Vacancies Find links to current vacancies, and information about recruitment to various types of role.
A drop of hope A collection of poems inspired by the words of those who have been vaccinated within the Crick, the reflections of the volunteers working at the vaccination centre, and the experiences our local communities.Exhibition entry: Available to view between May and August 2021
Coronavirus (COVID-19) research Crick researchers are working at the forefront of the scientific response to answer some of the most urgent questions about the SARS-CoV-2 pathogen, from how we can improve testing, to why it’s deadly in some people but causes no symptoms in others.
Coronavirus (COVID-19) response The Francis Crick Institute is working at the forefront of the scientific response to coronavirus, volunteering expertise and facilities to help tackle the COVID-19 pandemic.
Human stem cell derived spinal motor neurons (left) and astrocytes (right). Credit: Dr Giulia Tyzack (Patani Lab). Toggle to view hero caption Rickie Patani : Publications Lab MenuLab Menu Overview Lab news Publications Members Breadcrumb Research A Z of research labs Rickie Patani PublicationsYear published2021 (6)2020 (14)2019 (4)2018 (6)2017 (4)2016 (1) Facet Year publishedResearch topicsCell Biology (35)Neurosciences (35)Stem Cells (35)Computational & Systems Biology (7)Gene Expression (7)Genetics & Genomics (7)Tumour Biology (6)Biochemistry & Proteomics (4)Imaging (2)Microfabrication & Bioengineering (2)Chemical Biology & High Throughput (1)Developmental Biology (1)Genome Integrity & Repair (1)Human Biology & Physiology (1)Immunology (1)Model Organisms (1)Signalling & Oncogenes (1) Facet Research topicsPublication typeJournal article (35)Primary research (22)Review (11)Biography (1)Commentary (1) Facet Publication typeJournalBrain (9)Cell Reports (3)International Journal of Molecular Sciences (2)Journal of Neurotrauma (2)Nature Communications (2)Ageing Research Reviews (1)Aging Cell (1)Antioxidants (1)Brain Pathology (1)eLife (1)EMBO Reports (1)Expert opinion on therapeutic targets (1)Frontiers in Neurology (1)Glia (1)Journal of Neuroinflammation (1)Molecular Cell (1)Nature Medicine (1)Neuron (1)Nucleic Acids Research (1)Progress in Neurobiology (1)Scientific Reports (1)Stem Cells (1) Facet Journal Publications Displaying 1 - 20 of 35Last updated : 13 May 2021 03:57 The interplay of RNA binding proteins, oxidative stress and mitochondrial dysfunction in ALS Authors (3)Jasmine HarleyBen ClarkeRickie Patani Antioxidants Published 2 April 2021 Crick labsRickie PataniFull details A non-toxic concentration of telomerase inhibitor BIBR1532 fails to reduce TERT expression in a feeder-free induced pluripotent stem cell model of human motor neurogenesis Authors (4)Viren PandyaHamish CrerarJamie MitchellRickie Patani International Journal of Molecular Sciences Published 23 March 2021 Crick labsRickie PataniFull details Aberrant cytoplasmic intron retention is a blueprint for RNA binding protein mislocalization in amyotrophic lateral sclerosis Authors (9)Giulia TyzackJacob NeevesHamish CrerarPierre KleinOliver ZiffDoaa Taha Raphaëlle LuisierNicholas LuscombeRickie Patani Brain Published 9 March 2021 Crick labsRickie PataniNicholas LuscombeFull details Reactive astrocytes in ALS display diminished intron retention Authors (10)Oliver ZiffDoaa TahaHamish CrerarBen ClarkeAnob ChakrabartiGavin KellyJacob NeevesGiulia TyzackNicholas LuscombeRickie Patani Nucleic Acids Research Published 6 April 2021 Crick labs/ facilitiesRickie PataniNicholas LuscombeSonia GandhiBioinformatics and BiostatisticsScientific computingProteomicsAdvanced SequencingFull details Region-specific vulnerability in neurodegeneration: lessons from normal ageing Authors (2)Viren PandyaRickie Patani Ageing Research Reviews Published 1 May 2021 Crick labsRickie PataniFull details Automated and unbiased discrimination of ALS from control tissue at single cell resolution Authors (9)Cathleen HagemannGiulia TyzackDoaa Taha Helen Devine Linda Greensmith Jia NewcombeRickie PataniAndrea Serio Raphaëlle Luisier Brain Pathology Published 11 February 2021 Crick labsAndrea SerioRickie PataniFull details Astrocytes and microglia in neurodegenerative diseases: Lessons from human in vitro models Authors (3) Hannah FranklinBen ClarkeRickie Patani Progress in Neurobiology Published 1 May 2021 Crick labsRickie PataniFull details The microglial component of amyotrophic lateral sclerosis Authors (2)Ben ClarkeRickie Patani Brain Published 1 December 2020 Crick labsRickie PataniFull details FUS is lost from nuclei and gained in neurites of motor neurons in a human stem cell model of VCP-related ALS Authors (4)Jasmine HarleyCathleen HagemannAndrea SerioRickie Patani Brain Published 1 December 2020 Crick labsAndrea SerioRickie PataniFull details The FUS gene is dual-coding with both proteins contributing to FUS-mediated toxicity Authors (10) Marie A Brunet Jean-Francois Jacques Sonya NassariGiulia Tyzack Philip McGoldrick Lorne Zinman Steve Jean Janice RobertsonRickie Patani Xavier Roucou EMBO Reports Published 7 January 2021 Crick labsRickie PataniFull details Chloroquine, the coronavirus crisis, and neurodegeneration: A perspective Authors (3) Giona PedrioliRickie Patani Paolo Paganetti Frontiers in Neurology Published 13 November 2020 Crick labsRickie PataniFull details Stress-specific spatiotemporal responses of RNA-binding proteins in human stem-cell-derived motor neurons Authors (2)Jasmine HarleyRickie Patani International Journal of Molecular Sciences Published 6 November 2020 Crick labsRickie PataniFull details Cellular infiltration in traumatic brain injury Authors (7) Aftab Alam Eric P Thelin Tamara Tajsic Danyal Z Khan Abdelhakim KhellafRickie Patani Adel Helmy Journal of Neuroinflammation Published 3 November 2020 Crick labsRickie PataniFull details Human stem cell-derived astrocytes exhibit region-specific heterogeneity in their secretory profiles Authors (8)Ben ClarkeDoaa TahaOliver Ziff Aftab Alam Eric P Thelin Núria Marcó García Adel HelmyRickie Patani Brain Published 1 October 2020 Crick labs/ facilitiesRickie PataniBioinformatics and BiostatisticsFull details The FUS about SFPQ in FTLD spectrum disorders Authors (1)Rickie Patani Brain Published 1 August 2020 Crick labsRickie PataniFull details Paraspeckle components NONO and PSPC1 are not mislocalized from motor neuron nuclei in sporadic ALS Authors (6)Giulia Tyzack Giulia Manferrari Jia NewcombeNicholas Luscombe Raphaelle LuisierRickie Patani Brain Published 1 August 2020 Crick labsRickie PataniNicholas LuscombeFull details Novel therapeutic targets for amyotrophic lateral sclerosis: ribonucleoproteins and cellular autonomy Authors (2)Yiran WangRickie Patani Expert opinion on therapeutic targets Published 2 October 2020 Crick labsRickie PataniFull details Regionally encoded functional heterogeneity of astrocytes in health and disease: A perspective Authors (4)Ben ClarkeDoaa TahaGiulia TyzackRickie Patani Glia Published 1 January 2021 Crick labsRickie PataniFull details Human stem cell models of disease and the prognosis of academic medicine Authors (1)Rickie Patani Nature Medicine Published 9 April 2020 Crick labsRickie PataniFull details Distinct responses of neurons and astrocytes to TDP-43 proteinopathy in amyotrophic lateral sclerosis Authors (10) Phillip Smethurst Emmanuel RisseGiulia TyzackJamie MitchellDoaa Taha Yun-Ru Chen Jia Newcombe John Collinge Katie SidleRickie Patani Brain Published 10 February 2020 Crick labsRickie PataniFull details Pagination Current page 1 Page 2 Next page Next Last page Last Share the page Share on Twitter Share on Facebook Share on LinkedIn Share on Email
The interplay of RNA binding proteins, oxidative stress and mitochondrial dysfunction in ALS Authors (3)Jasmine HarleyBen ClarkeRickie Patani Antioxidants Published 2 April 2021 Crick labsRickie PataniFull details
A non-toxic concentration of telomerase inhibitor BIBR1532 fails to reduce TERT expression in a feeder-free induced pluripotent stem cell model of human motor neurogenesis Authors (4)Viren PandyaHamish CrerarJamie MitchellRickie Patani International Journal of Molecular Sciences Published 23 March 2021 Crick labsRickie PataniFull details
Aberrant cytoplasmic intron retention is a blueprint for RNA binding protein mislocalization in amyotrophic lateral sclerosis Authors (9)Giulia TyzackJacob NeevesHamish CrerarPierre KleinOliver ZiffDoaa Taha Raphaëlle LuisierNicholas LuscombeRickie Patani Brain Published 9 March 2021 Crick labsRickie PataniNicholas LuscombeFull details
Reactive astrocytes in ALS display diminished intron retention Authors (10)Oliver ZiffDoaa TahaHamish CrerarBen ClarkeAnob ChakrabartiGavin KellyJacob NeevesGiulia TyzackNicholas LuscombeRickie Patani Nucleic Acids Research Published 6 April 2021 Crick labs/ facilitiesRickie PataniNicholas LuscombeSonia GandhiBioinformatics and BiostatisticsScientific computingProteomicsAdvanced SequencingFull details
Region-specific vulnerability in neurodegeneration: lessons from normal ageing Authors (2)Viren PandyaRickie Patani Ageing Research Reviews Published 1 May 2021 Crick labsRickie PataniFull details
Automated and unbiased discrimination of ALS from control tissue at single cell resolution Authors (9)Cathleen HagemannGiulia TyzackDoaa Taha Helen Devine Linda Greensmith Jia NewcombeRickie PataniAndrea Serio Raphaëlle Luisier Brain Pathology Published 11 February 2021 Crick labsAndrea SerioRickie PataniFull details
Astrocytes and microglia in neurodegenerative diseases: Lessons from human in vitro models Authors (3) Hannah FranklinBen ClarkeRickie Patani Progress in Neurobiology Published 1 May 2021 Crick labsRickie PataniFull details
The microglial component of amyotrophic lateral sclerosis Authors (2)Ben ClarkeRickie Patani Brain Published 1 December 2020 Crick labsRickie PataniFull details
FUS is lost from nuclei and gained in neurites of motor neurons in a human stem cell model of VCP-related ALS Authors (4)Jasmine HarleyCathleen HagemannAndrea SerioRickie Patani Brain Published 1 December 2020 Crick labsAndrea SerioRickie PataniFull details
The FUS gene is dual-coding with both proteins contributing to FUS-mediated toxicity Authors (10) Marie A Brunet Jean-Francois Jacques Sonya NassariGiulia Tyzack Philip McGoldrick Lorne Zinman Steve Jean Janice RobertsonRickie Patani Xavier Roucou EMBO Reports Published 7 January 2021 Crick labsRickie PataniFull details
Chloroquine, the coronavirus crisis, and neurodegeneration: A perspective Authors (3) Giona PedrioliRickie Patani Paolo Paganetti Frontiers in Neurology Published 13 November 2020 Crick labsRickie PataniFull details
Stress-specific spatiotemporal responses of RNA-binding proteins in human stem-cell-derived motor neurons Authors (2)Jasmine HarleyRickie Patani International Journal of Molecular Sciences Published 6 November 2020 Crick labsRickie PataniFull details
Cellular infiltration in traumatic brain injury Authors (7) Aftab Alam Eric P Thelin Tamara Tajsic Danyal Z Khan Abdelhakim KhellafRickie Patani Adel Helmy Journal of Neuroinflammation Published 3 November 2020 Crick labsRickie PataniFull details
Human stem cell-derived astrocytes exhibit region-specific heterogeneity in their secretory profiles Authors (8)Ben ClarkeDoaa TahaOliver Ziff Aftab Alam Eric P Thelin Núria Marcó García Adel HelmyRickie Patani Brain Published 1 October 2020 Crick labs/ facilitiesRickie PataniBioinformatics and BiostatisticsFull details
The FUS about SFPQ in FTLD spectrum disorders Authors (1)Rickie Patani Brain Published 1 August 2020 Crick labsRickie PataniFull details
Paraspeckle components NONO and PSPC1 are not mislocalized from motor neuron nuclei in sporadic ALS Authors (6)Giulia Tyzack Giulia Manferrari Jia NewcombeNicholas Luscombe Raphaelle LuisierRickie Patani Brain Published 1 August 2020 Crick labsRickie PataniNicholas LuscombeFull details
Novel therapeutic targets for amyotrophic lateral sclerosis: ribonucleoproteins and cellular autonomy Authors (2)Yiran WangRickie Patani Expert opinion on therapeutic targets Published 2 October 2020 Crick labsRickie PataniFull details
Regionally encoded functional heterogeneity of astrocytes in health and disease: A perspective Authors (4)Ben ClarkeDoaa TahaGiulia TyzackRickie Patani Glia Published 1 January 2021 Crick labsRickie PataniFull details
Human stem cell models of disease and the prognosis of academic medicine Authors (1)Rickie Patani Nature Medicine Published 9 April 2020 Crick labsRickie PataniFull details
Distinct responses of neurons and astrocytes to TDP-43 proteinopathy in amyotrophic lateral sclerosis Authors (10) Phillip Smethurst Emmanuel RisseGiulia TyzackJamie MitchellDoaa Taha Yun-Ru Chen Jia Newcombe John Collinge Katie SidleRickie Patani Brain Published 10 February 2020 Crick labsRickie PataniFull details
