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Breadcrumb Rickie Patani Patani lab Human Stem Cells and Neurodegeneration Laboratory : Publications Lab contentLab contentIn this section Overview Vacancies Lab news Publications Members Human stem cell derived spinal motor neurons (left) and astrocytes (right). Credit: Dr Giulia Tyzack (Patani Lab). Toggle to view hero caption PublicationsYear published2023 (4)2022 (1)2021 (1) Facet Year publishedResearch topicsCell Biology (6)Neurosciences (6)Stem Cells (6)Computational & Systems Biology (5)Genetics & Genomics (5)Gene Expression (4)Genome Integrity & Repair (4)Tumour Biology (4)Biochemistry & Proteomics (3)Model Organisms (2)Structural Biology & Biophysics (2)Cell Cycle & Chromosomes (1)Infectious Disease (1) (-)Chemical Biology & High Throughput (6) Facet Research topicsPublication typeJournal article (6)Primary research (6) Facet Publication typeJournalNucleic Acids Research (2)Life Science Alliance (1)Nature Communications (1)Neuron (1)npj Parkinsons Disease (1) Facet Journal Publications Displaying 1 - 6 of 6Last updated : 18 April 2024 03:34 Transcriptome-wide RNA binding analysis of C9orf72 poly(PR) dipeptides Authors (14) Rubika BalendraIgor Ruiz De Los Mozos Hana M Odeh Idoia Glaria Carmelo Milioto Katherine M Wilson[...] Stephen MartinRickie Patani James ShorterJernej Ule Adrian M Isaacs Life Science Alliance Published 1 September 2023 Crick labs/ facilitiesJernej UleRickie PataniStructural BiologyHigh Throughput ScreeningFull details Nucleocytoplasmic mRNA redistribution accompanies RNA binding protein mislocalization in ALS motor neurons and is restored by VCP ATPase inhibition Authors (10)Oliver ZiffJasmine HarleyYiran WangJacob NeevesGiulia Tyzack Fairouz IbrahimMark SkehelAnob ChakrabartiGavin KellyRickie Patani Neuron Published 4 October 2023 Crick labs/ facilitiesJernej UleRickie PataniProteomicsBioinformatics and BiostatisticsFull details Direct m6A recognition by IMP1 underlays an alternative model of target selection for non-canonical methyl-readers Authors (12)Giuseppe Nicastro Giancarlo AbisPierre Klein Sofia Esteban-Serna Christopher Gallagher Belen Chaves-Arquero[...] Angelo Miguel Figueiredo Stephen R MartinRickie PataniIan Taylor Andres Ramos Nucleic Acids Research Published 8 September 2023 Crick labs/ facilitiesIan TaylorRickie PataniStructural BiologyMRC Biomedical NMR CentreFull details Integrated transcriptome landscape of ALS identifies genome instability linked to TDP-43 pathology Authors (14)Oliver ZiffJacob NeevesJamie MitchellGiulia Tyzack Carlos Martinez-Ruiz Raphaelle Luisier[...]Simon Boulton Ammar Al-ChalabiGavin Kelly Jack HumphreyRickie Patani Nature Communications Published 20 April 2023 Crick labs/ facilitiesJernej UleRickie PataniSimon BoultonBioinformatics and BiostatisticsScientific computingFull details Protein aggregation and calcium dysregulation are hallmarks of familial Parkinson's disease in midbrain dopaminergic neurons Authors (26)Gurvir VirdiMinee ChoiJames EvansZhi YaoDilan Athauda Stephanie Strohbuecker[...] Tilo Kunath Mathew H Horrocks Andrey Y AbramovRickie PataniSonia Gandhi npj Parkinsons Disease Published 24 November 2022 Crick labs/ facilitiesRickie PataniSonia GandhiBioinformatics and BiostatisticsAdvanced SequencingLight MicroscopyFlow CytometryFull details Reactive astrocytes in ALS display diminished intron retention Authors (10)Oliver ZiffDoaa TahaHamish CrerarBen ClarkeAnob ChakrabartiGavin KellyJacob NeevesGiulia TyzackNicholas LuscombeRickie Patani Nucleic Acids Research Published 6 April 2021 Crick labs/ facilitiesRickie PataniNicholas LuscombeSonia GandhiBioinformatics and BiostatisticsScientific computingProteomicsAdvanced SequencingFull details Share the page Share on Twitter Share on Facebook Share on LinkedIn Share on Email
Transcriptome-wide RNA binding analysis of C9orf72 poly(PR) dipeptides Authors (14) Rubika BalendraIgor Ruiz De Los Mozos Hana M Odeh Idoia Glaria Carmelo Milioto Katherine M Wilson[...] Stephen MartinRickie Patani James ShorterJernej Ule Adrian M Isaacs Life Science Alliance Published 1 September 2023 Crick labs/ facilitiesJernej UleRickie PataniStructural BiologyHigh Throughput ScreeningFull details
Nucleocytoplasmic mRNA redistribution accompanies RNA binding protein mislocalization in ALS motor neurons and is restored by VCP ATPase inhibition Authors (10)Oliver ZiffJasmine HarleyYiran WangJacob NeevesGiulia Tyzack Fairouz IbrahimMark SkehelAnob ChakrabartiGavin KellyRickie Patani Neuron Published 4 October 2023 Crick labs/ facilitiesJernej UleRickie PataniProteomicsBioinformatics and BiostatisticsFull details
Direct m6A recognition by IMP1 underlays an alternative model of target selection for non-canonical methyl-readers Authors (12)Giuseppe Nicastro Giancarlo AbisPierre Klein Sofia Esteban-Serna Christopher Gallagher Belen Chaves-Arquero[...] Angelo Miguel Figueiredo Stephen R MartinRickie PataniIan Taylor Andres Ramos Nucleic Acids Research Published 8 September 2023 Crick labs/ facilitiesIan TaylorRickie PataniStructural BiologyMRC Biomedical NMR CentreFull details
Integrated transcriptome landscape of ALS identifies genome instability linked to TDP-43 pathology Authors (14)Oliver ZiffJacob NeevesJamie MitchellGiulia Tyzack Carlos Martinez-Ruiz Raphaelle Luisier[...]Simon Boulton Ammar Al-ChalabiGavin Kelly Jack HumphreyRickie Patani Nature Communications Published 20 April 2023 Crick labs/ facilitiesJernej UleRickie PataniSimon BoultonBioinformatics and BiostatisticsScientific computingFull details
Protein aggregation and calcium dysregulation are hallmarks of familial Parkinson's disease in midbrain dopaminergic neurons Authors (26)Gurvir VirdiMinee ChoiJames EvansZhi YaoDilan Athauda Stephanie Strohbuecker[...] Tilo Kunath Mathew H Horrocks Andrey Y AbramovRickie PataniSonia Gandhi npj Parkinsons Disease Published 24 November 2022 Crick labs/ facilitiesRickie PataniSonia GandhiBioinformatics and BiostatisticsAdvanced SequencingLight MicroscopyFlow CytometryFull details
Reactive astrocytes in ALS display diminished intron retention Authors (10)Oliver ZiffDoaa TahaHamish CrerarBen ClarkeAnob ChakrabartiGavin KellyJacob NeevesGiulia TyzackNicholas LuscombeRickie Patani Nucleic Acids Research Published 6 April 2021 Crick labs/ facilitiesRickie PataniNicholas LuscombeSonia GandhiBioinformatics and BiostatisticsScientific computingProteomicsAdvanced SequencingFull details