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Breadcrumb Robert J Wilkinson Wilkinson lab Tuberculosis Laboratory : Publications Lab contentLab contentIn this section Overview Areas of interest Publications Members Vacancies News Khayelitsha, South Africa: a peri-urban township of around 400000 people 30 km from the centre of Cape Town. In Khayelitsha the chances of developing tuberculosis in any year are around 1%, much higher if a person is HIV-coinfected. 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Series B, Biological Sciences (1)PLOS Genetics (1)Proceedings of the National Academy of Sciences of USA (1)Science Translational Medicine (1)Scientifica (1)Seminars in Immunopathology (1)Southern African Journal of HIV Medicine (1)Southern African Journal of Infectious Diseases (1)The Lancet (1)Thorax (1)Trends in Immunology (1)Trials (1)Tropical Medicine and International Health (1)Wellcome Open Res (1) Facet Journal Publications Displaying 1 - 20 of 362Last updated : 29 March 2024 02:51 COVID-19 in non-hospitalised adults caused by either SARS-CoV-2 sub-variants Omicron BA.1, BA.2, BA.4/5 or Delta associates with similar illness duration, symptom severity and viral kinetics, irrespective of vaccination history Authors (37) Hermaleigh Townsley Joshua Gahir Timothy W Russell David GreenwoodEdward Carr Matala Dyke[...]Sonia Gandhi Adam J KucharskiCharles SwantonDavid LV Bauer Emma C Wall PLOS ONE Published 21 March 2024 Crick labs/ facilitiesRobert J WilkinsonCharles SwantonGeorge KassiotisSonia GandhiSteve GamblinRupert BealeDavid LV BauerBiological Research FacilityBioinformatics and BiostatisticsAdvanced SequencingFull details Integrated plasma proteomics identifies tuberculosis-specific diagnostic biomarkers Authors (17) Hannah F Schiff Naomi F Walker Cesar Ugarte-Gil Marc Tebruegge Antigoni Manousopoulou Spiros D Garbis[...] Christopher H WoelkRobert Wilkinson Liku B Tezera Diana Garay-Baquero Paul Elkington JCI insight Published 21 March 2024 Crick labsRobert J WilkinsonFull details A nanopore sequencing-based pharmacogenomic panel to personalize tuberculosis drug dosing Authors (10) Renu Verma Kesia Esther da Silva Neesha Rockwood Roeland E Wasmann Nombuso Yende Taeksun Song Eugene Kim Paolo DentiRobert Wilkinson Jason R Andrews American Journal of Respiratory and Critical Care Medicine Published 5 March 2024 Crick labsRobert J WilkinsonFull details Stable and homogeneous SPION-infused Photo-Resins for 3D-printing magnetic hydrogels Authors (6) Ali A Mohammed Keyu Yao Ieva Ragaisyte Dominic Crestani Connor W MyantAlessandra Pinna Applied Materials Today Published 1 April 2024 Crick labsRobert J WilkinsonFull details Lithiated porous silicon nanowires stimulate periodontal regeneration Authors (27) Martti Kaasalainen Ran Zhang Priya Vashisth Anahid Ahmadi Birjandi Mark S'Ari Davide Alessandro Martella[...] Ana Angelova Volponi Jarno Salonen Nicole Hondow Paul Sharpe Ciro Chiappini Nature Communications Published 12 January 2024 Crick labsRobert J WilkinsonFull details Quantitative measurement of antibiotic resistance in Mycobacterium tuberculosis reveals genetic determinants of resistance and susceptibility in a target gene approach Authors (1) The CRyPTIC Consortium Nature Communications Published 12 January 2024 Crick labsRobert J WilkinsonFull details Influence of vitamin D supplementation on bone mineral content, bone turnover markers and fracture risk in South African schoolchildren: multicentre double-blind randomised placebo-controlled trial (ViDiKids) Authors (18) Keren Middelkoop Lisa K Micklesfield Neil Walker Justine Stewart Carmen Delport David A Jolliffe[...] Nicholas C Harvey Richard L HooperRobert Wilkinson Linda-Gail Bekker Adrian R Martineau Journal of Bone and Mineral Research Published 10 January 2024 Crick labsRobert J WilkinsonFull details Recent advances in understanding the human host immune response in tuberculous meningitis Authors (3)James Barnacle Angharad G DavisRobert Wilkinson Frontiers in Immunology Published 9 January 2024 Crick labsRobert J WilkinsonFull details Changing character and waning impact of COVID-19 at a tertiary centre in Cape Town, South Africa Authors (20) Lucas E Hermans Petro Booysen Linda Boloko Marguerite Adriaanse Timothy J de Wet Aimee R Lifson[...] Ntobeko AB Ntusi Carolyn Williamson Mary-Ann Davies Graeme Meintjes Sean Wasserman Southern African Journal of Infectious Diseases Published 18 December 2023 Crick labsRobert J WilkinsonFull details BACH1 promotes tissue necrosis and Mycobacterium tuberculosis susceptibility Authors (26) Eduardo P Amaral Sivaranjani Namasivayam Artur TL Queiroz Eduardo Fukutani Kerry L Hilligan Kate Aberman[...] Kazuhiko Igarashi Thomas Scriba Katrin D Mayer-Barber Bruno B Andrade Alan Sher Nature Microbiology Published 1 January 2024 Crick labsRobert J WilkinsonFull details A preclinical model of TB meningitis to determine drug penetration and activity at the sites of disease Authors (12) Faye Lanni Rosleine Antilus Sainte Mark Hansen Jr. Paul Parigi Firat Kaya Katherine LoMauro[...]Robert Wilkinson Sean Wasserman Brendan K Podell Martin Gengenbacher Véronique Dartois Antimicrobial Agents and Chemotherapy Published 1 December 2023 Crick labs/ facilitiesRobert J WilkinsonIn Vivo ImagingBiological Research FacilityFull details Immune interaction between SARS-CoV-2 and Mycobacterium tuberculosis Authors (6) Petro BooysenKatalin Wilkinson Dylan Sheerin Robyn Waters Anna K CoussensRobert Wilkinson Frontiers in Immunology Published 27 September 2023 Crick labsRobert J WilkinsonFull details Linezolid population pharmacokinetic model in plasma and cerebrospinal fluid among patients with tuberculosis meningitis Authors (10) Noha Abdelgawad Sean Wasserman Mahmoud Tareq Abdelwahab Angharad Davis Cari Stek Lubbe Wiesner John Black Graeme MeintjesRobert Wilkinson Paolo Denti Journal of Infectious Diseases Published 22 September 2023 Crick labsRobert J WilkinsonFull details Derivation of a high-resolution CT-based, semi-automated radiographic score in tuberculosis and its relationship to bacillary load and antitubercular therapy Authors (9) Catherine Riou Elsa du Bruyn Grace Hyun J Kim Irene da Costa Jihey Lee Alan SherRobert Wilkinson Brian W Allwood Jonathan Goldin European Respiratory Journal Published 21 September 2023 Crick labsRobert J WilkinsonFull details Neutrophil extracellular trap formation and gene programs distinguish TST/IGRA sensitization outcomes among Mycobacterium tuberculosis exposed persons living with HIV Authors (17) Elouise E Kroon Wilian Correa-Macedo Rachel Evans Allison Seeger Lize Engelbrecht Jurgen A Kriel[...] Marlo MöllerRobert Wilkinson Anna K Coussens Erwin Schurr Eileen G Hoal PLOS Genetics Published 24 August 2023 Crick labsRobert J WilkinsonFull details Differential effects of SARS-CoV-2 variants on central nervous system cells and blood-brain barrier functions Authors (6)Alize ProustChristophe Queval Ruth HarveyLorin Adams Michael BennettRobert Wilkinson Journal of Neuroinflammation Published 3 August 2023 Crick labs/ facilitiesRobert J WilkinsonWorldwide Influenza CentreHigh Throughput ScreeningLight MicroscopyFull details Recent advances in the treatment of tuberculosis Authors (18) Ilaria Motta Martin Boeree Dumitru Chesov Keertan Dheda Gunar Günther C Robert Horsburgh JR[...] Zarir Udwadia Reinout Van Crevel Gustavo E VelásquezRobert Wilkinson Lorenzo Guglielmetti Clinical Microbiology and Infection Published 22 July 2023 Crick labsRobert J WilkinsonFull details Relationship between LTA4H promotor polymorphism and tuberculosis-associated immune reconstitution inflammatory syndrome and its prevention with prednisone Authors (8) Cari Stek Muki Shey Khuthala Mnika Charlotte Schutz Friedrich ThienemannRobert Wilkinson Lutgarde Lynen Graeme Meintjes Open Forum Infectious Diseases Published 1 July 2023 Crick labsRobert J WilkinsonFull details Treatment of tuberculous meningitis: Overdue for concerted action Authors (5)Robert Wilkinson Joseph Donovan Guy E Thwaites Reinout van Crevel Sean Wasserman Tuberculosis Published 1 September 2023 Crick labsRobert J WilkinsonFull details Nanocomposite hydrogels with polymer grafted silica nanoparticles, using glucose oxidase Authors (5) Ali A Mohammed Siwei Li Tian Sang Julian R JonesAlessandra Pinna Gels Published 13 June 2023 Crick labsRobert J WilkinsonFull details Pagination Current page 1 Page 2 Page 3 Page 4 Page 5 Page 6 Page 7 Page 8 Page 9 … Next page Next Last page 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COVID-19 in non-hospitalised adults caused by either SARS-CoV-2 sub-variants Omicron BA.1, BA.2, BA.4/5 or Delta associates with similar illness duration, symptom severity and viral kinetics, irrespective of vaccination history Authors (37) Hermaleigh Townsley Joshua Gahir Timothy W Russell David GreenwoodEdward Carr Matala Dyke[...]Sonia Gandhi Adam J KucharskiCharles SwantonDavid LV Bauer Emma C Wall PLOS ONE Published 21 March 2024 Crick labs/ facilitiesRobert J WilkinsonCharles SwantonGeorge KassiotisSonia GandhiSteve GamblinRupert BealeDavid LV BauerBiological Research FacilityBioinformatics and BiostatisticsAdvanced SequencingFull details
Integrated plasma proteomics identifies tuberculosis-specific diagnostic biomarkers Authors (17) Hannah F Schiff Naomi F Walker Cesar Ugarte-Gil Marc Tebruegge Antigoni Manousopoulou Spiros D Garbis[...] Christopher H WoelkRobert Wilkinson Liku B Tezera Diana Garay-Baquero Paul Elkington JCI insight Published 21 March 2024 Crick labsRobert J WilkinsonFull details
A nanopore sequencing-based pharmacogenomic panel to personalize tuberculosis drug dosing Authors (10) Renu Verma Kesia Esther da Silva Neesha Rockwood Roeland E Wasmann Nombuso Yende Taeksun Song Eugene Kim Paolo DentiRobert Wilkinson Jason R Andrews American Journal of Respiratory and Critical Care Medicine Published 5 March 2024 Crick labsRobert J WilkinsonFull details
Stable and homogeneous SPION-infused Photo-Resins for 3D-printing magnetic hydrogels Authors (6) Ali A Mohammed Keyu Yao Ieva Ragaisyte Dominic Crestani Connor W MyantAlessandra Pinna Applied Materials Today Published 1 April 2024 Crick labsRobert J WilkinsonFull details
Lithiated porous silicon nanowires stimulate periodontal regeneration Authors (27) Martti Kaasalainen Ran Zhang Priya Vashisth Anahid Ahmadi Birjandi Mark S'Ari Davide Alessandro Martella[...] Ana Angelova Volponi Jarno Salonen Nicole Hondow Paul Sharpe Ciro Chiappini Nature Communications Published 12 January 2024 Crick labsRobert J WilkinsonFull details
Quantitative measurement of antibiotic resistance in Mycobacterium tuberculosis reveals genetic determinants of resistance and susceptibility in a target gene approach Authors (1) The CRyPTIC Consortium Nature Communications Published 12 January 2024 Crick labsRobert J WilkinsonFull details
Influence of vitamin D supplementation on bone mineral content, bone turnover markers and fracture risk in South African schoolchildren: multicentre double-blind randomised placebo-controlled trial (ViDiKids) Authors (18) Keren Middelkoop Lisa K Micklesfield Neil Walker Justine Stewart Carmen Delport David A Jolliffe[...] Nicholas C Harvey Richard L HooperRobert Wilkinson Linda-Gail Bekker Adrian R Martineau Journal of Bone and Mineral Research Published 10 January 2024 Crick labsRobert J WilkinsonFull details
Recent advances in understanding the human host immune response in tuberculous meningitis Authors (3)James Barnacle Angharad G DavisRobert Wilkinson Frontiers in Immunology Published 9 January 2024 Crick labsRobert J WilkinsonFull details
Changing character and waning impact of COVID-19 at a tertiary centre in Cape Town, South Africa Authors (20) Lucas E Hermans Petro Booysen Linda Boloko Marguerite Adriaanse Timothy J de Wet Aimee R Lifson[...] Ntobeko AB Ntusi Carolyn Williamson Mary-Ann Davies Graeme Meintjes Sean Wasserman Southern African Journal of Infectious Diseases Published 18 December 2023 Crick labsRobert J WilkinsonFull details
BACH1 promotes tissue necrosis and Mycobacterium tuberculosis susceptibility Authors (26) Eduardo P Amaral Sivaranjani Namasivayam Artur TL Queiroz Eduardo Fukutani Kerry L Hilligan Kate Aberman[...] Kazuhiko Igarashi Thomas Scriba Katrin D Mayer-Barber Bruno B Andrade Alan Sher Nature Microbiology Published 1 January 2024 Crick labsRobert J WilkinsonFull details
A preclinical model of TB meningitis to determine drug penetration and activity at the sites of disease Authors (12) Faye Lanni Rosleine Antilus Sainte Mark Hansen Jr. Paul Parigi Firat Kaya Katherine LoMauro[...]Robert Wilkinson Sean Wasserman Brendan K Podell Martin Gengenbacher Véronique Dartois Antimicrobial Agents and Chemotherapy Published 1 December 2023 Crick labs/ facilitiesRobert J WilkinsonIn Vivo ImagingBiological Research FacilityFull details
Immune interaction between SARS-CoV-2 and Mycobacterium tuberculosis Authors (6) Petro BooysenKatalin Wilkinson Dylan Sheerin Robyn Waters Anna K CoussensRobert Wilkinson Frontiers in Immunology Published 27 September 2023 Crick labsRobert J WilkinsonFull details
Linezolid population pharmacokinetic model in plasma and cerebrospinal fluid among patients with tuberculosis meningitis Authors (10) Noha Abdelgawad Sean Wasserman Mahmoud Tareq Abdelwahab Angharad Davis Cari Stek Lubbe Wiesner John Black Graeme MeintjesRobert Wilkinson Paolo Denti Journal of Infectious Diseases Published 22 September 2023 Crick labsRobert J WilkinsonFull details
Derivation of a high-resolution CT-based, semi-automated radiographic score in tuberculosis and its relationship to bacillary load and antitubercular therapy Authors (9) Catherine Riou Elsa du Bruyn Grace Hyun J Kim Irene da Costa Jihey Lee Alan SherRobert Wilkinson Brian W Allwood Jonathan Goldin European Respiratory Journal Published 21 September 2023 Crick labsRobert J WilkinsonFull details
Neutrophil extracellular trap formation and gene programs distinguish TST/IGRA sensitization outcomes among Mycobacterium tuberculosis exposed persons living with HIV Authors (17) Elouise E Kroon Wilian Correa-Macedo Rachel Evans Allison Seeger Lize Engelbrecht Jurgen A Kriel[...] Marlo MöllerRobert Wilkinson Anna K Coussens Erwin Schurr Eileen G Hoal PLOS Genetics Published 24 August 2023 Crick labsRobert J WilkinsonFull details
Differential effects of SARS-CoV-2 variants on central nervous system cells and blood-brain barrier functions Authors (6)Alize ProustChristophe Queval Ruth HarveyLorin Adams Michael BennettRobert Wilkinson Journal of Neuroinflammation Published 3 August 2023 Crick labs/ facilitiesRobert J WilkinsonWorldwide Influenza CentreHigh Throughput ScreeningLight MicroscopyFull details
Recent advances in the treatment of tuberculosis Authors (18) Ilaria Motta Martin Boeree Dumitru Chesov Keertan Dheda Gunar Günther C Robert Horsburgh JR[...] Zarir Udwadia Reinout Van Crevel Gustavo E VelásquezRobert Wilkinson Lorenzo Guglielmetti Clinical Microbiology and Infection Published 22 July 2023 Crick labsRobert J WilkinsonFull details
Relationship between LTA4H promotor polymorphism and tuberculosis-associated immune reconstitution inflammatory syndrome and its prevention with prednisone Authors (8) Cari Stek Muki Shey Khuthala Mnika Charlotte Schutz Friedrich ThienemannRobert Wilkinson Lutgarde Lynen Graeme Meintjes Open Forum Infectious Diseases Published 1 July 2023 Crick labsRobert J WilkinsonFull details
Treatment of tuberculous meningitis: Overdue for concerted action Authors (5)Robert Wilkinson Joseph Donovan Guy E Thwaites Reinout van Crevel Sean Wasserman Tuberculosis Published 1 September 2023 Crick labsRobert J WilkinsonFull details
Nanocomposite hydrogels with polymer grafted silica nanoparticles, using glucose oxidase Authors (5) Ali A Mohammed Siwei Li Tian Sang Julian R JonesAlessandra Pinna Gels Published 13 June 2023 Crick labsRobert J WilkinsonFull details