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Breadcrumb Sergi Garcia Manyes Garcia Manyes lab Single Molecule Mechanobiology Laboratory : Publications Lab contentLab contentIn this section Overview Vacancies Publications Publications Displaying 1 - 20 of 31Last updated : 18 April 2024 03:54 Single-molecule magnetic tweezers to probe the equilibrium dynamics of individual proteins at physiologically relevant forces and timescales Authors (3) Rafael Tapia-Rojo Marc MoraSergi Garcia-Manyes Nature Protocols Published 11 March 2024 Crick labsSergi Garcia-ManyesFull details Acinar-ductal cell rearrangement drives branching morphogenesis of the murine pancreas in an IGF/PI3K-dependent manner Authors (7) Jean-Francois Darrigrand Anna Salowka Alejo Torres-Cano Rafael Tapia-Rojo Tong ZhuSergi Garcia-Manyes Francesca M Spagnoli Developmental Cell Published 5 February 2024 Crick labsSergi Garcia-ManyesFull details Unfolding and refolding proteins using single-molecule AFM Authors (3) Marc Mora Rafael Tapia-RojoSergi Garcia-Manyes Methods in Molecular Biology Crick labsSergi Garcia-ManyesFull details Myc-dependent dedifferentiation of Gata6+ epidermal cells resembles reversal of terminal differentiation Authors (13) Miguel Bernabé-Rubio Shahnawaz Ali Priyanka G Bhosale Georgina Goss Seyedeh Atefeh Mobasseri Rafael Tapia-Rojo[...] Matteo Battilocchi Inês M Tomás Clarisse GanierSergi Garcia-Manyes Fiona M Watt Nature Cell Biology Published 1 October 2023 Crick labsSergi Garcia-ManyesFull details Enzyme-less nanopore detection of post-translational modifications within long polypeptides Authors (7) Pablo Martin-Baniandres Wei-Hsuan Lan Stephanie Board Mercedes Romero-RuizSergi Garcia-Manyes Yujia Qing Hagan Bayley Nature Nanotechnology Published 1 November 2023 Crick labsSergi Garcia-ManyesFull details Allosteric activation of vinculin by talin Authors (12) Florian Franz Rafael Tapia-Rojo Sabina Winograd-Katz Rajaa Boujemaa-Paterski Wenhong Li Tamar Unger[...] Camilo Aponte-SantamariaSergi Garcia-Manyes Ohad Medalia Benjamin Geiger Frauke Gräter Nature Communications Published 18 July 2023 Crick labsSergi Garcia-ManyesFull details Enhanced statistical sampling reveals microscopic complexity in the talin mechanosensor folding energy landscape Authors (7) Rafael Tapia-Rojo Marc Mora Stephanie BoardJane Walker Rajaa Boujemaa-Paterski Ohad MedaliaSergi Garcia-Manyes Nature Physics Published 1 January 2023 Crick labsSergi Garcia-ManyesFull details The role of single-protein elasticity in mechanobiology Authors (2) Amy EM BeedleSergi Garcia-Manyes Nature Reviews Materials Published 1 January 2023 Crick labsSergi Garcia-ManyesFull details Understanding the role of mechanics in nucleocytoplasmic transport Authors (4) Ion Andreu Ignasi Granero-MoyaSergi Garcia-Manyes Pere Roca-Cusachs APL Bioengineering Published 29 June 2022 Crick labsSergi Garcia-ManyesFull details A single-molecule strategy to capture non-native intramolecular and intermolecular protein disulfide bridges Authors (6) Marc Mora Stephanie Board Olivier Languin-CattoënLaura Masino Guillaume StirnemannSergi Garcia-Manyes Nano Letters Published 25 May 2022 Crick labs/ facilitiesSergi Garcia-ManyesStructural BiologyFull details The ESCRT machinery counteracts Nesprin-2G-mediated mechanical forces during nuclear envelope repair Authors (12) Samuel S Wallis Leandro N Ventimiglia Evita Otigbah Elvira Infante Miguel Angel Cuesta-Geijo Gururaj Rao Kidiyoor[...] Roland A Fleck Marco FoianiSergi Garcia-Manyes Juan Martin-Serrano Monica Agromayor Developmental Cell Published 6 December 2021 Crick labsSergi Garcia-ManyesFull details Molecular fluctuations as a ruler of force-induced protein conformations Authors (6) Andrew Stannard Marc Mora Amy EM Beedle Marta Castro-López Stephanie BoardSergi Garcia-Manyes Nano Letters Published 14 April 2021 Crick labsSergi Garcia-ManyesFull details Protein nanomechanics: The power of stretching Authors (2) Marc MoraSergi Garcia-Manyes Europhysics News Published 1 September 2020 Crick labsSergi Garcia-ManyesFull details The nanomechanics of individual proteins Authors (3) Marc Mora Andrew StannardSergi Garcia-Manyes Chemical Society Reviews Published 7 October 2020 Crick labsSergi Garcia-ManyesFull details The mechanical stability of proteins regulates their translocation rate into the cell nucleus Authors (14) Elvira Infante Andrew Stannard Stephanie J Board Palma Rico-Lastres Elena Rostkova Amy EM Beedle[...] Fani Panagaki Vinoth Sundar Rajan Catherine Shanahan Pere Roca-CusachsSergi Garcia-Manyes Nature Physics Published 1 September 2019 Crick labsSergi Garcia-ManyesFull details Patterning of human epidermal stem cells on undulating elastomer substrates reflects differences in cell stiffness Authors (7) Seyedeh Atefeh Mobasseri Sebastiaan Zijl Vasiliki Salameti Gernot Walko Andrew StannardSergi Garcia-Manyes Fiona M Watt Acta Biomaterialia Published 15 March 2019 Crick labsSergi Garcia-ManyesFull details Controlling anomalous diffusion in lipid membranes Authors (6) Helena LE Coker Matthew R Cheetham Daniel R Kattnig Yong J WangSergi Garcia-Manyes Mark I Wallace Biophysics Journal Published 19 March 2019 Crick labsSergi Garcia-ManyesFull details Forcing the reversibility of a mechanochemical reaction Authors (6) Amy EM Beedle Marc MoraColin DavisBram Snijders Guillaume StirnemannSergi Garcia-Manyes Nature Communications Published 8 August 2018 Crick labs/ facilitiesSergi Garcia-ManyesProteomicsFull details DNA binding induces a nanomechanical switch in the RRM1 domain of TDP-43 Authors (7) Yong Jian Wang Palma Rico-Lastres Ainhoa Lezamiz Marc Mora Carles Solsona Guillaume StirnemannSergi Garcia-Manyes Journal of Physical Chemistry Letters Published 19 July 2018 Crick labsSergi Garcia-ManyesFull details The force-dependent mechanism of DnaK-mediated mechanical folding Authors (4) Judit Perales-Calvo David Giganti Guillaume StirnemannSergi Garcia-Manyes Science advances Published 2 February 2018 Crick labsSergi Garcia-ManyesFull details Pagination Current 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Single-molecule magnetic tweezers to probe the equilibrium dynamics of individual proteins at physiologically relevant forces and timescales Authors (3) Rafael Tapia-Rojo Marc MoraSergi Garcia-Manyes Nature Protocols Published 11 March 2024 Crick labsSergi Garcia-ManyesFull details
Acinar-ductal cell rearrangement drives branching morphogenesis of the murine pancreas in an IGF/PI3K-dependent manner Authors (7) Jean-Francois Darrigrand Anna Salowka Alejo Torres-Cano Rafael Tapia-Rojo Tong ZhuSergi Garcia-Manyes Francesca M Spagnoli Developmental Cell Published 5 February 2024 Crick labsSergi Garcia-ManyesFull details
Unfolding and refolding proteins using single-molecule AFM Authors (3) Marc Mora Rafael Tapia-RojoSergi Garcia-Manyes Methods in Molecular Biology Crick labsSergi Garcia-ManyesFull details
Myc-dependent dedifferentiation of Gata6+ epidermal cells resembles reversal of terminal differentiation Authors (13) Miguel Bernabé-Rubio Shahnawaz Ali Priyanka G Bhosale Georgina Goss Seyedeh Atefeh Mobasseri Rafael Tapia-Rojo[...] Matteo Battilocchi Inês M Tomás Clarisse GanierSergi Garcia-Manyes Fiona M Watt Nature Cell Biology Published 1 October 2023 Crick labsSergi Garcia-ManyesFull details
Enzyme-less nanopore detection of post-translational modifications within long polypeptides Authors (7) Pablo Martin-Baniandres Wei-Hsuan Lan Stephanie Board Mercedes Romero-RuizSergi Garcia-Manyes Yujia Qing Hagan Bayley Nature Nanotechnology Published 1 November 2023 Crick labsSergi Garcia-ManyesFull details
Allosteric activation of vinculin by talin Authors (12) Florian Franz Rafael Tapia-Rojo Sabina Winograd-Katz Rajaa Boujemaa-Paterski Wenhong Li Tamar Unger[...] Camilo Aponte-SantamariaSergi Garcia-Manyes Ohad Medalia Benjamin Geiger Frauke Gräter Nature Communications Published 18 July 2023 Crick labsSergi Garcia-ManyesFull details
Enhanced statistical sampling reveals microscopic complexity in the talin mechanosensor folding energy landscape Authors (7) Rafael Tapia-Rojo Marc Mora Stephanie BoardJane Walker Rajaa Boujemaa-Paterski Ohad MedaliaSergi Garcia-Manyes Nature Physics Published 1 January 2023 Crick labsSergi Garcia-ManyesFull details
The role of single-protein elasticity in mechanobiology Authors (2) Amy EM BeedleSergi Garcia-Manyes Nature Reviews Materials Published 1 January 2023 Crick labsSergi Garcia-ManyesFull details
Understanding the role of mechanics in nucleocytoplasmic transport Authors (4) Ion Andreu Ignasi Granero-MoyaSergi Garcia-Manyes Pere Roca-Cusachs APL Bioengineering Published 29 June 2022 Crick labsSergi Garcia-ManyesFull details
A single-molecule strategy to capture non-native intramolecular and intermolecular protein disulfide bridges Authors (6) Marc Mora Stephanie Board Olivier Languin-CattoënLaura Masino Guillaume StirnemannSergi Garcia-Manyes Nano Letters Published 25 May 2022 Crick labs/ facilitiesSergi Garcia-ManyesStructural BiologyFull details
The ESCRT machinery counteracts Nesprin-2G-mediated mechanical forces during nuclear envelope repair Authors (12) Samuel S Wallis Leandro N Ventimiglia Evita Otigbah Elvira Infante Miguel Angel Cuesta-Geijo Gururaj Rao Kidiyoor[...] Roland A Fleck Marco FoianiSergi Garcia-Manyes Juan Martin-Serrano Monica Agromayor Developmental Cell Published 6 December 2021 Crick labsSergi Garcia-ManyesFull details
Molecular fluctuations as a ruler of force-induced protein conformations Authors (6) Andrew Stannard Marc Mora Amy EM Beedle Marta Castro-López Stephanie BoardSergi Garcia-Manyes Nano Letters Published 14 April 2021 Crick labsSergi Garcia-ManyesFull details
Protein nanomechanics: The power of stretching Authors (2) Marc MoraSergi Garcia-Manyes Europhysics News Published 1 September 2020 Crick labsSergi Garcia-ManyesFull details
The nanomechanics of individual proteins Authors (3) Marc Mora Andrew StannardSergi Garcia-Manyes Chemical Society Reviews Published 7 October 2020 Crick labsSergi Garcia-ManyesFull details
The mechanical stability of proteins regulates their translocation rate into the cell nucleus Authors (14) Elvira Infante Andrew Stannard Stephanie J Board Palma Rico-Lastres Elena Rostkova Amy EM Beedle[...] Fani Panagaki Vinoth Sundar Rajan Catherine Shanahan Pere Roca-CusachsSergi Garcia-Manyes Nature Physics Published 1 September 2019 Crick labsSergi Garcia-ManyesFull details
Patterning of human epidermal stem cells on undulating elastomer substrates reflects differences in cell stiffness Authors (7) Seyedeh Atefeh Mobasseri Sebastiaan Zijl Vasiliki Salameti Gernot Walko Andrew StannardSergi Garcia-Manyes Fiona M Watt Acta Biomaterialia Published 15 March 2019 Crick labsSergi Garcia-ManyesFull details
Controlling anomalous diffusion in lipid membranes Authors (6) Helena LE Coker Matthew R Cheetham Daniel R Kattnig Yong J WangSergi Garcia-Manyes Mark I Wallace Biophysics Journal Published 19 March 2019 Crick labsSergi Garcia-ManyesFull details
Forcing the reversibility of a mechanochemical reaction Authors (6) Amy EM Beedle Marc MoraColin DavisBram Snijders Guillaume StirnemannSergi Garcia-Manyes Nature Communications Published 8 August 2018 Crick labs/ facilitiesSergi Garcia-ManyesProteomicsFull details
DNA binding induces a nanomechanical switch in the RRM1 domain of TDP-43 Authors (7) Yong Jian Wang Palma Rico-Lastres Ainhoa Lezamiz Marc Mora Carles Solsona Guillaume StirnemannSergi Garcia-Manyes Journal of Physical Chemistry Letters Published 19 July 2018 Crick labsSergi Garcia-ManyesFull details
The force-dependent mechanism of DnaK-mediated mechanical folding Authors (4) Judit Perales-Calvo David Giganti Guillaume StirnemannSergi Garcia-Manyes Science advances Published 2 February 2018 Crick labsSergi Garcia-ManyesFull details
