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Breadcrumb Rickie Patani Patani lab Human Stem Cells and Neurodegeneration Laboratory : Publications Lab contentLab contentIn this section Overview Vacancies Lab news Publications Members Human stem cell derived spinal motor neurons (left) and astrocytes (right). Credit: Dr Giulia Tyzack (Patani Lab). Toggle to view hero caption PublicationsYear published2023 (1)2022 (2)2021 (1)2020 (6)2019 (2) Facet Year publishedResearch topicsCell Biology (12)Stem Cells (12)Computational & Systems Biology (3)Gene Expression (3)Genetics & Genomics (3)Tumour Biology (3)Biochemistry & Proteomics (1)Imaging (1)Microfabrication & Bioengineering (1) (-)Neurosciences (12) Facet Research topicsPublication typeJournal article (12)Primary research (8)Review (3)Commentary (1) Facet Publication typeJournal (-)Brain (12) Facet Journal Publications Displaying 1 - 12 of 12Last updated : 28 March 2024 03:35 Elevated 4R tau contributes to endolysosomal dysfunction and neurodegeneration in VCP-related frontotemporal dementia Authors (2)Oi Ying (Christy) HungRickie Patani Brain Published 1 March 2024 Crick labsRickie PataniFull details The role of astrocytes in prion-like mechanisms of neurodegeneration Authors (5) Phillip SmethurstHannah FranklinBen Clarke Katie SidleRickie Patani Brain Published 1 January 2022 Crick labsRickie PataniFull details Astrocytes display cell autonomous and diverse early reactive states in familial amyotrophic lateral sclerosis Authors (14)Doaa TahaBen Clarke Claire E HallGiulia TyzackOliver Ziff Linda Greensmith[...] Eric P Thelin Nuria Marco Garcia Adel Helmy Christopher R SibleyRickie Patani Brain Published 1 February 2022 Crick labsRickie PataniFull details Aberrant cytoplasmic intron retention is a blueprint for RNA binding protein mislocalization in VCP-related amyotrophic lateral sclerosis Authors (9)Giulia TyzackJacob NeevesHamish CrerarPierre KleinOliver ZiffDoaa Taha Raphaëlle LuisierNicholas LuscombeRickie Patani Brain Published 1 July 2021 Crick labsRickie PataniNicholas LuscombeFull details The microglial component of amyotrophic lateral sclerosis Authors (2)Ben ClarkeRickie Patani Brain Published 1 December 2020 Crick labsRickie PataniFull details FUS is lost from nuclei and gained in neurites of motor neurons in a human stem cell model of VCP-related ALS Authors (4)Jasmine HarleyCathleen HagemannAndrea SerioRickie Patani Brain Published 1 December 2020 Crick labsAndrea SerioRickie PataniFull details Human stem cell-derived astrocytes exhibit region-specific heterogeneity in their secretory profiles Authors (8)Ben ClarkeDoaa TahaOliver Ziff Aftab Alam Eric P Thelin Núria Marcó García Adel HelmyRickie Patani Brain Published 1 October 2020 Crick labs/ facilitiesRickie PataniBioinformatics and BiostatisticsFull details The FUS about SFPQ in FTLD spectrum disorders Authors (1)Rickie Patani Brain Published 1 August 2020 Crick labsRickie PataniFull details Paraspeckle components NONO and PSPC1 are not mislocalized from motor neuron nuclei in sporadic ALS Authors (6)Giulia Tyzack Giulia Manferrari Jia NewcombeNicholas Luscombe Raphaelle LuisierRickie Patani Brain Published 1 August 2020 Crick labsRickie PataniNicholas LuscombeFull details Distinct responses of neurons and astrocytes to TDP-43 proteinopathy in amyotrophic lateral sclerosis Authors (10) Phillip Smethurst Emmanuel RisseGiulia TyzackJamie MitchellDoaa Taha Yun-Ru Chen Jia Newcombe John Collinge Katie SidleRickie Patani Brain Published 10 February 2020 Crick labsRickie PataniFull details Decoding the relationship between ageing and amyotrophic lateral sclerosis: a cellular perspective Authors (2)Viren PandyaRickie Patani Brain Published 1 April 2020 Crick labsRickie PataniFull details Widespread FUS mislocalization is a molecular hallmark of amyotrophic lateral sclerosis Authors (12)Giulia Tyzack Raphaelle LuisierDoaa TahaJacob NeevesMiha ModicJamie Mitchell[...] Linda Greensmith Jia NewcombeJernej UleNicholas LuscombeRickie Patani Brain Published 1 September 2019 Crick labsJernej UleRickie PataniNicholas LuscombeFull details Share the page Share on Twitter Share on Facebook Share on LinkedIn Share on Email
Elevated 4R tau contributes to endolysosomal dysfunction and neurodegeneration in VCP-related frontotemporal dementia Authors (2)Oi Ying (Christy) HungRickie Patani Brain Published 1 March 2024 Crick labsRickie PataniFull details
The role of astrocytes in prion-like mechanisms of neurodegeneration Authors (5) Phillip SmethurstHannah FranklinBen Clarke Katie SidleRickie Patani Brain Published 1 January 2022 Crick labsRickie PataniFull details
Astrocytes display cell autonomous and diverse early reactive states in familial amyotrophic lateral sclerosis Authors (14)Doaa TahaBen Clarke Claire E HallGiulia TyzackOliver Ziff Linda Greensmith[...] Eric P Thelin Nuria Marco Garcia Adel Helmy Christopher R SibleyRickie Patani Brain Published 1 February 2022 Crick labsRickie PataniFull details
Aberrant cytoplasmic intron retention is a blueprint for RNA binding protein mislocalization in VCP-related amyotrophic lateral sclerosis Authors (9)Giulia TyzackJacob NeevesHamish CrerarPierre KleinOliver ZiffDoaa Taha Raphaëlle LuisierNicholas LuscombeRickie Patani Brain Published 1 July 2021 Crick labsRickie PataniNicholas LuscombeFull details
The microglial component of amyotrophic lateral sclerosis Authors (2)Ben ClarkeRickie Patani Brain Published 1 December 2020 Crick labsRickie PataniFull details
FUS is lost from nuclei and gained in neurites of motor neurons in a human stem cell model of VCP-related ALS Authors (4)Jasmine HarleyCathleen HagemannAndrea SerioRickie Patani Brain Published 1 December 2020 Crick labsAndrea SerioRickie PataniFull details
Human stem cell-derived astrocytes exhibit region-specific heterogeneity in their secretory profiles Authors (8)Ben ClarkeDoaa TahaOliver Ziff Aftab Alam Eric P Thelin Núria Marcó García Adel HelmyRickie Patani Brain Published 1 October 2020 Crick labs/ facilitiesRickie PataniBioinformatics and BiostatisticsFull details
The FUS about SFPQ in FTLD spectrum disorders Authors (1)Rickie Patani Brain Published 1 August 2020 Crick labsRickie PataniFull details
Paraspeckle components NONO and PSPC1 are not mislocalized from motor neuron nuclei in sporadic ALS Authors (6)Giulia Tyzack Giulia Manferrari Jia NewcombeNicholas Luscombe Raphaelle LuisierRickie Patani Brain Published 1 August 2020 Crick labsRickie PataniNicholas LuscombeFull details
Distinct responses of neurons and astrocytes to TDP-43 proteinopathy in amyotrophic lateral sclerosis Authors (10) Phillip Smethurst Emmanuel RisseGiulia TyzackJamie MitchellDoaa Taha Yun-Ru Chen Jia Newcombe John Collinge Katie SidleRickie Patani Brain Published 10 February 2020 Crick labsRickie PataniFull details
Decoding the relationship between ageing and amyotrophic lateral sclerosis: a cellular perspective Authors (2)Viren PandyaRickie Patani Brain Published 1 April 2020 Crick labsRickie PataniFull details
Widespread FUS mislocalization is a molecular hallmark of amyotrophic lateral sclerosis Authors (12)Giulia Tyzack Raphaelle LuisierDoaa TahaJacob NeevesMiha ModicJamie Mitchell[...] Linda Greensmith Jia NewcombeJernej UleNicholas LuscombeRickie Patani Brain Published 1 September 2019 Crick labsJernej UleRickie PataniNicholas LuscombeFull details