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Breadcrumb Robert J Wilkinson Wilkinson lab Tuberculosis Laboratory : Publications Lab contentLab contentIn this section Overview Areas of interest Publications Members Vacancies News Khayelitsha, South Africa: a peri-urban township of around 400000 people 30 km from the centre of Cape Town. In Khayelitsha the chances of developing tuberculosis in any year are around 1%, much higher if a person is HIV-coinfected. Toggle to view hero caption PublicationsYear published (-)2020 (24) Facet Year publishedResearch topicsHuman Biology & Physiology (24)Immunology (24)Infectious Disease (24)Model Organisms (24)Cell Biology (1)Imaging (1) Facet Research topicsPublication typeJournal article (24)Primary research (15)Review (4)Commentary (3)Method (1)Systematic review (1) Facet Publication typeJournalClinical Infectious Diseases (3)Wellcome Open Research (3)Antimicrobial Agents and Chemotherapy (2)JCI insight (2)BMJ Open (1)British Journal of Clinical Pharmacology (1)Clinical and Translational Immunology (1)EBioMedicine (1)eLife (1)ESC Heart Failure (1)Future Virology (1)JAIDS: Journal of Acquired Immune Deficiency Syndromes (1)Lancet HIV (1)Lancet Infectious Diseases (1)Microbes and Infection (1)Molecular Biology and Evolution (1)Mucosal Immunology (1)Wellcome Open Res (1) Facet Journal Publications Displaying 1 - 20 of 24Last updated : 18 April 2024 03:48 Isoniazid preventive therapy plus antiretroviral therapy for the prevention of tuberculosis: a systematic review and meta-analysis of individual participant data Authors (16) Jennifer M Ross Anani Badje Molebogeng X Rangaka A Sarah Walker Adrienne E Shapiro Katherine K Thomas[...]Robert Wilkinson Nathan Ford Jonathan E Golub Brian G Williams Ruanne V Barnabas Lancet HIV Published 1 January 2021 Crick labsRobert J WilkinsonFull details Diagnostic accuracy of the INSHI consensus case definition for the diagnosis of paradoxical tuberculosis-IRIS Authors (11) Cari Stek Jozefien Buyze Joris Menten Charlotte Schutz Friedrich Thienemann Lisette Blumenthal Gary Maartens Tom BoylesRobert Wilkinson Graeme Meintjes Lutgarde Lynen JAIDS: Journal of Acquired Immune Deficiency Syndromes Published 15 April 2021 Crick labsRobert J WilkinsonFull details An observational study identifying highly tuberculosis-exposed, HIV-1-positive but persistently TB, tuberculin and IGRA negative persons with M. tuberculosis specific antibodies in Cape Town, South Africa Authors (13) Elouise E Kroon Craig J Kinnear Marianna Orlova Stephanie Fischinger Sally Shin Sihaam Boolay[...]Robert Wilkinson Galit Alter Erwin Schurr Eileen G Hoal Marlo Möller EBioMedicine Published 1 November 2020 Crick labsRobert J WilkinsonFull details Disease extent and anti-tubercular treatment response correlates with Mycobacterium tuberculosis-specific CD4 T-cell phenotype regardless of HIV-1 status Authors (9) Catherine Riou Elsa Du Bruyn Sheena Ruzive Rene T Goliath Cecilia S Lindestam Arlehamn Alessandro Sette Alan Sher Daniel L BarberRobert Wilkinson Clinical and Translational Immunology Published 28 September 2020 Crick labsRobert J WilkinsonFull details Natural polymorphisms in Mycobacterium tuberculosis conferring resistance to delamanid in drug-naive patients Authors (17) Martina L Reichmuth Rico Hömke Kathrin Zürcher Peter Sander Anchalee Avihingsanon Jimena Collantes[...] Erik C Böttger Sebastien Gagneux Matthias Egger Peter M Keller International epidemiology Databases to Evaluate AIDS (IeDEA) Antimicrobial Agents and Chemotherapy Published 1 November 2020 Crick labsRobert J WilkinsonFull details Protocol for systematic review and meta-analysis: impact of statins as immune-modulatory agents on inflammatory markers in adults with chronic diseases Authors (13) Solima Sabeel Bongani Motaung Mumin Ozturk Sandra Mukasa Andre Pascal Kengne Dirk Blom[...] Gunar GüntherRobert Wilkinson Claudia Schacht Friedrich Thienemann Reto Guler BMJ Open Published 13 August 2020 Crick labsRobert J WilkinsonFull details Comprehensive plasma proteomic profiling reveals biomarkers for active tuberculosis Authors (17) Diana J Garay-Baquero Cory H White Naomi F Walker Marc Tebruegge Hannah F Schiff Cesar Ugarte-Gil[...]Robert Wilkinson Liku B Tezera Christopher H Woelk Spiros D Garbis Paul Elkington JCI insight Published 17 September 2020 Crick labsRobert J WilkinsonFull details HIV coinfection is associated with low-fitness rpoB variants in rifampicin-resistant Mycobacterium tuberculosis Authors (21) Chloé Loiseau Daniela Brites Miriam Reinhard Kathrin Zürcher Sonia Borrell Marie Ballif[...] Nicola Zetola Basra Doulla Erik C Böttger Matthias Egger Sebastien Gagneux Antimicrobial Agents and Chemotherapy Published 21 September 2020 Crick labsRobert J WilkinsonFull details Mycobacterium tuberculosis-specific CD4 T cells expressing CD153 inversely associate with bacterial load and disease severity in human tuberculosis Authors (8) Elsa Du Bruyn Sheena Ruzive Cecilia S Lindestam Arlehamn Alessandro Sette Alan Sher Daniel L BarberRobert Wilkinson Catherine Riou Mucosal Immunology Published 1 March 2021 Crick labsRobert J WilkinsonFull details Elevated N-terminal prohormone of brain natriuretic peptide among persons living with HIV in a South African peri-urban township Authors (11) Tess E Peterson Jason V Baker Lye-Yeng Wong Adam Rupert Ntobeko AB Ntusi Hanif EsmailRobert Wilkinson Irini Sereti Graeme Meintjes Mpiko Ntsekhe Friedrich Thienemann ESC Heart Failure Published 1 October 2020 Crick labsRobert J WilkinsonFull details Xpert MTB/RIF Ultra for the diagnosis of tuberculous meningitis: A small step forward Authors (7) Joseph Donovan Fiona V Cresswell Nguyen Thuy Thuong Thuong David R Boulware Guy E Thwaites Nathan C Bahr Tuberculous Meningitis International Research Consortium Clinical Infectious Diseases Published 15 October 2020 Crick labsRobert J WilkinsonFull details Tuberculosis and type 2 diabetes mellitus: an inflammatory danger signal in the time of coronavirus disease 2019 Authors (1)Robert Wilkinson Clinical Infectious Diseases Published 1 January 2021 Crick labsRobert J WilkinsonFull details Mycobacterium tuberculosis cords within lymphatic endothelial cells to evade host immunity Authors (9) Thomas R LernerChristophe QuevalRachel LaiMatt RussellTony FearnsDaniel GreenwoodLucy CollinsonRobert WilkinsonMaximiliano Gutierrez JCI insight Published 21 May 2020 Crick labs/ facilitiesRobert J WilkinsonMaximiliano GutierrezElectron MicroscopyFull details The Mtb-HIV syndemic interaction: why treating M. tuberculosis infection may be crucial for HIV-1 eradication Authors (6) Robyn Waters Mthawelanga Ndengane Melissa-Rose Abrahams Collin R DiedrichRobert Wilkinson Anna K Coussens Future Virology Published 1 February 2020 Crick labsRobert J WilkinsonFull details GenomegaMap: Within-species genome-wide dN/dS estimation from over 10,000 genomes Authors (2) Daniel J Wilson The CRyPTIC Consortium Molecular Biology and Evolution Published 1 August 2020 Crick labsRobert J WilkinsonFull details Management of intracranial tuberculous mass lesions: how long should we treat for? Authors (9) Suzaan Marais Ronald Van Toorn Felicia C Chow Abi Manesh Omar K Siddiqi Anthony Figaji Johan F Schoeman Graeme Meintjes Tuberculous Meningitis International Research Consortium Wellcome Open Research Published 26 February 2020 Crick labsRobert J WilkinsonFull details Anti-PD-1 immunotherapy leads to tuberculosis reactivation via dysregulation of TNF-α Authors (19) Liku B Tezera Magdalena K Bielecka Paul Ogongo Naomi F Walker Matthew Ellis Diana J Garay-Baquero[...] Salah Mansour Gareth J Thomas Christian H Ottensmeier Alasdair Leslie Paul T Elkington eLife Published 24 February 2020 Crick labsRobert J WilkinsonFull details The immunopathogenesis of tuberculous pericarditis Authors (7) Patrick Howlett Elsa Du Bruyn Hazel Morrison Isiguzo C GodsentKatalin Wilkinson Mpiko NtsekheRobert Wilkinson Microbes and Infection Published 1 May 2020 Crick labsRobert J WilkinsonFull details Checklists to guide the supportive and critical care of tuberculous meningitis Authors (7) Joseph Donovan Ursula K Rohlwink Elizabeth W Tucker Nguyen Thi Thu Hiep Guy E Thwaites Anthony A Figaji Tuberculous Meningitis International Research Consortium Wellcome Open Research Published 7 February 2020 Crick labsRobert J WilkinsonFull details Establishing the cascade of care for patients with tuberculous meningitis Authors (5) Darma Imran Philip C Hill Jacob McKnight Reinout van Crevel Tuberculous Meningitis International Research Consortium Wellcome Open Research Published 30 January 2020 Crick labsRobert J WilkinsonFull details Pagination Current page 1 Page 2 Next page Next Last page Last Share the page Share on Twitter Share on Facebook Share on LinkedIn Share on Email
Isoniazid preventive therapy plus antiretroviral therapy for the prevention of tuberculosis: a systematic review and meta-analysis of individual participant data Authors (16) Jennifer M Ross Anani Badje Molebogeng X Rangaka A Sarah Walker Adrienne E Shapiro Katherine K Thomas[...]Robert Wilkinson Nathan Ford Jonathan E Golub Brian G Williams Ruanne V Barnabas Lancet HIV Published 1 January 2021 Crick labsRobert J WilkinsonFull details
Diagnostic accuracy of the INSHI consensus case definition for the diagnosis of paradoxical tuberculosis-IRIS Authors (11) Cari Stek Jozefien Buyze Joris Menten Charlotte Schutz Friedrich Thienemann Lisette Blumenthal Gary Maartens Tom BoylesRobert Wilkinson Graeme Meintjes Lutgarde Lynen JAIDS: Journal of Acquired Immune Deficiency Syndromes Published 15 April 2021 Crick labsRobert J WilkinsonFull details
An observational study identifying highly tuberculosis-exposed, HIV-1-positive but persistently TB, tuberculin and IGRA negative persons with M. tuberculosis specific antibodies in Cape Town, South Africa Authors (13) Elouise E Kroon Craig J Kinnear Marianna Orlova Stephanie Fischinger Sally Shin Sihaam Boolay[...]Robert Wilkinson Galit Alter Erwin Schurr Eileen G Hoal Marlo Möller EBioMedicine Published 1 November 2020 Crick labsRobert J WilkinsonFull details
Disease extent and anti-tubercular treatment response correlates with Mycobacterium tuberculosis-specific CD4 T-cell phenotype regardless of HIV-1 status Authors (9) Catherine Riou Elsa Du Bruyn Sheena Ruzive Rene T Goliath Cecilia S Lindestam Arlehamn Alessandro Sette Alan Sher Daniel L BarberRobert Wilkinson Clinical and Translational Immunology Published 28 September 2020 Crick labsRobert J WilkinsonFull details
Natural polymorphisms in Mycobacterium tuberculosis conferring resistance to delamanid in drug-naive patients Authors (17) Martina L Reichmuth Rico Hömke Kathrin Zürcher Peter Sander Anchalee Avihingsanon Jimena Collantes[...] Erik C Böttger Sebastien Gagneux Matthias Egger Peter M Keller International epidemiology Databases to Evaluate AIDS (IeDEA) Antimicrobial Agents and Chemotherapy Published 1 November 2020 Crick labsRobert J WilkinsonFull details
Protocol for systematic review and meta-analysis: impact of statins as immune-modulatory agents on inflammatory markers in adults with chronic diseases Authors (13) Solima Sabeel Bongani Motaung Mumin Ozturk Sandra Mukasa Andre Pascal Kengne Dirk Blom[...] Gunar GüntherRobert Wilkinson Claudia Schacht Friedrich Thienemann Reto Guler BMJ Open Published 13 August 2020 Crick labsRobert J WilkinsonFull details
Comprehensive plasma proteomic profiling reveals biomarkers for active tuberculosis Authors (17) Diana J Garay-Baquero Cory H White Naomi F Walker Marc Tebruegge Hannah F Schiff Cesar Ugarte-Gil[...]Robert Wilkinson Liku B Tezera Christopher H Woelk Spiros D Garbis Paul Elkington JCI insight Published 17 September 2020 Crick labsRobert J WilkinsonFull details
HIV coinfection is associated with low-fitness rpoB variants in rifampicin-resistant Mycobacterium tuberculosis Authors (21) Chloé Loiseau Daniela Brites Miriam Reinhard Kathrin Zürcher Sonia Borrell Marie Ballif[...] Nicola Zetola Basra Doulla Erik C Böttger Matthias Egger Sebastien Gagneux Antimicrobial Agents and Chemotherapy Published 21 September 2020 Crick labsRobert J WilkinsonFull details
Mycobacterium tuberculosis-specific CD4 T cells expressing CD153 inversely associate with bacterial load and disease severity in human tuberculosis Authors (8) Elsa Du Bruyn Sheena Ruzive Cecilia S Lindestam Arlehamn Alessandro Sette Alan Sher Daniel L BarberRobert Wilkinson Catherine Riou Mucosal Immunology Published 1 March 2021 Crick labsRobert J WilkinsonFull details
Elevated N-terminal prohormone of brain natriuretic peptide among persons living with HIV in a South African peri-urban township Authors (11) Tess E Peterson Jason V Baker Lye-Yeng Wong Adam Rupert Ntobeko AB Ntusi Hanif EsmailRobert Wilkinson Irini Sereti Graeme Meintjes Mpiko Ntsekhe Friedrich Thienemann ESC Heart Failure Published 1 October 2020 Crick labsRobert J WilkinsonFull details
Xpert MTB/RIF Ultra for the diagnosis of tuberculous meningitis: A small step forward Authors (7) Joseph Donovan Fiona V Cresswell Nguyen Thuy Thuong Thuong David R Boulware Guy E Thwaites Nathan C Bahr Tuberculous Meningitis International Research Consortium Clinical Infectious Diseases Published 15 October 2020 Crick labsRobert J WilkinsonFull details
Tuberculosis and type 2 diabetes mellitus: an inflammatory danger signal in the time of coronavirus disease 2019 Authors (1)Robert Wilkinson Clinical Infectious Diseases Published 1 January 2021 Crick labsRobert J WilkinsonFull details
Mycobacterium tuberculosis cords within lymphatic endothelial cells to evade host immunity Authors (9) Thomas R LernerChristophe QuevalRachel LaiMatt RussellTony FearnsDaniel GreenwoodLucy CollinsonRobert WilkinsonMaximiliano Gutierrez JCI insight Published 21 May 2020 Crick labs/ facilitiesRobert J WilkinsonMaximiliano GutierrezElectron MicroscopyFull details
The Mtb-HIV syndemic interaction: why treating M. tuberculosis infection may be crucial for HIV-1 eradication Authors (6) Robyn Waters Mthawelanga Ndengane Melissa-Rose Abrahams Collin R DiedrichRobert Wilkinson Anna K Coussens Future Virology Published 1 February 2020 Crick labsRobert J WilkinsonFull details
GenomegaMap: Within-species genome-wide dN/dS estimation from over 10,000 genomes Authors (2) Daniel J Wilson The CRyPTIC Consortium Molecular Biology and Evolution Published 1 August 2020 Crick labsRobert J WilkinsonFull details
Management of intracranial tuberculous mass lesions: how long should we treat for? Authors (9) Suzaan Marais Ronald Van Toorn Felicia C Chow Abi Manesh Omar K Siddiqi Anthony Figaji Johan F Schoeman Graeme Meintjes Tuberculous Meningitis International Research Consortium Wellcome Open Research Published 26 February 2020 Crick labsRobert J WilkinsonFull details
Anti-PD-1 immunotherapy leads to tuberculosis reactivation via dysregulation of TNF-α Authors (19) Liku B Tezera Magdalena K Bielecka Paul Ogongo Naomi F Walker Matthew Ellis Diana J Garay-Baquero[...] Salah Mansour Gareth J Thomas Christian H Ottensmeier Alasdair Leslie Paul T Elkington eLife Published 24 February 2020 Crick labsRobert J WilkinsonFull details
The immunopathogenesis of tuberculous pericarditis Authors (7) Patrick Howlett Elsa Du Bruyn Hazel Morrison Isiguzo C GodsentKatalin Wilkinson Mpiko NtsekheRobert Wilkinson Microbes and Infection Published 1 May 2020 Crick labsRobert J WilkinsonFull details
Checklists to guide the supportive and critical care of tuberculous meningitis Authors (7) Joseph Donovan Ursula K Rohlwink Elizabeth W Tucker Nguyen Thi Thu Hiep Guy E Thwaites Anthony A Figaji Tuberculous Meningitis International Research Consortium Wellcome Open Research Published 7 February 2020 Crick labsRobert J WilkinsonFull details
Establishing the cascade of care for patients with tuberculous meningitis Authors (5) Darma Imran Philip C Hill Jacob McKnight Reinout van Crevel Tuberculous Meningitis International Research Consortium Wellcome Open Research Published 30 January 2020 Crick labsRobert J WilkinsonFull details