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Breadcrumb Robert J Wilkinson Wilkinson lab Tuberculosis Laboratory : Publications Lab contentLab contentIn this section Overview Areas of interest Publications Members Vacancies News Khayelitsha, South Africa: a peri-urban township of around 400000 people 30 km from the centre of Cape Town. In Khayelitsha the chances of developing tuberculosis in any year are around 1%, much higher if a person is HIV-coinfected. Toggle to view hero caption PublicationsYear published (-)2018 (28) Facet Year publishedResearch topicsHuman Biology & Physiology (28)Immunology (28)Infectious Disease (28)Model Organisms (28)Computational & Systems Biology (4)Chemical Biology & High Throughput (1)Developmental Biology (1)Gene Expression (1)Genetics & Genomics (1)Genome Integrity & Repair (1)Signalling & Oncogenes (1)Stem Cells (1)Tumour Biology (1) Facet Research topicsPublication typeJournal article (28)Primary research (16)Review (10)Commentary (1)Method (1) Facet Publication typeJournalFrontiers in Immunology (3)Current Opinion in HIV and AIDS (2)New England Journal of Medicine (2)AIDS (1)Annual Review of Immunology (1)Bioinformatics (1)Clinical Infectious Diseases (1)Clinical Pharmacokinetics (1)Current Treatment Options in Neurology (1)Diabetes Research and Clinical Practice (1)EJNMMI Research (1)Expert Review of Respiratory Medicine (1)Frontiers in Microbiology (1)Innate Immunity (1)Journal of Acquired Immune Deficiency Syndromes (1)Journal of Clinical Microbiology (1)Journal of Infection (1)Lancet (1)Nature Communications (1)Nature Immunology (1)Nature Microbiology (1)PLOS ONE (1)Proceedings of the National Academy of Sciences of the United States of America (1)Wellcome Open Research (1) Facet Journal Publications Displaying 1 - 20 of 28Last updated : 18 April 2024 03:38 The effect of antiretroviral treatment on selected genes in whole blood from HIV-infected adults sensitised by Mycobacterium tuberculosis Authors (8) Nishtha Jhilmeet David M Lowe Catherine Riou Thomas J Scriba Anna Coussens Rene GoliathRobert WilkinsonKatalin Wilkinson PLOS ONE Published 27 December 2018 Crick labsRobert J WilkinsonFull details Application of machine learning techniques to tuberculosis drug resistance analysis Authors (9) Samaneh Kouchaki Yang Yang Timothy M Walker A Sarah Walker Daniel J Wilson Timothy EA Peto Derrick W Crook CRyPTIC Consortium David A Clifton Bioinformatics Published 1 July 2019 Crick labsRobert J WilkinsonFull details Prednisone for the prevention of paradoxical tuberculosis-associated IRIS Authors (15) Graeme Meintjes Cari Stek Lisette Blumenthal Friedrich Thienemann Charlotte Schutz Jozefien Buyze[...] Robert Colebunders Gary MaartensRobert Wilkinson Lutgarde Lynen PredART Trial Team New England Journal of Medicine Published 15 November 2018 Crick labsRobert J WilkinsonFull details ANIMA: Association network integration for multiscale analysis Authors (4) Armin DeffurRobert Wilkinson Bongani M Mayosi Nicola M Mulder Wellcome Open Research Published 14 November 2018 Crick labsRobert J WilkinsonFull details Neutrophils: Innate effectors of TB resistance? Authors (9) Elouise E Kroon Anna K Coussens Craig Kinnear Marianna Orlova Marlo Möller Allison SeegerRobert Wilkinson Eileen G Hoal Erwin Schurr Frontiers in Immunology Published 14 November 2018 Crick labsRobert J WilkinsonFull details A systematic review on the effect of HIV infection on the pharmacokinetics of first-line tuberculosis drugs Authors (21) Alper Daskapan Lusiana R Idrus Maarten J Postma Bob Wilffert Jos GW Kosterink Ymkje Stienstra[...] Geetha Ramachandran Neesha RockwoodRobert Wilkinson Tjip S van der Werf Jan-Willem C Alffenaar Clinical Pharmacokinetics Published 1 June 2019 Crick labsRobert J WilkinsonFull details The immune mechanisms of lung parenchymal damage in tuberculosis and the role of host-directed therapy Authors (6) Cari Stek Brian Allwood Naomi F WalkerRobert Wilkinson Lutgarde Lynen Graeme Meintjes Frontiers in Microbiology Published 30 October 2018 Crick labsRobert J WilkinsonFull details The value of transcriptomics in advancing knowledge of the immune response and diagnosis in tuberculosis Authors (5)Akul SinghaniaRobert Wilkinson Marc Rodrigue Pranabashis HaldarAnne O'Garra Nature Immunology Published 1 November 2018 Crick labsRobert J WilkinsonAnne O’GarraFull details Projected population-wide impact of antiretroviral therapy-linked isoniazid preventive therapy in a high-burden setting Authors (7) Emily A Kendall Andrew S Azman Gary Maartens Andrew BoulleRobert Wilkinson David W Dowdy Molebogeng X Rangaka AIDS Published 1 March 2019 Crick labsRobert J WilkinsonFull details Recent progress in understanding immune activation in the pathogenesis in HIV-tuberculosis co-infection Authors (6) Elsa du Bruyn Nashied Peton Hanif Esmail Patrick J Howlett Anna K CoussensRobert Wilkinson Current Opinion in HIV and AIDS Published 5 October 2018 Crick labsRobert J WilkinsonFull details Plasma biomarkers to detect prevalent or predict progressive tuberculosis associated with human immunodeficiency virus-1 Authors (10) Maia Lesosky Molebogeng X Rangaka Cara Pienaar Anna K Coussens Rene Goliath Shaheed Mathee Judith Mwansa-Kambafwile Gary MaartensRobert WilkinsonKatalin Wilkinson Clinical Infectious Diseases Published 15 July 2019 Crick labsRobert J WilkinsonFull details Phase 2b controlled trial of M72/AS01E vaccine to prevent tuberculosis Authors (26) O Van Der Meeren M Hatherill V NdubaRobert Wilkinson M Muyoyeta E Van Brakel[...] A Bollaerts AM Ginsberg TG Evans P Gillard DR Tait New England Journal of Medicine Published 25 October 2018 Crick labsRobert J WilkinsonFull details Improving the microbiological diagnosis of tuberculous meningitis: A prospective, international, multicentre comparison of conventional and modified Ziehl-Neelsen stain, GeneXpert, and culture of cerebrospinal fluid Authors (23) A Dorothee Heemskerk Joseph Donovan Do Dang Anh Thu Suzaan Marais Lidya Chaidir Vu Thi Mong Dung[...] Rovina Ruslami Graeme Meintjes Reinout van CrevelRobert Wilkinson Guy E Thwaites Journal of Infection Published 1 December 2018 Crick labsRobert J WilkinsonFull details Host resistance to pulmonary Mycobacterium tuberculosis infection requires CD153 expression Authors (17) Michelle A Sallin Keith D Kauffman Catherine Riou Elsa Du Bruyn Taylor W Foreman Shunsuke Sakai[...] Ian N Moore Alessandro Sette Cecilia S Lindestam ArlehamnRobert Wilkinson Daniel L Barber Nature Microbiology Published 10 September 2018 Crick labsRobert J WilkinsonFull details PD-1 expression on Mycobacterium tuberculosis-specific CD4 T cells is associated with bacterial load in human tuberculosis Authors (9) Cheryl L Day Deborah A Abrahams Rubina Bunjun Lynnett Stone Marwou de Kock Gerhard WalzlRobert Wilkinson Wendy A Burgers Willem A Hanekom Frontiers in Immunology Published 31 August 2018 Crick labsRobert J WilkinsonFull details Corticosteroids as an adjunct to tuberculosis therapy Authors (7) Charlotte Schutz Angharad G Davis Bianca Sossen Rachel PJ Lai Mpiko Ntsekhe Yolande XR HarleyRobert Wilkinson Expert Review of Respiratory Medicine Published 23 August 2018 Crick labsRobert J WilkinsonFull details The tuberculosis-associated immune reconstitution inflammatory syndrome: recent advances in clinical and pathogenesis research Authors (5) Naomi F Walker Cari Stek Sean WassermanRobert Wilkinson Graeme Meintjes Current Opinion in HIV and AIDS Published 1 November 2018 Crick labsRobert J WilkinsonFull details A semi-automatic technique to quantify complex tuberculous lung lesions on 18F-fluorodeoxyglucose positron emission tomography/computerised tomography images Authors (18) Stephanus T Malherbe Patrick Dupont Ilse Kant Petri Ahlers Magdalena Kriel André G Loxton[...] Katharina Ronacher Jill Winter Gerhard Walzl James M Warwick The Catalysis Biomarker Consortium EJNMMI Research Published 25 June 2018 Crick labsRobert J WilkinsonFull details A modular transcriptional signature identifies phenotypic heterogeneity of human tuberculosis infection Authors (15)Akul Singhania Raman VermaChristine Graham Jo Lee Trang Tran Matthew Richardson[...] Karine Kaiser Marc Rodrigue Gerrit Woltmann Pranabashis HaldarAnne O'Garra Nature Communications Published 19 June 2018 Crick labs/ facilitiesRobert J WilkinsonAnne O’GarraBioinformatics and BiostatisticsAdvanced SequencingFull details Contribution of APCs to mucosal-associated invariant T cell activation in infectious disease and cancer Authors (4) Muki Shehu Shey Avuyonke BalfourKatalin Wilkinson Graeme Meintjes Innate Immunity Published 1 May 2018 Crick labsRobert J WilkinsonFull details Pagination Current page 1 Page 2 Next page Next Last page Last Share the page Share on Twitter Share on Facebook Share on LinkedIn Share on Email
The effect of antiretroviral treatment on selected genes in whole blood from HIV-infected adults sensitised by Mycobacterium tuberculosis Authors (8) Nishtha Jhilmeet David M Lowe Catherine Riou Thomas J Scriba Anna Coussens Rene GoliathRobert WilkinsonKatalin Wilkinson PLOS ONE Published 27 December 2018 Crick labsRobert J WilkinsonFull details
Application of machine learning techniques to tuberculosis drug resistance analysis Authors (9) Samaneh Kouchaki Yang Yang Timothy M Walker A Sarah Walker Daniel J Wilson Timothy EA Peto Derrick W Crook CRyPTIC Consortium David A Clifton Bioinformatics Published 1 July 2019 Crick labsRobert J WilkinsonFull details
Prednisone for the prevention of paradoxical tuberculosis-associated IRIS Authors (15) Graeme Meintjes Cari Stek Lisette Blumenthal Friedrich Thienemann Charlotte Schutz Jozefien Buyze[...] Robert Colebunders Gary MaartensRobert Wilkinson Lutgarde Lynen PredART Trial Team New England Journal of Medicine Published 15 November 2018 Crick labsRobert J WilkinsonFull details
ANIMA: Association network integration for multiscale analysis Authors (4) Armin DeffurRobert Wilkinson Bongani M Mayosi Nicola M Mulder Wellcome Open Research Published 14 November 2018 Crick labsRobert J WilkinsonFull details
Neutrophils: Innate effectors of TB resistance? Authors (9) Elouise E Kroon Anna K Coussens Craig Kinnear Marianna Orlova Marlo Möller Allison SeegerRobert Wilkinson Eileen G Hoal Erwin Schurr Frontiers in Immunology Published 14 November 2018 Crick labsRobert J WilkinsonFull details
A systematic review on the effect of HIV infection on the pharmacokinetics of first-line tuberculosis drugs Authors (21) Alper Daskapan Lusiana R Idrus Maarten J Postma Bob Wilffert Jos GW Kosterink Ymkje Stienstra[...] Geetha Ramachandran Neesha RockwoodRobert Wilkinson Tjip S van der Werf Jan-Willem C Alffenaar Clinical Pharmacokinetics Published 1 June 2019 Crick labsRobert J WilkinsonFull details
The immune mechanisms of lung parenchymal damage in tuberculosis and the role of host-directed therapy Authors (6) Cari Stek Brian Allwood Naomi F WalkerRobert Wilkinson Lutgarde Lynen Graeme Meintjes Frontiers in Microbiology Published 30 October 2018 Crick labsRobert J WilkinsonFull details
The value of transcriptomics in advancing knowledge of the immune response and diagnosis in tuberculosis Authors (5)Akul SinghaniaRobert Wilkinson Marc Rodrigue Pranabashis HaldarAnne O'Garra Nature Immunology Published 1 November 2018 Crick labsRobert J WilkinsonAnne O’GarraFull details
Projected population-wide impact of antiretroviral therapy-linked isoniazid preventive therapy in a high-burden setting Authors (7) Emily A Kendall Andrew S Azman Gary Maartens Andrew BoulleRobert Wilkinson David W Dowdy Molebogeng X Rangaka AIDS Published 1 March 2019 Crick labsRobert J WilkinsonFull details
Recent progress in understanding immune activation in the pathogenesis in HIV-tuberculosis co-infection Authors (6) Elsa du Bruyn Nashied Peton Hanif Esmail Patrick J Howlett Anna K CoussensRobert Wilkinson Current Opinion in HIV and AIDS Published 5 October 2018 Crick labsRobert J WilkinsonFull details
Plasma biomarkers to detect prevalent or predict progressive tuberculosis associated with human immunodeficiency virus-1 Authors (10) Maia Lesosky Molebogeng X Rangaka Cara Pienaar Anna K Coussens Rene Goliath Shaheed Mathee Judith Mwansa-Kambafwile Gary MaartensRobert WilkinsonKatalin Wilkinson Clinical Infectious Diseases Published 15 July 2019 Crick labsRobert J WilkinsonFull details
Phase 2b controlled trial of M72/AS01E vaccine to prevent tuberculosis Authors (26) O Van Der Meeren M Hatherill V NdubaRobert Wilkinson M Muyoyeta E Van Brakel[...] A Bollaerts AM Ginsberg TG Evans P Gillard DR Tait New England Journal of Medicine Published 25 October 2018 Crick labsRobert J WilkinsonFull details
Improving the microbiological diagnosis of tuberculous meningitis: A prospective, international, multicentre comparison of conventional and modified Ziehl-Neelsen stain, GeneXpert, and culture of cerebrospinal fluid Authors (23) A Dorothee Heemskerk Joseph Donovan Do Dang Anh Thu Suzaan Marais Lidya Chaidir Vu Thi Mong Dung[...] Rovina Ruslami Graeme Meintjes Reinout van CrevelRobert Wilkinson Guy E Thwaites Journal of Infection Published 1 December 2018 Crick labsRobert J WilkinsonFull details
Host resistance to pulmonary Mycobacterium tuberculosis infection requires CD153 expression Authors (17) Michelle A Sallin Keith D Kauffman Catherine Riou Elsa Du Bruyn Taylor W Foreman Shunsuke Sakai[...] Ian N Moore Alessandro Sette Cecilia S Lindestam ArlehamnRobert Wilkinson Daniel L Barber Nature Microbiology Published 10 September 2018 Crick labsRobert J WilkinsonFull details
PD-1 expression on Mycobacterium tuberculosis-specific CD4 T cells is associated with bacterial load in human tuberculosis Authors (9) Cheryl L Day Deborah A Abrahams Rubina Bunjun Lynnett Stone Marwou de Kock Gerhard WalzlRobert Wilkinson Wendy A Burgers Willem A Hanekom Frontiers in Immunology Published 31 August 2018 Crick labsRobert J WilkinsonFull details
Corticosteroids as an adjunct to tuberculosis therapy Authors (7) Charlotte Schutz Angharad G Davis Bianca Sossen Rachel PJ Lai Mpiko Ntsekhe Yolande XR HarleyRobert Wilkinson Expert Review of Respiratory Medicine Published 23 August 2018 Crick labsRobert J WilkinsonFull details
The tuberculosis-associated immune reconstitution inflammatory syndrome: recent advances in clinical and pathogenesis research Authors (5) Naomi F Walker Cari Stek Sean WassermanRobert Wilkinson Graeme Meintjes Current Opinion in HIV and AIDS Published 1 November 2018 Crick labsRobert J WilkinsonFull details
A semi-automatic technique to quantify complex tuberculous lung lesions on 18F-fluorodeoxyglucose positron emission tomography/computerised tomography images Authors (18) Stephanus T Malherbe Patrick Dupont Ilse Kant Petri Ahlers Magdalena Kriel André G Loxton[...] Katharina Ronacher Jill Winter Gerhard Walzl James M Warwick The Catalysis Biomarker Consortium EJNMMI Research Published 25 June 2018 Crick labsRobert J WilkinsonFull details
A modular transcriptional signature identifies phenotypic heterogeneity of human tuberculosis infection Authors (15)Akul Singhania Raman VermaChristine Graham Jo Lee Trang Tran Matthew Richardson[...] Karine Kaiser Marc Rodrigue Gerrit Woltmann Pranabashis HaldarAnne O'Garra Nature Communications Published 19 June 2018 Crick labs/ facilitiesRobert J WilkinsonAnne O’GarraBioinformatics and BiostatisticsAdvanced SequencingFull details
Contribution of APCs to mucosal-associated invariant T cell activation in infectious disease and cancer Authors (4) Muki Shehu Shey Avuyonke BalfourKatalin Wilkinson Graeme Meintjes Innate Immunity Published 1 May 2018 Crick labsRobert J WilkinsonFull details