierre Klein
Sofia Esteban-Serna
Christopher Gallagher
Belen Chaves-Arquero
[...]
Angelo Miguel Figueiredo
Stephen R Martin
Rickie Patani
Ian Taylor
Andres Ramos

Nucleic Acids Research

Published 8 September 2023

Crick labs/ facilities

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Functional roles of reactive astrocytes in neuroinflammation and neurodegeneration

Authors (3)

Rickie Patani
Giles E Hardingham
Shane A Liddelow

Nature Reviews Neurology

Published 1 July 2023

Crick labs

Rickie Patani

Full details

Modelling the inflammatory response of traumatic brain injury using human induced pluripotent stem cell derived microglia

Authors (11)

Aftab Alam
Tanya Singh
Saeed Kayhanian
Jonathan Tjerkaski
Nuria Marco Garcia
Keri Carpenter
Rickie Patani
Caroline Lindblad
Eric Peter Thelin
Yasir Ahmed Syed
Adel Helmy

Journal of Neurotrauma

Published 1 June 2023

Crick labs

Rickie Patani

Full details

UK PhD students’ call to action amid the cost-of-living crisis

Authors (2)

Emma R Francis
Hannah Franklin

Nature Human Behaviour

Published 17 May 2023

Crick labs

Rickie Patani

Full details

Integrated transcriptome landscape of ALS identifies genome instability linked to TDP-43 pathology

Authors (14)

Oliver Ziff
Jacob Neeves
Jamie Mitchell
Giulia Tyzack
Carlos Martinez-Ruiz
Raphaelle Luisier
[...]
Simon Boulton
Ammar Al-Chalabi
Gavin Kelly
Jack Humphrey
Rickie Patani

Nature Communications

Published 20 April 2023

Crick labs/ facilities

Full details

Molecular mechanisms of amyotrophic lateral sclerosis as broad therapeutic targets for gene therapy applications utilizing adeno-associated viral vectors

Authors (4)

Jessica Merjane
Roger Chung
Rickie Patani
Leszek Lisowski

Medicinal Research Reviews

Published 1 July 2023

Crick labs

Rickie Patani

Full details

Protein aggregation and calcium dysregulation are hallmarks of familial Parkinson's disease in midbrain dopaminergic neurons

Authors (26)

Gurvir Virdi
Minee Choi
James Evans
Zhi Yao
Dilan Athauda
Stephanie Strohbuecker
[...]
Tilo Kunath
Mathew H Horrocks
Andrey Y Abramov
Rickie Patani
Sonia Gandhi

npj Parkinsons Disease

Published 24 November 2022

Crick labs/ facilities

Full details

Physiological intron retaining transcripts in the cytoplasm abound during human motor neurogenesis

Authors (9)

Genome Research

Published 1 October 2022

Crick labs

Rickie Patani

Full details

The role of astrocytes in prion-like mechanisms of neurodegeneration

Authors (5)

Phillip Smethurst
Hannah Franklin
Ben Clarke
Katie Sidle
Rickie Patani

Brain

Published 1 January 2022

Crick labs

Rickie Patani

Full details

Axonal length determines distinct homeostatic phenotypes in human iPSC derived motor neurons on a bioengineered platform

Authors (8)

Cathleen Hagemann
Carmen Moreno Gonzalez
Ludovica Guetta
Giulia Tyzack
Ciro Chiappini
Andrea Legati
Rickie Patani
Andrea Serio

Advanced Healthcare Materials

Published 18 May 2022

Crick labs

Full details

Astrocytes display cell autonomous and diverse early reactive states in familial amyotrophic lateral sclerosis

Authors (14)

Doaa Taha
Ben Clarke
Claire E Hall
Giulia Tyzack
Oliver Ziff
Linda Greensmith
[...]
Eric P Thelin
Nuria Marco Garcia
Adel Helmy
Christopher R Sibley
Rickie Patani

Brain

Published 1 February 2022

Crick labs

Rickie Patani

Full details

Meta-analysis of human and mouse ALS astrocytes reveals multi-omic signatures of inflammatory reactive states

Authors (6)

Genome Research

Published 1 January 2022

Crick labs/ facilities

Full details

Elevated 4R-tau in astrocytes from asymptomatic carriers of the MAPT 10+16 intronic mutation

Authors (13)

Núria Setó-Salvia
Noemi Esteras
Rohan de Silva
Eduardo de Pablo-Fernandez
Charles Arber
Christina E Toomey
[...]
Jonathan D Rohrer
Andrey Y Abramov
Rickie Patani
Selina Wray
Thomas T Warner

Journal of Cellular and Molecular Medicine

Published 1 February 2022

Crick labs

Rickie Patani

Full details

Image-based deep learning reveals the responses of human motor neurons to stress and VCP-related ALS

Authors (4)

Colombine Verzat
Jasmine Harley
Rickie Patani
Raphaëlle Luisier

Neuropathology and Applied Neurobiology

Published 1 February 2022

Crick labs

Rickie Patani

Full details

TDP-43 condensation properties specify its RNA-binding and regulatory repertoire

Authors (17)

Martina Hallegger
Anob Chakrabarti
Flora Lee
Bo Lim Lee
Aram G Amalietti
Hana M Odeh
[...]
Rickie Patani
Nicolas L Fawzi
James Shorter
Nicholas Luscombe
Jernej Ule

Cell

Published 2 September 2021

Crick labs/ facilities

Full details

TDP-43 and FUS mislocalization in VCP mutant motor neurons is reversed by pharmacological inhibition of the VCP D2 ATPase domain

Authors (4)

Brain Communications

Published 6 August 2021

Crick labs

Full details

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From local to global: preparing for the next pandemic

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Transcriptome-wide RNA binding analysis of C9orf72 poly(PR) dipeptides

Nonsense-mediated mRNA decay in neuronal physiology and neurodegeneration

Amplifying the heat shock response ameliorates ALS and FTD pathology in mouse and human models

Nucleocytoplasmic mRNA redistribution accompanies RNA binding protein mislocalization in ALS motor neurons and is restored by VCP ATPase inhibition

Direct m6A recognition by IMP1 underlays an alternative model of target selection for non-canonical methyl-readers

Functional roles of reactive astrocytes in neuroinflammation and neurodegeneration

Modelling the inflammatory response of traumatic brain injury using human induced pluripotent stem cell derived microglia

UK PhD students’ call to action amid the cost-of-living crisis

Integrated transcriptome landscape of ALS identifies genome instability linked to TDP-43 pathology

Molecular mechanisms of amyotrophic lateral sclerosis as broad therapeutic targets for gene therapy applications utilizing adeno-associated viral vectors

Protein aggregation and calcium dysregulation are hallmarks of familial Parkinson's disease in midbrain dopaminergic neurons

Physiological intron retaining transcripts in the cytoplasm abound during human motor neurogenesis

The role of astrocytes in prion-like mechanisms of neurodegeneration

Axonal length determines distinct homeostatic phenotypes in human iPSC derived motor neurons on a bioengineered platform

Astrocytes display cell autonomous and diverse early reactive states in familial amyotrophic lateral sclerosis

Meta-analysis of human and mouse ALS astrocytes reveals multi-omic signatures of inflammatory reactive states

Elevated 4R-tau in astrocytes from asymptomatic carriers of the MAPT 10+16 intronic mutation

Image-based deep learning reveals the responses of human motor neurons to stress and VCP-related ALS

TDP-43 condensation properties specify its RNA-binding and regulatory repertoire

TDP-43 and FUS mislocalization in VCP mutant motor neurons is reversed by pharmacological inhibition of the VCP D2 ATPase domain

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From local to global: preparing for the next pandemic

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