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Coronavirus (COVID-19) research Crick researchers are working at the forefront of the scientific response to answer some of the most urgent questions about the SARS-CoV-2 pathogen, from how we can improve testing, to why it’s deadly in some people but causes no symptoms in others.
Breadcrumb Rupert Beale Beale lab Cell Biology of Infection Laboratory : Publications Lab contentLab contentIn this section Overview Members Vacancies Publications PublicationsYear published2022 (6)2021 (26)2020 (8)2016 (1) Facet Year publishedResearch topicsCell Biology (41)Infectious Disease (41)Immunology (40)Chemical Biology & High Throughput (26)Genetics & Genomics (24)Genome Integrity & Repair (24)Model Organisms (22)Computational & Systems Biology (20)Structural Biology & Biophysics (20)Cell Cycle & Chromosomes (19)Tumour Biology (19)Human Biology & Physiology (18)Signalling & Oncogenes (16)Stem Cells (16)Biochemistry & Proteomics (15)Metabolism (13)Neurosciences (12)Imaging (8)Developmental Biology (5)Synthetic Biology (5)Gene Expression (2)Microfabrication & Bioengineering (1) Facet Research topicsPublication typeJournal article (41)Primary research (28)Review (4)Commentary (3)Method (3)Letter (2)Systematic review (1) Facet Publication typeJournalBiochemical Journal (7)The Lancet (6)Autophagy (3)Science (3)Lancet (2)Nature (2)Annals of Internal Medicine (1)BMC Medicine (1)Cancer Cell (1)Cell Reports (1)eLife (1)Journal of the American Society of Nephrology (1)Journal of Virology (1)Kidney International (1)Kidney International Reports (1)Lancet Infectious Diseases (1)Mayo Clinic Proceedings (1)Molecular Cell (1)Nature Biotechnology (1)Science advances (1)Science Immunology (1)STAR Protocols (1)Stem Cell Reports (1)Wellcome Open Research (1) Facet Journal Publications Displaying 1 - 20 of 41Last updated : 03 July 2022 02:44 Targeting TLR4 during vaccination boosts MAdCAM-1+ lymphoid stromal cell activation and promotes the aged germinal center response Authors (11) Alice E Denton James Dooley Isabella Cinti Alyssa Silva-Cayetano Sigrid Fra-Bido Silvia Innocentin Danika L Hill Edward J Carr Andrew NJ McKenzie Adrian Liston Michelle A Linterman Science Immunology Published 6 May 2022 Crick labsRupert BealeFull details The V-ATPase complex regulates non-canonical Atg8-family protein lipidation through ATG16L1 recruitment Authors (7) Lewis Timimi Carmen Figueras-Novoa Elena Marcassa Oliver Florey J Kenneth BaillieRupert BealeRachel Ulferts Autophagy Published 8 March 2022 Crick labsRupert BealeFull details The impact of vaccination on incidence and outcomes of SARS-CoV-2 infection in patients with kidney failure in Scotland Authors (20) Samira Bell Jacqueline Campbell Emilie Lambourg Chrissie Watters Martin O'Neil Alison Almond[...] Jamie P Traynor Vinod Sanu Peter Thomson Shona Methven Patrick B Mark Journal of the American Society of Nephrology Published 1 April 2022 Crick labsRupert BealeFull details Omicron neutralising antibodies after third COVID-19 vaccine dose in patients with cancer Authors (62)Annika FendlerScott ShepherdLewis AuMary Wu Ruth Harvey Andreas M Schmitt[...] Emma Nicholson Susanna Walker James LarkinSamra Turajlic The CAPTURE consortium The Lancet Published 5 March 2022 Crick labs/ facilitiesRobert J WilkinsonSamra TurajlicCharles SwantonJohn McCauleyGeorge KassiotisSonia GandhiSteve GamblinRupert BealeDavid LV BauerWorldwide Influenza CentreStructural BiologyMetabolomicsHigh Throughput ScreeningBiological Research FacilityBioinformatics and BiostatisticsAdvanced SequencingScientific computingFull details Omicron neutralising antibodies after COVID-19 vaccination in haemodialysis patients Authors (19) Edward J CarrMary Wu Ruth Harvey Roseanne E Billany Emma C WallGavin Kelly[...] Rachel B Jones Rona M Smith Stephen McAdoo Michelle WillicombeRupert Beale The Lancet Published 26 February 2022 Crick labs/ facilitiesCharles SwantonGitta StockingerJohn McCauleyGeorge KassiotisSonia GandhiSteve GamblinRupert BealeDavid LV BauerWorldwide Influenza CentreHigh Throughput ScreeningBioinformatics and BiostatisticsFull details Three-dose vaccination elicits neutralising antibodies against omicron Authors (26)Mary Wu Emma C Wall Edward J Carr Ruth Harvey Hermaleigh TownsleyHarriet Mears[...] Vincenzo Libri Bryan WilliamsSonia GandhiCharles SwantonDavid LV Bauer The Lancet Published 19 February 2022 Crick labs/ facilitiesCharles SwantonGitta StockingerJohn McCauleyGeorge KassiotisSonia GandhiSteve GamblinRupert BealeDavid LV BauerWorldwide Influenza CentreStructural BiologyHigh Throughput ScreeningBioinformatics and BiostatisticsScientific computingFull details Immune responses following third COVID-19 vaccination are reduced in patients with hematological malignancies compared to patients with solid cancer Authors (65)Annika FendlerScott ShepherdLewis AuKatalin WilkinsonMary Wu Andreas M Schmitt[...] Susanna WalkerRobert Wilkinson James LarkinSamra Turajlic CAPTURE consortium Cancer Cell Published 14 February 2022 Crick labs/ facilitiesRobert J WilkinsonSamra TurajlicCharles SwantonJohn McCauleyGeorge KassiotisSonia GandhiSteve GamblinRupert BealeDavid LV BauerWorldwide Influenza CentreStructural BiologyProteomicsMetabolomicsHigh Throughput ScreeningBioinformatics and BiostatisticsAdvanced SequencingScientific computingFull details Subtractive CRISPR screen identifies the ATG16L1/vacuolar ATPase axis as required for non-canonical LC3 lipidation Authors (9) Elena Marcassa Lewis Timimi Liam Changwoo Lee Andrew DaleyBeatriz Montaner Suzanne Dawn Turner Oliver Florey John Kenneth BaillieRupert Beale Cell Reports Published 26 October 2021 Crick labs/ facilitiesRupert BealeLight MicroscopyFlow CytometryCell ServicesFull details Infecting human hematopoietic stem and progenitor cells with SARS-CoV-2 Authors (4) Hector Huerga EncaboAneesh SharmaRupert BealeDominique Bonnet STAR Protocols Published 17 December 2021 Crick labs/ facilitiesDominique BonnetRupert BealeFlow CytometryFull details Neutralising antibodies after COVID-19 vaccination in UK haemodialysis patients Authors (86) Edward J CarrMary Wu Ruth Harvey Emma C WallGavin KellySaira Hussain[...]Emma RussellAndy RiddellSvend KjaerAnnabel BorgChloe Roustan The Lancet Published 18 September 2021 Crick labs/ facilitiesCharles SwantonGitta StockingerJohn McCauleyGeorge KassiotisSonia GandhiSteve GamblinRupert BealeDavid LV BauerWorldwide Influenza CentreStructural BiologyPeptide ChemistryHigh Throughput ScreeningFlow CytometryBiological Research FacilityBioinformatics and BiostatisticsScientific computingAdvanced SequencingFull details Reduced antibody cross-reactivity following infection with B.1.1.7 than with parental SARS-CoV-2 strains Authors (30)Nikhil FaulknerKevin NgMary Wu Ruth Harvey Marios Margaritis Stavroula Paraskevopoulou[...]Michael HowellDavid LV Bauer Eleni Nastouli SAFER InvestigatorsGeorge Kassiotis eLife Published 29 July 2021 Crick labs/ facilitiesCharles SwantonGeorge KassiotisSonia GandhiSteve GamblinRupert BealeDavid LV BauerWorldwide Influenza CentreStructural BiologyHigh Throughput ScreeningFlow CytometryCell ServicesFull details Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of nsp15 endoribonuclease Authors (14)Berta Canal Ryo FujisawaAllison McClure Tom D DeeganMary WuRachel Ulferts[...]Jingkun ZengRupert BealeMichael Howell Karim LabibJohn Diffley Biochemical Journal Published 16 July 2021 Crick labs/ facilitiesJohn DiffleyRupert BealeHigh Throughput ScreeningFull details An isoform of Dicer protects mammalian stem cells against multiple RNA viruses Authors (9)Michael Buck Probir ChakravartyJoana Do Vale Viegas Silva CarvalhoBruno Goncalves FredericoAna Matos Cardoso Da SilvaLyn HealyRachel UlfertsRupert BealeCaetano Reis e Sousa Science Published 9 July 2021 Crick labs/ facilitiesCaetano Reis e SousaRupert BealeHuman Embryonic Stem CellExperimental HistopathologyBioinformatics and BiostatisticsFlow CytometryAdvanced SequencingFull details Mapping the human genetic architecture of COVID-19 Authors (1) COVID-19 Host Genetics Initiative Nature Published 16 December 2021 Crick labsRupert BealeFull details Review of early immune response to SARS-CoV-2 vaccination among patients with CKD Authors (11) Edward J Carr Andreas Kronbichler Matthew Graham-Brown Graham Abra Christos Argyropoulos Lorraine Harper Edgar V Lerma Rita S Suri Joel Topf Michelle Willicombe Swapnil Hiremath Kidney International Reports Published 1 September 2021 Crick labsRupert BealeFull details Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of nsp12/7/8 RNA-dependent RNA polymerase Authors (12)Agostina BertolinFlorian WeissmannJingkun ZengViktor PosseJennifer MilliganBerta Canal[...]Mary WuLucy DruryMichael HowellRupert BealeJohn Diffley Biochemical Journal Published 16 July 2021 Crick labs/ facilitiesJohn DiffleyRupert BealeHigh Throughput ScreeningFull details Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of nsp14/nsp10 exoribonuclease Authors (19)Berta CanalAllison McClureJoseph CurranMary WuRachel UlfertsFlorian Weissmann[...]Clovis Basier Karim LabibRupert BealeMichael HowellJohn Diffley Biochemical Journal Published 16 July 2021 Crick labs/ facilitiesPaul NurseJohn DiffleyRupert BealeHigh Throughput ScreeningStructural BiologyFermentationFull details Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of nsp13 helicase Authors (19)Jingkun ZengFlorian WeissmannAgostina BertolinViktor PosseBerta CanalRachel Ulferts[...]Svend KjaerJohn MccauleyMichael HowellRupert BealeJohn Diffley Biochemical Journal Published 16 July 2021 Crick labs/ facilitiesJohn McCauleyJohn DiffleyRupert BealeWorldwide Influenza CentreStructural BiologyHigh Throughput ScreeningFull details Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of Nsp5 main protease Authors (22)Jennifer MilliganTheresa ZeisnerGeorge PapageorgiouDhira JoshiChristelle SoudyRachel Ulferts[...]Michael HowellRupert Beale Karim LabibNicola O'ReillyJohn Diffley Biochemical Journal Published 16 July 2021 Crick labs/ facilitiesPaul NurseJohn DiffleyRupert BealePeptide ChemistryHigh Throughput ScreeningFull details Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of Nsp3 papain-like protease Authors (19)Chew Theng LimKang Wei TanMary WuRachel Ulferts Lee A ArmstrongEiko Ozono[...]Nicola O'ReillyRupert Beale Yogesh Kulathu Karim LabibJohn Diffley Biochemical Journal Published 16 July 2021 Crick labs/ facilitiesJohn DiffleyRupert BealePeptide ChemistryHigh Throughput ScreeningFull details Pagination Current page 1 Page 2 Page 3 Next page Next Last page Last Share the page Share on Twitter Share on Facebook Share on LinkedIn Share on Email
Targeting TLR4 during vaccination boosts MAdCAM-1+ lymphoid stromal cell activation and promotes the aged germinal center response Authors (11) Alice E Denton James Dooley Isabella Cinti Alyssa Silva-Cayetano Sigrid Fra-Bido Silvia Innocentin Danika L Hill Edward J Carr Andrew NJ McKenzie Adrian Liston Michelle A Linterman Science Immunology Published 6 May 2022 Crick labsRupert BealeFull details
The V-ATPase complex regulates non-canonical Atg8-family protein lipidation through ATG16L1 recruitment Authors (7) Lewis Timimi Carmen Figueras-Novoa Elena Marcassa Oliver Florey J Kenneth BaillieRupert BealeRachel Ulferts Autophagy Published 8 March 2022 Crick labsRupert BealeFull details
The impact of vaccination on incidence and outcomes of SARS-CoV-2 infection in patients with kidney failure in Scotland Authors (20) Samira Bell Jacqueline Campbell Emilie Lambourg Chrissie Watters Martin O'Neil Alison Almond[...] Jamie P Traynor Vinod Sanu Peter Thomson Shona Methven Patrick B Mark Journal of the American Society of Nephrology Published 1 April 2022 Crick labsRupert BealeFull details
Omicron neutralising antibodies after third COVID-19 vaccine dose in patients with cancer Authors (62)Annika FendlerScott ShepherdLewis AuMary Wu Ruth Harvey Andreas M Schmitt[...] Emma Nicholson Susanna Walker James LarkinSamra Turajlic The CAPTURE consortium The Lancet Published 5 March 2022 Crick labs/ facilitiesRobert J WilkinsonSamra TurajlicCharles SwantonJohn McCauleyGeorge KassiotisSonia GandhiSteve GamblinRupert BealeDavid LV BauerWorldwide Influenza CentreStructural BiologyMetabolomicsHigh Throughput ScreeningBiological Research FacilityBioinformatics and BiostatisticsAdvanced SequencingScientific computingFull details
Omicron neutralising antibodies after COVID-19 vaccination in haemodialysis patients Authors (19) Edward J CarrMary Wu Ruth Harvey Roseanne E Billany Emma C WallGavin Kelly[...] Rachel B Jones Rona M Smith Stephen McAdoo Michelle WillicombeRupert Beale The Lancet Published 26 February 2022 Crick labs/ facilitiesCharles SwantonGitta StockingerJohn McCauleyGeorge KassiotisSonia GandhiSteve GamblinRupert BealeDavid LV BauerWorldwide Influenza CentreHigh Throughput ScreeningBioinformatics and BiostatisticsFull details
Three-dose vaccination elicits neutralising antibodies against omicron Authors (26)Mary Wu Emma C Wall Edward J Carr Ruth Harvey Hermaleigh TownsleyHarriet Mears[...] Vincenzo Libri Bryan WilliamsSonia GandhiCharles SwantonDavid LV Bauer The Lancet Published 19 February 2022 Crick labs/ facilitiesCharles SwantonGitta StockingerJohn McCauleyGeorge KassiotisSonia GandhiSteve GamblinRupert BealeDavid LV BauerWorldwide Influenza CentreStructural BiologyHigh Throughput ScreeningBioinformatics and BiostatisticsScientific computingFull details
Immune responses following third COVID-19 vaccination are reduced in patients with hematological malignancies compared to patients with solid cancer Authors (65)Annika FendlerScott ShepherdLewis AuKatalin WilkinsonMary Wu Andreas M Schmitt[...] Susanna WalkerRobert Wilkinson James LarkinSamra Turajlic CAPTURE consortium Cancer Cell Published 14 February 2022 Crick labs/ facilitiesRobert J WilkinsonSamra TurajlicCharles SwantonJohn McCauleyGeorge KassiotisSonia GandhiSteve GamblinRupert BealeDavid LV BauerWorldwide Influenza CentreStructural BiologyProteomicsMetabolomicsHigh Throughput ScreeningBioinformatics and BiostatisticsAdvanced SequencingScientific computingFull details
Subtractive CRISPR screen identifies the ATG16L1/vacuolar ATPase axis as required for non-canonical LC3 lipidation Authors (9) Elena Marcassa Lewis Timimi Liam Changwoo Lee Andrew DaleyBeatriz Montaner Suzanne Dawn Turner Oliver Florey John Kenneth BaillieRupert Beale Cell Reports Published 26 October 2021 Crick labs/ facilitiesRupert BealeLight MicroscopyFlow CytometryCell ServicesFull details
Infecting human hematopoietic stem and progenitor cells with SARS-CoV-2 Authors (4) Hector Huerga EncaboAneesh SharmaRupert BealeDominique Bonnet STAR Protocols Published 17 December 2021 Crick labs/ facilitiesDominique BonnetRupert BealeFlow CytometryFull details
Neutralising antibodies after COVID-19 vaccination in UK haemodialysis patients Authors (86) Edward J CarrMary Wu Ruth Harvey Emma C WallGavin KellySaira Hussain[...]Emma RussellAndy RiddellSvend KjaerAnnabel BorgChloe Roustan The Lancet Published 18 September 2021 Crick labs/ facilitiesCharles SwantonGitta StockingerJohn McCauleyGeorge KassiotisSonia GandhiSteve GamblinRupert BealeDavid LV BauerWorldwide Influenza CentreStructural BiologyPeptide ChemistryHigh Throughput ScreeningFlow CytometryBiological Research FacilityBioinformatics and BiostatisticsScientific computingAdvanced SequencingFull details
Reduced antibody cross-reactivity following infection with B.1.1.7 than with parental SARS-CoV-2 strains Authors (30)Nikhil FaulknerKevin NgMary Wu Ruth Harvey Marios Margaritis Stavroula Paraskevopoulou[...]Michael HowellDavid LV Bauer Eleni Nastouli SAFER InvestigatorsGeorge Kassiotis eLife Published 29 July 2021 Crick labs/ facilitiesCharles SwantonGeorge KassiotisSonia GandhiSteve GamblinRupert BealeDavid LV BauerWorldwide Influenza CentreStructural BiologyHigh Throughput ScreeningFlow CytometryCell ServicesFull details
Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of nsp15 endoribonuclease Authors (14)Berta Canal Ryo FujisawaAllison McClure Tom D DeeganMary WuRachel Ulferts[...]Jingkun ZengRupert BealeMichael Howell Karim LabibJohn Diffley Biochemical Journal Published 16 July 2021 Crick labs/ facilitiesJohn DiffleyRupert BealeHigh Throughput ScreeningFull details
An isoform of Dicer protects mammalian stem cells against multiple RNA viruses Authors (9)Michael Buck Probir ChakravartyJoana Do Vale Viegas Silva CarvalhoBruno Goncalves FredericoAna Matos Cardoso Da SilvaLyn HealyRachel UlfertsRupert BealeCaetano Reis e Sousa Science Published 9 July 2021 Crick labs/ facilitiesCaetano Reis e SousaRupert BealeHuman Embryonic Stem CellExperimental HistopathologyBioinformatics and BiostatisticsFlow CytometryAdvanced SequencingFull details
Mapping the human genetic architecture of COVID-19 Authors (1) COVID-19 Host Genetics Initiative Nature Published 16 December 2021 Crick labsRupert BealeFull details
Review of early immune response to SARS-CoV-2 vaccination among patients with CKD Authors (11) Edward J Carr Andreas Kronbichler Matthew Graham-Brown Graham Abra Christos Argyropoulos Lorraine Harper Edgar V Lerma Rita S Suri Joel Topf Michelle Willicombe Swapnil Hiremath Kidney International Reports Published 1 September 2021 Crick labsRupert BealeFull details
Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of nsp12/7/8 RNA-dependent RNA polymerase Authors (12)Agostina BertolinFlorian WeissmannJingkun ZengViktor PosseJennifer MilliganBerta Canal[...]Mary WuLucy DruryMichael HowellRupert BealeJohn Diffley Biochemical Journal Published 16 July 2021 Crick labs/ facilitiesJohn DiffleyRupert BealeHigh Throughput ScreeningFull details
Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of nsp14/nsp10 exoribonuclease Authors (19)Berta CanalAllison McClureJoseph CurranMary WuRachel UlfertsFlorian Weissmann[...]Clovis Basier Karim LabibRupert BealeMichael HowellJohn Diffley Biochemical Journal Published 16 July 2021 Crick labs/ facilitiesPaul NurseJohn DiffleyRupert BealeHigh Throughput ScreeningStructural BiologyFermentationFull details
Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of nsp13 helicase Authors (19)Jingkun ZengFlorian WeissmannAgostina BertolinViktor PosseBerta CanalRachel Ulferts[...]Svend KjaerJohn MccauleyMichael HowellRupert BealeJohn Diffley Biochemical Journal Published 16 July 2021 Crick labs/ facilitiesJohn McCauleyJohn DiffleyRupert BealeWorldwide Influenza CentreStructural BiologyHigh Throughput ScreeningFull details
Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of Nsp5 main protease Authors (22)Jennifer MilliganTheresa ZeisnerGeorge PapageorgiouDhira JoshiChristelle SoudyRachel Ulferts[...]Michael HowellRupert Beale Karim LabibNicola O'ReillyJohn Diffley Biochemical Journal Published 16 July 2021 Crick labs/ facilitiesPaul NurseJohn DiffleyRupert BealePeptide ChemistryHigh Throughput ScreeningFull details
Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of Nsp3 papain-like protease Authors (19)Chew Theng LimKang Wei TanMary WuRachel Ulferts Lee A ArmstrongEiko Ozono[...]Nicola O'ReillyRupert Beale Yogesh Kulathu Karim LabibJohn Diffley Biochemical Journal Published 16 July 2021 Crick labs/ facilitiesJohn DiffleyRupert BealePeptide ChemistryHigh Throughput ScreeningFull details