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Breadcrumb Rickie Patani Patani lab Human Stem Cells and Neurodegeneration Laboratory : Publications Lab contentLab contentIn this section Overview Vacancies Lab news Publications Members Human stem cell derived spinal motor neurons (left) and astrocytes (right). Credit: Dr Giulia Tyzack (Patani Lab). Toggle to view hero caption PublicationsYear published2023 (3)2022 (1)2021 (5)2020 (1)2019 (1)2018 (1)2017 (2) Facet Year publishedResearch topicsCell Biology (14)Computational & Systems Biology (14)Neurosciences (14)Stem Cells (14)Gene Expression (13)Tumour Biology (11)Biochemistry & Proteomics (9)Chemical Biology & High Throughput (5)Genome Integrity & Repair (4)Cell Cycle & Chromosomes (1)Model Organisms (1)Structural Biology & Biophysics (1) (-)Genetics & Genomics (14) Facet Research topicsPublication typeJournal article (14)Primary research (14) Facet Publication typeJournalBrain (3)Cell Reports (2)Nature Communications (2)Cell (1)Genome Research (1)Life Science Alliance (1)Nature (1)Neuron (1)npj Parkinsons Disease (1)Nucleic Acids Research (1) Facet Journal Publications Displaying 1 - 14 of 14Last updated : 28 March 2024 02:28 Transcriptome-wide RNA binding analysis of C9orf72 poly(PR) dipeptides Authors (14) Rubika BalendraIgor Ruiz De Los Mozos Hana M Odeh Idoia Glaria Carmelo Milioto Katherine M Wilson[...] Stephen MartinRickie Patani James ShorterJernej Ule Adrian M Isaacs Life Science Alliance Published 1 September 2023 Crick labs/ facilitiesJernej UleRickie PataniStructural BiologyHigh Throughput ScreeningFull details Nucleocytoplasmic mRNA redistribution accompanies RNA binding protein mislocalization in ALS motor neurons and is restored by VCP ATPase inhibition Authors (10)Oliver ZiffJasmine HarleyYiran WangJacob NeevesGiulia Tyzack Fairouz IbrahimMark SkehelAnob ChakrabartiGavin KellyRickie Patani Neuron Published 4 October 2023 Crick labs/ facilitiesJernej UleRickie PataniProteomicsBioinformatics and BiostatisticsFull details Integrated transcriptome landscape of ALS identifies genome instability linked to TDP-43 pathology Authors (14)Oliver ZiffJacob NeevesJamie MitchellGiulia Tyzack Carlos Martinez-Ruiz Raphaelle Luisier[...]Simon Boulton Ammar Al-ChalabiGavin Kelly Jack HumphreyRickie Patani Nature Communications Published 20 April 2023 Crick labs/ facilitiesJernej UleRickie PataniSimon BoultonBioinformatics and BiostatisticsScientific computingFull details Protein aggregation and calcium dysregulation are hallmarks of familial Parkinson's disease in midbrain dopaminergic neurons Authors (26)Gurvir VirdiMinee ChoiJames EvansZhi YaoDilan Athauda Stephanie Strohbuecker[...] Tilo Kunath Mathew H Horrocks Andrey Y AbramovRickie PataniSonia Gandhi npj Parkinsons Disease Published 24 November 2022 Crick labs/ facilitiesRickie PataniSonia GandhiBioinformatics and BiostatisticsAdvanced SequencingLight MicroscopyFlow CytometryFull details Meta-analysis of human and mouse ALS astrocytes reveals multi-omic signatures of inflammatory reactive states Authors (6)Oliver ZiffBen ClarkeDoaa TahaHamish CrerarNicholas LuscombeRickie Patani Genome Research Published 1 January 2022 Crick labs/ facilitiesRickie PataniNicholas LuscombeScientific computingProteomicsBioinformatics and BiostatisticsAdvanced SequencingFull details TDP-43 condensation properties specify its RNA-binding and regulatory repertoire Authors (17)Martina HalleggerAnob ChakrabartiFlora Lee Bo Lim Lee Aram G Amalietti Hana M Odeh[...]Rickie Patani Nicolas L Fawzi James ShorterNicholas LuscombeJernej Ule Cell Published 2 September 2021 Crick labs/ facilitiesJernej UleRickie PataniNicholas LuscombeLight MicroscopyAdvanced SequencingFull details MIR-NATs repress MAPT translation and aid proteostasis in neurodegeneration Authors (34) Roberto Simone Faiza Javad Warren EmmettOscar Wilkins Filipa Lourenço Almeida Natalia Barahona-Torres[...] Per Svenningsson Thomas T Warner Vincent PlagnolJernej Ule Rohan de Silva Nature Published 3 June 2021 Crick labsJernej UleRickie PataniFull details Aberrant cytoplasmic intron retention is a blueprint for RNA binding protein mislocalization in VCP-related amyotrophic lateral sclerosis Authors (9)Giulia TyzackJacob NeevesHamish CrerarPierre KleinOliver ZiffDoaa Taha Raphaëlle LuisierNicholas LuscombeRickie Patani Brain Published 1 July 2021 Crick labsRickie PataniNicholas LuscombeFull details Reactive astrocytes in ALS display diminished intron retention Authors (10)Oliver ZiffDoaa TahaHamish CrerarBen ClarkeAnob ChakrabartiGavin KellyJacob NeevesGiulia TyzackNicholas LuscombeRickie Patani Nucleic Acids Research Published 6 April 2021 Crick labs/ facilitiesRickie PataniNicholas LuscombeSonia GandhiBioinformatics and BiostatisticsScientific computingProteomicsAdvanced SequencingFull details Paraspeckle components NONO and PSPC1 are not mislocalized from motor neuron nuclei in sporadic ALS Authors (6)Giulia Tyzack Giulia Manferrari Jia NewcombeNicholas Luscombe Raphaelle LuisierRickie Patani Brain Published 1 August 2020 Crick labsRickie PataniNicholas LuscombeFull details Widespread FUS mislocalization is a molecular hallmark of amyotrophic lateral sclerosis Authors (12)Giulia Tyzack Raphaelle LuisierDoaa TahaJacob NeevesMiha ModicJamie Mitchell[...] Linda Greensmith Jia NewcombeJernej UleNicholas LuscombeRickie Patani Brain Published 1 September 2019 Crick labsJernej UleRickie PataniNicholas LuscombeFull details Intron retention and nuclear loss of SFPQ are molecular hallmarks of ALS Authors (13) Raphaelle LuisierGiulia Tyzack Claire E HallJamie MitchellHelen DevineDoaa Taha[...] Linda Greensmith Jia NewcombeJernej UleNicholas LuscombeRickie Patani Nature Communications Published 22 May 2018 Crick labsJernej UleRickie PataniNicholas LuscombeFull details Progressive motor neuron pathology and the role of astrocytes in a human stem cell model of VCP-related ALS Authors (24) Claire E Hall Zhi YaoMinee ChoiGiulia TyzackAndrea Serio Raphaelle Luisier[...] Christopher R Sibley Andras LakatosJernej UleSonia GandhiRickie Patani Cell Reports Published 30 May 2017 Crick labsJernej UleAndrea SerioRickie PataniNicholas LuscombeSonia GandhiFull details Major shifts in glial regional identity are a transcriptional hallmark of human brain aging Authors (12) Lilach Soreq UK Brain Expression Consortium North American Brain Expression Consortium Jamie Rose Eyal Soreq John Hardy[...] Mark R Cookson Colin Smith Mina RytenRickie PataniJernej Ule Cell Reports Published 10 January 2017 Crick labsJernej UleRickie PataniFull details Share the page Share on Twitter Share on Facebook Share on LinkedIn Share on Email
Transcriptome-wide RNA binding analysis of C9orf72 poly(PR) dipeptides Authors (14) Rubika BalendraIgor Ruiz De Los Mozos Hana M Odeh Idoia Glaria Carmelo Milioto Katherine M Wilson[...] Stephen MartinRickie Patani James ShorterJernej Ule Adrian M Isaacs Life Science Alliance Published 1 September 2023 Crick labs/ facilitiesJernej UleRickie PataniStructural BiologyHigh Throughput ScreeningFull details
Nucleocytoplasmic mRNA redistribution accompanies RNA binding protein mislocalization in ALS motor neurons and is restored by VCP ATPase inhibition Authors (10)Oliver ZiffJasmine HarleyYiran WangJacob NeevesGiulia Tyzack Fairouz IbrahimMark SkehelAnob ChakrabartiGavin KellyRickie Patani Neuron Published 4 October 2023 Crick labs/ facilitiesJernej UleRickie PataniProteomicsBioinformatics and BiostatisticsFull details
Integrated transcriptome landscape of ALS identifies genome instability linked to TDP-43 pathology Authors (14)Oliver ZiffJacob NeevesJamie MitchellGiulia Tyzack Carlos Martinez-Ruiz Raphaelle Luisier[...]Simon Boulton Ammar Al-ChalabiGavin Kelly Jack HumphreyRickie Patani Nature Communications Published 20 April 2023 Crick labs/ facilitiesJernej UleRickie PataniSimon BoultonBioinformatics and BiostatisticsScientific computingFull details
Protein aggregation and calcium dysregulation are hallmarks of familial Parkinson's disease in midbrain dopaminergic neurons Authors (26)Gurvir VirdiMinee ChoiJames EvansZhi YaoDilan Athauda Stephanie Strohbuecker[...] Tilo Kunath Mathew H Horrocks Andrey Y AbramovRickie PataniSonia Gandhi npj Parkinsons Disease Published 24 November 2022 Crick labs/ facilitiesRickie PataniSonia GandhiBioinformatics and BiostatisticsAdvanced SequencingLight MicroscopyFlow CytometryFull details
Meta-analysis of human and mouse ALS astrocytes reveals multi-omic signatures of inflammatory reactive states Authors (6)Oliver ZiffBen ClarkeDoaa TahaHamish CrerarNicholas LuscombeRickie Patani Genome Research Published 1 January 2022 Crick labs/ facilitiesRickie PataniNicholas LuscombeScientific computingProteomicsBioinformatics and BiostatisticsAdvanced SequencingFull details
TDP-43 condensation properties specify its RNA-binding and regulatory repertoire Authors (17)Martina HalleggerAnob ChakrabartiFlora Lee Bo Lim Lee Aram G Amalietti Hana M Odeh[...]Rickie Patani Nicolas L Fawzi James ShorterNicholas LuscombeJernej Ule Cell Published 2 September 2021 Crick labs/ facilitiesJernej UleRickie PataniNicholas LuscombeLight MicroscopyAdvanced SequencingFull details
MIR-NATs repress MAPT translation and aid proteostasis in neurodegeneration Authors (34) Roberto Simone Faiza Javad Warren EmmettOscar Wilkins Filipa Lourenço Almeida Natalia Barahona-Torres[...] Per Svenningsson Thomas T Warner Vincent PlagnolJernej Ule Rohan de Silva Nature Published 3 June 2021 Crick labsJernej UleRickie PataniFull details
Aberrant cytoplasmic intron retention is a blueprint for RNA binding protein mislocalization in VCP-related amyotrophic lateral sclerosis Authors (9)Giulia TyzackJacob NeevesHamish CrerarPierre KleinOliver ZiffDoaa Taha Raphaëlle LuisierNicholas LuscombeRickie Patani Brain Published 1 July 2021 Crick labsRickie PataniNicholas LuscombeFull details
Reactive astrocytes in ALS display diminished intron retention Authors (10)Oliver ZiffDoaa TahaHamish CrerarBen ClarkeAnob ChakrabartiGavin KellyJacob NeevesGiulia TyzackNicholas LuscombeRickie Patani Nucleic Acids Research Published 6 April 2021 Crick labs/ facilitiesRickie PataniNicholas LuscombeSonia GandhiBioinformatics and BiostatisticsScientific computingProteomicsAdvanced SequencingFull details
Paraspeckle components NONO and PSPC1 are not mislocalized from motor neuron nuclei in sporadic ALS Authors (6)Giulia Tyzack Giulia Manferrari Jia NewcombeNicholas Luscombe Raphaelle LuisierRickie Patani Brain Published 1 August 2020 Crick labsRickie PataniNicholas LuscombeFull details
Widespread FUS mislocalization is a molecular hallmark of amyotrophic lateral sclerosis Authors (12)Giulia Tyzack Raphaelle LuisierDoaa TahaJacob NeevesMiha ModicJamie Mitchell[...] Linda Greensmith Jia NewcombeJernej UleNicholas LuscombeRickie Patani Brain Published 1 September 2019 Crick labsJernej UleRickie PataniNicholas LuscombeFull details
Intron retention and nuclear loss of SFPQ are molecular hallmarks of ALS Authors (13) Raphaelle LuisierGiulia Tyzack Claire E HallJamie MitchellHelen DevineDoaa Taha[...] Linda Greensmith Jia NewcombeJernej UleNicholas LuscombeRickie Patani Nature Communications Published 22 May 2018 Crick labsJernej UleRickie PataniNicholas LuscombeFull details
Progressive motor neuron pathology and the role of astrocytes in a human stem cell model of VCP-related ALS Authors (24) Claire E Hall Zhi YaoMinee ChoiGiulia TyzackAndrea Serio Raphaelle Luisier[...] Christopher R Sibley Andras LakatosJernej UleSonia GandhiRickie Patani Cell Reports Published 30 May 2017 Crick labsJernej UleAndrea SerioRickie PataniNicholas LuscombeSonia GandhiFull details
Major shifts in glial regional identity are a transcriptional hallmark of human brain aging Authors (12) Lilach Soreq UK Brain Expression Consortium North American Brain Expression Consortium Jamie Rose Eyal Soreq John Hardy[...] Mark R Cookson Colin Smith Mina RytenRickie PataniJernej Ule Cell Reports Published 10 January 2017 Crick labsJernej UleRickie PataniFull details