Publications

Nucleocytoplasmic mRNA redistribution accompanies RNA binding protein mislocalization in ALS motor neurons and is restored by VCP ATPase inhibition

Authors (10)

Neuron

Published 4 October 2023

Crick labs/ facilities

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Integrated transcriptome landscape of ALS identifies genome instability linked to TDP-43 pathology

Authors (14)

Oliver Ziff
Jacob Neeves
Jamie Mitchell
Giulia Tyzack
Carlos Martinez-Ruiz
Raphaelle Luisier
[...]
Simon Boulton
Ammar Al-Chalabi
Gavin Kelly
Jack Humphrey
Rickie Patani

Nature Communications

Published 20 April 2023

Crick labs/ facilities

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Protein aggregation and calcium dysregulation are hallmarks of familial Parkinson's disease in midbrain dopaminergic neurons

Authors (26)

Gurvir Virdi
Minee Choi
James Evans
Zhi Yao
Dilan Athauda
Stephanie Strohbuecker
[...]
Tilo Kunath
Mathew H Horrocks
Andrey Y Abramov
Rickie Patani
Sonia Gandhi

npj Parkinsons Disease

Published 24 November 2022

Crick labs/ facilities

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Meta-analysis of human and mouse ALS astrocytes reveals multi-omic signatures of inflammatory reactive states

Authors (6)

Genome Research

Published 1 January 2022

Crick labs/ facilities

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TDP-43 condensation properties specify its RNA-binding and regulatory repertoire

Authors (17)

Martina Hallegger
Anob Chakrabarti
Flora Lee
Bo Lim Lee
Aram G Amalietti
Hana M Odeh
[...]
Rickie Patani
Nicolas L Fawzi
James Shorter
Nicholas Luscombe
Jernej Ule

Cell

Published 2 September 2021

Crick labs/ facilities

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Aberrant cytoplasmic intron retention is a blueprint for RNA binding protein mislocalization in VCP-related amyotrophic lateral sclerosis

Authors (9)

Brain

Published 1 July 2021

Crick labs

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Paraspeckle components NONO and PSPC1 are not mislocalized from motor neuron nuclei in sporadic ALS

Authors (6)

Brain

Published 1 August 2020

Crick labs

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Widespread FUS mislocalization is a molecular hallmark of amyotrophic lateral sclerosis

Authors (12)

Brain

Published 1 September 2019

Crick labs

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Intron retention and nuclear loss of SFPQ are molecular hallmarks of ALS

Authors (13)

Raphaelle Luisier
Giulia Tyzack
Claire E Hall
Jamie Mitchell
Helen Devine
Doaa Taha
[...]
Linda Greensmith
Jia Newcombe
Jernej Ule
Nicholas Luscombe
Rickie Patani

Nature Communications

Published 22 May 2018

Crick labs

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Progressive motor neuron pathology and the role of astrocytes in a human stem cell model of VCP-related ALS

Authors (24)

Claire E Hall
Zhi Yao
Minee Choi
Giulia Tyzack
Andrea Serio
Raphaelle Luisier
[...]
Christopher R Sibley
Andras Lakatos
Jernej Ule
Sonia Gandhi
Rickie Patani

Cell Reports

Published 30 May 2017

Crick labs

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Postdoctoral clinical fellows

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Nucleocytoplasmic mRNA redistribution accompanies RNA binding protein mislocalization in ALS motor neurons and is restored by VCP ATPase inhibition

Integrated transcriptome landscape of ALS identifies genome instability linked to TDP-43 pathology

Protein aggregation and calcium dysregulation are hallmarks of familial Parkinson's disease in midbrain dopaminergic neurons

Meta-analysis of human and mouse ALS astrocytes reveals multi-omic signatures of inflammatory reactive states

TDP-43 condensation properties specify its RNA-binding and regulatory repertoire

Aberrant cytoplasmic intron retention is a blueprint for RNA binding protein mislocalization in VCP-related amyotrophic lateral sclerosis

Reactive astrocytes in ALS display diminished intron retention

Paraspeckle components NONO and PSPC1 are not mislocalized from motor neuron nuclei in sporadic ALS

Widespread FUS mislocalization is a molecular hallmark of amyotrophic lateral sclerosis

Intron retention and nuclear loss of SFPQ are molecular hallmarks of ALS

Progressive motor neuron pathology and the role of astrocytes in a human stem cell model of VCP-related ALS

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