Publications

First person – Alex van Vliet

Authors (1)

Alexander Van Vliet

Journal of Cell Science

Published 15 February 2024

Crick labs

Sharon Tooze

Full details

Prion protein conversion at two distinct cellular sites precedes fibrillisation

Authors (6)

Juan Manuel Ribes
Mitali P Patel
Hazim A Halim
Antonio Berretta
Sharon Tooze
Peter-Christian Klöhn

Nature Communications

Published 15 December 2023

Crick labs

Sharon Tooze

Full details

ATG9B is a tissue-specific homotrimeric lipid scramblase that can compensate for ATG9A

Authors (8)

Autophagy

Published 1 March 2024

Crick labs/ facilities

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ATG3 proteins possess a unique amphipathic α-helix essential for the Atg8/LC3 lipidation reaction

Authors (4)

Taki Nishimura
Gianmarco Lazzeri
Sharon Tooze
Roberto Covino

Autophagy

Published 1 January 2024

Crick labs

Sharon Tooze

Full details

Unique amphipathic α helix drives membrane insertion and enzymatic activity of ATG3

Authors (5)

Taki Nishimura
Gianmarco Lazzeri
Noboru Mizushima
Roberto Covino
Sharon Tooze

Science advances

Published 23 June 2023

Crick labs/ facilities

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Imaging ATG9A, a multi-spanning membrane protein

Authors (4)

Journal of Visualized Experiments

Published 16 June 2023

Crick labs/ facilities

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Autophagosome membrane expansion is mediated by the N-terminus and cis-membrane association of human ATG8s

Authors (9)

Wenxin Zhang
Taki Nishimura
Deepanshi Gahlot
Chieko Saito
Colin Davis
Harold Jefferies
Anne Schreiber
Lipi Thukral
Sharon Tooze

eLife

Published 8 June 2023

Crick labs/ facilities

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Membrane association of the ATG8 conjugation machinery emerges as a key regulatory feature for autophagosome biogenesis

Authors (7)

Sharon Tooze
Wenxin Zhang
Gianmarco Lazzeri
Deepanshi Gahlot
Lipi Thukral
Roberto Covino
Taki Nishimura

FEBS Letters

Published 1 January 2024

Crick labs

Sharon Tooze

Full details

Atg8 family proteins, LIR/AIM motifs and other interaction modes

Authors (17)

Vladimir V Rogov
Ioannis P Nezis
Panagiotis Tsapras
Hong Zhang
Yasin Dagdas
Nobuo N Noda
[...]
Zvulun Elazar
Sharon Tooze
Ivan Dikic
Trond Lamark
Terje Johansen

Autophagy Reports

Published 31 December 2023

Crick labs/ facilities

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Loss of NDR1/2 kinases impairs endomembrane trafficking and autophagy leading to neurodegeneration

Authors (14)

Flavia Roşianu
Simeon Mihaylov
Noreen Eder
Antonie Martiniuc
Suzanne Claxton
Helen R Flynn
[...]
Mark Skehel
Bram Snijders
Matthias Krause
Sharon Tooze
Sila Ultanir

Life Science Alliance

Published 1 February 2023

Crick labs/ facilities

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ATG9A and ATG2A form a heteromeric complex essential for autophagosome formation

Authors (15)

Molecular Cell

Published 17 November 2022

Crick labs/ facilities

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Unraveling membrane properties at the organelle-level with LipidDyn

Authors (12)

Simone Scrima
Matteo Tiberti
Alessia Campo
Elisabeth Corcelle-Termeau
Delphine Judith
Mads Møller Foged
[...]
Sharon Tooze
Marja Jäättelä
Kenji Maeda
Matteo Lambrughi
Elena Papaleo

Computational and Structural Biotechnology Journal

Published 11 July 2022

Crick labs

Sharon Tooze

Full details

Autophagy tunes chondrocyte differentiation and joint developmental precision in zebrafish

Authors (5)

Joanna J Moss
Martina Wirth
Sharon Tooze
Chrissy L Hammond
Jon D Lane

Autophagy Reports

Published 3 May 2022

Crick labs

Sharon Tooze

Full details

Quality control: Maintaining molecular order and preventing cellular chaos

Authors (12)

Sonya Neal
Fumiaki Ohtake
Ana Maria Cuervo
Ramanujan S Hegde
Ursula Jakob
Michael Lazarou
[...]
Zhijian J Chen
Sharon Tooze
James E Haber
Kylie J Walters
F Ulrich Hartl

Mol Cell

Published 21 April 2022

Crick labs

Sharon Tooze

Full details

Autophagy coordinates chondrocyte development and early joint formation in zebrafish

Authors (5)

Joanna J Moss
Martina Wirth
Sharon Tooze
Jon D Lane
Chrissy L Hammond

The FASEB Journal

Published 1 November 2021

Crick labs/ facilities

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The ingenious ULKs: expanding the repertoire of the ULK complex with phosphoproteomics

Authors (2)

Autophagy

Published 1 December 2021

Crick labs

Sharon Tooze

Full details

Homozygous missense WIPI2 variants cause a congenital disorder of autophagy with neurodevelopmental impairments of variable clinical severity and disease course

Authors (15)

Reza Maroofian
Andrea Gubas
Rauan Kaiyrzhanov
Marcello Scala
Khalid Hundallah
Mariasavina Severino
[...]
Fazal Rahim
Henry Houlden
Sharon Tooze
Norah S Alsaleh
Maha S Zaki

Brain Communications

Published 3 September 2021

Crick labs

Sharon Tooze

Full details

Autophagy in major human diseases

Authors (59)

Daniel J Klionsky
Giulia Petroni
Ravi K Amaravadi
Eric H Baehrecke
Andrea Ballabio
Patricia Boya
[...]
Junying Yuan
Zhenyu Yue
Qing Zhong
Lorenzo Galluzzi
Federico Pietrocola

The EMBO Journal

Published 1 October 2021

Crick labs

Sharon Tooze

Full details

Autophagy modulates endothelial junctions to restrain neutrophil diapedesis during inflammation

Authors (25)

Natalia Reglero-Real
Lorena Pérez-Gutiérrez
Azumi Yoshimura
Loïc Rolas
José Garrido-Mesa
Anna Barkaway
[...]
Thomas D Nightingale
Lucy Collinson
Mauro Perretti
Ezra Aksoy
Sussan Nourshargh

Immunity

Published 14 September 2021

Crick labs/ facilities

Full details

SAMM50 is a receptor for basal piecemeal mitophagy and acts with SQSTM1/p62 in OXPHOS-induced mitophagy

Authors (5)

Yakubu Princely Abudu
Stephane Mouilleron
Sharon Tooze
Trond Lamark
Terje Johansen

Autophagy

Published 18 July 2021

Crick labs/ facilities

Full details

Research case studies

Postdoctoral clinical fellows

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: Publications

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Journal

First person – Alex van Vliet

Prion protein conversion at two distinct cellular sites precedes fibrillisation

ATG9B is a tissue-specific homotrimeric lipid scramblase that can compensate for ATG9A

ATG3 proteins possess a unique amphipathic α-helix essential for the Atg8/LC3 lipidation reaction

Unique amphipathic α helix drives membrane insertion and enzymatic activity of ATG3

Imaging ATG9A, a multi-spanning membrane protein

Autophagosome membrane expansion is mediated by the N-terminus and cis-membrane association of human ATG8s

Membrane association of the ATG8 conjugation machinery emerges as a key regulatory feature for autophagosome biogenesis

Atg8 family proteins, LIR/AIM motifs and other interaction modes

Loss of NDR1/2 kinases impairs endomembrane trafficking and autophagy leading to neurodegeneration

ATG9A and ATG2A form a heteromeric complex essential for autophagosome formation

Unraveling membrane properties at the organelle-level with LipidDyn

Autophagy tunes chondrocyte differentiation and joint developmental precision in zebrafish

Quality control: Maintaining molecular order and preventing cellular chaos

Autophagy coordinates chondrocyte development and early joint formation in zebrafish

The ingenious ULKs: expanding the repertoire of the ULK complex with phosphoproteomics

Homozygous missense WIPI2 variants cause a congenital disorder of autophagy with neurodevelopmental impairments of variable clinical severity and disease course

Autophagy in major human diseases

Autophagy modulates endothelial junctions to restrain neutrophil diapedesis during inflammation

SAMM50 is a receptor for basal piecemeal mitophagy and acts with SQSTM1/p62 in OXPHOS-induced mitophagy

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