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Breadcrumb Robert J Wilkinson Wilkinson lab Tuberculosis Laboratory : Publications Lab contentLab contentIn this section Overview Areas of interest Publications Members Vacancies News Khayelitsha, South Africa: a peri-urban township of around 400000 people 30 km from the centre of Cape Town. In Khayelitsha the chances of developing tuberculosis in any year are around 1%, much higher if a person is HIV-coinfected. Toggle to view hero caption PublicationsYear published2024 (1)2023 (3)2022 (2)2021 (7)2019 (1)2018 (1) Facet Year publishedResearch topicsHuman Biology & Physiology (15)Immunology (15)Infectious Disease (15)Model Organisms (15)Computational & Systems Biology (14)Genetics & Genomics (14)Genome Integrity & Repair (14)Tumour Biology (14)Cell Biology (10)Signalling & Oncogenes (9)Stem Cells (9)Biochemistry & Proteomics (8)Cell Cycle & Chromosomes (8)Metabolism (8)Neurosciences (8)Structural Biology & Biophysics (8)Developmental Biology (6)Gene Expression (2)Imaging (2)Synthetic Biology (2) (-)Chemical Biology & High Throughput (15) Facet Research topicsPublication typeJournal article (15)Primary research (15) Facet Publication typeJournalNature Cancer (3)ACS Central Science (1)Cancer Cell (1)Cell Reports Medicine (1)Frontiers in Immunology (1)Journal of Neuroinflammation (1)mBio (1)Nature (1)Nature Communications (1)Nature Medicine (1)PLOS ONE (1)Proceedings of the National Academy of Sciences of the United States of America (1)The Lancet (1) Facet Journal Publications Displaying 1 - 15 of 15Last updated : 19 April 2024 02:49 COVID-19 in non-hospitalised adults caused by either SARS-CoV-2 sub-variants Omicron BA.1, BA.2, BA.4/5 or Delta associates with similar illness duration, symptom severity and viral kinetics, irrespective of vaccination history Authors (37) Hermaleigh Townsley Joshua Gahir Timothy W Russell David GreenwoodEdward Carr Matala Dyke[...]Sonia Gandhi Adam J KucharskiCharles SwantonDavid LV Bauer Emma C Wall PLOS ONE Published 21 March 2024 Crick labs/ facilitiesRobert J WilkinsonCharles SwantonGeorge KassiotisSonia GandhiSteve GamblinRupert BealeDavid LV BauerBiological Research FacilityBioinformatics and BiostatisticsAdvanced SequencingFull details Differential effects of SARS-CoV-2 variants on central nervous system cells and blood-brain barrier functions Authors (6)Alize ProustChristophe Queval Ruth HarveyLorin Adams Michael BennettRobert Wilkinson Journal of Neuroinflammation Published 3 August 2023 Crick labs/ facilitiesRobert J WilkinsonWorldwide Influenza CentreHigh Throughput ScreeningLight MicroscopyFull details Antibodies against endogenous retroviruses promote lung cancer immunotherapy Authors (51)Kevin NgJesse BoumelhaKatey EnfieldJorge Almagro Hongui Cha Oriol Pich[...] Se-Hoon LeeSamra TurajlicCharles SwantonJulian DownwardGeorge Kassiotis Nature Published 20 April 2023 Crick labs/ facilitiesRobert J WilkinsonPeter Van LooSamra TurajlicCharles SwantonGeorge KassiotisJulian DownwardAxel BehrensFlow CytometryExperimental HistopathologyBioinformatics and BiostatisticsAdvanced SequencingScientific computingProteomicsLight MicroscopyCell ServicesBiological Research FacilityFull details O-linked sialoglycans modulate the proteolysis of SARS-CoV-2 spike and likely contribute to the mutational trajectory in variants of concern Authors (22)Edgar Gonzalez-RodriguezMia Zol-HanlonGanka Bineva-ToddAndrea MarchesiMark Skehel Keira E Mahoney[...]Robert Wilkinson Emma C Wall Ramón Hurtado-Guerrero Stacy A MalakerBen Schumann ACS Central Science Published 22 March 2023 Crick labs/ facilitiesRobert J WilkinsonBen SchumannSteve GamblinStructural BiologyProteomicsChemical BiologyFull details Functional immune responses against SARS-CoV-2 variants of concern after fourth COVID-19 vaccine dose or infection in patients with blood cancer Authors (64)Annika FendlerScott ShepherdLewis AuMary Wu Ruth HarveyKatalin Wilkinson[...] Emma Nicholson Susanna WalkerRobert Wilkinson James LarkinSamra Turajlic Cell Reports Medicine Published 18 October 2022 Crick labs/ facilitiesRobert J WilkinsonSamra TurajlicCharles SwantonGeorge KassiotisSonia GandhiSteve GamblinRupert BealeDavid LV BauerWorldwide Influenza CentreStructural BiologyMetabolomicsHigh Throughput ScreeningScientific computingFull details Omicron neutralising antibodies after third COVID-19 vaccine dose in patients with cancer Authors (62)Annika FendlerScott ShepherdLewis AuMary Wu Ruth Harvey Andreas M Schmitt[...] Emma Nicholson Susanna Walker James LarkinSamra Turajlic The CAPTURE consortium The Lancet Published 5 March 2022 Crick labs/ facilitiesRobert J WilkinsonSamra TurajlicCharles SwantonNicola LewisGeorge KassiotisSonia GandhiSteve GamblinRupert BealeDavid LV BauerWorldwide Influenza CentreStructural BiologyMetabolomicsHigh Throughput ScreeningBiological Research FacilityBioinformatics and BiostatisticsAdvanced SequencingScientific computingFull details Immune responses following third COVID-19 vaccination are reduced in patients with hematological malignancies compared to patients with solid cancer Authors (65)Annika FendlerScott ShepherdLewis AuKatalin WilkinsonMary Wu Andreas M Schmitt[...] Susanna WalkerRobert Wilkinson James LarkinSamra Turajlic CAPTURE consortium Cancer Cell Published 14 February 2022 Crick labs/ facilitiesRobert J WilkinsonSamra TurajlicCharles SwantonNicola LewisGeorge KassiotisSonia GandhiSteve GamblinRupert BealeDavid LV BauerWorldwide Influenza CentreStructural BiologyProteomicsMetabolomicsHigh Throughput ScreeningBioinformatics and BiostatisticsAdvanced SequencingScientific computingFull details Transcriptomic characterization of tuberculous sputum reveals a host Warburg effect and microbial cholesterol catabolism Authors (11)Rachel Lai Teresa Cortes Suzaan Marais Neesha Rockwood Melissa L BurkeAcely Garza-Garcia Stuart Horswell Abdul K Sesay Anne O’Garra Douglas B YoungRobert Wilkinson mBio Published 7 December 2021 Crick labs/ facilitiesRobert J WilkinsonAnne O’GarraLuiz Pedro CarvalhoBioinformatics and BiostatisticsAdvanced SequencingFull details Adaptive immunity and neutralizing antibodies against SARS-CoV-2 variants of concern following vaccination in patients with cancer: the CAPTURE study Authors (98)Annika FendlerScott ShepherdLewis AuKatalin WilkinsonMary WuFiona Byrne[...] Susanna WalkerRobert Wilkinson James LarkinSamra Turajlic CAPTURE Consortium Nature Cancer Published 1 December 2021 Crick labs/ facilitiesRobert J WilkinsonSamra TurajlicCharles SwantonNicola LewisGeorge KassiotisSonia GandhiSteve GamblinDavid LV BauerWorldwide Influenza CentreMetabolomicsHigh Throughput ScreeningFlow CytometryBioinformatics and BiostatisticsAdvanced SequencingScientific computingFull details Adaptive immunity and neutralizing antibodies against SARS-CoV-2 variants of concern following vaccination in patients with cancer: the CAPTURE study Authors (98)Annika FendlerScott ShepherdLewis AuKatalin WilkinsonMary WuFiona Byrne[...] Susanna WalkerRobert Wilkinson James LarkinSamra Turajlic The CAPTURE Consortium Nature Cancer Published 1 December 2021 Crick labs/ facilitiesRobert J WilkinsonSamra TurajlicCharles SwantonNicola LewisGeorge KassiotisSonia GandhiSteve GamblinDavid LV BauerWorldwide Influenza CentreMetabolomicsHigh Throughput ScreeningFlow CytometryBioinformatics and BiostatisticsAdvanced SequencingScientific computingFull details Functional antibody and T cell immunity following SARS-CoV-2 infection, including by variants of concern, in patients with cancer: the CAPTURE study Authors (89)Annika FendlerLewis AuScott ShepherdFiona ByrneMaddalena Cerrone Laura Amanda Boos[...]George Kassiotis James LarkinRobert WilkinsonSamra Turajlic The CAPTURE consortium Nature Cancer Published 1 December 2021 Crick labs/ facilitiesRobert J WilkinsonSamra TurajlicCharles SwantonNicola LewisGeorge KassiotisSonia GandhiSteve GamblinWorldwide Influenza CentreProteomicsMetabolomicsHigh Throughput ScreeningFlow CytometryExperimental HistopathologyBioinformatics and BiostatisticsAdvanced SequencingScientific computingFull details Cytokine release syndrome in a patient with colorectal cancer after vaccination with BNT162b2 Authors (35) Lewis Au Annika Fendler Scott TC Shepherd Karolina RzeniewiczMaddalena Cerrone Fiona Byrne[...] Susana Banerjee Naureen Starling Ian Chau CAPTURE Consortium Samra Turajlic Nature Medicine Published 1 August 2021 Crick labs/ facilitiesRobert J WilkinsonSamra TurajlicCharles SwantonNicola LewisGeorge KassiotisSonia GandhiWorldwide Influenza CentreAdvanced SequencingScientific computingFull details Antiretroviral treatment-induced decrease in immune activation contributes to reduced susceptibility to Tuberculosis in HIV-1/Mtb co-infected persons Authors (8)Katalin WilkinsonDeborah Schneider-Luftman Rachel Lai Christopher Barrington Nishtha Jhilmeet David M LoweGavin KellyRobert Wilkinson Frontiers in Immunology Published 5 March 2021 Crick labs/ facilitiesRobert J WilkinsonBioinformatics and BiostatisticsAdvanced SequencingFull details Tuberculous meningitis in children is characterized by compartmentalized immune responses and neural excitotoxicity Authors (13) Ursula K Rohlwink Anthony FigajiKatalin Wilkinson Stuart Horswell Abdul K Sesay Armin Deffur[...] Ronald Van Toorn Brian Eley Michael LevinRobert WilkinsonRachel Lai Nature Communications Published 21 August 2019 Crick labs/ facilitiesRobert J WilkinsonBioinformatics and BiostatisticsAdvanced SequencingFull details Complement pathway gene activation and rising circulating immune complexes characterize early disease in HIV-associated tuberculosis Authors (10) Hanif EsmailRachel Lai Maia LesoskyKatalin WilkinsonChristine Graham Stuart Horswell Anna K Coussens Clifton E BarryAnne O'GarraRobert Wilkinson Proceedings of the National Academy of Sciences of the United States of America Published 30 January 2018 Crick labs/ facilitiesRobert J WilkinsonAnne O’GarraBioinformatics and BiostatisticsFull details Share the page Share on Twitter Share on Facebook Share on LinkedIn Share on Email
COVID-19 in non-hospitalised adults caused by either SARS-CoV-2 sub-variants Omicron BA.1, BA.2, BA.4/5 or Delta associates with similar illness duration, symptom severity and viral kinetics, irrespective of vaccination history Authors (37) Hermaleigh Townsley Joshua Gahir Timothy W Russell David GreenwoodEdward Carr Matala Dyke[...]Sonia Gandhi Adam J KucharskiCharles SwantonDavid LV Bauer Emma C Wall PLOS ONE Published 21 March 2024 Crick labs/ facilitiesRobert J WilkinsonCharles SwantonGeorge KassiotisSonia GandhiSteve GamblinRupert BealeDavid LV BauerBiological Research FacilityBioinformatics and BiostatisticsAdvanced SequencingFull details
Differential effects of SARS-CoV-2 variants on central nervous system cells and blood-brain barrier functions Authors (6)Alize ProustChristophe Queval Ruth HarveyLorin Adams Michael BennettRobert Wilkinson Journal of Neuroinflammation Published 3 August 2023 Crick labs/ facilitiesRobert J WilkinsonWorldwide Influenza CentreHigh Throughput ScreeningLight MicroscopyFull details
Antibodies against endogenous retroviruses promote lung cancer immunotherapy Authors (51)Kevin NgJesse BoumelhaKatey EnfieldJorge Almagro Hongui Cha Oriol Pich[...] Se-Hoon LeeSamra TurajlicCharles SwantonJulian DownwardGeorge Kassiotis Nature Published 20 April 2023 Crick labs/ facilitiesRobert J WilkinsonPeter Van LooSamra TurajlicCharles SwantonGeorge KassiotisJulian DownwardAxel BehrensFlow CytometryExperimental HistopathologyBioinformatics and BiostatisticsAdvanced SequencingScientific computingProteomicsLight MicroscopyCell ServicesBiological Research FacilityFull details
O-linked sialoglycans modulate the proteolysis of SARS-CoV-2 spike and likely contribute to the mutational trajectory in variants of concern Authors (22)Edgar Gonzalez-RodriguezMia Zol-HanlonGanka Bineva-ToddAndrea MarchesiMark Skehel Keira E Mahoney[...]Robert Wilkinson Emma C Wall Ramón Hurtado-Guerrero Stacy A MalakerBen Schumann ACS Central Science Published 22 March 2023 Crick labs/ facilitiesRobert J WilkinsonBen SchumannSteve GamblinStructural BiologyProteomicsChemical BiologyFull details
Functional immune responses against SARS-CoV-2 variants of concern after fourth COVID-19 vaccine dose or infection in patients with blood cancer Authors (64)Annika FendlerScott ShepherdLewis AuMary Wu Ruth HarveyKatalin Wilkinson[...] Emma Nicholson Susanna WalkerRobert Wilkinson James LarkinSamra Turajlic Cell Reports Medicine Published 18 October 2022 Crick labs/ facilitiesRobert J WilkinsonSamra TurajlicCharles SwantonGeorge KassiotisSonia GandhiSteve GamblinRupert BealeDavid LV BauerWorldwide Influenza CentreStructural BiologyMetabolomicsHigh Throughput ScreeningScientific computingFull details
Omicron neutralising antibodies after third COVID-19 vaccine dose in patients with cancer Authors (62)Annika FendlerScott ShepherdLewis AuMary Wu Ruth Harvey Andreas M Schmitt[...] Emma Nicholson Susanna Walker James LarkinSamra Turajlic The CAPTURE consortium The Lancet Published 5 March 2022 Crick labs/ facilitiesRobert J WilkinsonSamra TurajlicCharles SwantonNicola LewisGeorge KassiotisSonia GandhiSteve GamblinRupert BealeDavid LV BauerWorldwide Influenza CentreStructural BiologyMetabolomicsHigh Throughput ScreeningBiological Research FacilityBioinformatics and BiostatisticsAdvanced SequencingScientific computingFull details
Immune responses following third COVID-19 vaccination are reduced in patients with hematological malignancies compared to patients with solid cancer Authors (65)Annika FendlerScott ShepherdLewis AuKatalin WilkinsonMary Wu Andreas M Schmitt[...] Susanna WalkerRobert Wilkinson James LarkinSamra Turajlic CAPTURE consortium Cancer Cell Published 14 February 2022 Crick labs/ facilitiesRobert J WilkinsonSamra TurajlicCharles SwantonNicola LewisGeorge KassiotisSonia GandhiSteve GamblinRupert BealeDavid LV BauerWorldwide Influenza CentreStructural BiologyProteomicsMetabolomicsHigh Throughput ScreeningBioinformatics and BiostatisticsAdvanced SequencingScientific computingFull details
Transcriptomic characterization of tuberculous sputum reveals a host Warburg effect and microbial cholesterol catabolism Authors (11)Rachel Lai Teresa Cortes Suzaan Marais Neesha Rockwood Melissa L BurkeAcely Garza-Garcia Stuart Horswell Abdul K Sesay Anne O’Garra Douglas B YoungRobert Wilkinson mBio Published 7 December 2021 Crick labs/ facilitiesRobert J WilkinsonAnne O’GarraLuiz Pedro CarvalhoBioinformatics and BiostatisticsAdvanced SequencingFull details
Adaptive immunity and neutralizing antibodies against SARS-CoV-2 variants of concern following vaccination in patients with cancer: the CAPTURE study Authors (98)Annika FendlerScott ShepherdLewis AuKatalin WilkinsonMary WuFiona Byrne[...] Susanna WalkerRobert Wilkinson James LarkinSamra Turajlic CAPTURE Consortium Nature Cancer Published 1 December 2021 Crick labs/ facilitiesRobert J WilkinsonSamra TurajlicCharles SwantonNicola LewisGeorge KassiotisSonia GandhiSteve GamblinDavid LV BauerWorldwide Influenza CentreMetabolomicsHigh Throughput ScreeningFlow CytometryBioinformatics and BiostatisticsAdvanced SequencingScientific computingFull details
Adaptive immunity and neutralizing antibodies against SARS-CoV-2 variants of concern following vaccination in patients with cancer: the CAPTURE study Authors (98)Annika FendlerScott ShepherdLewis AuKatalin WilkinsonMary WuFiona Byrne[...] Susanna WalkerRobert Wilkinson James LarkinSamra Turajlic The CAPTURE Consortium Nature Cancer Published 1 December 2021 Crick labs/ facilitiesRobert J WilkinsonSamra TurajlicCharles SwantonNicola LewisGeorge KassiotisSonia GandhiSteve GamblinDavid LV BauerWorldwide Influenza CentreMetabolomicsHigh Throughput ScreeningFlow CytometryBioinformatics and BiostatisticsAdvanced SequencingScientific computingFull details
Functional antibody and T cell immunity following SARS-CoV-2 infection, including by variants of concern, in patients with cancer: the CAPTURE study Authors (89)Annika FendlerLewis AuScott ShepherdFiona ByrneMaddalena Cerrone Laura Amanda Boos[...]George Kassiotis James LarkinRobert WilkinsonSamra Turajlic The CAPTURE consortium Nature Cancer Published 1 December 2021 Crick labs/ facilitiesRobert J WilkinsonSamra TurajlicCharles SwantonNicola LewisGeorge KassiotisSonia GandhiSteve GamblinWorldwide Influenza CentreProteomicsMetabolomicsHigh Throughput ScreeningFlow CytometryExperimental HistopathologyBioinformatics and BiostatisticsAdvanced SequencingScientific computingFull details
Cytokine release syndrome in a patient with colorectal cancer after vaccination with BNT162b2 Authors (35) Lewis Au Annika Fendler Scott TC Shepherd Karolina RzeniewiczMaddalena Cerrone Fiona Byrne[...] Susana Banerjee Naureen Starling Ian Chau CAPTURE Consortium Samra Turajlic Nature Medicine Published 1 August 2021 Crick labs/ facilitiesRobert J WilkinsonSamra TurajlicCharles SwantonNicola LewisGeorge KassiotisSonia GandhiWorldwide Influenza CentreAdvanced SequencingScientific computingFull details
Antiretroviral treatment-induced decrease in immune activation contributes to reduced susceptibility to Tuberculosis in HIV-1/Mtb co-infected persons Authors (8)Katalin WilkinsonDeborah Schneider-Luftman Rachel Lai Christopher Barrington Nishtha Jhilmeet David M LoweGavin KellyRobert Wilkinson Frontiers in Immunology Published 5 March 2021 Crick labs/ facilitiesRobert J WilkinsonBioinformatics and BiostatisticsAdvanced SequencingFull details
Tuberculous meningitis in children is characterized by compartmentalized immune responses and neural excitotoxicity Authors (13) Ursula K Rohlwink Anthony FigajiKatalin Wilkinson Stuart Horswell Abdul K Sesay Armin Deffur[...] Ronald Van Toorn Brian Eley Michael LevinRobert WilkinsonRachel Lai Nature Communications Published 21 August 2019 Crick labs/ facilitiesRobert J WilkinsonBioinformatics and BiostatisticsAdvanced SequencingFull details
Complement pathway gene activation and rising circulating immune complexes characterize early disease in HIV-associated tuberculosis Authors (10) Hanif EsmailRachel Lai Maia LesoskyKatalin WilkinsonChristine Graham Stuart Horswell Anna K Coussens Clifton E BarryAnne O'GarraRobert Wilkinson Proceedings of the National Academy of Sciences of the United States of America Published 30 January 2018 Crick labs/ facilitiesRobert J WilkinsonAnne O’GarraBioinformatics and BiostatisticsFull details