Staff and visitors to the Crick during the coronavirus outbreak Our priority is the safety of everyone at the Crick. We are closed to visitors, and staff are encouraged to work from home wherever possible.
Coronavirus (COVID-19) research Crick researchers are working at the forefront of the scientific response to answer some of the most urgent questions about the SARS-CoV-2 pathogen, from how we can improve testing, to why it’s deadly in some people but causes no symptoms in others.
Francis Crick Institute coronavirus (COVID-19) response The Francis Crick Institute is working at the forefront of the scientific response to coronavirus, volunteering expertise and facilities to help tackle the COVID-19 pandemic.
Human stem cell derived spinal motor neurons (left) and astrocytes (right). Credit: Dr Giulia Tyzack (Patani Lab). Toggle to view hero caption Rickie Patani : Publications Lab MenuLab Menu Overview Lab news Publications Members Breadcrumb Home Research Labs Rickie Patani Publications PublicationsResearch topicsCell Biology (17)Neurosciences (17)Stem Cells (17)Biochemistry & Proteomics (4)Computational & Systems Biology (4)Gene Expression (4)Genetics & Genomics (4)Tumour Biology (3)Developmental Biology (1)Human Biology & Physiology (1)Immunology (1)Model Organisms (1)Signalling & Oncogenes (1)Year published2020 (2)2019 (5)2018 (6)2017 (3)2016 (1)JournalBrain (3)Cell Reports (3)Journal of Neurotrauma (2)Nature Communications (2)Aging Cell (1)eLife (1)Molecular Cell (1)Nature Medicine (1)Neuron (1)Scientific Reports (1)Stem Cells (1)Publication typeJournal article (17)Primary research (13)Review (3)Biography (1) Publications Displaying 1 - 17 of 17Last updated : 04 June 2020 02:42 Human stem cell models of disease and the prognosis of academic medicine Authors Journal Nature Medicine Publication date 9 April 2020 Crick labsRickie PataniFull details Distinct responses of neurons and astrocytes to TDP-43 proteinopathy in amyotrophic lateral sclerosis Authors Phillip Smethurst Emmanuel RisseGiulia TyzackJamie MitchellDoaa Taha Yun-Ru Chen Jia Newcombe John Collinge Katie SidleRickie Patani Journal Brain Publication date 10 February 2020 Crick labsRickie PataniFull details Decoding the relationship between ageing and amyotrophic lateral sclerosis: a cellular perspective AuthorsViren PandyaRickie Patani Journal Brain Publication date 1 April 2020 Crick labsRickie PataniFull details Delineating astrocytic cytokine responses in a human stem cell model of neural trauma Authorstotal 12 Eric Peter Thelin Claire E HallGiulia Tyzack Arvid Frostell Susan Giorgi-Coll Aftab Alam[...]Jamie Mitchell Tamara Tajsic Peter J HutchinsonRickie Patani Adel Helmy Journal Journal of Neurotrauma Publication date 1 January 2020 Crick labsRickie PataniFull details Widespread FUS mislocalization is a molecular hallmark of amyotrophic lateral sclerosis Authorstotal 12Giulia Tyzack Raphaelle LuisierDoaa TahaJacob NeevesMiha ModicJamie Mitchell[...] Linda Greensmith Jia NewcombeJernej UleNicholas LuscombeRickie Patani Journal Brain Publication date 1 September 2019 Crick labsNicholas LuscombeJernej UleRickie PataniFull details Gene expression analysis reveals early dysregulation of disease pathways and links Chmp7 to pathogenesis of spinal and bulbar muscular atrophy Authors Bilal Malik Helen DevineRickie Patani Albert R La Spada Michael G Hanna Linda Greensmith Journal Scientific Reports Publication date 5 March 2019 Crick labsRickie PataniFull details Harnessing cellular aging in human stem cell models of amyotrophic lateral sclerosis AuthorsOliver ZiffRickie Patani Journal Aging Cell Publication date 1 February 2019 Crick labsRickie PataniFull details Intron retention and nuclear loss of SFPQ are molecular hallmarks of ALS Authorstotal 13 Raphaelle Luisier Giulia E Tyzack Claire E HallJamie Mitchell Helen DevineDoaa Taha[...] Linda Greensmith Jia NewcombeJernej UleNicholas LuscombeRickie Patani Journal Nature Communications Publication date 22 May 2018 Crick labsNicholas LuscombeJernej UleRickie PataniFull details A liquid to solid phase transition underlying pathological Huntingtin exon1 aggregation Authors TR Peskett F Rau J O'DriscollRickie Patani AR Lowe HR Saibil Journal Molecular Cell Publication date 17 May 2018 Crick labsRickie PataniFull details Kir4.1-dependent astrocyte-fast motor neuron interactions are required for peak strength Authorstotal 14 Kevin W Kelley Lucile Ben Haim Lucas Schirmer Giulia E Tyzack Michaela Tolman John G Miller[...] Yongjie YangRickie Patani Andras Lakatos Erik M Ullian David H Rowitch Journal Neuron Publication date 18 April 2018 Crick labsRickie PataniFull details Three-dimensional human iPSC-derived artificial skeletal muscles model muscular dystrophies and enable multilineage tissue engineering Authorstotal 22 Sara Martina Maffioletti Shilpita Sarcar Alexander BH Henderson Ingra Mannhardt Luca Pinton Louise Anne Moyle[...]Rickie Patani Peter S Zammit Dominic J Wells Thomas EschenhagenFrancesco Saverio Tedesco Journal Cell Reports Publication date 17 April 2018 Crick labsRickie PataniFrancesco Saverio TedescoFull details Concise review: The cellular conspiracy of Amyotrophic Lateral Sclerosis AuthorsAndrea SerioRickie Patani Journal Stem Cells Publication date 1 March 2018 Crick labsRickie PataniFull details Elucidating pro-inflammatory cytokine responses after traumatic brain injury in a human stem cell model Authors Eric Peter Thelin Claire E Hall Kunal Gupta Keri LH Carpenter Siddharthan Chandran Peter J HutchinsonRickie Patani Adel Helmy Journal Journal of Neurotrauma Publication date 15 January 2018 Crick labsRickie PataniFull details A neuroprotective astrocyte state is induced by neuronal signal EphB1 but fails in ALS models Authorstotal 13 Giulia E Tyzack Claire E Hall Christopher R Sibley Tomasz Cymes Serhiy Forostyak Giulia Carlino[...] Su-Chun Zhang George M Gibbons Jia NewcombeRickie Patani András Lakatos Journal Nature Communications Publication date 27 October 2017 Crick labsRickie PataniFull details Progressive motor neuron pathology and the role of astrocytes in a human stem cell model of VCP-related ALS Authorstotal 24 Claire E Hall Zhi Yao Minee Choi Giulia E TyzackAndrea Serio Raphaelle Luisier[...] Christopher R Sibley Andras LakatosJernej UleSonia GandhiRickie Patani Journal Cell Reports Publication date 30 May 2017 Crick labsNicholas LuscombeJernej UleRickie PataniSonia GandhiFull details Major shifts in glial regional identity are a transcriptional hallmark of human brain aging Authorstotal 12 Lilach Soreq UK Brain Expression Consortium North American Brain Expression Consortium Jamie Rose Eyal Soreq John Hardy[...] Mark R Cookson Colin Smith Mina RytenRickie PataniJernej Ule Journal Cell Reports Publication date 10 January 2017 Crick labsJernej UleRickie PataniFull details Evidence for evolutionary divergence of activity-dependent gene expression in developing neurons Authorstotal 22 Jing Qiu Jamie McQueen Bilada Bilican Owen Dando Dario Magnani Karolina Punovuori[...] David JA Wyllie Elizabeth MC Fisher Sally Lowell Siddharthan Chandran Giles E Hardingham Journal eLife Publication date 1 October 2016 Crick labsVictor TybulewiczRickie PataniFull details Share the page Share on Twitter Share on Facebook Share on LinkedIn Share on Email
Human stem cell models of disease and the prognosis of academic medicine Authors Journal Nature Medicine Publication date 9 April 2020 Crick labsRickie PataniFull details
Distinct responses of neurons and astrocytes to TDP-43 proteinopathy in amyotrophic lateral sclerosis Authors Phillip Smethurst Emmanuel RisseGiulia TyzackJamie MitchellDoaa Taha Yun-Ru Chen Jia Newcombe John Collinge Katie SidleRickie Patani Journal Brain Publication date 10 February 2020 Crick labsRickie PataniFull details
Decoding the relationship between ageing and amyotrophic lateral sclerosis: a cellular perspective AuthorsViren PandyaRickie Patani Journal Brain Publication date 1 April 2020 Crick labsRickie PataniFull details
Delineating astrocytic cytokine responses in a human stem cell model of neural trauma Authorstotal 12 Eric Peter Thelin Claire E HallGiulia Tyzack Arvid Frostell Susan Giorgi-Coll Aftab Alam[...]Jamie Mitchell Tamara Tajsic Peter J HutchinsonRickie Patani Adel Helmy Journal Journal of Neurotrauma Publication date 1 January 2020 Crick labsRickie PataniFull details
Widespread FUS mislocalization is a molecular hallmark of amyotrophic lateral sclerosis Authorstotal 12Giulia Tyzack Raphaelle LuisierDoaa TahaJacob NeevesMiha ModicJamie Mitchell[...] Linda Greensmith Jia NewcombeJernej UleNicholas LuscombeRickie Patani Journal Brain Publication date 1 September 2019 Crick labsNicholas LuscombeJernej UleRickie PataniFull details
Gene expression analysis reveals early dysregulation of disease pathways and links Chmp7 to pathogenesis of spinal and bulbar muscular atrophy Authors Bilal Malik Helen DevineRickie Patani Albert R La Spada Michael G Hanna Linda Greensmith Journal Scientific Reports Publication date 5 March 2019 Crick labsRickie PataniFull details
Harnessing cellular aging in human stem cell models of amyotrophic lateral sclerosis AuthorsOliver ZiffRickie Patani Journal Aging Cell Publication date 1 February 2019 Crick labsRickie PataniFull details
Intron retention and nuclear loss of SFPQ are molecular hallmarks of ALS Authorstotal 13 Raphaelle Luisier Giulia E Tyzack Claire E HallJamie Mitchell Helen DevineDoaa Taha[...] Linda Greensmith Jia NewcombeJernej UleNicholas LuscombeRickie Patani Journal Nature Communications Publication date 22 May 2018 Crick labsNicholas LuscombeJernej UleRickie PataniFull details
A liquid to solid phase transition underlying pathological Huntingtin exon1 aggregation Authors TR Peskett F Rau J O'DriscollRickie Patani AR Lowe HR Saibil Journal Molecular Cell Publication date 17 May 2018 Crick labsRickie PataniFull details
Kir4.1-dependent astrocyte-fast motor neuron interactions are required for peak strength Authorstotal 14 Kevin W Kelley Lucile Ben Haim Lucas Schirmer Giulia E Tyzack Michaela Tolman John G Miller[...] Yongjie YangRickie Patani Andras Lakatos Erik M Ullian David H Rowitch Journal Neuron Publication date 18 April 2018 Crick labsRickie PataniFull details
Three-dimensional human iPSC-derived artificial skeletal muscles model muscular dystrophies and enable multilineage tissue engineering Authorstotal 22 Sara Martina Maffioletti Shilpita Sarcar Alexander BH Henderson Ingra Mannhardt Luca Pinton Louise Anne Moyle[...]Rickie Patani Peter S Zammit Dominic J Wells Thomas EschenhagenFrancesco Saverio Tedesco Journal Cell Reports Publication date 17 April 2018 Crick labsRickie PataniFrancesco Saverio TedescoFull details
Concise review: The cellular conspiracy of Amyotrophic Lateral Sclerosis AuthorsAndrea SerioRickie Patani Journal Stem Cells Publication date 1 March 2018 Crick labsRickie PataniFull details
Elucidating pro-inflammatory cytokine responses after traumatic brain injury in a human stem cell model Authors Eric Peter Thelin Claire E Hall Kunal Gupta Keri LH Carpenter Siddharthan Chandran Peter J HutchinsonRickie Patani Adel Helmy Journal Journal of Neurotrauma Publication date 15 January 2018 Crick labsRickie PataniFull details
A neuroprotective astrocyte state is induced by neuronal signal EphB1 but fails in ALS models Authorstotal 13 Giulia E Tyzack Claire E Hall Christopher R Sibley Tomasz Cymes Serhiy Forostyak Giulia Carlino[...] Su-Chun Zhang George M Gibbons Jia NewcombeRickie Patani András Lakatos Journal Nature Communications Publication date 27 October 2017 Crick labsRickie PataniFull details
Progressive motor neuron pathology and the role of astrocytes in a human stem cell model of VCP-related ALS Authorstotal 24 Claire E Hall Zhi Yao Minee Choi Giulia E TyzackAndrea Serio Raphaelle Luisier[...] Christopher R Sibley Andras LakatosJernej UleSonia GandhiRickie Patani Journal Cell Reports Publication date 30 May 2017 Crick labsNicholas LuscombeJernej UleRickie PataniSonia GandhiFull details
Major shifts in glial regional identity are a transcriptional hallmark of human brain aging Authorstotal 12 Lilach Soreq UK Brain Expression Consortium North American Brain Expression Consortium Jamie Rose Eyal Soreq John Hardy[...] Mark R Cookson Colin Smith Mina RytenRickie PataniJernej Ule Journal Cell Reports Publication date 10 January 2017 Crick labsJernej UleRickie PataniFull details
Evidence for evolutionary divergence of activity-dependent gene expression in developing neurons Authorstotal 22 Jing Qiu Jamie McQueen Bilada Bilican Owen Dando Dario Magnani Karolina Punovuori[...] David JA Wyllie Elizabeth MC Fisher Sally Lowell Siddharthan Chandran Giles E Hardingham Journal eLife Publication date 1 October 2016 Crick labsVictor TybulewiczRickie PataniFull details
