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Breadcrumb Rupert Beale Beale lab Cell Biology of Infection Laboratory : Publications Lab contentLab contentIn this section Overview Members Vacancies Publications PublicationsYear published2024 (3)2023 (15)2022 (13)2021 (26)2020 (8)2016 (1) Facet Year publishedResearch topicsCell Biology (66)Infectious Disease (66)Immunology (65)Chemical Biology & High Throughput (38)Genetics & Genomics (35)Genome Integrity & Repair (35)Model Organisms (33)Computational & Systems Biology (31)Structural Biology & Biophysics (30)Tumour Biology (30)Cell Cycle & Chromosomes (29)Human Biology & Physiology (29)Stem Cells (28)Signalling & Oncogenes (25)Neurosciences (24)Metabolism (23)Biochemistry & Proteomics (20)Imaging (13)Developmental Biology (8)Synthetic Biology (6)Gene Expression (3)Microfabrication & Bioengineering (2) Facet Research topicsPublication typeJournal article (66)Primary research (47)Letter (8)Review (4)Commentary (3)Method (3)Systematic review (1) Facet Publication typeJournalThe Lancet (9)Biochemical Journal (7)Autophagy (3)Lancet Infectious Diseases (3)Science (3)Cancer Cell (2)Cell Reports (2)Clinical Kidney Journal (2)Journal of Infection (2)Lancet (2)Nature (2)The Lancet Regional Health - Europe (2)Annals of Internal Medicine (1)BMC Medicine (1)BMJ Open (1)Cell Reports Medicine (1)Clinical Infectious Diseases (1)Developmental Cell (1)eLife (1)Journal of Clinical Virology (1)Journal of the American Society of Nephrology (1)Journal of Virology (1)Kidney International (1)Kidney International Reports (1)Mayo Clinic Proceedings (1)mBio (1)Molecular Cell (1)Nature Aging (1)Nature Biotechnology (1)Nature Immunology (1)New England Journal of Medicine (1)PLOS Biology (1)PLOS ONE (1)Science advances (1)Science Immunology (1)Science Translational Medicine (1)STAR Protocols (1)Stem Cell Reports (1)Wellcome Open Research (1) Facet Journal Publications Displaying 41 - 60 of 66Last updated : 17 April 2024 03:21 Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of Nsp5 main protease Authors (22)Jennifer MilliganTheresa ZeisnerGeorge PapageorgiouDhira JoshiChristelle SoudyRachel Ulferts[...]Michael HowellRupert Beale Karim LabibNicola O'ReillyJohn Diffley Biochemical Journal Published 16 July 2021 Crick labs/ facilitiesPaul NurseJohn DiffleyRupert BealeHigh Throughput ScreeningFull details Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of nsp12/7/8 RNA-dependent RNA polymerase Authors (12)Agostina BertolinFlorian WeissmannJingkun ZengViktor PosseJennifer MilliganBerta Canal[...]Mary WuLucy DruryMichael HowellRupert BealeJohn Diffley Biochemical Journal Published 16 July 2021 Crick labs/ facilitiesJohn DiffleyRupert BealeHigh Throughput ScreeningFull details Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of nsp14/nsp10 exoribonuclease Authors (19)Berta CanalAllison McClureJoseph CurranMary WuRachel UlfertsFlorian Weissmann[...]Clovis Basier Karim LabibRupert BealeMichael HowellJohn Diffley Biochemical Journal Published 16 July 2021 Crick labs/ facilitiesPaul NurseJohn DiffleyRupert BealeHigh Throughput ScreeningStructural BiologyFermentationFull details Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of Nsp3 papain-like protease Authors (19)Chew Theng LimKang Wei TanMary WuRachel Ulferts Lee A ArmstrongEiko Ozono[...]Nicola O'ReillyRupert Beale Yogesh Kulathu Karim LabibJohn Diffley Biochemical Journal Published 16 July 2021 Crick labs/ facilitiesJohn DiffleyRupert BealeHigh Throughput ScreeningFull details Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of Nsp14 RNA cap methyltransferase Authors (21)Saz BasuTiffany MakRachel UlfertsMary Wu Tom Deegan Ryo Fujisawa[...]Rupert Beale Victoria H CowlingMichael Howell Karim LabibJohn Diffley Biochemical Journal Published 16 July 2021 Crick labs/ facilitiesPaul NurseJohn DiffleyRupert BealeHigh Throughput ScreeningFull details Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of nsp13 helicase Authors (19)Jingkun ZengFlorian WeissmannAgostina BertolinViktor PosseBerta CanalRachel Ulferts[...]Svend KjaerJohn MccauleyMichael HowellRupert BealeJohn Diffley Biochemical Journal Published 16 July 2021 Crick labs/ facilitiesNicola LewisJohn DiffleyRupert BealeWorldwide Influenza CentreStructural BiologyHigh Throughput ScreeningFull details AZD1222-induced neutralising antibody activity against SARS-CoV-2 Delta VOC Authors (24) Emma C WallMary Wu Ruth HarveyGavin KellyScott WarchalChelsea Sawyer[...] Vincenzo Libri Bryan WilliamsCharles SwantonSonia GandhiDavid LV Bauer Lancet Published 17 July 2021 Crick labs/ facilitiesCharles SwantonNicola LewisGeorge KassiotisSonia GandhiSteve GamblinRupert BealeDavid LV BauerWorldwide Influenza CentreHigh Throughput ScreeningFlow CytometryBioinformatics and BiostatisticsScientific computingFull details Neutralising antibody activity against SARS-CoV-2 VOCs B.1.617.2 and B.1.351 by BNT162b2 vaccination Authors (25) Emma C WallMary Wu Ruth HarveyGavin KellyScott WarchalChelsea Sawyer[...] Vincenzo Libri Bryan WilliamsCharles SwantonSonia GandhiDavid LV Bauer The Lancet Published 19 June 2021 Crick labs/ facilitiesCharles SwantonNicola LewisGeorge KassiotisSonia GandhiSteve GamblinRupert BealeDavid LV BauerWorldwide Influenza CentreHigh Throughput ScreeningFlow CytometryBioinformatics and BiostatisticsAdvanced SequencingScientific computingFull details Targeting the conserved stem loop 2 motif in the SARS-CoV-2 genome Authors (18) Valeria Lulla Michal P Wandel Katarzyna J BandyraRachel UlfertsMary Wu Tom Dendooven[...] William Scott Yiliang Ding Andrew E Firth Kotryna Bloznelyte Ben F Luisi Journal of Virology Published 1 July 2021 Crick labs/ facilitiesRupert BealeHigh Throughput ScreeningStructural BiologyFull details Estimating the effectiveness of routine asymptomatic PCR testing at different frequencies for the detection of SARS-CoV-2 infections Authors (10) Joel Hellewell Timothy W Russell SAFER Investigators and Field Study Team Crick COVID-19 Consortium CMMID COVID-19 working groupRupert BealeGavin Kelly Catherine Houlihan Eleni Nastouli Adam J Kucharski BMC Medicine Published 27 April 2021 Crick labs/ facilitiesRupert BealeBioinformatics and BiostatisticsFull details Non-canonical autophagy drives alternative ATG8 conjugation to phosphatidylserine Authors (14) Joanne Durgan Alf H Lystad Katherine Sloan Sven R Carlsson Michael I WilsonElena Marcassa[...] Michael J WakelamRupert Beale Anne Simonsen David Oxley Oliver Florey Molecular Cell Published 6 May 2021 Crick labsRupert BealeFull details SARS-CoV-2 can recruit a haem metabolite to evade antibody immunity Authors (40)Annachiara RosaVal Pye Carl Graham Luke Muir Jeffrey SeowKevin Ng[...] Richard S TedderGeorge Kassiotis Laura E Mccoy Katie J DooresPeter Cherepanov Science advances Published 28 May 2021 Crick labs/ facilitiesPeter RosenthalGeorge KassiotisSteve GamblinPeter Cherepanov Rupert BealeStructural BiologyMetabolomicsFlow CytometryFull details Seroprevalence of antibody to S1 spike protein following vaccination against COVID-19 in patients receiving haemodialysis: a call to arms Authors (15) RE Billany H Selvaskandan SF Adenwalla Kl Hull DS March JO Burton[...] PW Bird CW Holmes R Baines NJ Brunskill MP Graham-Brown Kidney International Published 1 June 2021 Crick labsRupert BealeFull details Immunity to SARS-CoV-2 variants of concern Authors (3) Daniel M Altmann Rosemary J BoytonRupert Beale Science Published 12 March 2021 Crick labsRupert BealeFull details Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition) Authors (2929) Daniel J Klionsky Amal Kamal Abdel-Aziz Sara Abdelfatah Mahmoud Abdellatif Asghar Abdoli Steffen Abel[...] Shigeru Oshima Yueguang Rong Judith C Sluimer Christina L Stallings Chun-Kit Tong Autophagy Published 1 January 2021 Crick labsSharon ToozeRupert BealeFull details Human erythroid progenitors are directly infected by SARS-CoV-2: Implications for emerging erythropoiesis in severe COVID-19 patients Authors (11)Hector Huerga EncaboWilliam GreyManuel Garcia Albornoz Henry WoodRachel Ulferts Iker Valle Aramburu Austin G Kulasekararaj Ghulam MuftiVenizelos PapayannopoulosRupert BealeDominique Bonnet Stem Cell Reports Published 9 March 2021 Crick labs/ facilitiesVenizelos PapayannopoulosDominique BonnetRupert BealeFlow CytometryFull details SARS-CoV-2 detection by a clinical diagnostic RT-LAMP assay Authors (40)Michael BuckEnzo PoirierAna Matos Cardoso Da SilvaBruno Frederico J CantonSam Barrell[...]Charles SwantonSamra TurajlicMary WuCaetano Reis e Sousa The Crick COVID-19 Consortium Wellcome Open Research Published 21 May 2021 Crick labs/ facilitiesSamra TurajlicCharles SwantonCaetano Reis e SousaGeorge KassiotisSonia GandhiRupert BealeMetabolomicsHigh Throughput ScreeningGenetic Modification ServiceBiological Research FacilityAdvanced SequencingStructural BiologyScientific computingFull details Genetic mechanisms of critical illness in Covid-19 Authors (72) Erola Pairo-Castineira Sara Clohisey Lucija Klaric Andrew D Bretherick Konrad Rawlik Dorota Pasko[...] Malcolm G Semple Andrew Law Veronique Vitart James F Wilson J Kenneth Baillie Nature Published 4 March 2021 Crick labsRupert BealeFull details Preexisting and de novo humoral immunity to SARS-CoV-2 in humans Authors (47)Kevin NgNikhil Faulkner Georgina H CornishAnnachiara Rosa Ruth HarveySaira Hussain[...]Steve Gamblin Laura E MccoyPeter Cherepanov Eleni NastouliGeorge Kassiotis Science Published 11 December 2020 Crick labs/ facilitiesCharles SwantonGitta StockingerNicola LewisGeorge KassiotisSonia GandhiSteve GamblinPeter Cherepanov Rupert BealeWorldwide Influenza CentreStructural BiologyFlow CytometryHigh Throughput ScreeningCell ServicesFull details Scientific consensus on the COVID-19 pandemic: we need to act now Authors (31) Nisreen A Alwan Rochelle Ann Burgess Simon AshworthRupert Beale Nahid Bhadelia Debby Bogaert[...] Devi SridharCharles Swanton Rochelle P Walensky Gavin Yamey Hisham Ziauddeen Lancet Published 31 October 2020 Crick labsCharles SwantonRupert BealeFull details Pagination First page First Previous page Previous Page 1 Page 2 Current page 3 Page 4 Next page Next Last page Last Share the page Share on Twitter Share on Facebook Share on LinkedIn Share on Email
Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of Nsp5 main protease Authors (22)Jennifer MilliganTheresa ZeisnerGeorge PapageorgiouDhira JoshiChristelle SoudyRachel Ulferts[...]Michael HowellRupert Beale Karim LabibNicola O'ReillyJohn Diffley Biochemical Journal Published 16 July 2021 Crick labs/ facilitiesPaul NurseJohn DiffleyRupert BealeHigh Throughput ScreeningFull details
Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of nsp12/7/8 RNA-dependent RNA polymerase Authors (12)Agostina BertolinFlorian WeissmannJingkun ZengViktor PosseJennifer MilliganBerta Canal[...]Mary WuLucy DruryMichael HowellRupert BealeJohn Diffley Biochemical Journal Published 16 July 2021 Crick labs/ facilitiesJohn DiffleyRupert BealeHigh Throughput ScreeningFull details
Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of nsp14/nsp10 exoribonuclease Authors (19)Berta CanalAllison McClureJoseph CurranMary WuRachel UlfertsFlorian Weissmann[...]Clovis Basier Karim LabibRupert BealeMichael HowellJohn Diffley Biochemical Journal Published 16 July 2021 Crick labs/ facilitiesPaul NurseJohn DiffleyRupert BealeHigh Throughput ScreeningStructural BiologyFermentationFull details
Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of Nsp3 papain-like protease Authors (19)Chew Theng LimKang Wei TanMary WuRachel Ulferts Lee A ArmstrongEiko Ozono[...]Nicola O'ReillyRupert Beale Yogesh Kulathu Karim LabibJohn Diffley Biochemical Journal Published 16 July 2021 Crick labs/ facilitiesJohn DiffleyRupert BealeHigh Throughput ScreeningFull details
Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of Nsp14 RNA cap methyltransferase Authors (21)Saz BasuTiffany MakRachel UlfertsMary Wu Tom Deegan Ryo Fujisawa[...]Rupert Beale Victoria H CowlingMichael Howell Karim LabibJohn Diffley Biochemical Journal Published 16 July 2021 Crick labs/ facilitiesPaul NurseJohn DiffleyRupert BealeHigh Throughput ScreeningFull details
Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of nsp13 helicase Authors (19)Jingkun ZengFlorian WeissmannAgostina BertolinViktor PosseBerta CanalRachel Ulferts[...]Svend KjaerJohn MccauleyMichael HowellRupert BealeJohn Diffley Biochemical Journal Published 16 July 2021 Crick labs/ facilitiesNicola LewisJohn DiffleyRupert BealeWorldwide Influenza CentreStructural BiologyHigh Throughput ScreeningFull details
AZD1222-induced neutralising antibody activity against SARS-CoV-2 Delta VOC Authors (24) Emma C WallMary Wu Ruth HarveyGavin KellyScott WarchalChelsea Sawyer[...] Vincenzo Libri Bryan WilliamsCharles SwantonSonia GandhiDavid LV Bauer Lancet Published 17 July 2021 Crick labs/ facilitiesCharles SwantonNicola LewisGeorge KassiotisSonia GandhiSteve GamblinRupert BealeDavid LV BauerWorldwide Influenza CentreHigh Throughput ScreeningFlow CytometryBioinformatics and BiostatisticsScientific computingFull details
Neutralising antibody activity against SARS-CoV-2 VOCs B.1.617.2 and B.1.351 by BNT162b2 vaccination Authors (25) Emma C WallMary Wu Ruth HarveyGavin KellyScott WarchalChelsea Sawyer[...] Vincenzo Libri Bryan WilliamsCharles SwantonSonia GandhiDavid LV Bauer The Lancet Published 19 June 2021 Crick labs/ facilitiesCharles SwantonNicola LewisGeorge KassiotisSonia GandhiSteve GamblinRupert BealeDavid LV BauerWorldwide Influenza CentreHigh Throughput ScreeningFlow CytometryBioinformatics and BiostatisticsAdvanced SequencingScientific computingFull details
Targeting the conserved stem loop 2 motif in the SARS-CoV-2 genome Authors (18) Valeria Lulla Michal P Wandel Katarzyna J BandyraRachel UlfertsMary Wu Tom Dendooven[...] William Scott Yiliang Ding Andrew E Firth Kotryna Bloznelyte Ben F Luisi Journal of Virology Published 1 July 2021 Crick labs/ facilitiesRupert BealeHigh Throughput ScreeningStructural BiologyFull details
Estimating the effectiveness of routine asymptomatic PCR testing at different frequencies for the detection of SARS-CoV-2 infections Authors (10) Joel Hellewell Timothy W Russell SAFER Investigators and Field Study Team Crick COVID-19 Consortium CMMID COVID-19 working groupRupert BealeGavin Kelly Catherine Houlihan Eleni Nastouli Adam J Kucharski BMC Medicine Published 27 April 2021 Crick labs/ facilitiesRupert BealeBioinformatics and BiostatisticsFull details
Non-canonical autophagy drives alternative ATG8 conjugation to phosphatidylserine Authors (14) Joanne Durgan Alf H Lystad Katherine Sloan Sven R Carlsson Michael I WilsonElena Marcassa[...] Michael J WakelamRupert Beale Anne Simonsen David Oxley Oliver Florey Molecular Cell Published 6 May 2021 Crick labsRupert BealeFull details
SARS-CoV-2 can recruit a haem metabolite to evade antibody immunity Authors (40)Annachiara RosaVal Pye Carl Graham Luke Muir Jeffrey SeowKevin Ng[...] Richard S TedderGeorge Kassiotis Laura E Mccoy Katie J DooresPeter Cherepanov Science advances Published 28 May 2021 Crick labs/ facilitiesPeter RosenthalGeorge KassiotisSteve GamblinPeter Cherepanov Rupert BealeStructural BiologyMetabolomicsFlow CytometryFull details
Seroprevalence of antibody to S1 spike protein following vaccination against COVID-19 in patients receiving haemodialysis: a call to arms Authors (15) RE Billany H Selvaskandan SF Adenwalla Kl Hull DS March JO Burton[...] PW Bird CW Holmes R Baines NJ Brunskill MP Graham-Brown Kidney International Published 1 June 2021 Crick labsRupert BealeFull details
Immunity to SARS-CoV-2 variants of concern Authors (3) Daniel M Altmann Rosemary J BoytonRupert Beale Science Published 12 March 2021 Crick labsRupert BealeFull details
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition) Authors (2929) Daniel J Klionsky Amal Kamal Abdel-Aziz Sara Abdelfatah Mahmoud Abdellatif Asghar Abdoli Steffen Abel[...] Shigeru Oshima Yueguang Rong Judith C Sluimer Christina L Stallings Chun-Kit Tong Autophagy Published 1 January 2021 Crick labsSharon ToozeRupert BealeFull details
Human erythroid progenitors are directly infected by SARS-CoV-2: Implications for emerging erythropoiesis in severe COVID-19 patients Authors (11)Hector Huerga EncaboWilliam GreyManuel Garcia Albornoz Henry WoodRachel Ulferts Iker Valle Aramburu Austin G Kulasekararaj Ghulam MuftiVenizelos PapayannopoulosRupert BealeDominique Bonnet Stem Cell Reports Published 9 March 2021 Crick labs/ facilitiesVenizelos PapayannopoulosDominique BonnetRupert BealeFlow CytometryFull details
SARS-CoV-2 detection by a clinical diagnostic RT-LAMP assay Authors (40)Michael BuckEnzo PoirierAna Matos Cardoso Da SilvaBruno Frederico J CantonSam Barrell[...]Charles SwantonSamra TurajlicMary WuCaetano Reis e Sousa The Crick COVID-19 Consortium Wellcome Open Research Published 21 May 2021 Crick labs/ facilitiesSamra TurajlicCharles SwantonCaetano Reis e SousaGeorge KassiotisSonia GandhiRupert BealeMetabolomicsHigh Throughput ScreeningGenetic Modification ServiceBiological Research FacilityAdvanced SequencingStructural BiologyScientific computingFull details
Genetic mechanisms of critical illness in Covid-19 Authors (72) Erola Pairo-Castineira Sara Clohisey Lucija Klaric Andrew D Bretherick Konrad Rawlik Dorota Pasko[...] Malcolm G Semple Andrew Law Veronique Vitart James F Wilson J Kenneth Baillie Nature Published 4 March 2021 Crick labsRupert BealeFull details
Preexisting and de novo humoral immunity to SARS-CoV-2 in humans Authors (47)Kevin NgNikhil Faulkner Georgina H CornishAnnachiara Rosa Ruth HarveySaira Hussain[...]Steve Gamblin Laura E MccoyPeter Cherepanov Eleni NastouliGeorge Kassiotis Science Published 11 December 2020 Crick labs/ facilitiesCharles SwantonGitta StockingerNicola LewisGeorge KassiotisSonia GandhiSteve GamblinPeter Cherepanov Rupert BealeWorldwide Influenza CentreStructural BiologyFlow CytometryHigh Throughput ScreeningCell ServicesFull details
Scientific consensus on the COVID-19 pandemic: we need to act now Authors (31) Nisreen A Alwan Rochelle Ann Burgess Simon AshworthRupert Beale Nahid Bhadelia Debby Bogaert[...] Devi SridharCharles Swanton Rochelle P Walensky Gavin Yamey Hisham Ziauddeen Lancet Published 31 October 2020 Crick labsCharles SwantonRupert BealeFull details