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Breadcrumb Robert J Wilkinson Wilkinson lab Tuberculosis Laboratory : Publications Lab contentLab contentIn this section Overview Areas of interest Publications Members Vacancies News Khayelitsha, South Africa: a peri-urban township of around 400000 people 30 km from the centre of Cape Town. In Khayelitsha the chances of developing tuberculosis in any year are around 1%, much higher if a person is HIV-coinfected. Toggle to view hero caption PublicationsYear published (-)2015 (28) Facet Year publishedResearch topicsHuman Biology & Physiology (22)Immunology (22)Infectious Disease (22)Model Organisms (22)Computational & Systems Biology (1) Facet Research topicsPublication typeJournal article (28)Primary research (16)Review (7)Commentary (4)Letter (1) Facet Publication typeJournalJournal of Immunology (2)AIDS (1)AIDS Research and Therapy (1)American Journal of Respiratory and Critical Care Medicine (1)Annals of the American Thoracic Society (1)Annals of Translational Medicine (1)BMC Genomics (1)BMC Infectious Diseases (1)Clinical Medicine (1)EBioMedicine (1)European Journal of Immunology (1)European Respiratory Journal (1)Future Microbiology (1)HIV/AIDS - Research and Palliative Care (1)Journal of Acquired Immune Deficiency Syndromes (1)Journal of Clinical Microbiology (1)Journal of Experimental Medicine (1)Journal of Infection (1)Lancet HIV (1)Lancet Respiratory Medicine (1)Nature Communications (1)Nature Reviews Drug Discovery (1)PLOS ONE (1)PLOS Pathogens (1)Proceedings of the National Academy of Sciences of USA (1)Seminars in Immunopathology (1)Tuberculosis (1) Facet Journal Publications Displaying 1 - 20 of 28Last updated : 25 April 2024 02:46 Flow cytometry to assess cerebrospinal fluid fungal burden in cryptococcal meningitis Authors (9) James E Scriven Lisa M Graham Charlotte Schutz Thomas J ScribaRobert Wilkinson David R Boulware Graeme Meintjes David G Lalloo Britta C Urban Journal of Clinical Microbiology Published 1 March 2016 Crick labsRobert J WilkinsonFull details A compartmentalized profibrotic immune response characterizes pericardial tuberculosis, irrespective of HIV-1 infection Authors (11) Kerryn Matthews Armin Deffur Mpiko Ntsekhe Faisal Syed James BW Russell Kemi Tibazarwa Janine Wolske Johan Brink Bongani M MayosiRobert WilkinsonKatalin Wilkinson American Journal of Respiratory and Critical Care Medicine Published 15 December 2015 Crick labsRobert J WilkinsonFull details Understanding and intervening in HIV-associated tuberculosis Authors (2) Neesha RockwoodRobert Wilkinson Clinical Medicine Published 1 December 2015 Crick labsRobert J WilkinsonFull details Population tailored modification of tuberculosis specific interferon-gamma release assay Authors (10) Kata Horvati Szilvia Bősze Hannah P Gideon Bernadett Bacsa Tamás G Szabó Rene Goliath Molebogeng X Rangaka Ferenc HudeczRobert WilkinsonKatalin Wilkinson Journal of Infection Published 1 February 2016 Crick labsRobert J WilkinsonFull details Are the present doses of anti tubercular drugs adequate for severe disease? Authors (2) S MaraisRobert Wilkinson EBioMedicine Published 1 November 2015 Crick labsRobert J WilkinsonFull details Independent predictors of tuberculosis mortality in a high HIV prevalence setting: a retrospective cohort study Authors (5) Dominique J Pepper Michael SchomakerRobert Wilkinson Virginia de Azevedo Gary Maartens AIDS Research and Therapy Published 6 October 2015 Crick labsRobert J WilkinsonFull details HIV-1 tuberculosis-associated immune reconstitution inflammatory syndrome Authors (3) Rachel PJ Lai Graeme MeintjesRobert Wilkinson Seminars in Immunopathology Published 1 March 2016 Crick labsRobert J WilkinsonFull details Risk factors for acquired rifamycin and isoniazid resistance: a systematic review and meta-analysis Authors (4) Neesha Rockwood Leila H AbdullahiRobert Wilkinson Graeme Meintjes PLOS ONE Published 25 September 2015 Crick labsRobert J WilkinsonFull details HIV-tuberculosis-associated immune reconstitution inflammatory syndrome is characterized by Toll-like receptor and inflammasome signalling Authors (17)Rachel Lai Graeme MeintjesKatalin WilkinsonChristine Graham Suzaan Marais Helen Van der Plas[...] Gary Maartens Jacques Banchereau Damien ChaussabelAnne O'GarraRobert Wilkinson Nature Communications Published 24 September 2015 Crick labsRobert J WilkinsonAnne O’GarraFull details Management of latent Mycobacterium tuberculosis infection: WHO guidelines for low tuberculosis burden countries Authors (72) Haileyesus Getahun Alberto Matteelli Ibrahim Abubakar Mohamed Abdel Aziz Annabel Baddeley Draurio Barreira[...] Karin WeyerRobert Wilkinson Takashi Yoshiyama Jean Pierre Zellweger Mario Raviglione European Respiratory Journal Published 1 December 2015 Crick labsRobert J WilkinsonFull details Effect of antiretroviral therapy on HIV-mediated impairment of the neutrophil antimycobacterial response Authors (7) David M Lowe Nonzwakazi Bangani Rene Goliath Beate KampmannKatalin WilkinsonRobert Wilkinson Adrian R Martineau Annals of the American Thoracic Society Published 1 November 2015 Crick labsRobert J WilkinsonFull details Interleukin 27R regulates CD4+ T cell phenotype and impacts protective immunity during Mycobacterium tuberculosis infection Authors (19) Egidio Torrado Jeffrey J Fountain Mingfeng Liao Michael Tighe William W ReileyRachel Lai[...] K Kai McKinstry Tara M StruttRobert Wilkinson Susan L Swain Andrea M Cooper Journal of Experimental Medicine Published 24 August 2015 Crick labsRobert J WilkinsonFull details Towards host-directed therapies for tuberculosis Authors (65) Alimuddin Zumla Jeremiah Chakaya Michael Hoelscher Francine Ntoumi Roxana Rustomjee Cristina Vilaplana[...]Robert Wilkinson Bongani Mayosi Marco Schito Robert S Wallis Markus Maeurer Nature Reviews Drug Discovery Published 17 July 2015 Crick labsRobert J WilkinsonFull details Raised venous lactate and markers of intestinal translocation are associated with mortality among in-patients with HIV-associated TB in rural South Africa Authors (8) Sathyavani SubbaraoKatalin Wilkinson Clare L van Halsema Suhasini Subba Rao Tom Boyles Netanya S UtayRobert Wilkinson Graeme Meintjes Journal of Acquired Immune Deficiency Syndromes Published 1 December 2015 Crick labsRobert J WilkinsonFull details Six host-range restricted poxviruses from three genera induce distinct gene expression profiles in an in vivo mouse model Authors (6) Kristy Offerman Armin Deffur Olivia CaruleiRobert Wilkinson Nicola Douglass Anna-Lise Williamson BMC Genomics Published 8 July 2015 Crick labsRobert J WilkinsonFull details Phenylbutyrate is bacteriostatic against Mycobacterium tuberculosis and regulates the macrophage response to infection, synergistically with 25-hydroxy-vitamin D3 Authors (3) Anna K CoussensRobert Wilkinson Adrian R Martineau PLOS Pathogens Published 2 July 2015 Crick labsRobert J WilkinsonFull details Membrane type 1 matrix metalloproteinase regulates monocyte migration and collagen destruction in tuberculosis Authors (9) Tarangini Sathyamoorthy Liku B Tezera Naomi F Walker Sara Brilha Luisa Saraiva Francesco A MauriRobert Wilkinson Jon S Friedland Paul T Elkington Journal of Immunology Published 1 August 2015 Crick labsRobert J WilkinsonFull details High-dose vitamin D3 reduces deficiency caused by low UVB exposure and limits HIV-1 replication in urban Southern Africans Authors (6) Anna K Coussens Celeste E Naude Rene Goliath George ChaplinRobert Wilkinson Nina G Jablonski Proceedings of the National Academy of Sciences of USA Published 30 June 2015 Crick labsRobert J WilkinsonFull details ART and prevention of HIV-associated tuberculosis Authors (2) Stephen D LawnRobert Wilkinson Lancet HIV Published 1 June 2015 Crick labsRobert J WilkinsonFull details Paradoxical TB-IRIS in HIV-infected adults: a systematic review and meta-analysis Authors (6) Phiona E Namale Leila H Abdullahi Stacey Fine Monika KamkuemahRobert Wilkinson Graeme Meintjes Future Microbiology Published 1 June 2015 Crick labsRobert J WilkinsonFull 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Flow cytometry to assess cerebrospinal fluid fungal burden in cryptococcal meningitis Authors (9) James E Scriven Lisa M Graham Charlotte Schutz Thomas J ScribaRobert Wilkinson David R Boulware Graeme Meintjes David G Lalloo Britta C Urban Journal of Clinical Microbiology Published 1 March 2016 Crick labsRobert J WilkinsonFull details
A compartmentalized profibrotic immune response characterizes pericardial tuberculosis, irrespective of HIV-1 infection Authors (11) Kerryn Matthews Armin Deffur Mpiko Ntsekhe Faisal Syed James BW Russell Kemi Tibazarwa Janine Wolske Johan Brink Bongani M MayosiRobert WilkinsonKatalin Wilkinson American Journal of Respiratory and Critical Care Medicine Published 15 December 2015 Crick labsRobert J WilkinsonFull details
Understanding and intervening in HIV-associated tuberculosis Authors (2) Neesha RockwoodRobert Wilkinson Clinical Medicine Published 1 December 2015 Crick labsRobert J WilkinsonFull details
Population tailored modification of tuberculosis specific interferon-gamma release assay Authors (10) Kata Horvati Szilvia Bősze Hannah P Gideon Bernadett Bacsa Tamás G Szabó Rene Goliath Molebogeng X Rangaka Ferenc HudeczRobert WilkinsonKatalin Wilkinson Journal of Infection Published 1 February 2016 Crick labsRobert J WilkinsonFull details
Are the present doses of anti tubercular drugs adequate for severe disease? Authors (2) S MaraisRobert Wilkinson EBioMedicine Published 1 November 2015 Crick labsRobert J WilkinsonFull details
Independent predictors of tuberculosis mortality in a high HIV prevalence setting: a retrospective cohort study Authors (5) Dominique J Pepper Michael SchomakerRobert Wilkinson Virginia de Azevedo Gary Maartens AIDS Research and Therapy Published 6 October 2015 Crick labsRobert J WilkinsonFull details
HIV-1 tuberculosis-associated immune reconstitution inflammatory syndrome Authors (3) Rachel PJ Lai Graeme MeintjesRobert Wilkinson Seminars in Immunopathology Published 1 March 2016 Crick labsRobert J WilkinsonFull details
Risk factors for acquired rifamycin and isoniazid resistance: a systematic review and meta-analysis Authors (4) Neesha Rockwood Leila H AbdullahiRobert Wilkinson Graeme Meintjes PLOS ONE Published 25 September 2015 Crick labsRobert J WilkinsonFull details
HIV-tuberculosis-associated immune reconstitution inflammatory syndrome is characterized by Toll-like receptor and inflammasome signalling Authors (17)Rachel Lai Graeme MeintjesKatalin WilkinsonChristine Graham Suzaan Marais Helen Van der Plas[...] Gary Maartens Jacques Banchereau Damien ChaussabelAnne O'GarraRobert Wilkinson Nature Communications Published 24 September 2015 Crick labsRobert J WilkinsonAnne O’GarraFull details
Management of latent Mycobacterium tuberculosis infection: WHO guidelines for low tuberculosis burden countries Authors (72) Haileyesus Getahun Alberto Matteelli Ibrahim Abubakar Mohamed Abdel Aziz Annabel Baddeley Draurio Barreira[...] Karin WeyerRobert Wilkinson Takashi Yoshiyama Jean Pierre Zellweger Mario Raviglione European Respiratory Journal Published 1 December 2015 Crick labsRobert J WilkinsonFull details
Effect of antiretroviral therapy on HIV-mediated impairment of the neutrophil antimycobacterial response Authors (7) David M Lowe Nonzwakazi Bangani Rene Goliath Beate KampmannKatalin WilkinsonRobert Wilkinson Adrian R Martineau Annals of the American Thoracic Society Published 1 November 2015 Crick labsRobert J WilkinsonFull details
Interleukin 27R regulates CD4+ T cell phenotype and impacts protective immunity during Mycobacterium tuberculosis infection Authors (19) Egidio Torrado Jeffrey J Fountain Mingfeng Liao Michael Tighe William W ReileyRachel Lai[...] K Kai McKinstry Tara M StruttRobert Wilkinson Susan L Swain Andrea M Cooper Journal of Experimental Medicine Published 24 August 2015 Crick labsRobert J WilkinsonFull details
Towards host-directed therapies for tuberculosis Authors (65) Alimuddin Zumla Jeremiah Chakaya Michael Hoelscher Francine Ntoumi Roxana Rustomjee Cristina Vilaplana[...]Robert Wilkinson Bongani Mayosi Marco Schito Robert S Wallis Markus Maeurer Nature Reviews Drug Discovery Published 17 July 2015 Crick labsRobert J WilkinsonFull details
Raised venous lactate and markers of intestinal translocation are associated with mortality among in-patients with HIV-associated TB in rural South Africa Authors (8) Sathyavani SubbaraoKatalin Wilkinson Clare L van Halsema Suhasini Subba Rao Tom Boyles Netanya S UtayRobert Wilkinson Graeme Meintjes Journal of Acquired Immune Deficiency Syndromes Published 1 December 2015 Crick labsRobert J WilkinsonFull details
Six host-range restricted poxviruses from three genera induce distinct gene expression profiles in an in vivo mouse model Authors (6) Kristy Offerman Armin Deffur Olivia CaruleiRobert Wilkinson Nicola Douglass Anna-Lise Williamson BMC Genomics Published 8 July 2015 Crick labsRobert J WilkinsonFull details
Phenylbutyrate is bacteriostatic against Mycobacterium tuberculosis and regulates the macrophage response to infection, synergistically with 25-hydroxy-vitamin D3 Authors (3) Anna K CoussensRobert Wilkinson Adrian R Martineau PLOS Pathogens Published 2 July 2015 Crick labsRobert J WilkinsonFull details
Membrane type 1 matrix metalloproteinase regulates monocyte migration and collagen destruction in tuberculosis Authors (9) Tarangini Sathyamoorthy Liku B Tezera Naomi F Walker Sara Brilha Luisa Saraiva Francesco A MauriRobert Wilkinson Jon S Friedland Paul T Elkington Journal of Immunology Published 1 August 2015 Crick labsRobert J WilkinsonFull details
High-dose vitamin D3 reduces deficiency caused by low UVB exposure and limits HIV-1 replication in urban Southern Africans Authors (6) Anna K Coussens Celeste E Naude Rene Goliath George ChaplinRobert Wilkinson Nina G Jablonski Proceedings of the National Academy of Sciences of USA Published 30 June 2015 Crick labsRobert J WilkinsonFull details
ART and prevention of HIV-associated tuberculosis Authors (2) Stephen D LawnRobert Wilkinson Lancet HIV Published 1 June 2015 Crick labsRobert J WilkinsonFull details
Paradoxical TB-IRIS in HIV-infected adults: a systematic review and meta-analysis Authors (6) Phiona E Namale Leila H Abdullahi Stacey Fine Monika KamkuemahRobert Wilkinson Graeme Meintjes Future Microbiology Published 1 June 2015 Crick labsRobert J WilkinsonFull details