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Breadcrumb Robert J Wilkinson Wilkinson lab Tuberculosis Laboratory : Publications Lab contentLab contentIn this section Overview Areas of interest Publications Members Vacancies News Khayelitsha, South Africa: a peri-urban township of around 400000 people 30 km from the centre of Cape Town. In Khayelitsha the chances of developing tuberculosis in any year are around 1%, much higher if a person is HIV-coinfected. Toggle to view hero caption PublicationsYear published (-)2021 (38) Facet Year publishedResearch topicsHuman Biology & Physiology (38)Immunology (38)Infectious Disease (38)Model Organisms (38)Computational & Systems Biology (8)Chemical Biology & High Throughput (7)Genetics & Genomics (7)Genome Integrity & Repair (7)Tumour Biology (7)Biochemistry & Proteomics (5)Cell Biology (5)Metabolism (5)Neurosciences (5)Signalling & Oncogenes (5)Stem Cells (5)Structural Biology & Biophysics (5)Cell Cycle & Chromosomes (4)Developmental Biology (4)Gene Expression (1)Imaging (1)Synthetic Biology (1) Facet Research topicsPublication typeJournal article (38)Primary research (30)Review (5)Case report (1)Commentary (1)Systematic review (1) Facet Publication typeJournalFrontiers in Immunology (6)Nature Cancer (3)Scientific Reports (3)Wellcome Open Research (3)European Respiratory Journal (2)Journal of Clinical Investigation (2)Journal of the International AIDS Society (2)Lancet Microbe (2)Advances in Clinical Neuroscience and Rehabilitation (1)Antimicrobial Agents and Chemotherapy (1)Cancer Cell (1)EClinicalMedicine (1)Expert Opinion on Pharmacotherapy (1)HIV Medicine (1)International Journal of Molecular Sciences (1)Journal of Experimental Medicine (1)Journal of Immunology (1)mBio (1)Nature Communications (1)Nature Medicine (1)PLOS ONE (1)Science Translational Medicine (1)The Lancet Microbe (1) Facet Journal Publications Displaying 1 - 20 of 38Last updated : 20 April 2024 02:22 Immune responses following third COVID-19 vaccination are reduced in patients with hematological malignancies compared to patients with solid cancer Authors (65)Annika FendlerScott ShepherdLewis AuKatalin WilkinsonMary Wu Andreas M Schmitt[...] Susanna WalkerRobert Wilkinson James LarkinSamra Turajlic CAPTURE consortium Cancer Cell Published 14 February 2022 Crick labs/ facilitiesRobert J WilkinsonSamra TurajlicCharles SwantonNicola LewisGeorge KassiotisSonia GandhiSteve GamblinRupert BealeDavid LV BauerWorldwide Influenza CentreStructural BiologyProteomicsMetabolomicsHigh Throughput ScreeningBioinformatics and BiostatisticsAdvanced SequencingScientific computingFull details The in vivo transcriptomic blueprint of Mycobacterium tuberculosis in the lung Authors (4) Mariateresa CoppolaRachel LaiRobert Wilkinson Tom HM Ottenhoff Frontiers in Immunology Published 22 December 2021 Crick labsRobert J WilkinsonFull details Escape from recognition of SARS-CoV-2 variant spike epitopes but overall preservation of T cell immunity Authors (53) Catherine Riou Roanne Keeton Thandeka Moyo-Gwete Tandile Hermanus Prudence Kgagudi Richard Baguma[...] Alex Sigal Tamryn Smith Ziyaad Valley-Omar Dieter van der Westhuizen Kennedy Zvinairo Science Translational Medicine Published 9 February 2022 Crick labsRobert J WilkinsonFull details Transcriptomic characterization of tuberculous sputum reveals a host Warburg effect and microbial cholesterol catabolism Authors (11)Rachel Lai Teresa Cortes Suzaan Marais Neesha Rockwood Melissa L BurkeAcely Garza-Garcia Stuart Horswell Abdul K Sesay Anne O’Garra Douglas B YoungRobert Wilkinson mBio Published 7 December 2021 Crick labs/ facilitiesRobert J WilkinsonAnne O’GarraLuiz Pedro CarvalhoBioinformatics and BiostatisticsAdvanced SequencingFull details Intracranial tuberculoma and the challenges of global neurosurgery Authors (9) Holly A Roy Natasha Cascini Bini Ajay Sudipta Mukherjee Lucy McGavin Alice InmanRobert Wilkinson Peter C Whitfield Andrew Martin Advances in Clinical Neuroscience and Rehabilitation Published 2 December 2021 Crick labsRobert J WilkinsonFull details Baseline IL-6 is a biomarker for unfavourable tuberculosis treatment outcomes: a multisite discovery and validation study Authors (24) Akshay N Gupte Pavan Kumar Mariana Araújo-Pereira Vandana Kulkarni Mandar Paradkar Neeta Pradhan[...] Vidya Mave Subash Babu Hardy Kornfeld Bruno B Andrade Amita Gupta European Respiratory Journal Published 21 April 2022 Crick labsRobert J WilkinsonFull details Adaptive immunity and neutralizing antibodies against SARS-CoV-2 variants of concern following vaccination in patients with cancer: the CAPTURE study Authors (98)Annika FendlerScott ShepherdLewis AuKatalin WilkinsonMary WuFiona Byrne[...] Susanna WalkerRobert Wilkinson James LarkinSamra Turajlic CAPTURE Consortium Nature Cancer Published 1 December 2021 Crick labs/ facilitiesRobert J WilkinsonSamra TurajlicCharles SwantonNicola LewisGeorge KassiotisSonia GandhiSteve GamblinDavid LV BauerWorldwide Influenza CentreMetabolomicsHigh Throughput ScreeningFlow CytometryBioinformatics and BiostatisticsAdvanced SequencingScientific computingFull details Adaptive immunity and neutralizing antibodies against SARS-CoV-2 variants of concern following vaccination in patients with cancer: the CAPTURE study Authors (98)Annika FendlerScott ShepherdLewis AuKatalin WilkinsonMary WuFiona Byrne[...] Susanna WalkerRobert Wilkinson James LarkinSamra Turajlic The CAPTURE Consortium Nature Cancer Published 1 December 2021 Crick labs/ facilitiesRobert J WilkinsonSamra TurajlicCharles SwantonNicola LewisGeorge KassiotisSonia GandhiSteve GamblinDavid LV BauerWorldwide Influenza CentreMetabolomicsHigh Throughput ScreeningFlow CytometryBioinformatics and BiostatisticsAdvanced SequencingScientific computingFull details Functional antibody and T cell immunity following SARS-CoV-2 infection, including by variants of concern, in patients with cancer: the CAPTURE study Authors (89)Annika FendlerLewis AuScott ShepherdFiona ByrneMaddalena Cerrone Laura Amanda Boos[...]George Kassiotis James LarkinRobert WilkinsonSamra Turajlic The CAPTURE consortium Nature Cancer Published 1 December 2021 Crick labs/ facilitiesRobert J WilkinsonSamra TurajlicCharles SwantonNicola LewisGeorge KassiotisSonia GandhiSteve GamblinWorldwide Influenza CentreProteomicsMetabolomicsHigh Throughput ScreeningFlow CytometryExperimental HistopathologyBioinformatics and BiostatisticsAdvanced SequencingScientific computingFull details Flow cytometry method for absolute counting and single-cell phenotyping of mycobacteria Authors (10) David A Barr Charles Omollo Mandy Mason Anastasia KochRobert Wilkinson David G Lalloo Graeme Meintjes Valerie Mizrahi Digby F Warner Gerry Davies Scientific Reports Published 20 September 2021 Crick labsRobert J WilkinsonFull details Same-day antiretroviral therapy initiation for people living with HIV who have tuberculosis symptoms: a systematic review Authors (8) Rachael M Burke Hannah M Rickman Vindi Singh Thokozani Kalua Niklaus D Labhardt Mina HosseinipourRobert Wilkinson Peter MacPherson HIV Medicine Published 1 January 2022 Crick labsRobert J WilkinsonFull details Th22 cells are a major contributor to the mycobacterial CD4+ T cell response and are depleted during HIV infection Authors (10) Rubina Bunjun Fidilia MA Omondi Mohau S Makatsa Roanne Keeton Jerome M Wendoh Tracey L Müller Caryn SL PrenticeRobert Wilkinson Catherine Riou Wendy A Burgers Journal of Immunology Published 1 September 2021 Crick labsRobert J WilkinsonFull details Eosinophils are part of the granulocyte response in tuberculosis and promote host resistance in mice Authors (32) Andrea C Bohrer Ehydel Castro Zhidong Hu Artur TL Queiroz Claire E Tocheny Maike Assmann[...] Amy D Klion Bruno B Andrade Yanzheng Song Ka-Wing Wong Katrin D Mayer-Barber Journal of Experimental Medicine Published 4 October 2021 Crick labsRobert J WilkinsonFull details What is the optimum time to start antiretroviral therapy in people with HIV and tuberculosis coinfection? A systematic review and meta-analysis Authors (9) Rachael M Burke Hannah M Rickman Vindi Singh Elizabeth L Corbett Helen Ayles Andreas Jahn Mina C HosseinipourRobert Wilkinson Peter MacPherson Journal of the International AIDS Society Published 1 July 2021 Crick labsRobert J WilkinsonFull details Development of a fixed module repertoire for the analysis and interpretation of blood transcriptome data Authors (33) Matthew C Altman Darawan Rinchai Nicole Baldwin Mohammed Toufiq Elizabeth Whalen Mathieu Garand[...] Octavio Ramilo Karolina Palucka Virginia Pascual Jacques Banchereau Damien Chaussabel Nature Communications Published 19 July 2021 Crick labsRobert J WilkinsonAnne O’GarraFull details Radiological and functional evidence of the bronchial spread of tuberculosis: an observational analysis Authors (23) Ray Y Chen Xiang Yu Bronwyn Smith Xin Liu Jingcai Gao Andreas H Diacon[...] Stephanus T Malherbe Friedrich ThienemannRobert Wilkinson Gerhard Walzl Clifton E Barry Lancet Microbe Published 1 October 2021 Crick labsRobert J WilkinsonFull details Host directed therapies for tuberculous meningitis Authors (14) Angharad G Davis Joseph Donovan Marise Bremer Ronald Van Toorn Johan Schoeman Ariba Dadabhoy[...]Robert Wilkinson Nguyen Thuy Thuong Thuong Guy E Thwaites Nathan C Bahr Tuberculous Meningitis International Research Consortium Wellcome Open Research Published 1 July 2021 Crick labsRobert J WilkinsonFull details Dysregulation of the immune environment in the airways during HIV infection Authors (14) Rubina Bunjun Andreia P Soares Narjis Thawer Tracey L Müller Agano Kiravu Zekarias Ginbot[...] Florian von Groote-Bidlingmaier Catherine RiouRobert Wilkinson Gerhard Walzl Wendy A Burgers Frontiers in Immunology Published 1 June 2021 Crick labsRobert J WilkinsonFull details Strategies for the diagnosis and management of meningitis in HIV-infected adults in resource limited settings Authors (5) Marise Bremer Yakub E Kadernani Sean WassermanRobert Wilkinson Angharad G Davis Expert Opinion on Pharmacotherapy Published 21 June 2021 Crick labsRobert J WilkinsonFull details Rapid, simplified whole blood-based multiparameter assay to quantify and phenotype SARS-CoV-2 specific T cells Authors (9) Catherine Riou Georgia Schäfer Elsa du Bruyn Rene T Goliath Cari Stek Huihui Mou Deli HungKatalin WilkinsonRobert Wilkinson European Respiratory Journal Published 13 January 2022 Crick labsRobert J WilkinsonFull details Pagination Current page 1 Page 2 Next page Next Last page Last Share the page Share on Twitter Share on Facebook Share on LinkedIn Share on Email
Immune responses following third COVID-19 vaccination are reduced in patients with hematological malignancies compared to patients with solid cancer Authors (65)Annika FendlerScott ShepherdLewis AuKatalin WilkinsonMary Wu Andreas M Schmitt[...] Susanna WalkerRobert Wilkinson James LarkinSamra Turajlic CAPTURE consortium Cancer Cell Published 14 February 2022 Crick labs/ facilitiesRobert J WilkinsonSamra TurajlicCharles SwantonNicola LewisGeorge KassiotisSonia GandhiSteve GamblinRupert BealeDavid LV BauerWorldwide Influenza CentreStructural BiologyProteomicsMetabolomicsHigh Throughput ScreeningBioinformatics and BiostatisticsAdvanced SequencingScientific computingFull details
The in vivo transcriptomic blueprint of Mycobacterium tuberculosis in the lung Authors (4) Mariateresa CoppolaRachel LaiRobert Wilkinson Tom HM Ottenhoff Frontiers in Immunology Published 22 December 2021 Crick labsRobert J WilkinsonFull details
Escape from recognition of SARS-CoV-2 variant spike epitopes but overall preservation of T cell immunity Authors (53) Catherine Riou Roanne Keeton Thandeka Moyo-Gwete Tandile Hermanus Prudence Kgagudi Richard Baguma[...] Alex Sigal Tamryn Smith Ziyaad Valley-Omar Dieter van der Westhuizen Kennedy Zvinairo Science Translational Medicine Published 9 February 2022 Crick labsRobert J WilkinsonFull details
Transcriptomic characterization of tuberculous sputum reveals a host Warburg effect and microbial cholesterol catabolism Authors (11)Rachel Lai Teresa Cortes Suzaan Marais Neesha Rockwood Melissa L BurkeAcely Garza-Garcia Stuart Horswell Abdul K Sesay Anne O’Garra Douglas B YoungRobert Wilkinson mBio Published 7 December 2021 Crick labs/ facilitiesRobert J WilkinsonAnne O’GarraLuiz Pedro CarvalhoBioinformatics and BiostatisticsAdvanced SequencingFull details
Intracranial tuberculoma and the challenges of global neurosurgery Authors (9) Holly A Roy Natasha Cascini Bini Ajay Sudipta Mukherjee Lucy McGavin Alice InmanRobert Wilkinson Peter C Whitfield Andrew Martin Advances in Clinical Neuroscience and Rehabilitation Published 2 December 2021 Crick labsRobert J WilkinsonFull details
Baseline IL-6 is a biomarker for unfavourable tuberculosis treatment outcomes: a multisite discovery and validation study Authors (24) Akshay N Gupte Pavan Kumar Mariana Araújo-Pereira Vandana Kulkarni Mandar Paradkar Neeta Pradhan[...] Vidya Mave Subash Babu Hardy Kornfeld Bruno B Andrade Amita Gupta European Respiratory Journal Published 21 April 2022 Crick labsRobert J WilkinsonFull details
Adaptive immunity and neutralizing antibodies against SARS-CoV-2 variants of concern following vaccination in patients with cancer: the CAPTURE study Authors (98)Annika FendlerScott ShepherdLewis AuKatalin WilkinsonMary WuFiona Byrne[...] Susanna WalkerRobert Wilkinson James LarkinSamra Turajlic CAPTURE Consortium Nature Cancer Published 1 December 2021 Crick labs/ facilitiesRobert J WilkinsonSamra TurajlicCharles SwantonNicola LewisGeorge KassiotisSonia GandhiSteve GamblinDavid LV BauerWorldwide Influenza CentreMetabolomicsHigh Throughput ScreeningFlow CytometryBioinformatics and BiostatisticsAdvanced SequencingScientific computingFull details
Adaptive immunity and neutralizing antibodies against SARS-CoV-2 variants of concern following vaccination in patients with cancer: the CAPTURE study Authors (98)Annika FendlerScott ShepherdLewis AuKatalin WilkinsonMary WuFiona Byrne[...] Susanna WalkerRobert Wilkinson James LarkinSamra Turajlic The CAPTURE Consortium Nature Cancer Published 1 December 2021 Crick labs/ facilitiesRobert J WilkinsonSamra TurajlicCharles SwantonNicola LewisGeorge KassiotisSonia GandhiSteve GamblinDavid LV BauerWorldwide Influenza CentreMetabolomicsHigh Throughput ScreeningFlow CytometryBioinformatics and BiostatisticsAdvanced SequencingScientific computingFull details
Functional antibody and T cell immunity following SARS-CoV-2 infection, including by variants of concern, in patients with cancer: the CAPTURE study Authors (89)Annika FendlerLewis AuScott ShepherdFiona ByrneMaddalena Cerrone Laura Amanda Boos[...]George Kassiotis James LarkinRobert WilkinsonSamra Turajlic The CAPTURE consortium Nature Cancer Published 1 December 2021 Crick labs/ facilitiesRobert J WilkinsonSamra TurajlicCharles SwantonNicola LewisGeorge KassiotisSonia GandhiSteve GamblinWorldwide Influenza CentreProteomicsMetabolomicsHigh Throughput ScreeningFlow CytometryExperimental HistopathologyBioinformatics and BiostatisticsAdvanced SequencingScientific computingFull details
Flow cytometry method for absolute counting and single-cell phenotyping of mycobacteria Authors (10) David A Barr Charles Omollo Mandy Mason Anastasia KochRobert Wilkinson David G Lalloo Graeme Meintjes Valerie Mizrahi Digby F Warner Gerry Davies Scientific Reports Published 20 September 2021 Crick labsRobert J WilkinsonFull details
Same-day antiretroviral therapy initiation for people living with HIV who have tuberculosis symptoms: a systematic review Authors (8) Rachael M Burke Hannah M Rickman Vindi Singh Thokozani Kalua Niklaus D Labhardt Mina HosseinipourRobert Wilkinson Peter MacPherson HIV Medicine Published 1 January 2022 Crick labsRobert J WilkinsonFull details
Th22 cells are a major contributor to the mycobacterial CD4+ T cell response and are depleted during HIV infection Authors (10) Rubina Bunjun Fidilia MA Omondi Mohau S Makatsa Roanne Keeton Jerome M Wendoh Tracey L Müller Caryn SL PrenticeRobert Wilkinson Catherine Riou Wendy A Burgers Journal of Immunology Published 1 September 2021 Crick labsRobert J WilkinsonFull details
Eosinophils are part of the granulocyte response in tuberculosis and promote host resistance in mice Authors (32) Andrea C Bohrer Ehydel Castro Zhidong Hu Artur TL Queiroz Claire E Tocheny Maike Assmann[...] Amy D Klion Bruno B Andrade Yanzheng Song Ka-Wing Wong Katrin D Mayer-Barber Journal of Experimental Medicine Published 4 October 2021 Crick labsRobert J WilkinsonFull details
What is the optimum time to start antiretroviral therapy in people with HIV and tuberculosis coinfection? A systematic review and meta-analysis Authors (9) Rachael M Burke Hannah M Rickman Vindi Singh Elizabeth L Corbett Helen Ayles Andreas Jahn Mina C HosseinipourRobert Wilkinson Peter MacPherson Journal of the International AIDS Society Published 1 July 2021 Crick labsRobert J WilkinsonFull details
Development of a fixed module repertoire for the analysis and interpretation of blood transcriptome data Authors (33) Matthew C Altman Darawan Rinchai Nicole Baldwin Mohammed Toufiq Elizabeth Whalen Mathieu Garand[...] Octavio Ramilo Karolina Palucka Virginia Pascual Jacques Banchereau Damien Chaussabel Nature Communications Published 19 July 2021 Crick labsRobert J WilkinsonAnne O’GarraFull details
Radiological and functional evidence of the bronchial spread of tuberculosis: an observational analysis Authors (23) Ray Y Chen Xiang Yu Bronwyn Smith Xin Liu Jingcai Gao Andreas H Diacon[...] Stephanus T Malherbe Friedrich ThienemannRobert Wilkinson Gerhard Walzl Clifton E Barry Lancet Microbe Published 1 October 2021 Crick labsRobert J WilkinsonFull details
Host directed therapies for tuberculous meningitis Authors (14) Angharad G Davis Joseph Donovan Marise Bremer Ronald Van Toorn Johan Schoeman Ariba Dadabhoy[...]Robert Wilkinson Nguyen Thuy Thuong Thuong Guy E Thwaites Nathan C Bahr Tuberculous Meningitis International Research Consortium Wellcome Open Research Published 1 July 2021 Crick labsRobert J WilkinsonFull details
Dysregulation of the immune environment in the airways during HIV infection Authors (14) Rubina Bunjun Andreia P Soares Narjis Thawer Tracey L Müller Agano Kiravu Zekarias Ginbot[...] Florian von Groote-Bidlingmaier Catherine RiouRobert Wilkinson Gerhard Walzl Wendy A Burgers Frontiers in Immunology Published 1 June 2021 Crick labsRobert J WilkinsonFull details
Strategies for the diagnosis and management of meningitis in HIV-infected adults in resource limited settings Authors (5) Marise Bremer Yakub E Kadernani Sean WassermanRobert Wilkinson Angharad G Davis Expert Opinion on Pharmacotherapy Published 21 June 2021 Crick labsRobert J WilkinsonFull details
Rapid, simplified whole blood-based multiparameter assay to quantify and phenotype SARS-CoV-2 specific T cells Authors (9) Catherine Riou Georgia Schäfer Elsa du Bruyn Rene T Goliath Cari Stek Huihui Mou Deli HungKatalin WilkinsonRobert Wilkinson European Respiratory Journal Published 13 January 2022 Crick labsRobert J WilkinsonFull details