Publications

Loss of NDR1/2 kinases impairs endomembrane trafficking and autophagy leading to neurodegeneration

Authors (14)

Flavia Roşianu
Simeon Mihaylov
Noreen Eder
Antonie Martiniuc
Suzanne Claxton
Helen R Flynn
[...]
Mark Skehel
Bram Snijders
Matthias Krause
Sharon Tooze
Sila Ultanir

Life Science Alliance

Published 1 February 2023

Crick labs/ facilities

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ATG9A and ATG2A form a heteromeric complex essential for autophagosome formation

Authors (15)

Molecular Cell

Published 17 November 2022

Crick labs/ facilities

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Unraveling membrane properties at the organelle-level with LipidDyn

Authors (12)

Simone Scrima
Matteo Tiberti
Alessia Campo
Elisabeth Corcelle-Termeau
Delphine Judith
Mads Møller Foged
[...]
Sharon Tooze
Marja Jäättelä
Kenji Maeda
Matteo Lambrughi
Elena Papaleo

Computational and Structural Biotechnology Journal

Published 11 July 2022

Crick labs

Sharon Tooze

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Autophagy tunes chondrocyte differentiation and joint developmental precision in zebrafish

Authors (5)

Joanna J Moss
Martina Wirth
Sharon Tooze
Chrissy L Hammond
Jon D Lane

Autophagy Reports

Published 3 May 2022

Crick labs

Sharon Tooze

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Quality control: Maintaining molecular order and preventing cellular chaos

Authors (12)

Sonya Neal
Fumiaki Ohtake
Ana Maria Cuervo
Ramanujan S Hegde
Ursula Jakob
Michael Lazarou
[...]
Zhijian J Chen
Sharon Tooze
James E Haber
Kylie J Walters
F Ulrich Hartl

Mol Cell

Published 21 April 2022

Crick labs

Sharon Tooze

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Autophagy coordinates chondrocyte development and early joint formation in zebrafish

Authors (5)

Joanna J Moss
Martina Wirth
Sharon Tooze
Jon D Lane
Chrissy L Hammond

The FASEB Journal

Published 1 November 2021

Crick labs/ facilities

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The ingenious ULKs: expanding the repertoire of the ULK complex with phosphoproteomics

Authors (2)

Autophagy

Published 1 December 2021

Crick labs

Sharon Tooze

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Homozygous missense WIPI2 variants cause a congenital disorder of autophagy with neurodevelopmental impairments of variable clinical severity and disease course

Authors (15)

Reza Maroofian
Andrea Gubas
Rauan Kaiyrzhanov
Marcello Scala
Khalid Hundallah
Mariasavina Severino
[...]
Fazal Rahim
Henry Houlden
Sharon Tooze
Norah S Alsaleh
Maha S Zaki

Brain Communications

Published 3 September 2021

Crick labs

Sharon Tooze

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Autophagy in major human diseases

Authors (59)

Daniel J Klionsky
Giulia Petroni
Ravi K Amaravadi
Eric H Baehrecke
Andrea Ballabio
Patricia Boya
[...]
Junying Yuan
Zhenyu Yue
Qing Zhong
Lorenzo Galluzzi
Federico Pietrocola

The EMBO Journal

Published 1 October 2021

Crick labs

Sharon Tooze

Full details

Autophagy modulates endothelial junctions to restrain neutrophil diapedesis during inflammation

Authors (25)

Natalia Reglero-Real
Lorena Pérez-Gutiérrez
Azumi Yoshimura
Loïc Rolas
José Garrido-Mesa
Anna Barkaway
[...]
Thomas D Nightingale
Lucy Collinson
Mauro Perretti
Ezra Aksoy
Sussan Nourshargh

Immunity

Published 14 September 2021

Crick labs/ facilities

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SAMM50 is a receptor for basal piecemeal mitophagy and acts with SQSTM1/p62 in OXPHOS-induced mitophagy

Authors (5)

Yakubu Princely Abudu
Stephane Mouilleron
Sharon Tooze
Trond Lamark
Terje Johansen

Autophagy

Published 18 July 2021

Crick labs/ facilities

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ATG9A protects the plasma membrane from programmed and incidental permeabilization

Authors (24)

Aurore Claude-Taupin
Jingyue Jia
Zambarlal Bhujabal
Meriem Garfa-Traoré
Suresh Kumar
Gustavo Peixoto Duarte da Silva
[...]
Sharon Tooze
Muriel C Mari
Terje Johansen
Fulvio Reggiori
Vojo Deretic

Nature Cell Biology

Published 1 August 2021

Crick labs

Sharon Tooze

Full details

Phosphoproteomic identification of ULK substrates reveals VPS15-dependent ULK/VPS34 interplay in the regulation of autophagy

Authors (13)

Thomas Mercer
Yohei Ohashi
Stefan Boeing
Harold Jefferies
Stefano De Tito
Helen Flynn
[...]
Martina Wirth
David Frith
Bram Snijders
Roger Lee Williams
Sharon Tooze

The EMBO Journal

Published 15 July 2021

Crick labs/ facilities

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SAMM50 acts with p62 in piecemeal basal- and OXPHOS-induced mitophagy of SAM and MICOS components

Authors (16)

Yakubu Princely Abudu
Birendra Kumar Shrestha
Wenxin Zhang
Anthimi Palara
Hanne Britt Brenne
Kenneth Bowitz Larsen
[...]
Christian Behrends
Sharon Tooze
Stephane Mouilleron
Trond Lamark
Terje Johansen

Journal of Cell Biology

Published 2 August 2021

Crick labs/ facilities

Full details

ATG4: More than a protease?

Authors (2)

Robin Ketteler
Sharon Tooze

Trends in Cell Biology

Published 1 July 2021

Crick labs

Sharon Tooze

Full details

Membrane supply and remodeling during autophagosome biogenesis

Authors (3)

Rubén Gómez-Sánchez
Sharon Tooze
Fulvio Reggiori

Current Opinion in Cell Biology

Published 1 August 2021

Crick labs

Sharon Tooze

Full details

Phosphorylation of the LIR domain of SCOC modulates ATG8 binding affinity and specificity

Authors (15)

Martina Wirth
Stephane Mouilleron
Wenxin Zhang
Eva Sjottem
Yakubu Princely Abudu
Ashish Jain
[...]
Rebecca Lee
Dhira Joshi
Nicola O'Reilly
Terje Johansen
Sharon Tooze

Journal of Molecular Biology

Published 25 June 2021

Crick labs/ facilities

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Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)

Authors (2929)

Daniel J Klionsky
Amal Kamal Abdel-Aziz
Sara Abdelfatah
Mahmoud Abdellatif
Asghar Abdoli
Steffen Abel
[...]
Shigeru Oshima
Yueguang Rong
Judith C Sluimer
Christina L Stallings
Chun-Kit Tong

Autophagy

Published 1 January 2021

Crick labs

Full details

The phosphatidylinositol 3-phosphate binding protein SNX4 controls ATG9A recycling and autophagy

Authors (4)

Anthony Ravussin
Andreas Brech
Sharon Tooze
Harald Stenmark

Journal of Cell Science

Published 10 February 2021

Crick labs

Sharon Tooze

Full details

A new direction for Traffic

Authors (10)

Michael S Marks
Robert G Parton
Trina A Schroer
Sharon Tooze
Frances M Brodsky
Mark Marsh
Sandra L Schmid
Gillian M Griffiths
Tom H Stevens
Gerrit van Meer

Traffic

Published 1 December 2020

Crick labs

Sharon Tooze

Full details

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Publications

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Loss of NDR1/2 kinases impairs endomembrane trafficking and autophagy leading to neurodegeneration

ATG9A and ATG2A form a heteromeric complex essential for autophagosome formation

Unraveling membrane properties at the organelle-level with LipidDyn

Autophagy tunes chondrocyte differentiation and joint developmental precision in zebrafish

Quality control: Maintaining molecular order and preventing cellular chaos

Autophagy coordinates chondrocyte development and early joint formation in zebrafish

The ingenious ULKs: expanding the repertoire of the ULK complex with phosphoproteomics

Homozygous missense WIPI2 variants cause a congenital disorder of autophagy with neurodevelopmental impairments of variable clinical severity and disease course

Autophagy in major human diseases

Autophagy modulates endothelial junctions to restrain neutrophil diapedesis during inflammation

SAMM50 is a receptor for basal piecemeal mitophagy and acts with SQSTM1/p62 in OXPHOS-induced mitophagy

ATG9A protects the plasma membrane from programmed and incidental permeabilization

Phosphoproteomic identification of ULK substrates reveals VPS15-dependent ULK/VPS34 interplay in the regulation of autophagy

SAMM50 acts with p62 in piecemeal basal- and OXPHOS-induced mitophagy of SAM and MICOS components

ATG4: More than a protease?

Membrane supply and remodeling during autophagosome biogenesis

Phosphorylation of the LIR domain of SCOC modulates ATG8 binding affinity and specificity

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)

The phosphatidylinositol 3-phosphate binding protein SNX4 controls ATG9A recycling and autophagy

A new direction for Traffic

The Francis Crick Institute is a unique partnership between

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Vacancies

Cut + Paste exhibition

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About us

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Research topics

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