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Human stem cell derived spinal motor neurons (left) and astrocytes (right). Credit: Dr Giulia Tyzack (Patani Lab). Toggle to view hero caption Rickie Patani : Publications Lab MenuLab Menu Overview Lab news Publications Members Breadcrumb Home Research Labs Rickie Patani Publications PublicationsYear published2020 (3)2019 (3)2018 (4)2017 (4)2016 (1)Research topicsCell Biology (15)Neurosciences (15)Stem Cells (15)Computational & Systems Biology (5)Gene Expression (5)Genetics & Genomics (5)Biochemistry & Proteomics (4)Tumour Biology (4)Developmental Biology (1)Human Biology & Physiology (1)Immunology (1)Model Organisms (1)Signalling & Oncogenes (1)Publication typeJournal article (15) (-)Primary research (15)JournalBrain (4)Cell Reports (3)Journal of Neurotrauma (2)Nature Communications (2)eLife (1)Molecular Cell (1)Neuron (1)Scientific Reports (1) Publications Displaying 1 - 15 of 15Last updated : 23 October 2020 03:33 Human stem cell-derived astrocytes exhibit region-specific heterogeneity in their secretory profiles Authors (8)Ben ClarkeDoaa TahaOliver Ziff Aftab Alam Eric P Thelin Núria Marcó García Adel HelmyRickie Patani Brain Published 8 September 2020 Crick labs/ facilitiesRickie PataniBioinformatics and BiostatisticsFull details Paraspeckle components NONO and PSPC1 are not mislocalized from motor neuron nuclei in sporadic ALS Authors (6)Giulia Tyzack Giulia Manferrari Jia NewcombeNicholas Luscombe Raphaelle LuisierRickie Patani Brain Published 1 August 2020 Crick labsNicholas LuscombeRickie PataniFull details Distinct responses of neurons and astrocytes to TDP-43 proteinopathy in amyotrophic lateral sclerosis Authors (10) Phillip Smethurst Emmanuel RisseGiulia TyzackJamie MitchellDoaa Taha Yun-Ru Chen Jia Newcombe John Collinge Katie SidleRickie Patani Brain Published 10 February 2020 Crick labsRickie PataniFull details Delineating astrocytic cytokine responses in a human stem cell model of neural trauma Authors (12) Eric Peter Thelin Claire E HallGiulia Tyzack Arvid Frostell Susan Giorgi-Coll Aftab Alam[...]Jamie Mitchell Tamara Tajsic Peter J HutchinsonRickie Patani Adel Helmy Journal of Neurotrauma Published 1 January 2020 Crick labsRickie PataniFull details Widespread FUS mislocalization is a molecular hallmark of amyotrophic lateral sclerosis Authors (12)Giulia Tyzack Raphaelle LuisierDoaa TahaJacob NeevesMiha ModicJamie Mitchell[...] Linda Greensmith Jia NewcombeJernej UleNicholas LuscombeRickie Patani Brain Published 1 September 2019 Crick labsNicholas LuscombeJernej UleRickie PataniFull details Gene expression analysis reveals early dysregulation of disease pathways and links Chmp7 to pathogenesis of spinal and bulbar muscular atrophy Authors (6) Bilal Malik Helen DevineRickie Patani Albert R La Spada Michael G Hanna Linda Greensmith Scientific Reports Published 5 March 2019 Crick labsRickie PataniFull details Intron retention and nuclear loss of SFPQ are molecular hallmarks of ALS Authors (13) Raphaelle LuisierGiulia Tyzack Claire E HallJamie MitchellHelen DevineDoaa Taha[...] Linda Greensmith Jia NewcombeJernej UleNicholas LuscombeRickie Patani Nature Communications Published 22 May 2018 Crick labsNicholas LuscombeJernej UleRickie PataniFull details A liquid to solid phase transition underlying pathological Huntingtin exon1 aggregation Authors (6) TR Peskett F Rau J O'DriscollRickie Patani AR Lowe HR Saibil Molecular Cell Published 17 May 2018 Crick labsRickie PataniFull details Three-dimensional human iPSC-derived artificial skeletal muscles model muscular dystrophies and enable multilineage tissue engineering Authors (22) Sara Martina Maffioletti Shilpita Sarcar Alexander BH Henderson Ingra Mannhardt Luca Pinton Louise Anne Moyle[...]Rickie Patani Peter S Zammit Dominic J Wells Thomas EschenhagenFrancesco Saverio Tedesco Cell Reports Published 17 April 2018 Crick labsRickie PataniFrancesco Saverio TedescoFull details Kir4.1-dependent astrocyte-fast motor neuron interactions are required for peak strength Authors (14) Kevin W Kelley Lucile Ben Haim Lucas SchirmerGiulia Tyzack Michaela Tolman John G Miller[...] Yongjie YangRickie Patani Andras Lakatos Erik M Ullian David H Rowitch Neuron Published 18 April 2018 Crick labsRickie PataniFull details Elucidating pro-inflammatory cytokine responses after traumatic brain injury in a human stem cell model Authors (8) Eric Peter Thelin Claire E Hall Kunal Gupta Keri LH Carpenter Siddharthan Chandran Peter J HutchinsonRickie Patani Adel Helmy Journal of Neurotrauma Published 15 January 2018 Crick labsRickie PataniFull details A neuroprotective astrocyte state is induced by neuronal signal EphB1 but fails in ALS models Authors (13) Giulia E Tyzack Claire E Hall Christopher R Sibley Tomasz Cymes Serhiy Forostyak Giulia Carlino[...] Su-Chun Zhang George M Gibbons Jia NewcombeRickie Patani András Lakatos Nature Communications Published 27 October 2017 Crick labsRickie PataniFull details Progressive motor neuron pathology and the role of astrocytes in a human stem cell model of VCP-related ALS Authors (24) Claire E Hall Zhi Yao Minee Choi Giulia E TyzackAndrea Serio Raphaelle Luisier[...] Christopher R Sibley Andras LakatosJernej UleSonia GandhiRickie Patani Cell Reports Published 30 May 2017 Crick labsNicholas LuscombeJernej UleRickie PataniSonia GandhiAndrea SerioFull details Major shifts in glial regional identity are a transcriptional hallmark of human brain aging Authors (12) Lilach Soreq UK Brain Expression Consortium North American Brain Expression Consortium Jamie Rose Eyal Soreq John Hardy[...] Mark R Cookson Colin Smith Mina RytenRickie PataniJernej Ule Cell Reports Published 10 January 2017 Crick labsJernej UleRickie PataniFull details Evidence for evolutionary divergence of activity-dependent gene expression in developing neurons Authors (22) Jing Qiu Jamie McQueen Bilada Bilican Owen Dando Dario Magnani Karolina Punovuori[...] David JA Wyllie Elizabeth MC Fisher Sally Lowell Siddharthan Chandran Giles E Hardingham eLife Published 1 October 2016 Crick labsVictor TybulewiczRickie PataniFull details Share the page Share on Twitter 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Human stem cell-derived astrocytes exhibit region-specific heterogeneity in their secretory profiles Authors (8)Ben ClarkeDoaa TahaOliver Ziff Aftab Alam Eric P Thelin Núria Marcó García Adel HelmyRickie Patani Brain Published 8 September 2020 Crick labs/ facilitiesRickie PataniBioinformatics and BiostatisticsFull details
Paraspeckle components NONO and PSPC1 are not mislocalized from motor neuron nuclei in sporadic ALS Authors (6)Giulia Tyzack Giulia Manferrari Jia NewcombeNicholas Luscombe Raphaelle LuisierRickie Patani Brain Published 1 August 2020 Crick labsNicholas LuscombeRickie PataniFull details
Distinct responses of neurons and astrocytes to TDP-43 proteinopathy in amyotrophic lateral sclerosis Authors (10) Phillip Smethurst Emmanuel RisseGiulia TyzackJamie MitchellDoaa Taha Yun-Ru Chen Jia Newcombe John Collinge Katie SidleRickie Patani Brain Published 10 February 2020 Crick labsRickie PataniFull details
Delineating astrocytic cytokine responses in a human stem cell model of neural trauma Authors (12) Eric Peter Thelin Claire E HallGiulia Tyzack Arvid Frostell Susan Giorgi-Coll Aftab Alam[...]Jamie Mitchell Tamara Tajsic Peter J HutchinsonRickie Patani Adel Helmy Journal of Neurotrauma Published 1 January 2020 Crick labsRickie PataniFull details
Widespread FUS mislocalization is a molecular hallmark of amyotrophic lateral sclerosis Authors (12)Giulia Tyzack Raphaelle LuisierDoaa TahaJacob NeevesMiha ModicJamie Mitchell[...] Linda Greensmith Jia NewcombeJernej UleNicholas LuscombeRickie Patani Brain Published 1 September 2019 Crick labsNicholas LuscombeJernej UleRickie PataniFull details
Gene expression analysis reveals early dysregulation of disease pathways and links Chmp7 to pathogenesis of spinal and bulbar muscular atrophy Authors (6) Bilal Malik Helen DevineRickie Patani Albert R La Spada Michael G Hanna Linda Greensmith Scientific Reports Published 5 March 2019 Crick labsRickie PataniFull details
Intron retention and nuclear loss of SFPQ are molecular hallmarks of ALS Authors (13) Raphaelle LuisierGiulia Tyzack Claire E HallJamie MitchellHelen DevineDoaa Taha[...] Linda Greensmith Jia NewcombeJernej UleNicholas LuscombeRickie Patani Nature Communications Published 22 May 2018 Crick labsNicholas LuscombeJernej UleRickie PataniFull details
A liquid to solid phase transition underlying pathological Huntingtin exon1 aggregation Authors (6) TR Peskett F Rau J O'DriscollRickie Patani AR Lowe HR Saibil Molecular Cell Published 17 May 2018 Crick labsRickie PataniFull details
Three-dimensional human iPSC-derived artificial skeletal muscles model muscular dystrophies and enable multilineage tissue engineering Authors (22) Sara Martina Maffioletti Shilpita Sarcar Alexander BH Henderson Ingra Mannhardt Luca Pinton Louise Anne Moyle[...]Rickie Patani Peter S Zammit Dominic J Wells Thomas EschenhagenFrancesco Saverio Tedesco Cell Reports Published 17 April 2018 Crick labsRickie PataniFrancesco Saverio TedescoFull details
Kir4.1-dependent astrocyte-fast motor neuron interactions are required for peak strength Authors (14) Kevin W Kelley Lucile Ben Haim Lucas SchirmerGiulia Tyzack Michaela Tolman John G Miller[...] Yongjie YangRickie Patani Andras Lakatos Erik M Ullian David H Rowitch Neuron Published 18 April 2018 Crick labsRickie PataniFull details
Elucidating pro-inflammatory cytokine responses after traumatic brain injury in a human stem cell model Authors (8) Eric Peter Thelin Claire E Hall Kunal Gupta Keri LH Carpenter Siddharthan Chandran Peter J HutchinsonRickie Patani Adel Helmy Journal of Neurotrauma Published 15 January 2018 Crick labsRickie PataniFull details
A neuroprotective astrocyte state is induced by neuronal signal EphB1 but fails in ALS models Authors (13) Giulia E Tyzack Claire E Hall Christopher R Sibley Tomasz Cymes Serhiy Forostyak Giulia Carlino[...] Su-Chun Zhang George M Gibbons Jia NewcombeRickie Patani András Lakatos Nature Communications Published 27 October 2017 Crick labsRickie PataniFull details
Progressive motor neuron pathology and the role of astrocytes in a human stem cell model of VCP-related ALS Authors (24) Claire E Hall Zhi Yao Minee Choi Giulia E TyzackAndrea Serio Raphaelle Luisier[...] Christopher R Sibley Andras LakatosJernej UleSonia GandhiRickie Patani Cell Reports Published 30 May 2017 Crick labsNicholas LuscombeJernej UleRickie PataniSonia GandhiAndrea SerioFull details
Major shifts in glial regional identity are a transcriptional hallmark of human brain aging Authors (12) Lilach Soreq UK Brain Expression Consortium North American Brain Expression Consortium Jamie Rose Eyal Soreq John Hardy[...] Mark R Cookson Colin Smith Mina RytenRickie PataniJernej Ule Cell Reports Published 10 January 2017 Crick labsJernej UleRickie PataniFull details
Evidence for evolutionary divergence of activity-dependent gene expression in developing neurons Authors (22) Jing Qiu Jamie McQueen Bilada Bilican Owen Dando Dario Magnani Karolina Punovuori[...] David JA Wyllie Elizabeth MC Fisher Sally Lowell Siddharthan Chandran Giles E Hardingham eLife Published 1 October 2016 Crick labsVictor TybulewiczRickie PataniFull details
