Publications

The role of astrocytes in prion-like mechanisms of neurodegeneration

Authors (5)

Phillip Smethurst
Hannah Franklin
Ben Clarke
Katie Sidle
Rickie Patani

Brain

Published 1 January 2022

Crick labs

Rickie Patani

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Axonal length determines distinct homeostatic phenotypes in human iPSC derived motor neurons on a bioengineered platform

Authors (8)

Cathleen Hagemann
Carmen Moreno Gonzalez
Ludovica Guetta
Giulia Tyzack
Ciro Chiappini
Andrea Legati
Rickie Patani
Andrea Serio

Advanced Healthcare Materials

Published 18 May 2022

Crick labs

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Astrocytes display cell autonomous and diverse early reactive states in familial amyotrophic lateral sclerosis

Authors (14)

Doaa Taha
Ben Clarke
Claire E Hall
Giulia Tyzack
Oliver Ziff
Linda Greensmith
[...]
Eric P Thelin
Nuria Marco Garcia
Adel Helmy
Christopher R Sibley
Rickie Patani

Brain

Published 1 February 2022

Crick labs

Rickie Patani

Full details

Meta-analysis of human and mouse ALS astrocytes reveals multi-omic signatures of inflammatory reactive states

Authors (6)

Genome Research

Published 1 January 2022

Crick labs/ facilities

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Elevated 4R-tau in astrocytes from asymptomatic carriers of the MAPT 10+16 intronic mutation

Authors (13)

Núria Setó-Salvia
Noemi Esteras
Rohan de Silva
Eduardo de Pablo-Fernandez
Charles Arber
Christina E Toomey
[...]
Jonathan D Rohrer
Andrey Y Abramov
Rickie Patani
Selina Wray
Thomas T Warner

Journal of Cellular and Molecular Medicine

Published 1 February 2022

Crick labs

Rickie Patani

Full details

Image-based deep learning reveals the responses of human motor neurons to stress and VCP-related ALS

Authors (4)

Colombine Verzat
Jasmine Harley
Rickie Patani
Raphaëlle Luisier

Neuropathology and Applied Neurobiology

Published 1 February 2022

Crick labs

Rickie Patani

Full details

TDP-43 condensation properties specify its RNA-binding and regulatory repertoire

Authors (17)

Martina Hallegger
Anob Chakrabarti
Flora Lee
Bo Lim Lee
Aram G Amalietti
Hana M Odeh
[...]
Rickie Patani
Nicolas L Fawzi
James Shorter
Nicholas Luscombe
Jernej Ule

Cell

Published 2 September 2021

Crick labs/ facilities

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TDP-43 and FUS mislocalization in VCP mutant motor neurons is reversed by pharmacological inhibition of the VCP D2 ATPase domain

Authors (4)

Brain Communications

Published 6 August 2021

Crick labs

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MIR-NATs repress MAPT translation and aid proteostasis in neurodegeneration

Authors (34)

Roberto Simone
Faiza Javad
Warren Emmett
Oscar Wilkins
Filipa Lourenço Almeida
Natalia Barahona-Torres
[...]
Per Svenningsson
Thomas T Warner
Vincent Plagnol
Jernej Ule
Rohan de Silva

Nature

Published 3 June 2021

Crick labs

Full details

Unsupervised cell segmentation and labelling in neural tissue images

Authors (9)

S Iglesias-Rey
F Antunes-Santos
Cathleen Hagemann
D Gómez-Cabrero
H Bustince
Rickie Patani
Andrea Serio
B De Baets
C Lopez-Molina

Applied Sciences (Switzerland)

Published 21 April 2021

Crick labs

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The interplay of RNA binding proteins, oxidative stress and mitochondrial dysfunction in ALS

Authors (3)

Antioxidants

Published 2 April 2021

Crick labs

Rickie Patani

Full details

A non-toxic concentration of telomerase inhibitor BIBR1532 fails to reduce TERT expression in a feeder-free induced pluripotent stem cell model of human motor neurogenesis

Authors (4)

International Journal of Molecular Sciences

Published 23 March 2021

Crick labs

Rickie Patani

Full details

Aberrant cytoplasmic intron retention is a blueprint for RNA binding protein mislocalization in VCP-related amyotrophic lateral sclerosis

Authors (9)

Brain

Published 1 July 2021

Crick labs

Full details

Region-specific vulnerability in neurodegeneration: lessons from normal ageing

Authors (2)

Ageing Research Reviews

Published 1 May 2021

Crick labs

Rickie Patani

Full details

Automated and unbiased discrimination of ALS from control tissue at single cell resolution

Authors (9)

Cathleen Hagemann
Giulia Tyzack
Doaa Taha
Helen Devine
Linda Greensmith
Jia Newcombe
Rickie Patani
Andrea Serio
Raphaëlle Luisier

Brain Pathology

Published 1 July 2021

Crick labs

Full details

Astrocytes and microglia in neurodegenerative diseases: Lessons from human in vitro models

Authors (3)

Progress in Neurobiology

Published 1 May 2021

Crick labs

Rickie Patani

Full details

The microglial component of amyotrophic lateral sclerosis

Authors (2)

Brain

Published 1 December 2020

Crick labs

Rickie Patani

Full details

FUS is lost from nuclei and gained in neurites of motor neurons in a human stem cell model of VCP-related ALS

Authors (4)

Brain

Published 1 December 2020

Crick labs

Full details

The FUS gene is dual-coding with both proteins contributing to FUS-mediated toxicity

Authors (10)

Marie A Brunet
Jean-Francois Jacques
Sonya Nassari
Giulia Tyzack
Philip McGoldrick
Lorne Zinman
Steve Jean
Janice Robertson
Rickie Patani
Xavier Roucou

EMBO Reports

Published 7 January 2021

Crick labs

Rickie Patani

Full details

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Early career group leaders

Outwitting Cancer

Coronavirus (COVID-19) research

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Human Stem Cells and Neurodegeneration Laboratory
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The role of astrocytes in prion-like mechanisms of neurodegeneration

Axonal length determines distinct homeostatic phenotypes in human iPSC derived motor neurons on a bioengineered platform

Astrocytes display cell autonomous and diverse early reactive states in familial amyotrophic lateral sclerosis

Meta-analysis of human and mouse ALS astrocytes reveals multi-omic signatures of inflammatory reactive states

Elevated 4R-tau in astrocytes from asymptomatic carriers of the MAPT 10+16 intronic mutation

Image-based deep learning reveals the responses of human motor neurons to stress and VCP-related ALS

TDP-43 condensation properties specify its RNA-binding and regulatory repertoire

TDP-43 and FUS mislocalization in VCP mutant motor neurons is reversed by pharmacological inhibition of the VCP D2 ATPase domain

MIR-NATs repress MAPT translation and aid proteostasis in neurodegeneration

Unsupervised cell segmentation and labelling in neural tissue images

The interplay of RNA binding proteins, oxidative stress and mitochondrial dysfunction in ALS

A non-toxic concentration of telomerase inhibitor BIBR1532 fails to reduce TERT expression in a feeder-free induced pluripotent stem cell model of human motor neurogenesis

Aberrant cytoplasmic intron retention is a blueprint for RNA binding protein mislocalization in VCP-related amyotrophic lateral sclerosis

Reactive astrocytes in ALS display diminished intron retention

Region-specific vulnerability in neurodegeneration: lessons from normal ageing

Automated and unbiased discrimination of ALS from control tissue at single cell resolution

Astrocytes and microglia in neurodegenerative diseases: Lessons from human in vitro models

The microglial component of amyotrophic lateral sclerosis

FUS is lost from nuclei and gained in neurites of motor neurons in a human stem cell model of VCP-related ALS

The FUS gene is dual-coding with both proteins contributing to FUS-mediated toxicity

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