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Sex-reversed male XY mouse (left) and female XX mouse (right). Read the news article to find out more. Nitzan Gonen, a postdoc in Robin Lovell-Badge's lab led the researcher, working in partnership with GeMS. Toggle to view hero caption Robin Lovell-Badge : Publications Lab MenuLab Menu Overview Areas of interest Publications Members vacancies LAB NEWS Breadcrumb Home Research Labs Robin Lovell-Badge Publications PublicationsYear published2020 (5)2019 (5)2018 (3)2017 (6)2016 (6)2015 (6)2014 (6)2013 (8)2012 (11)2011 (8)2010 (7)Research topicsDevelopmental Biology (31)Genetics & Genomics (31)Model Organisms (31)Neurosciences (31)Stem Cells (31)Tumour Biology (31)Computational & Systems Biology (1)Gene Expression (1)Signalling & Oncogenes (1)Synthetic Biology (1)Publication typeJournal article (71)Primary research (45)Review (18)Commentary (7)Method (1)JournalDevelopment (5)PLOS ONE (5)Cell Stem Cell (3)Developmental Biology (3)Nature (3)Nature Biotechnology (3)Cancer Research (2)Developmental Cell (2)International Journal of Biochemistry & Cell Biology (2)Journal of Molecular Endocrinology (2)Methods in Molecular Biology (2)Nature Methods (2)PLOS Genetics (2)Proceedings of the National Academy of Sciences of the United States of America (2)Science (2)Sexual Development (2)Aging Cell (1)American Journal of Bioethics (1)Animal Technology and Welfare (1)Biology of Reproduction (1)Biology of Sex Differences (1)British Journal of Cancer (1)Cell (1)Cell Metabolism (1)Chromosome Research (1)Current Topics in Developmental Biology (1)eLife (1)Endocrine Connections (1)Endocrinology (1)European Journal of Neuroscience (1)Expert opinion on therapeutic targets (1)FEBS Journal (1)Frontiers in Physiology (1)Human Gene Therapy Methods (1)Journal of Cardiovascular Translational Research (1)Journal of Clinical Investigation (1)Journal of Neuroendocrinology (1)Mechanisms of Development (1)Molecular and Cellular Endocrinology (1)Nature Neuroscience (1)New England Journal of Medicine (1)Oncogenesis (1)Proceedings of the National Academy of Sciences (1)Scientific Reports (1)Trends in Endocrinology & Metabolism (1) Publications Displaying 1 - 20 of 71Last updated : 13 July 2020 02:03 Testis formation in XX individuals resulting from novel pathogenic variants in Wilms’ tumor 1 (WT1) gene Authors (33) Caroline EozenouNitzan Gonen Maria Sol Touzon Anne Jorgensen Svetlana A Yatsenko Leila Fusee[...] Ken McElreavey Alicia BelgoroskyRobin Lovell-Badge Aleksandar Rajkovic Anu Bashamboo Proceedings of the National Academy of Sciences Published 16 June 2020 Crick labs/ facilitiesRobin Lovell-BadgeExperimental HistopathologyBiological Research FacilityFull details Cell population characterisation and discovery using single cell technologies in endocrine systems Authors (2) Leonard Ym CheungKarine Rizzoti Journal of Molecular Endocrinology Published 1 June 2020 Crick labsRobin Lovell-BadgeFull details SOX3 promotes generation of committed spermatogonia in postnatal mouse testes Authors (7) Dale McAninch Juho-Antti Mäkelä Hue M La James N HughesRobin Lovell-Badge Robin M Hobbs Paul Q Thomas Scientific Reports Published 21 April 2020 Crick labsRobin Lovell-BadgeFull details Oestrogen in the chick embryo can induce chromosomally maleZZ left gonad epithelial cells to form an ovarian cortex that cansupport oogenesis Authors (5)Silvana Guioli Debiao Zhao Sunil Nandi Michael ClintonRobin Lovell-Badge Development Published 25 February 2020 Crick labs/ facilitiesRobin Lovell-BadgeLight MicroscopyBiological Research FacilityFull details Studies of mice deleted for Sox3 and uc482: relevance to X-linked hypoparathyroidism Authors (15) Katherine U Gaynor Irina V Grigorieva Samantha M Mirczuk Sian E Piret Kreepa G Kooblall Mark Stevenson[...] William D Fraser Tertius Hough Michael P WhyteRobin Lovell-Badge Rajesh Thakker Endocrine Connections Published 1 February 2020 Crick labsRobin Lovell-BadgeFull details Report of the 2018 RSPCA/UFAW rodent and rabbit welfare group meeting Authors (13) C Stevens P HawkinsRobin Lovell-Badge R Hubrecht H Golledge A Slaviero[...] R Terry K Hohlnaum D WellsThomas Snoeks J Marshall Animal Technology and Welfare Published 1 August 2019 Crick labsRobin Lovell-BadgeFull details The regulation of Sox9 expression in the gonad Authors (2)Nitzan GonenRobin Lovell-Badge Current Topics in Developmental Biology Published 13 February 2019 Crick labsRobin Lovell-BadgeFull details CRISPR babies: a view from the centre of the storm Authors (1)Robin Lovell-Badge Development Published 6 February 2019 Crick labsRobin Lovell-BadgeFull details Gonadal supporting cells acquire sex-specific chromatin landscapes during mammalian sex determination Authors (6) S Alexandra Garcia-Moreno Christopher R Futtner Isabella M SalamoneNitzan GonenRobin Lovell-Badge Danielle M Maatouk Developmental Biology Published 1 February 2019 Crick labs/ facilitiesRobin Lovell-BadgeBiological Research FacilityFull details After the storm - a responsible path for genome editing Authors (3) George Q DaleyRobin Lovell-Badge Julie Steffann New England Journal of Medicine Published 16 January 2019 Crick labsRobin Lovell-BadgeFull details Nervous system regionalization entails axial allocation before neural differentiation Authors (12)Vicki Metzis Sebastian Steinhauser Edvinas Pakanavicius Mina GoutiDespina StamatakiKenzo Ivanovitch[...] Teresa Rayon S Neda Mousavy GharavyRobin Lovell-BadgeNicholas LuscombeJames Briscoe Cell Published 18 October 2018 Crick labs/ facilitiesJames BriscoeRobin Lovell-BadgeNicholas LuscombeJim SmithAdvanced SequencingLight MicroscopyBioinformatics and BiostatisticsFlow CytometryScientific computingBiological Research FacilityFull details Sex reversal following deletion of a single distal enhancer of Sox9 Authors (10)Nitzan Gonen Chris R Futtner Sophie Wood S Alexandra Garcia-Moreno Isabella M Salamone Shiela C Samson Ryohei Sekido Francis Poulat Danielle M MaatoukRobin Lovell-Badge Science Published 29 June 2018 Crick labs/ facilitiesRobin Lovell-BadgeAdvanced SequencingExperimental HistopathologyFull details NOTCH activity differentially affects alternative cell fate acquisition and maintenance Authors (6) Leonard Cheung Paul Le Tissier Sam Goldsmith Mathias TreierRobin Lovell-BadgeKarine Rizzoti eLife Published 26 March 2018 Crick labs/ facilitiesRobin Lovell-BadgeLight MicroscopyBiological Research FacilityFull details High expression of MKP1/DUSP1 counteracts glioma stem cell activity and mediates HDAC inhibitor response Authors (24) Olatz Arrizabalaga Leire Moreno-Cugnon Jaione Auzmendi-Iriarte Paula Aldaz Inmaculada Ibañez de Cáceres Laura Garros-Regulez[...]Robin Lovell-Badge Cristobal Belda-Iniesta Nicolas Sampron Rosario Perona Ander Matheu Oncogenesis Published 14 December 2017 Crick labsRobin Lovell-BadgeFull details Assisted reproductive technologies to prevent human mitochondrial disease transmission Authors (6) Andy Greenfield Peter Braude Frances FlinterRobin Lovell-Badge Caroline Ogilvie Anthony CF Perry Nature Biotechnology Published 9 November 2017 Crick labsRobin Lovell-BadgeFull details Revisiting the Warnock rule Authors (15) J Benjamin Hurlbut Insoo Hyun Aaron D LevineRobin Lovell-Badge Jeantine E Lunshof Kirstin RW Matthews[...] Juliet Tizzard Mary Warnock Magdalena Zernicka-Goetz Qi Zhou Laurie Zoloth Nature Biotechnology Published 9 November 2017 Crick labsRobin Lovell-BadgeFull details Human embryo editing: Opportunities and importance of transnational cooperation Authors (10) Duanqing Pei David W Beier Ephrat Levy-Lahad Gary Marchant Janet Rossant Juan Carlos Izpisua BelmonteRobin Lovell-Badge Rudolf Jaenisch Alta Charo David Baltimore Cell Stem Cell Published 5 October 2017 Crick labsRobin Lovell-BadgeFull details Pivotal role of median eminence tanycytes for hypothalamic function and neurogenesis Authors (2)Karine RizzotiRobin Lovell-Badge Molecular and Cellular Endocrinology Published 13 August 2017 Crick labsRobin Lovell-BadgeFull details Normal levels of Sox9 expression in the developing mouse testis depend on the TES/TESCO enhancer, but this does not act alone Authors (5)Nitzan Gonen Alexander Quinn Helen C O'Neill Peter KoopmanRobin Lovell-Badge PLOS Genetics Published 1 January 2017 Crick labs/ facilitiesRobin Lovell-BadgeBiological Research FacilityFull details Debate on Germline Gene Editing Authors (8) Nathalie Cartier-Lacave Robin Ali Seppo Ylä-Herttuala Kazuto Kato Bernard BaetschiRobin Lovell-Badge Luigi Naldini Adrian Thrasher Human Gene Therapy Methods Published 1 August 2016 Crick labsRobin Lovell-BadgeFull details Pagination Current page 1 Page 2 Page 3 Page 4 Next page Next Last page Last Share the page Share on Twitter Share on Facebook Share on LinkedIn Share on Email
Testis formation in XX individuals resulting from novel pathogenic variants in Wilms’ tumor 1 (WT1) gene Authors (33) Caroline EozenouNitzan Gonen Maria Sol Touzon Anne Jorgensen Svetlana A Yatsenko Leila Fusee[...] Ken McElreavey Alicia BelgoroskyRobin Lovell-Badge Aleksandar Rajkovic Anu Bashamboo Proceedings of the National Academy of Sciences Published 16 June 2020 Crick labs/ facilitiesRobin Lovell-BadgeExperimental HistopathologyBiological Research FacilityFull details
Cell population characterisation and discovery using single cell technologies in endocrine systems Authors (2) Leonard Ym CheungKarine Rizzoti Journal of Molecular Endocrinology Published 1 June 2020 Crick labsRobin Lovell-BadgeFull details
SOX3 promotes generation of committed spermatogonia in postnatal mouse testes Authors (7) Dale McAninch Juho-Antti Mäkelä Hue M La James N HughesRobin Lovell-Badge Robin M Hobbs Paul Q Thomas Scientific Reports Published 21 April 2020 Crick labsRobin Lovell-BadgeFull details
Oestrogen in the chick embryo can induce chromosomally maleZZ left gonad epithelial cells to form an ovarian cortex that cansupport oogenesis Authors (5)Silvana Guioli Debiao Zhao Sunil Nandi Michael ClintonRobin Lovell-Badge Development Published 25 February 2020 Crick labs/ facilitiesRobin Lovell-BadgeLight MicroscopyBiological Research FacilityFull details
Studies of mice deleted for Sox3 and uc482: relevance to X-linked hypoparathyroidism Authors (15) Katherine U Gaynor Irina V Grigorieva Samantha M Mirczuk Sian E Piret Kreepa G Kooblall Mark Stevenson[...] William D Fraser Tertius Hough Michael P WhyteRobin Lovell-Badge Rajesh Thakker Endocrine Connections Published 1 February 2020 Crick labsRobin Lovell-BadgeFull details
Report of the 2018 RSPCA/UFAW rodent and rabbit welfare group meeting Authors (13) C Stevens P HawkinsRobin Lovell-Badge R Hubrecht H Golledge A Slaviero[...] R Terry K Hohlnaum D WellsThomas Snoeks J Marshall Animal Technology and Welfare Published 1 August 2019 Crick labsRobin Lovell-BadgeFull details
The regulation of Sox9 expression in the gonad Authors (2)Nitzan GonenRobin Lovell-Badge Current Topics in Developmental Biology Published 13 February 2019 Crick labsRobin Lovell-BadgeFull details
CRISPR babies: a view from the centre of the storm Authors (1)Robin Lovell-Badge Development Published 6 February 2019 Crick labsRobin Lovell-BadgeFull details
Gonadal supporting cells acquire sex-specific chromatin landscapes during mammalian sex determination Authors (6) S Alexandra Garcia-Moreno Christopher R Futtner Isabella M SalamoneNitzan GonenRobin Lovell-Badge Danielle M Maatouk Developmental Biology Published 1 February 2019 Crick labs/ facilitiesRobin Lovell-BadgeBiological Research FacilityFull details
After the storm - a responsible path for genome editing Authors (3) George Q DaleyRobin Lovell-Badge Julie Steffann New England Journal of Medicine Published 16 January 2019 Crick labsRobin Lovell-BadgeFull details
Nervous system regionalization entails axial allocation before neural differentiation Authors (12)Vicki Metzis Sebastian Steinhauser Edvinas Pakanavicius Mina GoutiDespina StamatakiKenzo Ivanovitch[...] Teresa Rayon S Neda Mousavy GharavyRobin Lovell-BadgeNicholas LuscombeJames Briscoe Cell Published 18 October 2018 Crick labs/ facilitiesJames BriscoeRobin Lovell-BadgeNicholas LuscombeJim SmithAdvanced SequencingLight MicroscopyBioinformatics and BiostatisticsFlow CytometryScientific computingBiological Research FacilityFull details
Sex reversal following deletion of a single distal enhancer of Sox9 Authors (10)Nitzan Gonen Chris R Futtner Sophie Wood S Alexandra Garcia-Moreno Isabella M Salamone Shiela C Samson Ryohei Sekido Francis Poulat Danielle M MaatoukRobin Lovell-Badge Science Published 29 June 2018 Crick labs/ facilitiesRobin Lovell-BadgeAdvanced SequencingExperimental HistopathologyFull details
NOTCH activity differentially affects alternative cell fate acquisition and maintenance Authors (6) Leonard Cheung Paul Le Tissier Sam Goldsmith Mathias TreierRobin Lovell-BadgeKarine Rizzoti eLife Published 26 March 2018 Crick labs/ facilitiesRobin Lovell-BadgeLight MicroscopyBiological Research FacilityFull details
High expression of MKP1/DUSP1 counteracts glioma stem cell activity and mediates HDAC inhibitor response Authors (24) Olatz Arrizabalaga Leire Moreno-Cugnon Jaione Auzmendi-Iriarte Paula Aldaz Inmaculada Ibañez de Cáceres Laura Garros-Regulez[...]Robin Lovell-Badge Cristobal Belda-Iniesta Nicolas Sampron Rosario Perona Ander Matheu Oncogenesis Published 14 December 2017 Crick labsRobin Lovell-BadgeFull details
Assisted reproductive technologies to prevent human mitochondrial disease transmission Authors (6) Andy Greenfield Peter Braude Frances FlinterRobin Lovell-Badge Caroline Ogilvie Anthony CF Perry Nature Biotechnology Published 9 November 2017 Crick labsRobin Lovell-BadgeFull details
Revisiting the Warnock rule Authors (15) J Benjamin Hurlbut Insoo Hyun Aaron D LevineRobin Lovell-Badge Jeantine E Lunshof Kirstin RW Matthews[...] Juliet Tizzard Mary Warnock Magdalena Zernicka-Goetz Qi Zhou Laurie Zoloth Nature Biotechnology Published 9 November 2017 Crick labsRobin Lovell-BadgeFull details
Human embryo editing: Opportunities and importance of transnational cooperation Authors (10) Duanqing Pei David W Beier Ephrat Levy-Lahad Gary Marchant Janet Rossant Juan Carlos Izpisua BelmonteRobin Lovell-Badge Rudolf Jaenisch Alta Charo David Baltimore Cell Stem Cell Published 5 October 2017 Crick labsRobin Lovell-BadgeFull details
Pivotal role of median eminence tanycytes for hypothalamic function and neurogenesis Authors (2)Karine RizzotiRobin Lovell-Badge Molecular and Cellular Endocrinology Published 13 August 2017 Crick labsRobin Lovell-BadgeFull details
Normal levels of Sox9 expression in the developing mouse testis depend on the TES/TESCO enhancer, but this does not act alone Authors (5)Nitzan Gonen Alexander Quinn Helen C O'Neill Peter KoopmanRobin Lovell-Badge PLOS Genetics Published 1 January 2017 Crick labs/ facilitiesRobin Lovell-BadgeBiological Research FacilityFull details
Debate on Germline Gene Editing Authors (8) Nathalie Cartier-Lacave Robin Ali Seppo Ylä-Herttuala Kazuto Kato Bernard BaetschiRobin Lovell-Badge Luigi Naldini Adrian Thrasher Human Gene Therapy Methods Published 1 August 2016 Crick labsRobin Lovell-BadgeFull details
