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Breadcrumb Rupert Beale Beale lab Cell Biology of Infection Laboratory : Publications Lab contentLab contentIn this section Overview Members Vacancies Publications PublicationsYear published2024 (3)2023 (15)2022 (13)2021 (26)2020 (8)2016 (1) Facet Year publishedResearch topicsCell Biology (66)Immunology (65)Chemical Biology & High Throughput (38)Genetics & Genomics (35)Genome Integrity & Repair (35)Model Organisms (33)Computational & Systems Biology (31)Structural Biology & Biophysics (30)Tumour Biology (30)Cell Cycle & Chromosomes (29)Human Biology & Physiology (29)Stem Cells (28)Signalling & Oncogenes (25)Neurosciences (24)Metabolism (23)Biochemistry & Proteomics (20)Imaging (13)Developmental Biology (8)Synthetic Biology (6)Gene Expression (3)Microfabrication & Bioengineering (2) (-)Infectious Disease (66) Facet Research topicsPublication typeJournal article (66)Primary research (47)Letter (8)Review (4)Commentary (3)Method (3)Systematic review (1) Facet Publication typeJournalThe Lancet (9)Biochemical Journal (7)Autophagy (3)Lancet Infectious Diseases (3)Science (3)Cancer Cell (2)Cell Reports (2)Clinical Kidney Journal (2)Journal of Infection (2)Lancet (2)Nature (2)The Lancet Regional Health - Europe (2)Annals of Internal Medicine (1)BMC Medicine (1)BMJ Open (1)Cell Reports Medicine (1)Clinical Infectious Diseases (1)Developmental Cell (1)eLife (1)Journal of Clinical Virology (1)Journal of the American Society of Nephrology (1)Journal of Virology (1)Kidney International (1)Kidney International Reports (1)Mayo Clinic Proceedings (1)mBio (1)Molecular Cell (1)Nature Aging (1)Nature Biotechnology (1)Nature Immunology (1)New England Journal of Medicine (1)PLOS Biology (1)PLOS ONE (1)Science advances (1)Science Immunology (1)Science Translational Medicine (1)STAR Protocols (1)Stem Cell Reports (1)Wellcome Open Research (1) Facet Journal Publications Displaying 1 - 20 of 66Last updated : 28 March 2024 02:09 COVID-19 in non-hospitalised adults caused by either SARS-CoV-2 sub-variants Omicron BA.1, BA.2, BA.4/5 or Delta associates with similar illness duration, symptom severity and viral kinetics, irrespective of vaccination history Authors (37) Hermaleigh Townsley Joshua Gahir Timothy W Russell David GreenwoodEdward Carr Matala Dyke[...]Sonia Gandhi Adam J KucharskiCharles SwantonDavid LV Bauer Emma C Wall PLOS ONE Published 21 March 2024 Crick labs/ facilitiesRobert J WilkinsonCharles SwantonGeorge KassiotisSonia GandhiSteve GamblinRupert BealeDavid LV BauerBiological Research FacilityBioinformatics and BiostatisticsAdvanced SequencingFull details Divergent performance of vaccines in the UK autumn 2023 COVID-19 booster campaign Authors (22) Marianne Shawe-Taylor David Greenwood Agnieszka Hobbs Giulia DowgierBecky PennTheo Sanderson[...]Sonia GandhiEdward CarrMary WuDavid LV Bauer Emma C Wall The Lancet Published 11 March 2024 Crick labs/ facilitiesCharles SwantonGeorge KassiotisSonia GandhiSteve GamblinMike BlackmanRupert BealeDavid LV BauerWorldwide Influenza CentreStructural BiologyHigh Throughput ScreeningBioinformatics and BiostatisticsAdvanced SequencingScientific computingFull details Combined analyses of within-host SARS-CoV-2 viral kinetics and information on past exposures to the virus in a human cohort identifies intrinsic differences of Omicron and Delta variants Authors (26) Timothy W Russell Hermaleigh Townsley Sam Abbott Joel HellewellEdward Carr Lloyd AC Chapman[...]Charles SwantonRupert BealeDavid LV Bauer Emma C Wall Adam J Kucharski PLOS Biology Published 30 January 2024 Crick labs/ facilitiesCharles SwantonSonia GandhiSteve GamblinRupert BealeDavid LV BauerWorldwide Influenza CentreBiological Research FacilityAdvanced SequencingFull details Effect of second booster vaccinations and prior infection against SARS-CoV-2 in the UK SIREN healthcare worker cohort Authors (22) PD Kirwan VJ Hall S Foulkes AD Otter K Munro D Sparkes[...] SIREN Study Group AM Presanis A Charlett D De Angelis S Hopkins The Lancet Regional Health - Europe Published 1 January 2024 Crick labsRupert BealeFull details SARS-CoV-2 mucosal neutralising immunity after vaccination Authors (38)Edward Carr Guilia Dowgier David Greenwood Lou S Herman Agnieszka Hobbs Martina Ragno[...]Charles SwantonSonia GandhiDavid LV Bauer Emma WallMary Wu Lancet Infectious Diseases Published 1 January 2024 Crick labs/ facilitiesCharles SwantonGeorge KassiotisSonia GandhiSteve GamblinRupert BealeDavid LV BauerWorldwide Influenza CentreHigh Throughput ScreeningBiological Research FacilityAdvanced SequencingFull details Antibody correlates of protection against Delta infection after vaccination: A nested case-control within the UK-based SIREN study Authors (16) Ana Atti Ferdinando InsalataEdward Carr Ashley D Otter Sarah FoulkesMary Wu[...] Susan Hopkins Andre CharlettRupert Beale Victoria Hall SIREN Study Group Journal of Infection Published 1 November 2023 Crick labsRupert BealeFull details Usp25-Erlin1/2 activity limits cholesterol flux to restrict virus infection Authors (12) Qi Wen Teo Ho Him Wong Tiaan Heunis Viktoriya Stancheva Asmaa Hachim Huibin Lv[...] Julian Ho Yun Lan Chris Ka Pun MokRachel Ulferts Sumana Sanyal Developmental Cell Published 20 November 2023 Crick labsRupert BealeFull details CD4+ and CD8+ T cells and antibodies are associated with protection against Delta vaccine breakthrough infection: a nested case-control study within the PITCH study Authors (31) Isabel Neale Mohammad Ali Barbara Kronsteiner Stephanie Longet Priyanka Abraham Alexandra S Deeks[...] Miles Carroll Teresa Lambe Paul Klenerman Susanna Dunachie PITCH Consortium mBio Published 1 October 2023 Crick labsRupert BealeFull details Comparative effectiveness of sotrovimab and molnupiravir for preventing severe COVID-19 outcomes in patients on kidney replacement therapy: observational study using the OpenSAFELY-UKRR and SRR databases Authors (25) Bang Zheng Jacqueline CampbellEdward Carr John Tazare Linda Nab Viyaasan Mahalingasivam[...] Brian MacKenna Samira Bell Laurie A Tomlinson Dorothea Nitsch OpenSAFELY Collaborative and LH&W NCS (or CONVALESCENCE) Collaborative Clinical Kidney Journal Published 1 November 2023 Crick labsRupert BealeFull details Swab pooling enables rapid expansion of high-throughput capacity for SARS-CoV-2 community testing Authors (16) Jamie FaggRupert Beale Matthias E Futschik Elena Turek David Chapman Susan Halstead[...] Harper Vansteenhouse Sarah Tunkel Anna Dominiczak Timothy EA Peto Tom Fowler Journal of Clinical Virology Published 1 October 2023 Crick labsRupert BealeFull details Commercial immunoglobulin products contain neutralizing antibodies against severe acute respiratory syndrome coronavirus 2 spike protein Authors (29) Vinit Upasani Katie TownsendMary WuEdward Carr Agnieszka Hobbs Giulia Dowgier[...]Rupert BealeSonia Gandhi Emma C Wall Laura McCoy David M Lowe Clinical Infectious Diseases Published 1 October 2023 Crick labsSonia GandhiRupert BealeFull details Independent SARS-CoV-2 staff testing protected academic and health-care institutions in northwest London Authors (54) Chris BaileyTheo Sanderson Hermaleigh Townsley Jacki Goldman James RM BlackGeorge Young[...]Jerome NicodSonia GandhiDavid LV Bauer Emma C WallCharles Swanton The Lancet Published 1 July 2023 Crick labs/ facilitiesSamra TurajlicCharles SwantonSam RodriquesSonia GandhiSteve GamblinMike BlackmanRupert BealeDavid LV BauerWorldwide Influenza CentreStructural BiologyMetabolomicsHigh Throughput ScreeningFlow CytometryBioinformatics and BiostatisticsAdvanced SequencingScientific computingBiological Research FacilityFull details Neutralising immunity to omicron sublineages BQ.1.1, XBB, and XBB.1.5 in healthy adults is boosted by bivalent BA.1-containing mRNA vaccination and previous Omicron infection Authors (36)Edward CarrMary Wu Joshua Gahir Ruth Harvey Hermaleigh Townsley Chris Bailey[...]Charles SwantonSonia GandhiDavid LV Bauer Emma C Wall Crick COVID Serology Consortium Lancet Infectious Diseases Published 1 July 2023 Crick labs/ facilitiesCharles SwantonGeorge KassiotisSonia GandhiSteve GamblinRupert BealeDavid LV BauerWorldwide Influenza CentreHigh Throughput ScreeningBiological Research FacilityAdvanced SequencingScientific computingFull details Spatial dysregulation of T follicular helper cells impairs vaccine responses in aging Authors (23) Alyssa Silva-Cayetano Sigrid Fra-Bido Philippe A Robert Silvia Innocentin Alice R Burton Emily M Watson[...] Dirk Baumjohann Marion Espeli Michael Meyer-Hermann Alice E Denton Michelle A Linterman Nature Immunology Published 1 July 2023 Crick labsRupert BealeFull details Comparative effectiveness of two- and three-dose COVID-19 vaccination schedules involving AZD1222 and BNT162b2 in people with kidney disease: a linked OpenSAFELY and UK Renal Registry cohort study Authors (20) The OpenSAFELY Collaborative Edward PK Parker Elsie MF Horne William J Hulme John Tazare Bang Zheng[...] Ben Goldacre Jonathan AC Sterne Dorothea Nitsch Laurie A Tomlinson The LH&W NCS (or CONVALESCENCE) Collaborative The Lancet Regional Health - Europe Published 1 July 2023 Crick labsRupert BealeFull details Sotrovimab restores neutralization against current Omicron subvariants in patients with blood cancer Authors (67)Mary WuScott Shepherd Annika FendlerEdward CarrLewis Au Ruth Harvey[...] Emma Nicholson James Larkin Emma C WallSamra Turajlic CAPTURE consortium Cancer Cell Published 8 May 2023 Crick labs/ facilitiesSamra TurajlicCharles SwantonNicola LewisGeorge KassiotisSonia GandhiSteve GamblinRupert BealeDavid LV BauerWorldwide Influenza CentreMetabolomicsHigh Throughput ScreeningBioinformatics and BiostatisticsScientific computingFull details Factors associated with COVID-19 vaccine uptake in people with kidney disease: an OpenSAFELY cohort study Authors (29) The OpenSAFELY Collaborative Edward PK Parker John Tazare William J Hulme Christopher BatesEdward Carr[...] Michelle Willicombe Bang Zheng Ben Goldacre Dorothea Nitsch Laurie A Tomlinson BMJ Open Published 31 January 2023 Crick labsRupert BealeFull details Strong peak immunogenicity but rapid antibody waning following third vaccine dose in older residents of care homes Authors (68) G Tut T Lancaster M Krutikov P Sylla D Bone E Spalkova[...] A Irwin-Singer A Hayward A Copas L Shallcross P Moss Nature Aging Published 1 January 2023 Crick labs/ facilitiesCharles SwantonSonia GandhiSteve GamblinRupert BealeWorldwide Influenza CentreStructural BiologyHigh Throughput ScreeningFlow CytometryBiological Research FacilityScientific computingFull details The memory B cell response to influenza vaccination is impaired in older persons Authors (7) Alice R Burton Stephane M Guillaume William S Foster Adam K Wheatley Danika L HillEdward Carr Michelle A Linterman Cell Reports Published 8 November 2022 Crick labsRupert BealeFull details WHO's therapeutics and COVID-19 living guideline on mAbs needs to be reassessed Authors (19)Mary WuEdward Carr Ruth HarveyHarriet MearsSvend Kjaer Hermaleigh Townsley[...] Bryan WilliamsSonia GandhiCharles Swanton Emma C WallDavid LV Bauer The Lancet Published 17 December 2022 Crick labs/ facilitiesCharles SwantonNicola LewisSonia GandhiSteve GamblinRupert BealeDavid LV BauerWorldwide Influenza CentreStructural BiologyHigh Throughput ScreeningFull details Pagination Current page 1 Page 2 Page 3 Page 4 Next page Next Last page Last Share the page Share on Twitter Share on Facebook Share on LinkedIn Share on Email
COVID-19 in non-hospitalised adults caused by either SARS-CoV-2 sub-variants Omicron BA.1, BA.2, BA.4/5 or Delta associates with similar illness duration, symptom severity and viral kinetics, irrespective of vaccination history Authors (37) Hermaleigh Townsley Joshua Gahir Timothy W Russell David GreenwoodEdward Carr Matala Dyke[...]Sonia Gandhi Adam J KucharskiCharles SwantonDavid LV Bauer Emma C Wall PLOS ONE Published 21 March 2024 Crick labs/ facilitiesRobert J WilkinsonCharles SwantonGeorge KassiotisSonia GandhiSteve GamblinRupert BealeDavid LV BauerBiological Research FacilityBioinformatics and BiostatisticsAdvanced SequencingFull details
Divergent performance of vaccines in the UK autumn 2023 COVID-19 booster campaign Authors (22) Marianne Shawe-Taylor David Greenwood Agnieszka Hobbs Giulia DowgierBecky PennTheo Sanderson[...]Sonia GandhiEdward CarrMary WuDavid LV Bauer Emma C Wall The Lancet Published 11 March 2024 Crick labs/ facilitiesCharles SwantonGeorge KassiotisSonia GandhiSteve GamblinMike BlackmanRupert BealeDavid LV BauerWorldwide Influenza CentreStructural BiologyHigh Throughput ScreeningBioinformatics and BiostatisticsAdvanced SequencingScientific computingFull details
Combined analyses of within-host SARS-CoV-2 viral kinetics and information on past exposures to the virus in a human cohort identifies intrinsic differences of Omicron and Delta variants Authors (26) Timothy W Russell Hermaleigh Townsley Sam Abbott Joel HellewellEdward Carr Lloyd AC Chapman[...]Charles SwantonRupert BealeDavid LV Bauer Emma C Wall Adam J Kucharski PLOS Biology Published 30 January 2024 Crick labs/ facilitiesCharles SwantonSonia GandhiSteve GamblinRupert BealeDavid LV BauerWorldwide Influenza CentreBiological Research FacilityAdvanced SequencingFull details
Effect of second booster vaccinations and prior infection against SARS-CoV-2 in the UK SIREN healthcare worker cohort Authors (22) PD Kirwan VJ Hall S Foulkes AD Otter K Munro D Sparkes[...] SIREN Study Group AM Presanis A Charlett D De Angelis S Hopkins The Lancet Regional Health - Europe Published 1 January 2024 Crick labsRupert BealeFull details
SARS-CoV-2 mucosal neutralising immunity after vaccination Authors (38)Edward Carr Guilia Dowgier David Greenwood Lou S Herman Agnieszka Hobbs Martina Ragno[...]Charles SwantonSonia GandhiDavid LV Bauer Emma WallMary Wu Lancet Infectious Diseases Published 1 January 2024 Crick labs/ facilitiesCharles SwantonGeorge KassiotisSonia GandhiSteve GamblinRupert BealeDavid LV BauerWorldwide Influenza CentreHigh Throughput ScreeningBiological Research FacilityAdvanced SequencingFull details
Antibody correlates of protection against Delta infection after vaccination: A nested case-control within the UK-based SIREN study Authors (16) Ana Atti Ferdinando InsalataEdward Carr Ashley D Otter Sarah FoulkesMary Wu[...] Susan Hopkins Andre CharlettRupert Beale Victoria Hall SIREN Study Group Journal of Infection Published 1 November 2023 Crick labsRupert BealeFull details
Usp25-Erlin1/2 activity limits cholesterol flux to restrict virus infection Authors (12) Qi Wen Teo Ho Him Wong Tiaan Heunis Viktoriya Stancheva Asmaa Hachim Huibin Lv[...] Julian Ho Yun Lan Chris Ka Pun MokRachel Ulferts Sumana Sanyal Developmental Cell Published 20 November 2023 Crick labsRupert BealeFull details
CD4+ and CD8+ T cells and antibodies are associated with protection against Delta vaccine breakthrough infection: a nested case-control study within the PITCH study Authors (31) Isabel Neale Mohammad Ali Barbara Kronsteiner Stephanie Longet Priyanka Abraham Alexandra S Deeks[...] Miles Carroll Teresa Lambe Paul Klenerman Susanna Dunachie PITCH Consortium mBio Published 1 October 2023 Crick labsRupert BealeFull details
Comparative effectiveness of sotrovimab and molnupiravir for preventing severe COVID-19 outcomes in patients on kidney replacement therapy: observational study using the OpenSAFELY-UKRR and SRR databases Authors (25) Bang Zheng Jacqueline CampbellEdward Carr John Tazare Linda Nab Viyaasan Mahalingasivam[...] Brian MacKenna Samira Bell Laurie A Tomlinson Dorothea Nitsch OpenSAFELY Collaborative and LH&W NCS (or CONVALESCENCE) Collaborative Clinical Kidney Journal Published 1 November 2023 Crick labsRupert BealeFull details
Swab pooling enables rapid expansion of high-throughput capacity for SARS-CoV-2 community testing Authors (16) Jamie FaggRupert Beale Matthias E Futschik Elena Turek David Chapman Susan Halstead[...] Harper Vansteenhouse Sarah Tunkel Anna Dominiczak Timothy EA Peto Tom Fowler Journal of Clinical Virology Published 1 October 2023 Crick labsRupert BealeFull details
Commercial immunoglobulin products contain neutralizing antibodies against severe acute respiratory syndrome coronavirus 2 spike protein Authors (29) Vinit Upasani Katie TownsendMary WuEdward Carr Agnieszka Hobbs Giulia Dowgier[...]Rupert BealeSonia Gandhi Emma C Wall Laura McCoy David M Lowe Clinical Infectious Diseases Published 1 October 2023 Crick labsSonia GandhiRupert BealeFull details
Independent SARS-CoV-2 staff testing protected academic and health-care institutions in northwest London Authors (54) Chris BaileyTheo Sanderson Hermaleigh Townsley Jacki Goldman James RM BlackGeorge Young[...]Jerome NicodSonia GandhiDavid LV Bauer Emma C WallCharles Swanton The Lancet Published 1 July 2023 Crick labs/ facilitiesSamra TurajlicCharles SwantonSam RodriquesSonia GandhiSteve GamblinMike BlackmanRupert BealeDavid LV BauerWorldwide Influenza CentreStructural BiologyMetabolomicsHigh Throughput ScreeningFlow CytometryBioinformatics and BiostatisticsAdvanced SequencingScientific computingBiological Research FacilityFull details
Neutralising immunity to omicron sublineages BQ.1.1, XBB, and XBB.1.5 in healthy adults is boosted by bivalent BA.1-containing mRNA vaccination and previous Omicron infection Authors (36)Edward CarrMary Wu Joshua Gahir Ruth Harvey Hermaleigh Townsley Chris Bailey[...]Charles SwantonSonia GandhiDavid LV Bauer Emma C Wall Crick COVID Serology Consortium Lancet Infectious Diseases Published 1 July 2023 Crick labs/ facilitiesCharles SwantonGeorge KassiotisSonia GandhiSteve GamblinRupert BealeDavid LV BauerWorldwide Influenza CentreHigh Throughput ScreeningBiological Research FacilityAdvanced SequencingScientific computingFull details
Spatial dysregulation of T follicular helper cells impairs vaccine responses in aging Authors (23) Alyssa Silva-Cayetano Sigrid Fra-Bido Philippe A Robert Silvia Innocentin Alice R Burton Emily M Watson[...] Dirk Baumjohann Marion Espeli Michael Meyer-Hermann Alice E Denton Michelle A Linterman Nature Immunology Published 1 July 2023 Crick labsRupert BealeFull details
Comparative effectiveness of two- and three-dose COVID-19 vaccination schedules involving AZD1222 and BNT162b2 in people with kidney disease: a linked OpenSAFELY and UK Renal Registry cohort study Authors (20) The OpenSAFELY Collaborative Edward PK Parker Elsie MF Horne William J Hulme John Tazare Bang Zheng[...] Ben Goldacre Jonathan AC Sterne Dorothea Nitsch Laurie A Tomlinson The LH&W NCS (or CONVALESCENCE) Collaborative The Lancet Regional Health - Europe Published 1 July 2023 Crick labsRupert BealeFull details
Sotrovimab restores neutralization against current Omicron subvariants in patients with blood cancer Authors (67)Mary WuScott Shepherd Annika FendlerEdward CarrLewis Au Ruth Harvey[...] Emma Nicholson James Larkin Emma C WallSamra Turajlic CAPTURE consortium Cancer Cell Published 8 May 2023 Crick labs/ facilitiesSamra TurajlicCharles SwantonNicola LewisGeorge KassiotisSonia GandhiSteve GamblinRupert BealeDavid LV BauerWorldwide Influenza CentreMetabolomicsHigh Throughput ScreeningBioinformatics and BiostatisticsScientific computingFull details
Factors associated with COVID-19 vaccine uptake in people with kidney disease: an OpenSAFELY cohort study Authors (29) The OpenSAFELY Collaborative Edward PK Parker John Tazare William J Hulme Christopher BatesEdward Carr[...] Michelle Willicombe Bang Zheng Ben Goldacre Dorothea Nitsch Laurie A Tomlinson BMJ Open Published 31 January 2023 Crick labsRupert BealeFull details
Strong peak immunogenicity but rapid antibody waning following third vaccine dose in older residents of care homes Authors (68) G Tut T Lancaster M Krutikov P Sylla D Bone E Spalkova[...] A Irwin-Singer A Hayward A Copas L Shallcross P Moss Nature Aging Published 1 January 2023 Crick labs/ facilitiesCharles SwantonSonia GandhiSteve GamblinRupert BealeWorldwide Influenza CentreStructural BiologyHigh Throughput ScreeningFlow CytometryBiological Research FacilityScientific computingFull details
The memory B cell response to influenza vaccination is impaired in older persons Authors (7) Alice R Burton Stephane M Guillaume William S Foster Adam K Wheatley Danika L HillEdward Carr Michelle A Linterman Cell Reports Published 8 November 2022 Crick labsRupert BealeFull details
WHO's therapeutics and COVID-19 living guideline on mAbs needs to be reassessed Authors (19)Mary WuEdward Carr Ruth HarveyHarriet MearsSvend Kjaer Hermaleigh Townsley[...] Bryan WilliamsSonia GandhiCharles Swanton Emma C WallDavid LV Bauer The Lancet Published 17 December 2022 Crick labs/ facilitiesCharles SwantonNicola LewisSonia GandhiSteve GamblinRupert BealeDavid LV BauerWorldwide Influenza CentreStructural BiologyHigh Throughput ScreeningFull details