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Breadcrumb Rickie Patani Patani lab Human Stem Cells and Neurodegeneration Laboratory : Publications Lab contentLab contentIn this section Overview Vacancies Lab news Publications Members Human stem cell derived spinal motor neurons (left) and astrocytes (right). Credit: Dr Giulia Tyzack (Patani Lab). Toggle to view hero caption PublicationsYear published2024 (2)2023 (12)2022 (5)2021 (13)2020 (14)2019 (4)2018 (6)2017 (4)2016 (1) Facet Year publishedResearch topicsNeurosciences (61)Stem Cells (61)Computational & Systems Biology (14)Genetics & Genomics (14)Gene Expression (13)Tumour Biology (11)Biochemistry & Proteomics (9)Chemical Biology & High Throughput (6)Imaging (5)Microfabrication & Bioengineering (5)Genome Integrity & Repair (4)Model Organisms (3)Structural Biology & Biophysics (2)Cell Cycle & Chromosomes (1)Developmental Biology (1)Human Biology & Physiology (1)Immunology (1)Infectious Disease (1)Signalling & Oncogenes (1) (-)Cell Biology (61) Facet Research topicsPublication typeJournal article (61)Primary research (42)Review (15)Commentary (2)Biography (1)Policy letter (1) Facet Publication typeJournalBrain (13)Nature Communications (4)Cell Reports (3)Journal of Neurotrauma (3)Genome Research (2)International Journal of Molecular Sciences (2)Neuron (2)Nucleic Acids Research (2)Advanced Healthcare Materials (1)Ageing Research Reviews (1)Aging Cell (1)Antioxidants (1)Applied Sciences (Switzerland) (1)Autophagy (1)Brain Communications (1)Brain Pathology (1)Cell (1)eLife (1)EMBO Reports (1)Expert opinion on therapeutic targets (1)Frontiers in Neurology (1)Glia (1)Journal of Cellular and Molecular Medicine (1)Journal of Neuroinflammation (1)Life Science Alliance (1)Medicinal Research Reviews (1)Molecular Cell (1)Molecular Neurobiology (1)Nature (1)Nature Human Behaviour (1)Nature Medicine (1)Nature Reviews Neurology (1)Neuropathology and Applied Neurobiology (1)npj Parkinsons Disease (1)Progress in Neurobiology (1)Scientific Reports (1)Stem Cells (1)Trends in Neurosciences (1) Facet Journal Publications Displaying 21 - 40 of 61Last updated : 20 April 2024 03:14 Elevated 4R-tau in astrocytes from asymptomatic carriers of the MAPT 10+16 intronic mutation Authors (13) Núria Setó-Salvia Noemi Esteras Rohan de Silva Eduardo de Pablo-Fernandez Charles Arber Christina E Toomey[...] Jonathan D Rohrer Andrey Y AbramovRickie Patani Selina Wray Thomas T Warner Journal of Cellular and Molecular Medicine Published 1 February 2022 Crick labsRickie PataniFull details Image-based deep learning reveals the responses of human motor neurons to stress and VCP-related ALS Authors (4) Colombine VerzatJasmine HarleyRickie Patani Raphaëlle Luisier Neuropathology and Applied Neurobiology Published 1 February 2022 Crick labsRickie PataniFull details TDP-43 condensation properties specify its RNA-binding and regulatory repertoire Authors (17)Martina HalleggerAnob ChakrabartiFlora Lee Bo Lim Lee Aram G Amalietti Hana M Odeh[...]Rickie Patani Nicolas L Fawzi James ShorterNicholas LuscombeJernej Ule Cell Published 2 September 2021 Crick labs/ facilitiesJernej UleRickie PataniNicholas LuscombeLight MicroscopyAdvanced SequencingFull details TDP-43 and FUS mislocalization in VCP mutant motor neurons is reversed by pharmacological inhibition of the VCP D2 ATPase domain Authors (4)Jasmine HarleyCathleen HagemannAndrea SerioRickie Patani Brain Communications Published 6 August 2021 Crick labsAndrea SerioRickie PataniFull details MIR-NATs repress MAPT translation and aid proteostasis in neurodegeneration Authors (34) Roberto Simone Faiza Javad Warren EmmettOscar Wilkins Filipa Lourenço Almeida Natalia Barahona-Torres[...] Per Svenningsson Thomas T Warner Vincent PlagnolJernej Ule Rohan de Silva Nature Published 3 June 2021 Crick labsJernej UleRickie PataniFull details Unsupervised cell segmentation and labelling in neural tissue images Authors (9) S Iglesias-Rey F Antunes-SantosCathleen Hagemann D Gómez-Cabrero H BustinceRickie PataniAndrea Serio B De Baets C Lopez-Molina Applied Sciences (Switzerland) Published 21 April 2021 Crick labsAndrea SerioRickie PataniFull details The interplay of RNA binding proteins, oxidative stress and mitochondrial dysfunction in ALS Authors (3)Jasmine HarleyBen ClarkeRickie Patani Antioxidants Published 2 April 2021 Crick labsRickie PataniFull details A non-toxic concentration of telomerase inhibitor BIBR1532 fails to reduce TERT expression in a feeder-free induced pluripotent stem cell model of human motor neurogenesis Authors (4)Viren PandyaHamish CrerarJamie MitchellRickie Patani International Journal of Molecular Sciences Published 23 March 2021 Crick labsRickie PataniFull details Aberrant cytoplasmic intron retention is a blueprint for RNA binding protein mislocalization in VCP-related amyotrophic lateral sclerosis Authors (9)Giulia TyzackJacob NeevesHamish CrerarPierre KleinOliver ZiffDoaa Taha Raphaëlle LuisierNicholas LuscombeRickie Patani Brain Published 1 July 2021 Crick labsRickie PataniNicholas LuscombeFull details Reactive astrocytes in ALS display diminished intron retention Authors (10)Oliver ZiffDoaa TahaHamish CrerarBen ClarkeAnob ChakrabartiGavin KellyJacob NeevesGiulia TyzackNicholas LuscombeRickie Patani Nucleic Acids Research Published 6 April 2021 Crick labs/ facilitiesRickie PataniNicholas LuscombeSonia GandhiBioinformatics and BiostatisticsScientific computingProteomicsAdvanced SequencingFull details Region-specific vulnerability in neurodegeneration: lessons from normal ageing Authors (2)Viren PandyaRickie Patani Ageing Research Reviews Published 1 May 2021 Crick labsRickie PataniFull details Automated and unbiased discrimination of ALS from control tissue at single cell resolution Authors (9)Cathleen HagemannGiulia TyzackDoaa Taha Helen Devine Linda Greensmith Jia NewcombeRickie PataniAndrea Serio Raphaëlle Luisier Brain Pathology Published 1 July 2021 Crick labsAndrea SerioRickie PataniFull details Astrocytes and microglia in neurodegenerative diseases: Lessons from human in vitro models Authors (3)Hannah FranklinBen ClarkeRickie Patani Progress in Neurobiology Published 1 May 2021 Crick labsRickie PataniFull details The microglial component of amyotrophic lateral sclerosis Authors (2)Ben ClarkeRickie Patani Brain Published 1 December 2020 Crick labsRickie PataniFull details FUS is lost from nuclei and gained in neurites of motor neurons in a human stem cell model of VCP-related ALS Authors (4)Jasmine HarleyCathleen HagemannAndrea SerioRickie Patani Brain Published 1 December 2020 Crick labsAndrea SerioRickie PataniFull details The FUS gene is dual-coding with both proteins contributing to FUS-mediated toxicity Authors (10) Marie A Brunet Jean-Francois Jacques Sonya NassariGiulia Tyzack Philip McGoldrick Lorne Zinman Steve Jean Janice RobertsonRickie Patani Xavier Roucou EMBO Reports Published 7 January 2021 Crick labsRickie PataniFull details Chloroquine, the coronavirus crisis, and neurodegeneration: A perspective Authors (3) Giona PedrioliRickie Patani Paolo Paganetti Frontiers in Neurology Published 13 November 2020 Crick labsRickie PataniFull details Stress-specific spatiotemporal responses of RNA-binding proteins in human stem-cell-derived motor neurons Authors (2)Jasmine HarleyRickie Patani International Journal of Molecular Sciences Published 6 November 2020 Crick labsRickie PataniFull details Cellular infiltration in traumatic brain injury Authors (7) Aftab Alam Eric P Thelin Tamara Tajsic Danyal Z Khan Abdelhakim KhellafRickie Patani Adel Helmy Journal of Neuroinflammation Published 3 November 2020 Crick labsRickie PataniFull details Human stem cell-derived astrocytes exhibit region-specific heterogeneity in their secretory profiles Authors (8)Ben ClarkeDoaa TahaOliver Ziff Aftab Alam Eric P Thelin Núria Marcó García Adel HelmyRickie Patani Brain Published 1 October 2020 Crick labs/ facilitiesRickie PataniBioinformatics and BiostatisticsFull details Pagination First page First Previous page Previous Page 1 Current page 2 Page 3 Page 4 Next page Next Last page Last Share the page Share on Twitter Share on Facebook Share on LinkedIn Share on Email
Elevated 4R-tau in astrocytes from asymptomatic carriers of the MAPT 10+16 intronic mutation Authors (13) Núria Setó-Salvia Noemi Esteras Rohan de Silva Eduardo de Pablo-Fernandez Charles Arber Christina E Toomey[...] Jonathan D Rohrer Andrey Y AbramovRickie Patani Selina Wray Thomas T Warner Journal of Cellular and Molecular Medicine Published 1 February 2022 Crick labsRickie PataniFull details
Image-based deep learning reveals the responses of human motor neurons to stress and VCP-related ALS Authors (4) Colombine VerzatJasmine HarleyRickie Patani Raphaëlle Luisier Neuropathology and Applied Neurobiology Published 1 February 2022 Crick labsRickie PataniFull details
TDP-43 condensation properties specify its RNA-binding and regulatory repertoire Authors (17)Martina HalleggerAnob ChakrabartiFlora Lee Bo Lim Lee Aram G Amalietti Hana M Odeh[...]Rickie Patani Nicolas L Fawzi James ShorterNicholas LuscombeJernej Ule Cell Published 2 September 2021 Crick labs/ facilitiesJernej UleRickie PataniNicholas LuscombeLight MicroscopyAdvanced SequencingFull details
TDP-43 and FUS mislocalization in VCP mutant motor neurons is reversed by pharmacological inhibition of the VCP D2 ATPase domain Authors (4)Jasmine HarleyCathleen HagemannAndrea SerioRickie Patani Brain Communications Published 6 August 2021 Crick labsAndrea SerioRickie PataniFull details
MIR-NATs repress MAPT translation and aid proteostasis in neurodegeneration Authors (34) Roberto Simone Faiza Javad Warren EmmettOscar Wilkins Filipa Lourenço Almeida Natalia Barahona-Torres[...] Per Svenningsson Thomas T Warner Vincent PlagnolJernej Ule Rohan de Silva Nature Published 3 June 2021 Crick labsJernej UleRickie PataniFull details
Unsupervised cell segmentation and labelling in neural tissue images Authors (9) S Iglesias-Rey F Antunes-SantosCathleen Hagemann D Gómez-Cabrero H BustinceRickie PataniAndrea Serio B De Baets C Lopez-Molina Applied Sciences (Switzerland) Published 21 April 2021 Crick labsAndrea SerioRickie PataniFull details
The interplay of RNA binding proteins, oxidative stress and mitochondrial dysfunction in ALS Authors (3)Jasmine HarleyBen ClarkeRickie Patani Antioxidants Published 2 April 2021 Crick labsRickie PataniFull details
A non-toxic concentration of telomerase inhibitor BIBR1532 fails to reduce TERT expression in a feeder-free induced pluripotent stem cell model of human motor neurogenesis Authors (4)Viren PandyaHamish CrerarJamie MitchellRickie Patani International Journal of Molecular Sciences Published 23 March 2021 Crick labsRickie PataniFull details
Aberrant cytoplasmic intron retention is a blueprint for RNA binding protein mislocalization in VCP-related amyotrophic lateral sclerosis Authors (9)Giulia TyzackJacob NeevesHamish CrerarPierre KleinOliver ZiffDoaa Taha Raphaëlle LuisierNicholas LuscombeRickie Patani Brain Published 1 July 2021 Crick labsRickie PataniNicholas LuscombeFull details
Reactive astrocytes in ALS display diminished intron retention Authors (10)Oliver ZiffDoaa TahaHamish CrerarBen ClarkeAnob ChakrabartiGavin KellyJacob NeevesGiulia TyzackNicholas LuscombeRickie Patani Nucleic Acids Research Published 6 April 2021 Crick labs/ facilitiesRickie PataniNicholas LuscombeSonia GandhiBioinformatics and BiostatisticsScientific computingProteomicsAdvanced SequencingFull details
Region-specific vulnerability in neurodegeneration: lessons from normal ageing Authors (2)Viren PandyaRickie Patani Ageing Research Reviews Published 1 May 2021 Crick labsRickie PataniFull details
Automated and unbiased discrimination of ALS from control tissue at single cell resolution Authors (9)Cathleen HagemannGiulia TyzackDoaa Taha Helen Devine Linda Greensmith Jia NewcombeRickie PataniAndrea Serio Raphaëlle Luisier Brain Pathology Published 1 July 2021 Crick labsAndrea SerioRickie PataniFull details
Astrocytes and microglia in neurodegenerative diseases: Lessons from human in vitro models Authors (3)Hannah FranklinBen ClarkeRickie Patani Progress in Neurobiology Published 1 May 2021 Crick labsRickie PataniFull details
The microglial component of amyotrophic lateral sclerosis Authors (2)Ben ClarkeRickie Patani Brain Published 1 December 2020 Crick labsRickie PataniFull details
FUS is lost from nuclei and gained in neurites of motor neurons in a human stem cell model of VCP-related ALS Authors (4)Jasmine HarleyCathleen HagemannAndrea SerioRickie Patani Brain Published 1 December 2020 Crick labsAndrea SerioRickie PataniFull details
The FUS gene is dual-coding with both proteins contributing to FUS-mediated toxicity Authors (10) Marie A Brunet Jean-Francois Jacques Sonya NassariGiulia Tyzack Philip McGoldrick Lorne Zinman Steve Jean Janice RobertsonRickie Patani Xavier Roucou EMBO Reports Published 7 January 2021 Crick labsRickie PataniFull details
Chloroquine, the coronavirus crisis, and neurodegeneration: A perspective Authors (3) Giona PedrioliRickie Patani Paolo Paganetti Frontiers in Neurology Published 13 November 2020 Crick labsRickie PataniFull details
Stress-specific spatiotemporal responses of RNA-binding proteins in human stem-cell-derived motor neurons Authors (2)Jasmine HarleyRickie Patani International Journal of Molecular Sciences Published 6 November 2020 Crick labsRickie PataniFull details
Cellular infiltration in traumatic brain injury Authors (7) Aftab Alam Eric P Thelin Tamara Tajsic Danyal Z Khan Abdelhakim KhellafRickie Patani Adel Helmy Journal of Neuroinflammation Published 3 November 2020 Crick labsRickie PataniFull details
Human stem cell-derived astrocytes exhibit region-specific heterogeneity in their secretory profiles Authors (8)Ben ClarkeDoaa TahaOliver Ziff Aftab Alam Eric P Thelin Núria Marcó García Adel HelmyRickie Patani Brain Published 1 October 2020 Crick labs/ facilitiesRickie PataniBioinformatics and BiostatisticsFull details