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Breadcrumb Robert J Wilkinson Wilkinson lab Tuberculosis Laboratory : Publications Lab contentLab contentIn this section Overview Areas of interest Publications Members Vacancies News Khayelitsha, South Africa: a peri-urban township of around 400000 people 30 km from the centre of Cape Town. In Khayelitsha the chances of developing tuberculosis in any year are around 1%, much higher if a person is HIV-coinfected. 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(16) Keren Middelkoop Lisa Micklesfield Justine Stewart Neil Walker David A Jolliffe Amy E Mendham[...] Cyrus Cooper Nicholas C HarveyRobert Wilkinson Linda-Gail Bekker Adrian R Martineau BMJ Paediatrics Open Published 10 April 2024 Crick labsRobert J WilkinsonFull details COVID-19 in non-hospitalised adults caused by either SARS-CoV-2 sub-variants Omicron BA.1, BA.2, BA.4/5 or Delta associates with similar illness duration, symptom severity and viral kinetics, irrespective of vaccination history Authors (37) Hermaleigh Townsley Joshua Gahir Timothy W Russell David GreenwoodEdward Carr Matala Dyke[...]Sonia Gandhi Adam J KucharskiCharles SwantonDavid LV Bauer Emma C Wall PLOS ONE Published 21 March 2024 Crick labs/ facilitiesRobert J WilkinsonCharles SwantonGeorge KassiotisSonia GandhiSteve GamblinRupert BealeDavid LV BauerBiological Research FacilityBioinformatics and BiostatisticsAdvanced SequencingFull details Integrated plasma proteomics identifies tuberculosis-specific diagnostic biomarkers Authors (17) Hannah F Schiff Naomi F Walker Cesar Ugarte-Gil Marc Tebruegge Antigoni Manousopoulou Spiros D Garbis[...] Christopher H WoelkRobert Wilkinson Liku B Tezera Diana Garay-Baquero Paul Elkington JCI insight Published 21 March 2024 Crick labsRobert J WilkinsonFull details A nanopore sequencing-based pharmacogenomic panel to personalize tuberculosis drug dosing Authors (10) Renu Verma Kesia Esther da Silva Neesha Rockwood Roeland E Wasmann Nombuso Yende Taeksun Song Eugene Kim Paolo DentiRobert Wilkinson Jason R Andrews American Journal of Respiratory and Critical Care Medicine Published 5 March 2024 Crick labsRobert J WilkinsonFull details Stable and homogeneous SPION-infused Photo-Resins for 3D-printing magnetic hydrogels Authors (6) Ali A Mohammed Keyu Yao Ieva Ragaisyte Dominic Crestani Connor W MyantAlessandra Pinna Applied Materials Today Published 1 April 2024 Crick labsRobert J WilkinsonFull details Lithiated porous silicon nanowires stimulate periodontal regeneration Authors (27) Martti Kaasalainen Ran Zhang Priya Vashisth Anahid Ahmadi Birjandi Mark S'Ari Davide Alessandro Martella[...] Ana Angelova Volponi Jarno Salonen Nicole Hondow Paul Sharpe Ciro Chiappini Nature Communications Published 12 January 2024 Crick labsRobert J WilkinsonFull details Quantitative measurement of antibiotic resistance in Mycobacterium tuberculosis reveals genetic determinants of resistance and susceptibility in a target gene approach Authors (1) The CRyPTIC Consortium Nature Communications Published 12 January 2024 Crick labsRobert J WilkinsonFull details Influence of vitamin D supplementation on bone mineral content, bone turnover markers and fracture risk in South African schoolchildren: multicentre double-blind randomised placebo-controlled trial (ViDiKids) Authors (18) Keren Middelkoop Lisa K Micklesfield Neil Walker Justine Stewart Carmen Delport David A Jolliffe[...] Nicholas C Harvey Richard L HooperRobert Wilkinson Linda-Gail Bekker Adrian R Martineau Journal of Bone and Mineral Research Published 10 January 2024 Crick labsRobert J WilkinsonFull details Changing character and waning impact of COVID-19 at a tertiary centre in Cape Town, South Africa Authors (20) Lucas E Hermans Petro Booysen Linda Boloko Marguerite Adriaanse Timothy J de Wet Aimee R Lifson[...] Ntobeko AB Ntusi Carolyn Williamson Mary-Ann Davies Graeme Meintjes Sean Wasserman Southern African Journal of Infectious Diseases Published 18 December 2023 Crick labsRobert J WilkinsonFull details BACH1 promotes tissue necrosis and Mycobacterium tuberculosis susceptibility Authors (26) Eduardo P Amaral Sivaranjani Namasivayam Artur TL Queiroz Eduardo Fukutani Kerry L Hilligan Kate Aberman[...] Kazuhiko Igarashi Thomas Scriba Katrin D Mayer-Barber Bruno B Andrade Alan Sher Nature Microbiology Published 1 January 2024 Crick labsRobert J WilkinsonFull details A preclinical model of TB meningitis to determine drug penetration and activity at the sites of disease Authors (12) Faye Lanni Rosleine Antilus Sainte Mark Hansen Jr. Paul Parigi Firat Kaya Katherine LoMauro[...]Robert Wilkinson Sean Wasserman Brendan K Podell Martin Gengenbacher Véronique Dartois Antimicrobial Agents and Chemotherapy Published 1 December 2023 Crick labs/ facilitiesRobert J WilkinsonIn Vivo ImagingBiological Research FacilityFull details Linezolid population pharmacokinetic model in plasma and cerebrospinal fluid among patients with tuberculosis meningitis Authors (10) Noha Abdelgawad Sean Wasserman Mahmoud Tareq Abdelwahab Angharad Davis Cari Stek Lubbe Wiesner John Black Graeme MeintjesRobert Wilkinson Paolo Denti Journal of Infectious Diseases Published 15 April 2024 Crick labsRobert J WilkinsonFull details Neutrophil extracellular trap formation and gene programs distinguish TST/IGRA sensitization outcomes among Mycobacterium tuberculosis exposed persons living with HIV Authors (17) Elouise E Kroon Wilian Correa-Macedo Rachel Evans Allison Seeger Lize Engelbrecht Jurgen A Kriel[...] Marlo MöllerRobert Wilkinson Anna K Coussens Erwin Schurr Eileen G Hoal PLOS Genetics Published 24 August 2023 Crick labsRobert J WilkinsonFull details Differential effects of SARS-CoV-2 variants on central nervous system cells and blood-brain barrier functions Authors (6)Alize ProustChristophe Queval Ruth HarveyLorin Adams Michael BennettRobert Wilkinson Journal of Neuroinflammation Published 3 August 2023 Crick labs/ facilitiesRobert J WilkinsonWorldwide Influenza CentreHigh Throughput ScreeningLight MicroscopyFull details Relationship between LTA4H promotor polymorphism and tuberculosis-associated immune reconstitution inflammatory syndrome and its prevention with prednisone Authors (8) Cari Stek Muki Shey Khuthala Mnika Charlotte Schutz Friedrich ThienemannRobert Wilkinson Lutgarde Lynen Graeme Meintjes Open Forum Infectious Diseases Published 1 July 2023 Crick labsRobert J WilkinsonFull details Nanocomposite hydrogels with polymer grafted silica nanoparticles, using glucose oxidase Authors (5) Ali A Mohammed Siwei Li Tian Sang Julian R JonesAlessandra Pinna Gels Published 13 June 2023 Crick labsRobert J WilkinsonFull details Vitamin D supplementation to prevent tuberculosis infection in South African schoolchildren: multicentre phase 3 double-blind randomized placebo-controlled trial (ViDiKids) Authors (16) Keren Middelkoop Justine Stewart Neil Walker Carmen Delport David A Jolliffe Anna K Coussens[...] Suzanne Filteau Richard L HooperRobert Wilkinson Linda-Gail Bekker Adrian R Martineau International Journal of Infectious Diseases Published 1 September 2023 Crick labsRobert J WilkinsonFull details Mycobacterial-specific secretion of cytokines and chemokines in healthcare workers with apparent resistance to infection with Mycobacterium tuberculosis Authors (12) Muki Shehu Shey Avuyonke Balfour Nomawethu Masina Abulele Bekiswa Charlotte Schutz Rene Goliath[...] Patrick DMC KatotoKatalin Wilkinson David Lewinsohn Deborah Anne Lewinsohn Graeme Meintjes Frontiers in Immunology Published 18 May 2023 Crick labsRobert J WilkinsonFull details Antibodies against endogenous retroviruses promote lung cancer immunotherapy Authors (51)Kevin NgJesse BoumelhaKatey EnfieldJorge Almagro Hongui Cha Oriol Pich[...] Se-Hoon LeeSamra TurajlicCharles SwantonJulian DownwardGeorge Kassiotis Nature Published 20 April 2023 Crick labs/ facilitiesRobert J WilkinsonPeter Van LooSamra TurajlicCharles SwantonGeorge KassiotisJulian DownwardAxel BehrensFlow CytometryExperimental HistopathologyBioinformatics and BiostatisticsAdvanced SequencingScientific computingProteomicsLight MicroscopyCell ServicesBiological Research FacilityFull details Back-to-Africa introductions of Mycobacterium tuberculosis as the main cause of tuberculosis in Dar es Salaam, Tanzania Authors (44) Michaela Zwyer Liliana K Rutaihwa Etthel Windels Jerry Hella Fabrizio Menardo Mohamed Sasamalo[...] Damien Portevin Klaus Reither Tanja Stadler Sebastien Gagneux Daniela Brites PLOS Pathogens Published 4 April 2023 Crick labsRobert J WilkinsonFull details Pagination Current page 1 Page 2 Page 3 Page 4 Page 5 Page 6 Page 7 Page 8 Page 9 … Next page Next Last page Last Share the page Share on Twitter Share on Facebook Share on LinkedIn Share on Email
Influence of vitamin D supplementation on growth, body composition, pubertal development and spirometry in South African schoolchildren: a randomised controlled trial (ViDiKids) Authors (16) Keren Middelkoop Lisa Micklesfield Justine Stewart Neil Walker David A Jolliffe Amy E Mendham[...] Cyrus Cooper Nicholas C HarveyRobert Wilkinson Linda-Gail Bekker Adrian R Martineau BMJ Paediatrics Open Published 10 April 2024 Crick labsRobert J WilkinsonFull details
COVID-19 in non-hospitalised adults caused by either SARS-CoV-2 sub-variants Omicron BA.1, BA.2, BA.4/5 or Delta associates with similar illness duration, symptom severity and viral kinetics, irrespective of vaccination history Authors (37) Hermaleigh Townsley Joshua Gahir Timothy W Russell David GreenwoodEdward Carr Matala Dyke[...]Sonia Gandhi Adam J KucharskiCharles SwantonDavid LV Bauer Emma C Wall PLOS ONE Published 21 March 2024 Crick labs/ facilitiesRobert J WilkinsonCharles SwantonGeorge KassiotisSonia GandhiSteve GamblinRupert BealeDavid LV BauerBiological Research FacilityBioinformatics and BiostatisticsAdvanced SequencingFull details
Integrated plasma proteomics identifies tuberculosis-specific diagnostic biomarkers Authors (17) Hannah F Schiff Naomi F Walker Cesar Ugarte-Gil Marc Tebruegge Antigoni Manousopoulou Spiros D Garbis[...] Christopher H WoelkRobert Wilkinson Liku B Tezera Diana Garay-Baquero Paul Elkington JCI insight Published 21 March 2024 Crick labsRobert J WilkinsonFull details
A nanopore sequencing-based pharmacogenomic panel to personalize tuberculosis drug dosing Authors (10) Renu Verma Kesia Esther da Silva Neesha Rockwood Roeland E Wasmann Nombuso Yende Taeksun Song Eugene Kim Paolo DentiRobert Wilkinson Jason R Andrews American Journal of Respiratory and Critical Care Medicine Published 5 March 2024 Crick labsRobert J WilkinsonFull details
Stable and homogeneous SPION-infused Photo-Resins for 3D-printing magnetic hydrogels Authors (6) Ali A Mohammed Keyu Yao Ieva Ragaisyte Dominic Crestani Connor W MyantAlessandra Pinna Applied Materials Today Published 1 April 2024 Crick labsRobert J WilkinsonFull details
Lithiated porous silicon nanowires stimulate periodontal regeneration Authors (27) Martti Kaasalainen Ran Zhang Priya Vashisth Anahid Ahmadi Birjandi Mark S'Ari Davide Alessandro Martella[...] Ana Angelova Volponi Jarno Salonen Nicole Hondow Paul Sharpe Ciro Chiappini Nature Communications Published 12 January 2024 Crick labsRobert J WilkinsonFull details
Quantitative measurement of antibiotic resistance in Mycobacterium tuberculosis reveals genetic determinants of resistance and susceptibility in a target gene approach Authors (1) The CRyPTIC Consortium Nature Communications Published 12 January 2024 Crick labsRobert J WilkinsonFull details
Influence of vitamin D supplementation on bone mineral content, bone turnover markers and fracture risk in South African schoolchildren: multicentre double-blind randomised placebo-controlled trial (ViDiKids) Authors (18) Keren Middelkoop Lisa K Micklesfield Neil Walker Justine Stewart Carmen Delport David A Jolliffe[...] Nicholas C Harvey Richard L HooperRobert Wilkinson Linda-Gail Bekker Adrian R Martineau Journal of Bone and Mineral Research Published 10 January 2024 Crick labsRobert J WilkinsonFull details
Changing character and waning impact of COVID-19 at a tertiary centre in Cape Town, South Africa Authors (20) Lucas E Hermans Petro Booysen Linda Boloko Marguerite Adriaanse Timothy J de Wet Aimee R Lifson[...] Ntobeko AB Ntusi Carolyn Williamson Mary-Ann Davies Graeme Meintjes Sean Wasserman Southern African Journal of Infectious Diseases Published 18 December 2023 Crick labsRobert J WilkinsonFull details
BACH1 promotes tissue necrosis and Mycobacterium tuberculosis susceptibility Authors (26) Eduardo P Amaral Sivaranjani Namasivayam Artur TL Queiroz Eduardo Fukutani Kerry L Hilligan Kate Aberman[...] Kazuhiko Igarashi Thomas Scriba Katrin D Mayer-Barber Bruno B Andrade Alan Sher Nature Microbiology Published 1 January 2024 Crick labsRobert J WilkinsonFull details
A preclinical model of TB meningitis to determine drug penetration and activity at the sites of disease Authors (12) Faye Lanni Rosleine Antilus Sainte Mark Hansen Jr. Paul Parigi Firat Kaya Katherine LoMauro[...]Robert Wilkinson Sean Wasserman Brendan K Podell Martin Gengenbacher Véronique Dartois Antimicrobial Agents and Chemotherapy Published 1 December 2023 Crick labs/ facilitiesRobert J WilkinsonIn Vivo ImagingBiological Research FacilityFull details
Linezolid population pharmacokinetic model in plasma and cerebrospinal fluid among patients with tuberculosis meningitis Authors (10) Noha Abdelgawad Sean Wasserman Mahmoud Tareq Abdelwahab Angharad Davis Cari Stek Lubbe Wiesner John Black Graeme MeintjesRobert Wilkinson Paolo Denti Journal of Infectious Diseases Published 15 April 2024 Crick labsRobert J WilkinsonFull details
Neutrophil extracellular trap formation and gene programs distinguish TST/IGRA sensitization outcomes among Mycobacterium tuberculosis exposed persons living with HIV Authors (17) Elouise E Kroon Wilian Correa-Macedo Rachel Evans Allison Seeger Lize Engelbrecht Jurgen A Kriel[...] Marlo MöllerRobert Wilkinson Anna K Coussens Erwin Schurr Eileen G Hoal PLOS Genetics Published 24 August 2023 Crick labsRobert J WilkinsonFull details
Differential effects of SARS-CoV-2 variants on central nervous system cells and blood-brain barrier functions Authors (6)Alize ProustChristophe Queval Ruth HarveyLorin Adams Michael BennettRobert Wilkinson Journal of Neuroinflammation Published 3 August 2023 Crick labs/ facilitiesRobert J WilkinsonWorldwide Influenza CentreHigh Throughput ScreeningLight MicroscopyFull details
Relationship between LTA4H promotor polymorphism and tuberculosis-associated immune reconstitution inflammatory syndrome and its prevention with prednisone Authors (8) Cari Stek Muki Shey Khuthala Mnika Charlotte Schutz Friedrich ThienemannRobert Wilkinson Lutgarde Lynen Graeme Meintjes Open Forum Infectious Diseases Published 1 July 2023 Crick labsRobert J WilkinsonFull details
Nanocomposite hydrogels with polymer grafted silica nanoparticles, using glucose oxidase Authors (5) Ali A Mohammed Siwei Li Tian Sang Julian R JonesAlessandra Pinna Gels Published 13 June 2023 Crick labsRobert J WilkinsonFull details
Vitamin D supplementation to prevent tuberculosis infection in South African schoolchildren: multicentre phase 3 double-blind randomized placebo-controlled trial (ViDiKids) Authors (16) Keren Middelkoop Justine Stewart Neil Walker Carmen Delport David A Jolliffe Anna K Coussens[...] Suzanne Filteau Richard L HooperRobert Wilkinson Linda-Gail Bekker Adrian R Martineau International Journal of Infectious Diseases Published 1 September 2023 Crick labsRobert J WilkinsonFull details
Mycobacterial-specific secretion of cytokines and chemokines in healthcare workers with apparent resistance to infection with Mycobacterium tuberculosis Authors (12) Muki Shehu Shey Avuyonke Balfour Nomawethu Masina Abulele Bekiswa Charlotte Schutz Rene Goliath[...] Patrick DMC KatotoKatalin Wilkinson David Lewinsohn Deborah Anne Lewinsohn Graeme Meintjes Frontiers in Immunology Published 18 May 2023 Crick labsRobert J WilkinsonFull details
Antibodies against endogenous retroviruses promote lung cancer immunotherapy Authors (51)Kevin NgJesse BoumelhaKatey EnfieldJorge Almagro Hongui Cha Oriol Pich[...] Se-Hoon LeeSamra TurajlicCharles SwantonJulian DownwardGeorge Kassiotis Nature Published 20 April 2023 Crick labs/ facilitiesRobert J WilkinsonPeter Van LooSamra TurajlicCharles SwantonGeorge KassiotisJulian DownwardAxel BehrensFlow CytometryExperimental HistopathologyBioinformatics and BiostatisticsAdvanced SequencingScientific computingProteomicsLight MicroscopyCell ServicesBiological Research FacilityFull details
Back-to-Africa introductions of Mycobacterium tuberculosis as the main cause of tuberculosis in Dar es Salaam, Tanzania Authors (44) Michaela Zwyer Liliana K Rutaihwa Etthel Windels Jerry Hella Fabrizio Menardo Mohamed Sasamalo[...] Damien Portevin Klaus Reither Tanja Stadler Sebastien Gagneux Daniela Brites PLOS Pathogens Published 4 April 2023 Crick labsRobert J WilkinsonFull details