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Breadcrumb Rupert Beale Beale lab Cell Biology of Infection Laboratory : Publications Lab contentLab contentIn this section Overview Members Vacancies Publications PublicationsYear published2024 (3)2023 (15)2022 (13)2021 (26)2020 (8)2016 (1) Facet Year publishedResearch topicsCell Biology (66)Infectious Disease (66)Immunology (65)Chemical Biology & High Throughput (38)Genetics & Genomics (35)Genome Integrity & Repair (35)Model Organisms (33)Computational & Systems Biology (31)Structural Biology & Biophysics (30)Tumour Biology (30)Cell Cycle & Chromosomes (29)Human Biology & Physiology (29)Stem Cells (28)Signalling & Oncogenes (25)Neurosciences (24)Metabolism (23)Biochemistry & Proteomics (20)Imaging (13)Developmental Biology (8)Synthetic Biology (6)Gene Expression (3)Microfabrication & Bioengineering (2) Facet Research topicsPublication typeJournal article (66)Primary research (47)Letter (8)Review (4)Commentary (3)Method (3)Systematic review (1) Facet Publication typeJournalThe Lancet (9)Biochemical Journal (7)Autophagy (3)Lancet Infectious Diseases (3)Science (3)Cancer Cell (2)Cell Reports (2)Clinical Kidney Journal (2)Journal of Infection (2)Lancet (2)Nature (2)The Lancet Regional Health - Europe (2)Annals of Internal Medicine (1)BMC Medicine (1)BMJ Open (1)Cell Reports Medicine (1)Clinical Infectious Diseases (1)Developmental Cell (1)eLife (1)Journal of Clinical Virology (1)Journal of the American Society of Nephrology (1)Journal of Virology (1)Kidney International (1)Kidney International Reports (1)Mayo Clinic Proceedings (1)mBio (1)Molecular Cell (1)Nature Aging (1)Nature Biotechnology (1)Nature Immunology (1)New England Journal of Medicine (1)PLOS Biology (1)PLOS ONE (1)Science advances (1)Science Immunology (1)Science Translational Medicine (1)STAR Protocols (1)Stem Cell Reports (1)Wellcome Open Research (1) Facet Journal Publications Displaying 21 - 40 of 66Last updated : 20 April 2024 02:43 Functional immune responses against SARS-CoV-2 variants of concern after fourth COVID-19 vaccine dose or infection in patients with blood cancer Authors (64)Annika FendlerScott ShepherdLewis AuMary Wu Ruth HarveyKatalin Wilkinson[...] Emma Nicholson Susanna WalkerRobert Wilkinson James LarkinSamra Turajlic Cell Reports Medicine Published 18 October 2022 Crick labs/ facilitiesRobert J WilkinsonSamra TurajlicCharles SwantonGeorge KassiotisSonia GandhiSteve GamblinRupert BealeDavid LV BauerWorldwide Influenza CentreStructural BiologyMetabolomicsHigh Throughput ScreeningScientific computingFull details Antibody correlates of protection from SARS-CoV-2 reinfection prior to vaccination: a nested case-control within the SIREN study Authors (37) Ana Atti Ferdinando InsalataEdward Carr Ashley D Otter Javier Castillo-OlivaresMary Wu[...] Susan Hopkins Tim Brooks Victoria Hall The SIREN Study Group The Crick COVID Immunity Pipeline Consortium Journal of Infection Published 1 November 2022 Crick labs/ facilitiesRupert BealeWorldwide Influenza CentreHigh Throughput ScreeningFull details SARS-CoV-2 S2-targeted vaccination elicits broadly neutralizing antibodies Authors (21)Kevin NgNikhil FaulknerKatja FinsterbuschMary Wu Ruth HarveySaira Hussain[...]Michael Howell Hisashi AraseAndreas WackDavid LV BauerGeorge Kassiotis Science Translational Medicine Published 27 July 2022 Crick labs/ facilitiesAndreas WackCharles SwantonNicola LewisGeorge KassiotisSonia GandhiSteve GamblinPeter Cherepanov Rupert BealeDavid LV BauerWorldwide Influenza CentreStructural BiologyHigh Throughput ScreeningFlow CytometryCell ServicesBiological Research FacilityFull details The impact of Omicron on outcomes following infection with SARS-CoV-2 in patients with kidney failure in Scotland Authors (14) Samira Bell Jacqueline Campbell Chrissie Watters Martin O'Neil Alison Almond Katharine Buck[...] Nicola Joss Wendy Metcalfe Elaine Spalding Shona Methven Patrick B Mark Clinical Kidney Journal Published 1 January 2023 Crick labsRupert BealeFull details Targeting TLR4 during vaccination boosts MAdCAM-1+ lymphoid stromal cell activation and promotes the aged germinal center response Authors (11) Alice E Denton James Dooley Isabella Cinti Alyssa Silva-Cayetano Sigrid Fra-Bido Silvia Innocentin Danika L HillEdward Carr Andrew NJ McKenzie Adrian Liston Michelle A Linterman Science Immunology Published 6 May 2022 Crick labsRupert BealeFull details The V-ATPase complex regulates non-canonical Atg8-family protein lipidation through ATG16L1 recruitment Authors (7) Lewis Timimi Carmen Figueras-NovoaElena Marcassa Oliver Florey J Kenneth BaillieRupert BealeRachel Ulferts Autophagy Published 8 March 2022 Crick labsRupert BealeFull details Protection against SARS-CoV-2 after Covid-19 vaccination and previous infection Authors (35) Victoria Hall Sarah Foulkes Ferdinando Insalata Peter Kirwan Ayoub Saei Ana Atti[...] Tim Brooks Jasmin Islam Andre Charlett Susan Hopkins The SIREN Study Group New England Journal of Medicine Published 31 March 2022 Crick labsRupert BealeFull details The impact of vaccination on incidence and outcomes of SARS-CoV-2 infection in patients with kidney failure in Scotland Authors (20) Samira Bell Jacqueline Campbell Emilie Lambourg Chrissie Watters Martin O'Neil Alison Almond[...] Jamie P Traynor Vinod Sanu Peter Thomson Shona Methven Patrick B Mark Journal of the American Society of Nephrology Published 1 April 2022 Crick labsRupert BealeFull details Omicron neutralising antibodies after third COVID-19 vaccine dose in patients with cancer Authors (62)Annika FendlerScott ShepherdLewis AuMary Wu Ruth Harvey Andreas M Schmitt[...] Emma Nicholson Susanna Walker James LarkinSamra Turajlic The CAPTURE consortium The Lancet Published 5 March 2022 Crick labs/ facilitiesRobert J WilkinsonSamra TurajlicCharles SwantonNicola LewisGeorge KassiotisSonia GandhiSteve GamblinRupert BealeDavid LV BauerWorldwide Influenza CentreStructural BiologyMetabolomicsHigh Throughput ScreeningBiological Research FacilityBioinformatics and BiostatisticsAdvanced SequencingScientific computingFull details Omicron neutralising antibodies after COVID-19 vaccination in haemodialysis patients Authors (19)Edward CarrMary Wu Ruth Harvey Roseanne E Billany Emma C WallGavin Kelly[...] Rachel B Jones Rona M Smith Stephen McAdoo Michelle WillicombeRupert Beale The Lancet Published 26 February 2022 Crick labs/ facilitiesCharles SwantonGitta StockingerNicola LewisGeorge KassiotisSonia GandhiSteve GamblinRupert BealeDavid LV BauerWorldwide Influenza CentreHigh Throughput ScreeningBioinformatics and BiostatisticsFull details Three-dose vaccination elicits neutralising antibodies against omicron Authors (26)Mary Wu Emma C WallEdward Carr Ruth Harvey Hermaleigh TownsleyHarriet Mears[...] Vincenzo Libri Bryan WilliamsSonia GandhiCharles SwantonDavid LV Bauer The Lancet Published 19 February 2022 Crick labs/ facilitiesCharles SwantonGitta StockingerNicola LewisGeorge KassiotisSonia GandhiSteve GamblinRupert BealeDavid LV BauerWorldwide Influenza CentreStructural BiologyHigh Throughput ScreeningBioinformatics and BiostatisticsScientific computingFull details Immune responses following third COVID-19 vaccination are reduced in patients with hematological malignancies compared to patients with solid cancer Authors (65)Annika FendlerScott ShepherdLewis AuKatalin WilkinsonMary Wu Andreas M Schmitt[...] Susanna WalkerRobert Wilkinson James LarkinSamra Turajlic CAPTURE consortium Cancer Cell Published 14 February 2022 Crick labs/ facilitiesRobert J WilkinsonSamra TurajlicCharles SwantonNicola LewisGeorge KassiotisSonia GandhiSteve GamblinRupert BealeDavid LV BauerWorldwide Influenza CentreStructural BiologyProteomicsMetabolomicsHigh Throughput ScreeningBioinformatics and BiostatisticsAdvanced SequencingScientific computingFull details Subtractive CRISPR screen identifies the ATG16L1/vacuolar ATPase axis as required for non-canonical LC3 lipidation Authors (10)Rachel UlfertsElena Marcassa Lewis Timimi Liam Changwoo Lee Andrew DaleyBeatriz Montaner Suzanne Dawn Turner Oliver Florey John Kenneth BaillieRupert Beale Cell Reports Published 26 October 2021 Crick labs/ facilitiesRupert BealeLight MicroscopyFlow CytometryCell ServicesFull details Infecting human hematopoietic stem and progenitor cells with SARS-CoV-2 Authors (5)Hector Huerga EncaboRachel UlfertsAneesh SharmaRupert BealeDominique Bonnet STAR Protocols Published 17 December 2021 Crick labs/ facilitiesDominique BonnetRupert BealeFlow CytometryFull details Neutralising antibodies after COVID-19 vaccination in UK haemodialysis patients Authors (86)Edward Carr Mary Wu Ruth Harvey Emma C WallGavin KellySaira Hussain[...]Emma RussellAndy RiddellSvend KjaerAnnabel BorgChloe Roustan The Lancet Published 18 September 2021 Crick labs/ facilitiesCharles SwantonGitta StockingerNicola LewisGeorge KassiotisSonia GandhiSteve GamblinRupert BealeDavid LV BauerWorldwide Influenza CentreStructural BiologyHigh Throughput ScreeningFlow CytometryBiological Research FacilityBioinformatics and BiostatisticsScientific computingAdvanced SequencingFull details Reduced antibody cross-reactivity following infection with B.1.1.7 than with parental SARS-CoV-2 strains Authors (30)Nikhil FaulknerKevin NgMary Wu Ruth Harvey Marios Margaritis Stavroula Paraskevopoulou[...]Michael HowellDavid LV Bauer Eleni Nastouli SAFER InvestigatorsGeorge Kassiotis eLife Published 29 July 2021 Crick labs/ facilitiesCharles SwantonGeorge KassiotisSonia GandhiSteve GamblinRupert BealeDavid LV BauerWorldwide Influenza CentreStructural BiologyHigh Throughput ScreeningFlow CytometryCell ServicesFull details Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of nsp15 endoribonuclease Authors (14)Berta Canal Ryo FujisawaAllison McClure Tom D DeeganMary WuRachel Ulferts[...]Jingkun ZengRupert BealeMichael Howell Karim LabibJohn Diffley Biochemical Journal Published 16 July 2021 Crick labs/ facilitiesJohn DiffleyRupert BealeHigh Throughput ScreeningFull details An isoform of Dicer protects mammalian stem cells against multiple RNA viruses Authors (10)Enzo PoirierMichael Buck Probir ChakravartyJoana Do Vale Viegas Silva CarvalhoBruno FredericoAna Matos Cardoso Da SilvaLyn HealyRachel UlfertsRupert BealeCaetano Reis e Sousa Science Published 9 July 2021 Crick labs/ facilitiesCaetano Reis e SousaRupert BealeHuman Embryonic Stem CellExperimental HistopathologyBioinformatics and BiostatisticsFlow CytometryAdvanced SequencingFull details Mapping the human genetic architecture of COVID-19 Authors (1) COVID-19 Host Genetics Initiative Nature Published 16 December 2021 Crick labsRupert BealeFull details Review of early immune response to SARS-CoV-2 vaccination among patients with CKD Authors (11)Edward Carr Andreas Kronbichler Matthew Graham-Brown Graham Abra Christos Argyropoulos Lorraine Harper Edgar V Lerma Rita S Suri Joel Topf Michelle Willicombe Swapnil Hiremath Kidney International Reports Published 1 September 2021 Crick 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Functional immune responses against SARS-CoV-2 variants of concern after fourth COVID-19 vaccine dose or infection in patients with blood cancer Authors (64)Annika FendlerScott ShepherdLewis AuMary Wu Ruth HarveyKatalin Wilkinson[...] Emma Nicholson Susanna WalkerRobert Wilkinson James LarkinSamra Turajlic Cell Reports Medicine Published 18 October 2022 Crick labs/ facilitiesRobert J WilkinsonSamra TurajlicCharles SwantonGeorge KassiotisSonia GandhiSteve GamblinRupert BealeDavid LV BauerWorldwide Influenza CentreStructural BiologyMetabolomicsHigh Throughput ScreeningScientific computingFull details
Antibody correlates of protection from SARS-CoV-2 reinfection prior to vaccination: a nested case-control within the SIREN study Authors (37) Ana Atti Ferdinando InsalataEdward Carr Ashley D Otter Javier Castillo-OlivaresMary Wu[...] Susan Hopkins Tim Brooks Victoria Hall The SIREN Study Group The Crick COVID Immunity Pipeline Consortium Journal of Infection Published 1 November 2022 Crick labs/ facilitiesRupert BealeWorldwide Influenza CentreHigh Throughput ScreeningFull details
SARS-CoV-2 S2-targeted vaccination elicits broadly neutralizing antibodies Authors (21)Kevin NgNikhil FaulknerKatja FinsterbuschMary Wu Ruth HarveySaira Hussain[...]Michael Howell Hisashi AraseAndreas WackDavid LV BauerGeorge Kassiotis Science Translational Medicine Published 27 July 2022 Crick labs/ facilitiesAndreas WackCharles SwantonNicola LewisGeorge KassiotisSonia GandhiSteve GamblinPeter Cherepanov Rupert BealeDavid LV BauerWorldwide Influenza CentreStructural BiologyHigh Throughput ScreeningFlow CytometryCell ServicesBiological Research FacilityFull details
The impact of Omicron on outcomes following infection with SARS-CoV-2 in patients with kidney failure in Scotland Authors (14) Samira Bell Jacqueline Campbell Chrissie Watters Martin O'Neil Alison Almond Katharine Buck[...] Nicola Joss Wendy Metcalfe Elaine Spalding Shona Methven Patrick B Mark Clinical Kidney Journal Published 1 January 2023 Crick labsRupert BealeFull details
Targeting TLR4 during vaccination boosts MAdCAM-1+ lymphoid stromal cell activation and promotes the aged germinal center response Authors (11) Alice E Denton James Dooley Isabella Cinti Alyssa Silva-Cayetano Sigrid Fra-Bido Silvia Innocentin Danika L HillEdward Carr Andrew NJ McKenzie Adrian Liston Michelle A Linterman Science Immunology Published 6 May 2022 Crick labsRupert BealeFull details
The V-ATPase complex regulates non-canonical Atg8-family protein lipidation through ATG16L1 recruitment Authors (7) Lewis Timimi Carmen Figueras-NovoaElena Marcassa Oliver Florey J Kenneth BaillieRupert BealeRachel Ulferts Autophagy Published 8 March 2022 Crick labsRupert BealeFull details
Protection against SARS-CoV-2 after Covid-19 vaccination and previous infection Authors (35) Victoria Hall Sarah Foulkes Ferdinando Insalata Peter Kirwan Ayoub Saei Ana Atti[...] Tim Brooks Jasmin Islam Andre Charlett Susan Hopkins The SIREN Study Group New England Journal of Medicine Published 31 March 2022 Crick labsRupert BealeFull details
The impact of vaccination on incidence and outcomes of SARS-CoV-2 infection in patients with kidney failure in Scotland Authors (20) Samira Bell Jacqueline Campbell Emilie Lambourg Chrissie Watters Martin O'Neil Alison Almond[...] Jamie P Traynor Vinod Sanu Peter Thomson Shona Methven Patrick B Mark Journal of the American Society of Nephrology Published 1 April 2022 Crick labsRupert BealeFull details
Omicron neutralising antibodies after third COVID-19 vaccine dose in patients with cancer Authors (62)Annika FendlerScott ShepherdLewis AuMary Wu Ruth Harvey Andreas M Schmitt[...] Emma Nicholson Susanna Walker James LarkinSamra Turajlic The CAPTURE consortium The Lancet Published 5 March 2022 Crick labs/ facilitiesRobert J WilkinsonSamra TurajlicCharles SwantonNicola LewisGeorge KassiotisSonia GandhiSteve GamblinRupert BealeDavid LV BauerWorldwide Influenza CentreStructural BiologyMetabolomicsHigh Throughput ScreeningBiological Research FacilityBioinformatics and BiostatisticsAdvanced SequencingScientific computingFull details
Omicron neutralising antibodies after COVID-19 vaccination in haemodialysis patients Authors (19)Edward CarrMary Wu Ruth Harvey Roseanne E Billany Emma C WallGavin Kelly[...] Rachel B Jones Rona M Smith Stephen McAdoo Michelle WillicombeRupert Beale The Lancet Published 26 February 2022 Crick labs/ facilitiesCharles SwantonGitta StockingerNicola LewisGeorge KassiotisSonia GandhiSteve GamblinRupert BealeDavid LV BauerWorldwide Influenza CentreHigh Throughput ScreeningBioinformatics and BiostatisticsFull details
Three-dose vaccination elicits neutralising antibodies against omicron Authors (26)Mary Wu Emma C WallEdward Carr Ruth Harvey Hermaleigh TownsleyHarriet Mears[...] Vincenzo Libri Bryan WilliamsSonia GandhiCharles SwantonDavid LV Bauer The Lancet Published 19 February 2022 Crick labs/ facilitiesCharles SwantonGitta StockingerNicola LewisGeorge KassiotisSonia GandhiSteve GamblinRupert BealeDavid LV BauerWorldwide Influenza CentreStructural BiologyHigh Throughput ScreeningBioinformatics and BiostatisticsScientific computingFull details
Immune responses following third COVID-19 vaccination are reduced in patients with hematological malignancies compared to patients with solid cancer Authors (65)Annika FendlerScott ShepherdLewis AuKatalin WilkinsonMary Wu Andreas M Schmitt[...] Susanna WalkerRobert Wilkinson James LarkinSamra Turajlic CAPTURE consortium Cancer Cell Published 14 February 2022 Crick labs/ facilitiesRobert J WilkinsonSamra TurajlicCharles SwantonNicola LewisGeorge KassiotisSonia GandhiSteve GamblinRupert BealeDavid LV BauerWorldwide Influenza CentreStructural BiologyProteomicsMetabolomicsHigh Throughput ScreeningBioinformatics and BiostatisticsAdvanced SequencingScientific computingFull details
Subtractive CRISPR screen identifies the ATG16L1/vacuolar ATPase axis as required for non-canonical LC3 lipidation Authors (10)Rachel UlfertsElena Marcassa Lewis Timimi Liam Changwoo Lee Andrew DaleyBeatriz Montaner Suzanne Dawn Turner Oliver Florey John Kenneth BaillieRupert Beale Cell Reports Published 26 October 2021 Crick labs/ facilitiesRupert BealeLight MicroscopyFlow CytometryCell ServicesFull details
Infecting human hematopoietic stem and progenitor cells with SARS-CoV-2 Authors (5)Hector Huerga EncaboRachel UlfertsAneesh SharmaRupert BealeDominique Bonnet STAR Protocols Published 17 December 2021 Crick labs/ facilitiesDominique BonnetRupert BealeFlow CytometryFull details
Neutralising antibodies after COVID-19 vaccination in UK haemodialysis patients Authors (86)Edward Carr Mary Wu Ruth Harvey Emma C WallGavin KellySaira Hussain[...]Emma RussellAndy RiddellSvend KjaerAnnabel BorgChloe Roustan The Lancet Published 18 September 2021 Crick labs/ facilitiesCharles SwantonGitta StockingerNicola LewisGeorge KassiotisSonia GandhiSteve GamblinRupert BealeDavid LV BauerWorldwide Influenza CentreStructural BiologyHigh Throughput ScreeningFlow CytometryBiological Research FacilityBioinformatics and BiostatisticsScientific computingAdvanced SequencingFull details
Reduced antibody cross-reactivity following infection with B.1.1.7 than with parental SARS-CoV-2 strains Authors (30)Nikhil FaulknerKevin NgMary Wu Ruth Harvey Marios Margaritis Stavroula Paraskevopoulou[...]Michael HowellDavid LV Bauer Eleni Nastouli SAFER InvestigatorsGeorge Kassiotis eLife Published 29 July 2021 Crick labs/ facilitiesCharles SwantonGeorge KassiotisSonia GandhiSteve GamblinRupert BealeDavid LV BauerWorldwide Influenza CentreStructural BiologyHigh Throughput ScreeningFlow CytometryCell ServicesFull details
Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of nsp15 endoribonuclease Authors (14)Berta Canal Ryo FujisawaAllison McClure Tom D DeeganMary WuRachel Ulferts[...]Jingkun ZengRupert BealeMichael Howell Karim LabibJohn Diffley Biochemical Journal Published 16 July 2021 Crick labs/ facilitiesJohn DiffleyRupert BealeHigh Throughput ScreeningFull details
An isoform of Dicer protects mammalian stem cells against multiple RNA viruses Authors (10)Enzo PoirierMichael Buck Probir ChakravartyJoana Do Vale Viegas Silva CarvalhoBruno FredericoAna Matos Cardoso Da SilvaLyn HealyRachel UlfertsRupert BealeCaetano Reis e Sousa Science Published 9 July 2021 Crick labs/ facilitiesCaetano Reis e SousaRupert BealeHuman Embryonic Stem CellExperimental HistopathologyBioinformatics and BiostatisticsFlow CytometryAdvanced SequencingFull details
Mapping the human genetic architecture of COVID-19 Authors (1) COVID-19 Host Genetics Initiative Nature Published 16 December 2021 Crick labsRupert BealeFull details
Review of early immune response to SARS-CoV-2 vaccination among patients with CKD Authors (11)Edward Carr Andreas Kronbichler Matthew Graham-Brown Graham Abra Christos Argyropoulos Lorraine Harper Edgar V Lerma Rita S Suri Joel Topf Michelle Willicombe Swapnil Hiremath Kidney International Reports Published 1 September 2021 Crick labsRupert BealeFull details